1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with genistein in 113 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 85 (75.22) | 18.2507 |
| 2000's | 26 (23.01) | 29.6817 |
| 2010's | 2 (1.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikeo, K; Koh, E; Kwaan, HC; Takahashi, K | 1 |
| Akimaru, K; Edashige, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Fisher, J; Hankins, WD; Isaacs, MA; Spivak, JL | 1 |
| Akimaru, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Endo, Y; Furuya, S; Matsui, Y; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Endo, Y; Furuya, S; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Chakkalath, HR; Jung, LK; Roy, AK | 1 |
| Akimaru, K; Inoue, M; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Fujita, Y; Kataoka, S; Kobuchi, H; Tanimura, M; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Colamonici, OR; Platanias, LC | 1 |
| Katabami, T; Nemoto, K; Ogura, M; Ohira, K; Okano, K; Shimizu, M; Suzuki, S; Tsukamoto, T; Yamada, Y; Yano, Y | 1 |
| Chrest, FJ; Gabrielson, EW; Lin, Y | 1 |
| Arakaki, N; Daikuhara, Y; Hara, H; Hirono, S; Ishii, T; Kawakami, S; Tsubouchi, H | 1 |
| Chow, AW; See, RH | 1 |
| Honma, Y; Hozumi, M; Kajigaya, S; Kasukabe, T; Miura, Y; Okabe-Kado, J; Suda, T | 1 |
| Nakajima, K; Wall, R | 1 |
| Eckert, D; Mufson, RA; Szabo, J | 1 |
| Toi, M; Umezaza, K | 1 |
| Hasegawa-Sasaki, H; Sasaki, T; Yamashita, Y | 1 |
| Grove, DS; Mastro, AM | 1 |
| Bhalla, RC; Chiang, JJ; Loeber, CP; Potts, JD; Runyan, RB; Sharma, RV | 1 |
| Fukuzawa, K; Inoue, I; Minami, K | 1 |
| Faris, M; Fu, SM; Gaskin, F; Parsons, JT | 1 |
| Amar, S; Champagne, C; Shapira, L; Takashiba, S; Van Dyke, TE | 1 |
| Walters, JD; Wojcik, MS | 1 |
| Blystone, SD; Brown, EJ; Graham, IL; Lindberg, FP | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Huang, CK; Liang, L | 1 |
| Borosky, SA; Boxer, PA; Coughenour, LL; Hajimohammadreza, I; Marcoux, FW; Probert, AW; Wang, KK | 1 |
| Kagaya, A; Kugaya, A; Motohashi, N; Uchitomi, Y; Yamawaki, S | 1 |
| Abel, K; Azad, N; Emanuele, NV; La Paglia, N; Mohagheghpour, N | 1 |
| Fusamoto, H; Hayashi, N; Horimoto, M; Ito, T; Kamada, T; Kaneko, A; Sasaki, Y; Tanaka, Y | 1 |
| Abraham, RT; Lutz, MP; Miller, LJ; Sutor, SL | 1 |
| Evans, SW; Thompson, D; Whicher, JT | 1 |
| Cazaux, CA; Cremaschi, GA; Gorelik, G; Sterin-Borda, L | 1 |
| Aoyagi, T; Eguchi, K; Kawabe, Y; Migita, K; Nagataki, S; Tsukada, T | 1 |
| Fujita, S; Horiuchi, T; Watanabe, I | 1 |
| Kitamura, T; Miyajima, A; Mufson, RA; Rao, P | 1 |
| Kondoh, S; Mue, S; Ohuchi, K; Tanabe, J; Watanabe, M | 1 |
| Gordon, PB; Holen, I; Seglen, PO | 1 |
| Fusamoto, H; Hayashi, N; Horimoto, M; Ito, T; Kamada, T; Kaneko, A; Kasahara, A; Sasaki, Y; Tanaka, Y | 1 |
| Kosaka, C; Masuda, J; Ogata, J; Sasaguri, T; Zen, K | 1 |
| Almazan, G; Radhakrishna, M | 1 |
| Butler, AP; Fischer, SM; Lee, WY; Locniskar, MF | 1 |
| Ruskoaho, H; Taskinen, P; Tóth, M | 1 |
| Combadière, C; el Benna, J; Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Goldstein, H; Kim, A | 1 |
| Kim, HD; Lim, RW; Park, DJ | 1 |
| Yang, YC; Yin, T | 1 |
| Bayat-Sarmadi, M; Houdebine, LM | 1 |
| Greenwel, P; Hu, W; Kohanski, RA; Ramirez, F | 1 |
| Duprè, S; Fontana, M; Kodama, H; Sagara, Y; Sugahara, K; Zhang, J | 1 |
| Breshnahan, BA; Kelefiotis, D; Lianos, EA; Stratidakis, I | 1 |
| Fuhrer, DK; Hamilton, J; Steussy, CN; Yang, L; Yang, YC | 1 |
| Koseki, N; Sato, H; Yoshizato, K | 1 |
| Isseroff, RR; Shi, B | 1 |
| Ahmad, MB; Devi, KU; Shivaji, S | 1 |
| Petersen, MM; Steadman, R; Williams, JD | 1 |
| Becker, E; Bershadsky, A; Chausovsky, A; Geiger, B; Lyubimova, A | 1 |
| Adachi, M; Imai, K; Minami, Y; Miyazaki, T; Reed, JC; Sekiya, M; Takayama, S; Taniguchi, T; Torigoe, T | 1 |
| Fujie, K; Handa, H; Nishihira, J; Sakamoto, W; Ueda, N; Yamamoto, S | 1 |
| Bäcker, A; Fandrey, J; Jelkmann, W; Kramer, HJ; Meyer-Lehnert, H; Vogel, V | 1 |
| Fabiani, R; Marchetti, C; Mastrandrea, V; Migliorati, G; Moraca, R; Morozzi, G; Nicoletti, I; Riccardi, C | 1 |
| Inagaki, M; Kagaya, A; Kugaya, A; Oyamada, T; Tawara, Y; Uchitomi, Y; Yamawaki, S; Zensho, H | 1 |
| Evans, DL; Jaso-Friedmann, L; Leary, JH | 1 |
| Imokawa, G; Kimura, M; Morisaki, N; Yada, Y | 1 |
| Crissman, HA; Sailer, BL; Steinkamp, JA; Valdez, JG | 1 |
| Jenab, S; Morris, PL | 1 |
| Hasebe, A; Sasaki, T; Shibata, K; Watanabe, T | 1 |
| Kodama, H; Sagara, Y; Sugahara, K; Yasuda, K; Zhang, J | 1 |
| Kandaswamy, V; Sen, S; Sil, P | 1 |
| Green, CB; Whalen, MM | 1 |
| Kodama, H; Kurashige, T; Masuoka, N; Ohta, J; Sagara, Y; Shimazaki, Y; Ubuka, T; Wakiguchi, H; Zhang, J | 1 |
| Bergelson, LD; Krifuks, O; Schlesinger, M | 1 |
| Almeida, CA; Goes, AM; Romano-Silva, MA | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
| Allshire, AP; Fuchsbauer, CM; Stapleton, MT | 1 |
| Hunzicker-Dunn, M; Lamm, ML; Rajagopalan-Gupta, RM | 1 |
| Gebert, CA; Park, SH; Waxman, DJ | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Fukuda, K; Ishida, H; Kodama, H; Koura, T; Miyoshi, S; Murata, M; Nakazawa, HK; Ogawa, S | 1 |
| Lee, SK; Stern, PH | 1 |
| Geertsma, MF; Nibbering, PH; Van Den Barselaar, MT; Van Furth, R; Zheng, L; Zomerdijk, TP | 1 |
| Isoherranen, K; Jansen, C; Punnonen, K; Uotila, P | 1 |
| Perkinton, MS; Sihra, TS; Williams, RJ | 1 |
| Cafferata, EG; Giordano, L; González-Guerrico, AM; Pivetta, OH; Santa-Coloma, TA | 1 |
| Anouar, Y; Castel, H; Cazin, L; Le Foll, F; Louiset, E; Vaudry, H | 1 |
| Goodman, SB; Schurman, DJ; Shida, J; Smith, RL; Trindade, MC | 1 |
| Dantin, F; Dubois, F; Mazière, C; Mazière, J; Santus, R | 1 |
| Ikewaki, N; Inoko, H; Inoue, H; Mori, N; Tamauchi, H; Yamada, A; Yamao, H | 1 |
| Garcia-Marin, LJ; Jensen, RT; Leyton, J; Moody, TW; Tapia, JA | 1 |
| Hojo, Y; Ikeda, U; Morishita, R; Okada, M; Shimada, K; Takahashi, M; Takizawa, T | 1 |
| Chen, H; Fetscher, C; Heusch, G; Michel, MC; Schäfers, RF; Wambach, G | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D | 1 |
| Colston, VL; Wheeler, TJ | 1 |
| Pyo, S; Rhee, DK; Um, SH | 1 |
| Fan, YP; Puri, RN; Rattan, S | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Cook, RC; Crowley, CM; Gin, SA; Keep, AM; Lee, CH; Van Breemen, C | 1 |
| Clark, CL; Martin, RJ; Robertson, AP; Trailovic, SM | 1 |
| Cui, WR; Li, A; Lin, JS; Wang, JL; Wu, BW; Wu, Y; Yuan, SY | 1 |
| Grinkevich, LN; Lisachev, PD; Merkulova, TI | 1 |
| Balabanova, L; Fedinec, AL; Leffler, CW; Parfenova, H; Sullivan, CD; Wang, X | 1 |
| Klink, M; Sulowska, Z; Tchorzewski, H | 1 |
| Aseichev, AV; Azizova, OA | 1 |
| Gemba, M; Kawai, Y; Kodawara, T; Kohda, Y | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Imai, H; Kitahara, J; Nakagawa, Y; Sakamoto, H; Tosaki, T | 1 |
| Li, DL; Li, YJ; Sun, WP; Xiao, FC; Zhang, LB; Zhou, SS; Zhou, YM | 1 |
| Hiwasa, T; Kumazawa, T; Sato, K; Suzuki, O; Takiguchi, M | 1 |
| Draheim, HJ; Lamodière, E; Moussaud, S; Savage, C | 1 |
| Pandey, AK; Sodhi, A | 1 |
| Satoh, N; Takahashi, K; Toyohira, Y; Yanagihara, N | 1 |
1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and genistein
| Article | Year |
|---|---|
Receptor associated phosphorylation following monoclonal antibody or synthetic peptide binding to nonspecific cytotoxic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Cytotoxicity, Immunologic; Genistein; Ictaluridae; Isoquinolines; Killer Cells, Natural; Molecular Sequence Data; Oxazolone; Peptides; Phosphorylation; Phosphoserine; Protein Kinase C; Quinolines; Serine; Sulfonamides; Tetradecanoylphorbol Acetate | 1998 |
112 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and genistein
| Article | Year |
|---|---|
Phosphorylation of a surface receptor bound urokinase-type plasminogen activator in a human metastatic carcinomatous cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Blotting, Western; Carcinoma; Cell Line; Cell Membrane; Genistein; Humans; Isoflavones; Isoquinolines; Kinetics; Neoplasm Metastasis; Phosphorus Radioisotopes; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Urokinase-Type Plasminogen Activator | 1992 |
Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cinnamates; Diglycerides; Genistein; Guinea Pigs; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Sulfides; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Erythropoiesis; Erythropoietin; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinases; Protein Tyrosine Phosphatases; Signal Transduction; Staurosporine; Vanadates; Zinc | 1992 |
Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Calcium; Dose-Response Relationship, Drug; Genistein; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Alkaloids; Animals; Diglycerides; Ethers, Cyclic; Exocytosis; Female; Genistein; Isoflavones; Isoquinolines; Male; Membrane Fusion; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Signal Transduction; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida | 1992 |
Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Chlortetracycline; Dibutyryl Cyclic GMP; Diglycerides; Ethers, Cyclic; Fluorescence; Genistein; Isoflavones; Isoquinolines; Male; Mice; Okadaic Acid; Peptide Fragments; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sperm Capacitation; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
CD7 augments T cell proliferation via the interleukin-2 autocrine pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Genistein; Humans; Interleukin-2; Isoflavones; Isoquinolines; Lymphocyte Activation; Mitogens; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; Up-Regulation | 1992 |
Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-alpha and granulocyte colony stimulating factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Blotting, Western; Cell Membrane; Cytosol; Genistein; Granulocyte Colony-Stimulating Factor; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 1992 |
Neutrophil priming by granulocyte colony stimulating factor and its modulation by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cinnamates; Genistein; Granulocyte Colony-Stimulating Factor; Humans; Isoflavones; Isoquinolines; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfides; Superoxides | 1992 |
Interferon alpha induces rapid tyrosine phosphorylation of the alpha subunit of its receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Dose-Response Relationship, Drug; Genistein; Humans; Interferon Type I; Isoflavones; Isoquinolines; Kinetics; Macromolecular Substances; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Interferon; Recombinant Proteins; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Intracellular signal transduction for interleukin-1 beta-induced endothelin production in human umbilical vein endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Endothelins; Endothelium, Vascular; Genistein; Humans; Indomethacin; Interleukin-1; Isoflavones; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; Signal Transduction; Sulfonamides; Umbilical Veins | 1992 |
Reversible G1 arrest of a human lung epithelial cell line by staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; G1 Phase; Genistein; Humans; Isoflavones; Isoquinolines; Phenols; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides | 1992 |
Effects of protein kinase inhibitors on the mitogenic activity of human hepatocyte growth factor on rat hepatocytes in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cells, Cultured; Genistein; Growth Substances; Hepatocyte Growth Factor; Isoflavones; Isoquinolines; Liver; Male; Mitogens; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides | 1992 |
Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bacterial Toxins; Cells, Cultured; Enterotoxins; Genistein; Humans; Interleukin-1; Isoflavones; Isoquinolines; Lipopolysaccharides; Monocytes; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staphylococcus aureus; Sulfonamides; Superantigens; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1992 |
Induction by some protein kinase inhibitors of differentiation of a mouse megakaryoblastic cell line established by coinfection with Abelson murine leukemia virus and recombinant SV40 retrovirus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Abelson murine leukemia virus; Acetylcholinesterase; Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Enzyme Induction; Gene Expression Regulation, Enzymologic; Genes, abl; Genistein; Isoflavones; Isoquinolines; Megakaryocytes; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphorylation; Piperazines; Protein Kinases; RNA, Messenger; Simian virus 40 | 1991 |
Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cycloheximide; DNA-Binding Proteins; Gene Expression Regulation; Genistein; Hybridomas; Immediate-Early Proteins; In Vitro Techniques; Interleukin-6; Isoflavones; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Tristetraprolin; Tyrosine | 1991 |
Human IL-3 induction of c-jun in normal monocytes is independent of tyrosine kinase and involves protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Enzyme Activation; Gene Expression Regulation; Genes, jun; Genistein; Humans; Interleukin-3; Isoflavones; Isoquinolines; Monocytes; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1992 |
[Inhibitors of growth factor functions, possible antineoplastic agents].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinomyces; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Genistein; Isoflavones; Isoquinolines; Mice; Phenols; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine | 1991 |
Suppression by staurosporine of Ca(2+)-mobilization triggered by ligation of antigen-specific receptors on t and B lymphocytes. An essential role of protein tyrosine kinase in the signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Bombesin; Calcium; Cell Line; Dinoprost; Genistein; Humans; Isoflavones; Isoquinolines; Piperazines; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; T-Lymphocytes; Type C Phospholipases; Vasopressins | 1991 |
Differential activation and inhibition of lymphocyte proliferation by modulators of protein kinase C: diacylglycerols, "rationally designed" activators and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cattle; Diglycerides; Down-Regulation; Enzyme Activation; Genistein; Indole Alkaloids; Isoflavones; Isoquinolines; Lymphocyte Activation; Piperazines; Protease Inhibitors; Protein Kinase C; Sphingosine; Sulfonamides; Type C Phospholipases | 1991 |
Signal transduction of a tissue interaction during embryonic heart development.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Chick Embryo; Cholera Toxin; Endothelium; Enzyme Activation; Extracellular Matrix Proteins; Fetal Heart; Genistein; GTP-Binding Proteins; Isoflavones; Isoquinolines; Myocardium; Pertussis Toxin; Phenotype; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Regulation of a non-selective cation channel of cultured porcine coronary artery smooth muscle cells by tyrosine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cations; Cell Membrane; Cells, Cultured; Coronary Vessels; Genistein; Ion Channels; Isoflavones; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Swine | 1994 |
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Burkitt Lymphoma; CD40 Antigens; Cell Line; Cell Line, Transformed; Enzyme Precursors; Genistein; Herpesvirus 4, Human; Humans; Intracellular Signaling Peptides and Proteins; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Palatine Tonsil; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; Sulfonamides; Syk Kinase; Tumor Cells, Cultured; Tyrosine | 1994 |
Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzoquinones; Diglycerides; Enzyme Activation; Gene Expression; Genistein; Humans; Interleukin-1; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Lipopolysaccharide Receptors; Lipopolysaccharides; Monocytes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Tumor Necrosis Factor-alpha | 1994 |
Polyamine transport in human promyelocytic leukemia cells and polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Genistein; Gramicidin; Humans; In Vitro Techniques; Ionomycin; Isoflavones; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Neutrophils; Piperazines; Protein Kinase Inhibitors; Putrescine; Spermidine; Spermine; Sulfonamides; Temperature; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Cell Adhesion; Cell Line; Cloning, Molecular; Fibronectins; Flow Cytometry; Genistein; Humans; Integrins; Isoflavones; Isoquinolines; Kinetics; Lactams, Macrocyclic; Leukemia, Erythroblastic, Acute; Naphthalenes; Phagocytosis; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinones; Receptors, Cytoadhesin; Receptors, Fibronectin; Receptors, Vitronectin; Rifabutin; Signal Transduction; Transfection; Tumor Cells, Cultured | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Activation of multiple protein kinases induced by cross-linking of Fc gamma RII in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Cross-Linking Reagents; Egtazic Acid; Enzyme Activation; Genistein; Humans; Isoflavones; Isoquinolines; Molecular Sequence Data; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Receptors, IgG; Superoxides | 1995 |
A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Genistein; Imidazoles; Indole Alkaloids; Isoflavones; Isoquinolines; Kinetics; N-Methylaspartate; Naphthalenes; Neurons; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrin | 1995 |
Inhibition of serotonin-induced Ca2+ mobilization by interleukin-1 beta in rat C6BU-1 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Neoplasms; Calcium; Cell Division; Enzyme Inhibitors; Genistein; Glioma; Growth Inhibitors; Interleukin-1; Isoflavones; Isoquinolines; Lipopolysaccharides; Piperazines; Protein Kinase C; Rats; Salmonella typhimurium; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction; Tumor Cells, Cultured | 1995 |
Signal requirements for production of luteinizing hormone releasing-hormone by human T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Genistein; Gonadotropin-Releasing Hormone; Humans; Interleukin-2; Isoflavones; Isoquinolines; Lectins, C-Type; Male; Middle Aged; Phytohemagglutinins; Piperazines; Protein Kinase C; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1995 |
Activation of Na+/H+ exchanger by hepatocyte growth factor in hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Cells, Cultured; Genistein; Hepatocyte Growth Factor; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides | 1995 |
A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cells, Cultured; Cholecystokinin; Genistein; Isoflavones; Isoquinolines; Kinetics; Male; Pancreas; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocellular; Genistein; Humans; Interleukin-1; Interleukin-6; Isoflavones; Isoquinolines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Down-regulation of beta-adrenergic receptors induced by mitogen activation of intracellular signaling events in lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Concanavalin A; Cyclic AMP; Down-Regulation; Genistein; In Vitro Techniques; Interleukin-2; Intracellular Fluid; Isoflavones; Isoquinolines; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Neuroimmunomodulation; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Receptors, Adrenergic, beta; Signal Transduction; Sulfonamides; T-Lymphocytes | 1995 |
The role of protein kinase in human synovial fibroblast growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arthritis, Rheumatoid; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cells, Cultured; Fibroblast Growth Factor 2; Fibroblasts; Genistein; Humans; Hyperplasia; Isoflavones; Isoquinolines; Kinetics; Lactams, Macrocyclic; Piperazines; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Synovial Membrane; Thymidine | 1995 |
Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Calcium; Cells, Cultured; Complement C2; Complement Factor B; Enzyme Activation; Fibroblasts; Genistein; Glioblastoma; Humans; Interferon gamma Receptor; Interferon-gamma; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Monocytes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Receptors, Interferon; Rifabutin; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Up-Regulation | 1995 |
Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Benzoquinones; Diglycerides; DNA, Complementary; Gene Expression Regulation; Genes, Immediate-Early; Genes, jun; Genistein; Hydrolysis; Interleukin-3; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Mice; Phosphatidylcholines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Quinones; Receptors, Interleukin-3; Recombinant Proteins; Rifabutin; Signal Transduction; Transcriptional Activation; Transfection | 1995 |
Possible roles of protein kinases in neutrophil chemotactic factor production by leucocytes in allergic inflammation in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cells, Cultured; Chemotactic Factors; Culture Media, Conditioned; Cycloheximide; Depression, Chemical; Dexamethasone; Genistein; Hypersensitivity; Indole Alkaloids; Inflammation; Isoelectric Focusing; Isoflavones; Isoquinolines; Leukocytes; Male; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1994 |
Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Autophagy; Cells, Cultured; Dose-Response Relationship, Drug; Endocytosis; Ethers, Cyclic; Flavanones; Flavonoids; Genistein; Isoflavones; Isoquinolines; Kinetics; Liver; Male; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Wistar | 1995 |
Characterization of signaling pathways to Na+/H+ exchanger activation with epidermal growth factor in hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Epidermal Growth Factor; Genistein; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Phenylephrine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Gene expression of monocyte chemoattractant protein-1 in human monocytes is regulated by cell density through protein tyrosine kinase and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Blotting, Northern; Cell Division; Cell Nucleus; Cells, Cultured; Chemokine CCL2; Chemotactic Factors; Cytokines; Gene Expression Regulation; Genistein; Humans; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Monocytes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Sulfonamides; Transcription, Genetic; Vanadates | 1994 |
Protein kinases mediate basic fibroblast growth factor's stimulation of proliferation and c-fos induction in oligodendrocyte progenitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Biomarkers; Brain; Brain Stem; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Gene Expression; Genes, fos; Genistein; Immunohistochemistry; Isoflavones; Isoquinolines; Kinetics; Oligodendroglia; Piperazines; Protein Kinase C; Protein Kinases; Rats; Rats, Sprague-Dawley; Stem Cells; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 1994 |
Signal transduction pathway(s) involved in phorbol ester and autocrine induction of interleukin-1 alpha mRNA in murine keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Activation; Gene Expression Regulation; Genistein; Interleukin-1; Isoflavones; Isoquinolines; Keratinocytes; Mice; Mitogen-Activated Protein Kinase 1; NF-kappa B; Piperazines; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 1994 |
Effects of genistein on cardiac contractile force and atrial natriuretic peptide secretion in the isolated perfused rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Diltiazem; Drug Interactions; Genistein; Hemodynamics; Isoflavones; Isoquinolines; Male; Myocardial Contraction; Perfusion; Piperazines; Protein-Tyrosine Kinases; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1994 |
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Genistein; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Immunoglobulin secretion and phosphorylation of common proteins are induced by IL-2, IL-4, and IL-6 in the factor responsive human B cell line, SKW6.4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; B-Lymphocytes; Base Sequence; Cell Line; DNA Probes; Genistein; Humans; Immunoglobulin M; Interleukin-2; Interleukin-4; Interleukin-6; Isoflavones; Isoquinolines; Molecular Sequence Data; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proteins; RNA, Messenger; Signal Transduction | 1993 |
Rapid induction of mouse virus-like (VL30) element transcripts by erythropoietin in murine erythroid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cloning, Molecular; Cycloheximide; DNA; DNA Transposable Elements; Erythroid Precursor Cells; Erythropoietin; Female; Friend murine leukemia virus; Gene Expression; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Staurosporine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Protein tyrosine phosphorylation and activation of primary response genes by interleukin 11 in B9-TY1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoquinones; Cell Differentiation; Cell Division; Gene Expression Regulation; Genes, jun; Genistein; Hybridomas; Interleukin-11; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Mice; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Quinones; Rifabutin; Transcription, Genetic | 1993 |
Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Alkaloids; Animals; Cells, Cultured; Epithelial Cells; Epithelium; Female; Gene Expression Regulation; Genistein; Isoflavones; Isoquinolines; Mammary Glands, Animal; Milk Proteins; Phenols; Phenylacetates; Piperazines; Polymyxin B; Pregnancy; Prolactin; Protein Kinase Inhibitors; Quercetin; Rabbits; Sphingosine; Staurosporine; Succinates | 1993 |
Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Collagen; Enzyme Inhibitors; Ethers, Cyclic; Fetus; Fibroblasts; Gene Expression; Genistein; Humans; Isoflavones; Isoquinolines; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Skin; Staurosporine; Transcription, Genetic; Transforming Growth Factor beta; Vanadates | 1995 |
Effect of cystathionine ketimine on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cystathionine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Superoxides; Time Factors | 1996 |
PGF2alpha-induced signaling events in glomerular mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cells, Cultured; Diglycerides; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Genistein; Glomerular Mesangium; Inositol Phosphates; Isoflavones; Isoquinolines; Molecular Sequence Data; Naphthalenes; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Virulence Factors, Bordetella | 1996 |
Interleukin-11 mRNA stabilization in phorbol ester-stimulated primate bone marrow stromal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Cell Line; Cell Nucleus; Dactinomycin; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Interleukin-11; Isoflavones; Isoquinolines; Kinetics; Luciferases; Naphthalenes; Open Reading Frames; Piperazines; Primates; Protein Kinase C; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Stromal Cells; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Transfection | 1996 |
Suppression of growth-associated phosphorylation of proteins of fibroblasts by collagen fibrils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood; Cell Division; Collagen; DNA; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Genistein; Humans; Hydrogen-Ion Concentration; Image Processing, Computer-Assisted; Isoflavones; Molecular Weight; Peptide Mapping; Phosphoproteins; Phosphorylation; Plastics; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Skin | 1996 |
Thapsigargin induces phosphorylation of the 27-kDa heat shock protein in human keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arsenites; Calcium; Calcium-Transporting ATPases; Cell Line; Enzyme Inhibitors; Genistein; Heat-Shock Proteins; Humans; Isoflavones; Keratinocytes; Phosphorylation; Thapsigargin | 1996 |
Acrosome membrane associated protein kinase activity in hamster spermatozoa.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Animals; Cricetinae; Cyclic AMP; Enzyme Inhibitors; Epididymis; Genistein; Heparin; Isoflavones; Male; Membrane Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Spermidine; Spermine | 1996 |
Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Calmodulin; Cytoplasmic Granules; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Genistein; Humans; Isoflavones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vanadates | 1996 |
Involvement of microtubules in the control of adhesion-dependent signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actin Cytoskeleton; Alkaloids; Animals; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; DNA; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Indoles; Integrins; Isoflavones; Mice; Microtubules; Myosin-Light-Chain Kinase; Nocodazole; Paclitaxel; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vinblastine | 1996 |
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Carrier Proteins; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Hematopoietic Stem Cells; Humans; Interleukin-2; Isoflavones; Janus Kinase 3; Lymphocytes; Mice; Phosphorylation; Phytohemagglutinins; Polyenes; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Receptors, Interleukin-2; RNA, Messenger; Serine; Signal Transduction; Sirolimus; Stimulation, Chemical; Tacrolimus; Transcription Factors; Transfection | 1996 |
Effect of vitamin E on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated rat macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Free Radical Scavengers; Genistein; Isoenzymes; Isoflavones; Lipopolysaccharides; Macrophages, Peritoneal; Male; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Vitamin E | 1996 |
Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Erythropoietin; Gallic Acid; Genistein; Ionophores; Isoflavones; Muscle, Smooth, Vascular; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Second Messenger Systems; Swine; Verapamil | 1997 |
Deoxycholic acid and SCFA-induced apoptosis in the human tumor cell-line HT-29 and possible mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Butyrates; Butyric Acid; Calcium; Chelating Agents; Colonic Neoplasms; Cycloheximide; Dactinomycin; Deoxycholic Acid; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Genistein; Humans; Isoflavones; Propionates; Protein Synthesis Inhibitors; Time Factors; Tumor Cells, Cultured | 1997 |
Modulation of endothelin-induced intracellular Ca2+ mobilization by interleukin-1 beta and lipopolysaccharide in C6 rat glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Endothelin-1; Enzyme Inhibitors; Genistein; Glioma; Interleukin-1; Isoflavones; Kinetics; Lipopolysaccharides; Protein-Tyrosine Kinases; Rats; Tumor Cells, Cultured | 1997 |
Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Cellular Senescence; Culture Media, Conditioned; Culture Media, Serum-Free; Cytokines; DNA; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Genistein; Growth Substances; Hepatocyte Growth Factor; Humans; Interleukin-1; Kinetics; Lactams, Macrocyclic; Melanocytes; Phloretin; Protein-Tyrosine Kinases; Quinones; Rifabutin; Skin; Stem Cell Factor; Thymidine | 1998 |
Apoptosis induced with different cycle-perturbing agents produces differential changes in the fluorescence lifetime of DNA-bound ethidium bromide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Camptothecin; Cell Cycle; Chromatin; Cycloheximide; DNA, Neoplasm; Enzyme Inhibitors; Ethidium; Flow Cytometry; Fluorescence; Fluorescent Dyes; Gamma Rays; Genistein; HL-60 Cells; Humans; Protein Synthesis Inhibitors | 1998 |
Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ ce
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; DNA-Binding Proteins; Enzyme Inhibitors; Genes, fos; Genistein; Growth Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; Lymphokines; Male; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Cytokine; Receptors, OSM-LIF; RNA, Messenger; Sertoli Cells; Signal Transduction; Spermatozoa; STAT1 Transcription Factor; STAT3 Transcription Factor; Testis; Trans-Activators; Transcription Factor AP-1; Transcription, Genetic | 1998 |
Mycoplasma salivarium induces interleukin-6 and interleukin-8 in human gingival fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cattle; Cell Fractionation; Cell Line; Densitometry; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression; Genistein; Gingiva; Humans; Interleukin-6; Interleukin-8; Mice; Mycoplasma; Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1997 |
The effects of serum iminodipeptides and prednisolone on superoxide generation and tyrosyl phosphorylation of proteins in neutrophils from a patient with prolidase deficiency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Proteins; Dipeptidases; Dipeptides; Enzyme Inhibitors; Genistein; Humans; Imines; Neutrophils; Phosphorylation; Prednisolone; Proline; Protein-Tyrosine Kinases; Staurosporine; Superoxides | 1998 |
Increased protein kinase C activity in myotrophin-induced myocyte growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Antisense Elements (Genetics); Cell Fractionation; Cells, Cultured; Enzyme Inhibitors; Female; Gene Expression Regulation; Genistein; Growth Substances; Intercellular Signaling Peptides and Proteins; Isoenzymes; Muscle Fibers, Skeletal; Myocardium; Myosin Heavy Chains; Pregnancy; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Signal Transduction; Staurosporine | 1998 |
Lysis-sensitive targets stimulate an elevation of cAMP in human natural killer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Antineoplastic Agents; Benzophenanthridines; Cyclic AMP; Enzyme Inhibitors; Genistein; Humans; Killer Cells, Natural; Neoplasms; Phenanthridines; Phosphodiesterase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 1998 |
Different effect of diastereoisomers of L-cystathionine sulfoxide on the stimulus coupled responses of human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Metabolism, Inborn Errors; Cystathionine; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase Inhibitors; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases: evidence from enzyme inhibitors and anti-CD45 antibodies.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; CD4 Antigens; CD4-Positive T-Lymphocytes; Down-Regulation; Enzyme Inhibitors; G(M1) Ganglioside; Gangliosides; Genistein; Humans; In Vitro Techniques; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphoprotein Phosphatases; Phytohemagglutinins; Protein Kinase Inhibitors; Staurosporine; Vanadates | 1998 |
Inhibition of protein kinases prevents lymphocyte activation by Schistosoma mansoni antigens and reduces in vitro [correction of in vivo] granuloma reaction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Helminth; Calcium; Cell Division; Chronic Disease; Enzyme Inhibitors; Genistein; Granuloma; Humans; Immunoblotting; Intestinal Diseases, Parasitic; Lymphocyte Activation; Lymphocytes; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Schistosoma mansoni; Schistosomiasis mansoni | 1998 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
BDM drives protein dephosphorylation and inhibits adenine nucleotide exchange in cardiomyocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Adhesion; Cell Membrane Permeability; Cells, Cultured; Diacetyl; Enzyme Inhibitors; Genistein; Heart; Male; Myocardial Contraction; Myocardium; Myofibrils; Phenanthridines; Protein Kinases; Rats; Rats, Wistar; Uncoupling Agents | 1998 |
Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cell-Free System; Chorionic Gonadotropin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Proteins; Ovary; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Receptors, LH; Time Factors; Tyrosine; Virulence Factors, Bordetella | 1999 |
Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; Electrophoresis; Female; Genistein; Growth Hormone; Growth Inhibitors; Janus Kinase 2; Leupeptins; Liver; Male; Milk Proteins; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, enhances L-type Ca2+ current and [Ca2+]i transient in cardiomyocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Growth Inhibitors; Guinea Pigs; Heart; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 1999 |
Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Enzyme Inhibitors; Genistein; Osteoblasts; Parathyroid Hormone; Protein Kinase C; Staurosporine; Thrombin | 1999 |
Arachidonic acid, but not its metabolites, is essential for FcgammaR-stimulated intracellular killing of Staphylococcus aureus by human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Immunoglobulin G; Indomethacin; Lipoxygenase Inhibitors; Monocytes; Oxygen; Phagocytosis; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Staphylococcus aureus; Sulfonamides | 1999 |
Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adult; Antioxidants; Blotting, Northern; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Inhibitors; Epidermis; Gene Expression; Genistein; Humans; Hydrogen Peroxide; Immunohistochemistry; Isoenzymes; Keratinocytes; Male; Membrane Proteins; Oxidants; Phosphoprotein Phosphatases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Ultraviolet Rays; Vanadates | 1999 |
Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Arachidonic Acid; Benzodiazepines; Benzothiadiazines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Genistein; GTP-Binding Proteins; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, AMPA; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1999 |
Interleukin-1beta regulates CFTR expression in human intestinal T84 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Benzoquinones; Cell Line; Colon; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Genistein; Humans; Indoles; Interleukin-1; Lactams, Macrocyclic; Maleimides; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2000 |
Regulation of GABAA receptor by protein tyrosine kinases in frog pituitary melanotrophs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Enzyme Inhibitors; Evoked Potentials; gamma-Aminobutyric Acid; Genistein; Patch-Clamp Techniques; Phenols; Pituitary Gland; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rana ridibunda; Receptors, GABA-A; Sulfonamides; Vanadates | 2000 |
Induction of interleukin-6 release in human osteoblast-like cells exposed to titanium particles in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cell Line; Cell Nucleus; Cyclic AMP-Dependent Protein Kinases; Cytochalasin B; DNA Primers; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Genistein; Humans; Interleukin-6; NF-kappa B; Osteoblasts; Protein Kinase C; RNA, Messenger; Stimulation, Chemical; Titanium; Transcription Factors | 2000 |
Biphasic effect of UVA radiation on STAT1 activity and tyrosine phosphorylation in cultured human keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; DNA; DNA-Binding Proteins; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Keratinocytes; Lipid Peroxidation; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Reactive Oxygen Species; STAT1 Transcription Factor; Thiobarbituric Acid Reactive Substances; Trans-Activators; Transcription, Genetic; Ultraviolet Rays | 2000 |
A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Antibodies, Monoclonal; Antibody Specificity; Calcium; Calmodulin; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Chelating Agents; Cycloheximide; Cytochalasin D; Edetic Acid; Endothelium, Vascular; Enzyme Inhibitors; Epitopes; Flow Cytometry; Genistein; HL-60 Cells; Humans; K562 Cells; Microtubules; Nocodazole; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins | 2000 |
Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bombesin; Carcinoma, Non-Small-Cell Lung; Cell Division; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrin-Releasing Peptide; Genistein; Humans; Lung Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 2001 |
Interaction between monocytes and vascular smooth muscle cells induces expression of hepatocyte growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Cardiovascular Diseases; Cell Communication; Cells, Cultured; Coculture Techniques; Enzyme Inhibitors; Gene Expression; Genistein; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Inflammation Mediators; Interleukin-1; Interleukin-6; Monocytes; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase Inhibitors; Protein Kinases; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction | 2001 |
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction | 2000 |
Stimulation of cardiac glucose transport by inhibitors of oxidative phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-O-Methylglucose; Animals; Azides; Biological Transport; Cell Fractionation; Cell Membrane; Dose-Response Relationship, Drug; Drug Interactions; Genistein; Glucose Transporter Type 4; Heart; In Vitro Techniques; Isoquinolines; Male; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Oxidative Phosphorylation; Perfusion; Phenols; Polymyxin B; Rats; Rats, Sprague-Dawley; Rotenone; Uncoupling Agents | 2001 |
Involvement of protein kinase C and tyrosin kinase in tumoricidal activation of macrophage induced by Streptococcus pneumoniae type II capsular polysaccharide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Carbohydrate Sequence; Drosophila Proteins; Enzyme Inhibitors; Genistein; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nitric Oxide; Polysaccharides; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Streptococcus pneumoniae; Toll-Like Receptor 2; Toll-Like Receptors; Tumor Necrosis Factor-alpha | 2002 |
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Angiotensin II; Animals; Dose-Response Relationship, Drug; Drug Combinations; Esophagus; Female; Flavonoids; Genistein; Imidazoles; Losartan; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Opossums; Pyridines; Rabbits; Species Specificity; Tyrphostins | 2002 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Contractile Proteins; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Phenylephrine; Phosphorylation; Potassium; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Saphenous Vein; Vasoconstriction; Vasoconstrictor Agents | 2002 |
Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest that CaM kinase and tyrosine kinase regulate sensitivity to levamisole.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amino Acid Sequence; Animals; Ascaris suum; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Levamisole; Membrane Potentials; Molecular Sequence Data; Patch-Clamp Techniques; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptors, Nicotinic; Staurosporine; Vasodilator Agents | 2002 |
Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Liver Neoplasms; Sodium-Hydrogen Exchangers; Sulfonamides; Tumor Cells, Cultured | 2003 |
Formation of AP-1 transcription factors during learning in Helix.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Casein Kinase II; CCAAT-Enhancer-Binding Proteins; Central Nervous System; DNA-Binding Proteins; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Exoribonucleases; Flavonoids; Genistein; Helix, Snails; Ionophores; Learning; Phorbol Esters; Protein Serine-Threonine Kinases; Serotonin; Transcription Factor AP-1 | 2003 |
Regulation of CO production in cerebral microvessels of newborn pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminolevulinic Acid; Animals; Animals, Newborn; Calcium; Calcium Signaling; Capillaries; Carbon Monoxide; Catalysis; Cerebrovascular Circulation; Cytosol; Enzyme Inhibitors; Genistein; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Ionomycin; Ionophores; Phosphorylation; Photosensitizing Agents; Swine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 2003 |
Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Adhesion; Cells, Cultured; Enzyme Inhibitors; Genistein; Humans; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide Donors; Nitroprusside; Oxidation-Reduction; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate; Vasodilator Agents | 2003 |
Mechanism of activation of ADP-induced platelet aggregation under the influence of oxidatively modified fibrinogen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Aspirin; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estrenes; Fibrinogen; Genistein; Humans; In Vitro Techniques; Oxidation-Reduction; Platelet Aggregation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Type C Phospholipases; Ultraviolet Rays | 2004 |
Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Cell Survival; Cephaloridine; Dose-Response Relationship, Drug; Free Radical Scavengers; Genistein; L-Lactate Dehydrogenase; Lipid Peroxidation; LLC-PK1 Cells; Phenols; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Swine; Thiobarbituric Acid Reactive Substances; Thiourea | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Antioxidants; Arachidonic Acid; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Endothelial Cells; Genistein; Glutathione; Humans; Hydrogen Peroxide; Maleates; Oxidants; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Umbilical Veins | 2007 |
Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiogenesis Inhibitors; Animals; Chloride Channels; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Genistein; Isoquinolines; Myocytes, Cardiac; Niflumic Acid; Nitrobenzoates; Patch-Clamp Techniques; Phenols; Potassium Channels; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Vanadates | 2007 |
Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Cycle; Cell Line, Transformed; Cell Proliferation; Cell Survival; Eflornithine; Fibroblasts; Flow Cytometry; Genistein; Hydroquinones; Mice; Models, Biological; NIH 3T3 Cells; PQQ Cofactor; ras Proteins; S-Nitroso-N-Acetylpenicillamine; Signal Transduction | 2007 |
Characterisation of K+ currents in the C8-B4 microglial cell line and their regulation by microglia activating stimuli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Apamin; Barium; Calcium; Cations; Cell Line; Charybdotoxin; Dose-Response Relationship, Drug; Drug Combinations; Elapid Venoms; Electrodes; Electrophysiology; Fluorescent Antibody Technique, Direct; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Interferon-gamma; Lipopolysaccharides; Membrane Potentials; Mice; Mice, Inbred C57BL; Microglia; Neurotoxins; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrazoles; Scorpion Venoms; Transforming Growth Factor beta | 2009 |
In vitro activation of murine peritoneal macrophages by recombinant YopJ: production of nitric oxide, proinflammatory cytokines and chemokines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Bacterial Proteins; Chemokines; Cytokines; Genistein; Immunoblotting; Inflammation; Interferon-gamma; Interleukin-12; Interleukin-6; Macrophage Activation; Macrophages, Peritoneal; Mice; Nitric Oxide; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin | 2011 |
Effects of various pharmacological agents on the function of norepinephrine transporter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Neurons; Animals; Cells, Cultured; Fluoxetine; Genistein; Humans; Ketamine; Nerve Endings; Nicotine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pentazocine; Sympathetic Nervous System; Synaptic Transmission | 2015 |