1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with gamma-aminobutyric acid in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (66.67) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Amatsu, M; Nishimura, S; Okada, Y | 1 |
| Alkon, DL; Matzel, LD | 1 |
| Aragon, C; Casado, M; Gimenez, C; Gomeza, J | 1 |
| Hashiba, Y; Hidaka, H; Ishikawa, N | 1 |
| Betz, H; Sato, K; Schloss, P | 1 |
| Carter, DB; Hamilton, BJ; Kurata, Y; Marszalec, W; Narahashi, T | 1 |
| Chiu, LM; Dunkley, PR; Sitges, M | 1 |
| Reis, DJ; Sun, MK | 1 |
| Cupello, A; Hydén, H; Rapallino, MV | 1 |
| Dunlop, J; Ennis, C; Minchin, MC; Rossiter, J | 1 |
| Fukura, H; Igarashi, M; Komiya, Y | 1 |
| Fukunaga, K; Kano, M; Konnerth, A | 1 |
| Hu, HZ; Li, ZW | 1 |
| Chiu, LM; Guarneros, A; Peña, F; Sitges, M | 1 |
| Himmelreich, NH; Pozdnyakova, NG; Storchak, LG | 1 |
| Konishi, S; Mitoma, H | 1 |
| Anouar, Y; Castel, H; Cazin, L; Le Foll, F; Louiset, E; Vaudry, H | 1 |
| Etgen, AM; Fiber, JM | 1 |
| Li, CX; Li, ZW; Si, JQ; Wang, LF; Yang, YL; Zhang, ZQ | 1 |
| An, J; Chen, CH; Guan, BC; Li, ZW; Tang, M; Yu, CG | 1 |
| Hjelmstad, GO; Warrier, A | 1 |
| Hou, X; Wang, X; Yang, B; Yu, G; Zhang, L; Zhou, J | 1 |
| Fong, P; Gong, KR; Guo, ZD; Ji, XM; Li, MY; Lv, GW; Niu, JZ; Yang, MF; Zhang, CW; Zhang, JG; Zhang, YB | 1 |
24 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and gamma-aminobutyric acid
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Post-inhibitory excitation of adenosine on neurotransmission in guinea pig hippocampal slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Adenosine; Animals; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoquinolines; Pentobarbital; Piperazines; Protein Kinase C; Synaptic Transmission | 1992 |
GABA-induced potentiation of neuronal excitability occurs during contiguous pairings with intracellular calcium elevation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brachyura; Calcium; Chloride Channels; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Isoquinolines; Kinetics; Membrane Potentials; Membrane Proteins; Neurons; Photoreceptor Cells; Picrotoxin; Piperazines; Protein Kinase C; Synapses; Time Factors | 1991 |
Inhibition of high-affinity gamma-aminobutyric acid uptake in primary astrocyte cultures by phorbol esters and phospholipase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Bacillus cereus; Biological Transport; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Isoquinolines; Kinetics; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1991 |
Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Calmodulin; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Heart Rate; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Sulfonamides; Vasodilator Agents | 1990 |
The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Carrier Proteins; Cell Line; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Isoquinolines; Kidney; Kinetics; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Selective effects of alcohols on gamma-aminobutyric acid A receptor subunits expressed in human embryonic kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Octanol; Base Sequence; Cell Line; Depression, Chemical; Embryo, Mammalian; Ethanol; gamma-Aminobutyric Acid; Humans; Ion Channels; Isoquinolines; Kidney; Kinetics; Macromolecular Substances; Molecular Sequence Data; Octanols; Piperazines; Protein Kinase Inhibitors; Receptors, GABA-A; Sensitivity and Specificity; Transfection | 1994 |
A role for calcium/calmodulin kinase(s) in the regulation of GABA exocytosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Exocytosis; gamma-Aminobutyric Acid; Isoquinolines; Membrane Potentials; Mice; Nerve Endings; Piperazines; Potassium | 1995 |
Inhibition of protein kinase C differentially affects baroreflex inhibition and hypoxic excitation of medullary vasomotor neurons in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Baroreflex; Denervation; Facial Nerve; GABA Antagonists; gamma-Aminobutyric Acid; Hypoxia; In Vitro Techniques; Iontophoresis; Isoquinolines; Male; Medulla Oblongata; Neurons; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spinal Cord; Sympathetic Nervous System | 1994 |
The increase in Cl- permeation across the Deiters' neuron membrane by GABA on its cytoplasmic side is abolished by protein kinase C (PKC) activators.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Membrane; Cell Membrane Permeability; Chlorides; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Male; Neurons; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Receptors, GABA-A; Vestibular Nucleus, Lateral | 1993 |
The effect of 3 calmodulin antagonists on K(+)-stimulated neurotransmitter release from rat cortical slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Kinetics; Piperazines; Potassium; Rats; Serotonin; Sulfonamides; Trifluoperazine | 1993 |
Signaling pathway downstream of GABAA receptor in the growth cone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Axons; Binding Sites; Calcium; Chlorides; Diazepam; Fetus; gamma-Aminobutyric Acid; GTPase-Activating Proteins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Models, Neurological; Muscimol; Myristoylated Alanine-Rich C Kinase Substrate; Neurites; Picrotoxin; Prosencephalon; Proteins; Rats; Rats, Wistar; Receptors, GABA-A; Signal Transduction; Verapamil | 1996 |
Ca(2+)-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cerebellum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Imidazoles; In Vitro Techniques; Kinetics; Marine Toxins; Membrane Potentials; Nerve Fibers; Oxazoles; Purkinje Cells; Rats; Receptors, GABA-A; Signal Transduction; Staurosporine | 1996 |
Modulation of nicotinic ACh-, GABAA- and 5-HT3-receptor functions by external H-7, a protein kinase inhibitor, in rat sensory neurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Adenosine Triphosphate; Allosteric Regulation; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; gamma-Aminobutyric Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons, Afferent; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Second Messenger Systems; Serotonin | 1997 |
Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Okadaic Acid; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sodium; Sodium Channels; Synaptosomes; Tetrodotoxin; Veratridine | 1998 |
Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Biological Transport; Brain Chemistry; Calcium; Carbon Radioisotopes; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Potassium Chloride; Rats; Sphingosine; Spider Venoms; Staurosporine; Sulfonamides; Synaptosomes | 1998 |
Monoaminergic long-term facilitation of GABA-mediated inhibitory transmission at cerebellar synapses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cerebellum; Colforsin; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Methiothepin; Neuronal Plasticity; Norepinephrine; Propranolol; Protein Kinase Inhibitors; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA; Serotonin; Sulfonamides; Synapses; Synaptic Transmission; Tetrodotoxin; Thionucleotides | 1999 |
Regulation of GABAA receptor by protein tyrosine kinases in frog pituitary melanotrophs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Enzyme Inhibitors; Evoked Potentials; gamma-Aminobutyric Acid; Genistein; Patch-Clamp Techniques; Phenols; Pituitary Gland; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rana ridibunda; Receptors, GABA-A; Sulfonamides; Vanadates | 2000 |
Modulation of GABA-augmented norepinephrine release in female rat brain slices by opioids and adenosine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Brain; Electric Stimulation; Enzyme Inhibitors; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hypothalamus; In Vitro Techniques; Narcotics; Norepinephrine; Parietal Lobe; Rats; Rats, Sprague-Dawley | 2001 |
Modulatory effect of substance P on GABA-activated currents from rat dorsal root ganglion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Separation; Female; gamma-Aminobutyric Acid; Ganglia, Spinal; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; Substance P | 2004 |
5-HT2 receptor mediated the potentiation of GABA-activated current in the membrane of the dorsal root ganglion neurons of rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyproheptadine; Female; gamma-Aminobutyric Acid; Ganglia, Spinal; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT2; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Signal Transduction | 2005 |
Protein kinase inhibitors reduce GABA but not glutamate release in the nucleus accumbens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Nucleus Accumbens; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley | 2007 |
Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred ICR; Neural Inhibition; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Protein Kinase Inhibitors; Receptors, GABA-A; Thalamic Nuclei | 2010 |
Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amines; Animals; Behavior, Animal; Cell Membrane; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electrophysiological Phenomena; Flavonoids; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; MAP Kinase Signaling System; Neurons; Pain Management; Phosphorylation; Protein Kinase C; Protein Transport; Rats; Spinal Cord; Visceral Pain | 2015 |