1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with cyclosporine in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (62.50) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| Kahan, BD; Kerman, RH; Kimball, P; Williams, J | 1 |
| Amano, H; Ito, M; Tomono, M; Toyoshima, K | 1 |
| Bevan, S; Boddeke, HW; Docherty, RJ; Yeats, JC | 1 |
| Keiser, HR; Oriji, GK | 1 |
| Castrucci, AM; da Silva, MA; Josefsson, L; Nery, LE | 1 |
| Marunaka, Y; Niisato, N; Shintani, Y | 1 |
| Chow, SC; Jondal, M; Osorio, LM; Rottenberg, M | 1 |
| Reinach, PS; Torres-zamorano, V; Wu, X; Yang, H | 1 |
| Alam, T; Hamawy, MM; Knechtle, SJ; Manthei, ER; Tsuchida, M | 1 |
| Hishinuma, S; Ogura, K | 1 |
| Farley, J; Huang, H | 1 |
| Hellsten, Y; Jensen, L; Kusuhara, K; Madsen, K; Pilegaard, H | 1 |
| Kojo, T; Komagiri, Y; Kubokawa, M; Nakamura, K | 1 |
| Bae, EH; Kim, IJ; Kim, SW; Lee, JU; Ma, SK; Park, CH; Park, JW | 1 |
| Burban, A; Burbank, M; Guguen-Guillouzo, C; Guillouzo, A; Le Guevel, R; Li, R; Sharanek, A | 1 |
16 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and cyclosporine
| Article | Year |
|---|---|
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Cyclosporine and rapamycin block protein kinase C-mediated induction of the activation signal, activator of DNA replication, in cell-free assay.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell-Free System; Cyclosporine; DNA Replication; Enzyme Induction; Humans; Immunosuppressive Agents; Isoquinolines; Lymphocyte Activation; Lymphocytes; Piperazines; Polyenes; Protein Kinase C; Sirolimus | 1993 |
Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Cell Survival; Cyclosporine; DNA Replication; Enzyme Inhibitors; Extracellular Space; Fibroblast Growth Factors; Isoquinolines; Lysophospholipids; Mice; Phosphoprotein Phosphatases; Piperazines; Signal Transduction; Tacrolimus | 1996 |
Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcineurin; Calcium; Calmodulin-Binding Proteins; Capsaicin; Cells, Cultured; Chelating Agents; Cyclosporine; Drug Resistance; Egtazic Acid; Enzyme Inhibitors; Evoked Potentials; Ganglia, Spinal; Ion Channel Gating; Ion Channels; Ligands; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats | 1996 |
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin | 1997 |
Cellular signalling of PCH-induced pigment aggregation in the crustacean Macrobrachium potiuna erythrophores.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chromatophores; Colforsin; Cyclosporine; In Vitro Techniques; Invertebrate Hormones; Neomycin; Okadaic Acid; Oligopeptides; Palaemonidae; Pigments, Biological; Pyrrolidonecarboxylic Acid; Signal Transduction; Trifluoperazine | 1997 |
Protein phosphatase 2B-dependent pathway of insulin action on single Cl- channel conductance in renal epithelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcineurin; Calcineurin Inhibitors; Calmodulin; Cell Line; Chloride Channels; Cyclosporine; Cytosol; Electric Conductivity; Enzyme Inhibitors; Epithelial Cells; Insulin; Isoquinolines; Kidney; Phenols; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides | 1998 |
Simultaneous cross-linking of CD6 and CD28 induces cell proliferation in resting T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antibodies, Monoclonal; Antigens, CD; Carcinogens; CD28 Antigens; CD3 Complex; Cell Division; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Indoles; Interleukin-2; Lymphocyte Activation; Maleimides; Protein Kinase C; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1998 |
ETA receptor mediated inhibition of intracellular pH regulation in cultured bovine corneal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arsenicals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclosporine; Diuretics; Egtazic Acid; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epithelium, Corneal; Hydrogen-Ion Concentration; Immunosuppressive Agents; Intracellular Fluid; Naphthalenes; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Endothelin; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1998 |
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CD28 Antigens; Cell Adhesion Molecules; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intracellular Fluid; Ionophores; Jurkat Cells; Lymphocyte Activation; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Up-Regulation | 1999 |
Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cyclosporine; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Histamine; Histamine H1 Antagonists; Humans; Kinetics; Okadaic Acid; Piperidines; Pyrilamine; Ranitidine; Receptors, Histamine H1; Sulfonamides; Tacrolimus; Tumor Cells, Cultured | 2000 |
PP1 inhibitors depolarize Hermissenda photoreceptors and reduce K+ currents.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cantharidin; Chromosomal Proteins, Non-Histone; Conditioning, Psychological; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; Histone Chaperones; Marine Toxins; Membrane Potentials; Mollusca; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Photoreceptor Cells, Invertebrate; Potassium; Potassium Channels; Protein Kinase C; Proteins; Transcription Factors | 2001 |
Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium Signaling; Cells, Cultured; Cyclosporine; Electric Stimulation; Gene Expression Regulation; Hexokinase; Ionomycin; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Kinases; Rats; Rats, Wistar; RNA-Binding Proteins; RNA, Messenger; Transcription Factors | 2007 |
Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cyclosporine; Humans; Indoles; Kidney Tubules, Proximal; Maleimides; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Inwardly Rectifying; Protein Kinase C | 2009 |
Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cyclosporine; Kidney Cortex; Kidney Diseases; Male; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction | 2011 |
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Bile Canaliculi; Cardiac Myosins; Cell Survival; Cells, Cultured; Chlorpromazine; Cyclosporine; Hepatocytes; Humans; Microscopy, Fluorescence; Myosin Light Chains; Myosin Type II; Myosin-Light-Chain Kinase; Phosphorylation; rho-Associated Kinases; Signal Transduction; Time-Lapse Imaging; Zonula Occludens-1 Protein | 2016 |