1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with cycloheximide in 93 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (10.75) | 18.7374 |
| 1990's | 71 (76.34) | 18.2507 |
| 2000's | 12 (12.90) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, KJ; Kwon, HB; Lee, CC; Schuetz, AW; Yoo, YR | 1 |
| Datta, R; Hass, R; Kharbanda, S; Kufe, D; Nakamura, T; Rubin, E | 1 |
| Tsuneishi, S | 1 |
| Ikeda, K; Kikuchi, T; Matsumoto, T; Morimoto, K; Nakano, T; Ogata, E; Okazaki, R; Sakamoto, A; Urakawa, K | 1 |
| Benveniste, EN; Chung, IY; Kwon, J | 1 |
| Amstad, PA; Cerutti, PA; Krupitza, G | 1 |
| Kumegawa, M; Oshima, T; Tanabe, T; Yamamoto, S; Yokoyama, C; Yoshimoto, T | 1 |
| Grove, RI; Kiener, PA; Mazzucco, CE; Radka, SF; Shoyab, M | 1 |
| Baldari, CT; Macchia, G; Massone, A; Telford, JL | 1 |
| Kelly, MD; Kollros, PR; Konkle, BA | 1 |
| Nakajima, K; Wall, R | 1 |
| Hargrove, ME; Ting, CC | 1 |
| Datta, R; Kharbanda, S; Kufe, D | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Davidson, MB; Furman, A; Molnar, IG; Yamaguchi, D | 1 |
| Matsuda, T; Noguchi, T; Takenaka, M; Tanaka, T; Yamada, K | 1 |
| Logan, CY; Manejwala, FM; Schultz, RM | 1 |
| Moore, JJ; Moore, RM; Vander Kooy, D | 1 |
| Beermann, ML; Shea, TB | 1 |
| Emoto, T; Hattori, Y; Hiraiwa, M; Kasai, K; Kuroda, H; Shimoda, S; Yamazaki, A | 1 |
| Akiyama, SK; Asseffa, A; Breton, P; Cha, JK; Grzegorzewski, K; Olden, K; White, SL | 1 |
| Kizaki, H; Odaka, C; Tadakuma, T | 1 |
| Goldthwait, DA; Lin, CS; Samols, D | 1 |
| Hartzell, P; McConkey, DJ; Orrenius, S | 1 |
| Mattila, P; Renkonen, R; Turunen, JP | 1 |
| Kato, K; Morimura, S; Tashiro, F; Ueno, Y | 1 |
| Johnson, AL; Tilly, JL | 1 |
| Alonso, M; Cárdenas, L; Carrera, AC; de Landázuri, MO; Sánchez-Madrid, F; Tugores, A | 1 |
| Levin, EG; Marotti, KR; Santell, L | 1 |
| Lichtman, MA; Segel, GB; Woodlock, TJ | 1 |
| Ishimura, Y; Kizaki, H; Muramatsu, J; Odaka, C; Tadakuma, T | 1 |
| Gilchrest, BA; Gordon, PR | 1 |
| Berlin, RD; Pearson, CM; Preston, SF; Volpi, M | 1 |
| Bhat, NK; Diaz de la Espina, SM; Fisher, RJ; Fujiwara, S; Papas, TS | 1 |
| Kizaki, H; Ohsaka, F; Sakurada, T; Shimada, H | 1 |
| Deli, E; Kiss, Z; Kuo, JF | 1 |
| Kachra, Z; Posner, BI; Yang, CR | 1 |
| Iitaka, M; Ishii, J; Kitahama, S | 1 |
| Endo, T; Kumegawa, M; Takahashi, Y; Taketani, Y; Yamamoto, S | 1 |
| Allen, JM; Balbi, D | 1 |
| Hügel, U; Klaus, G; May, T; Mayer, H; Mehls, O; Ritz, E; von Eichel, B | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Phillips, ME; Platt, JE | 1 |
| Clegg, JM; McKenna, TM; Williams, TJ | 1 |
| Dickson, RB; Johnson, GR; Martínez-Lacaci, I; Normanno, N; Plowman, GD; Saceda, M; Salomon, DS | 1 |
| Aggarwal, BB; Chan, H; Higuchi, M; Singh, S | 1 |
| Atkins, KB; Troen, BR | 1 |
| Kondoh, S; Mue, S; Ohuchi, K; Tanabe, J; Watanabe, M | 1 |
| Collado-Escobar, D; Mollinedo, F; Pérez-Sala, D | 1 |
| Farber, JL; Mizumoto, K; Rothman, RJ | 1 |
| Isselbacher, KJ; Ohta, T; Rhoads, DB; Shioda, T | 1 |
| Akagi, Y; Ito, K; Sawada, S | 1 |
| Kahri, A; Liu, J; Teppo, AM; Voutilainen, R | 1 |
| Howard, RL; Williams, B | 1 |
| Larsen, TH; Lillehaug, JR; Myking, O; Saetersdal, T | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Mitchell, MD; Pollard, JK | 1 |
| Hinko, A; Soloff, MS | 1 |
| Kim, HD; Lim, RW; Park, DJ | 1 |
| Bonjour, JP; Law, F; Rizzoli, R | 1 |
| Avioli, LV; Chaudhary, LR; Cheng, SL | 1 |
| Chang, KJ; Im, WB; Kim, JW; Kwon, HB; Lee, J; Schuetz, AW | 1 |
| Huang, H; Jan, KY; Kuo, CF; Wang, TS | 1 |
| Ha, TS; Kim, YH; Song, DK; Suh, HW; Wie, MB | 1 |
| Briand, P; Carlier, K; Joulin, V; Rouquet, N; Wiels, J | 1 |
| Fabiani, R; Marchetti, C; Mastrandrea, V; Migliorati, G; Moraca, R; Morozzi, G; Nicoletti, I; Riccardi, C | 1 |
| Chua, BH; Chua, CC; Hamdy, RC | 2 |
| Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H | 1 |
| Hirata, C; Kizaki, H; Onishi, Y; Sakurai, Y; Tanimoto, Y; Yamada, T | 1 |
| Moon, EA; O'Neill, C | 1 |
| Chen, JC; Davis, BH; Leon, MA; Leong, LC | 1 |
| Chen, JH; Lin, LY; Yu, CW | 1 |
| Fagin, JA; Maeda, S; Naito, S; Paul, R; Shimizu, S; Wang, J | 1 |
| Crissman, HA; Sailer, BL; Steinkamp, JA; Valdez, JG | 1 |
| Blanco-Rodríguez, J; Martínez-García, C | 1 |
| Ezawa, H; Harigaya, K; Ishii, G; Mikata, A; Nakajima, N | 1 |
| Huh, SO; Kim, YH; Lee, JK; Lee, KJ; Song, DK; Suh, HW; Won, JS | 1 |
| Gebert, CA; Park, SH; Waxman, DJ | 2 |
| Fujioka, A; Nagano, M; Nakahama, K; Sasaki, H; Shinoda, K | 1 |
| Cafferata, EG; Giordano, L; González-Guerrico, AM; Pivetta, OH; Santa-Coloma, TA | 1 |
| Ikewaki, N; Inoko, H; Inoue, H; Mori, N; Tamauchi, H; Yamada, A; Yamao, H | 1 |
| Miyata, Y; Nagano, M; Sato, S; Ui-Tei, K | 1 |
| Choi, MR; Suh, HW; Won, JS | 1 |
| Ganapathy, V; Hatanaka, T; Huang, W; Martindale, RG | 1 |
| Karube-Harada, A; Kashida, S; Kato, H; Nakamura, Y; Sugino, N; Takayama, H; Takiguchi, S; Yamagata, Y | 1 |
| Chang, YC; Hsieh, YS; Yang, SF | 1 |
| Chang, YC; Hsieh, YS; Lai, CC; Liu, JY; Yang, SF | 1 |
| Gimbrone, MA; Masuda, J; Ochi, H | 1 |
| Hsieh, HY; Hsieh, YS; Huang, CY; Kuo, SJ; Liu, JY; Tsai, JH; Wu, TT; Yu, SY | 1 |
| Bordin, M; Citi, S; D'Atri, F; Guillemot, L | 1 |
| Horiuchi, N; Maeda, T | 1 |
93 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and cycloheximide
| Article | Year |
|---|---|
Induction of ovulation and oocyte maturation of amphibian (Rana dybowskii) ovarian follicles by protein kinase C activation in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Colforsin; Cycloheximide; Enzyme Activation; Female; Isoquinolines; Oogenesis; Ovarian Follicle; Ovary; Ovulation Induction; Piperazines; Pituitary Gland; Progesterone; Protein Kinase C; Radioimmunoassay; Ranidae; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Division; Cycloheximide; Dactinomycin; Ethers, Cyclic; Gene Expression Regulation, Leukemic; Genes, jun; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Male; Monocytes; Neoplasm Proteins; Neoplastic Stem Cells; Okadaic Acid; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Regulation of neurite outgrowth through protein kinase C and protease nexin-1 in neuroblastoma cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cycloheximide; Dactinomycin; Humans; Isoquinolines; Molecular Sequence Data; Neurites; Neuroblastoma; Neurofilament Proteins; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; RNA, Messenger; RNA, Neoplasm; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate; Thrombin; Tumor Cells, Cultured | 1992 |
Transcriptional activation of c-fos and c-jun protooncogenes by serum growth factors in osteoblast-like MC3T3-E1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Cell Differentiation; Cycloheximide; Dactinomycin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Growth Substances; Insulin-Like Growth Factor I; Isoquinolines; Mice; Osteoblasts; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; Staurosporine; Transforming Growth Factor beta | 1992 |
Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Base Sequence; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Interferon-gamma; Interleukin-1; Isoquinolines; Lipopolysaccharides; Molecular Sequence Data; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; RNA, Messenger; Second Messenger Systems; Staurosporine; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1992 |
Mechanism of c-fos induction by active oxygen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Benzamides; Cell Line; Cycloheximide; DNA Repair; Genes, fos; Isoquinolines; Molecular Sequence Data; Oncogene Protein p65(gag-jun); Oncogene Proteins v-fos; Oxygen; Piperazines; Protein Kinase Inhibitors; Signal Transduction; Transcription, Genetic | 1992 |
cAMP-dependent induction of fatty acid cyclooxygenase mRNA in mouse osteoblastic cells (MC3T3-E1).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Blotting, Western; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Dinoprostone; Enzyme Induction; Epinephrine; Gene Expression; Isoquinolines; Mice; Osteoblasts; Piperazines; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides | 1991 |
Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cross-Linking Reagents; Cycloheximide; DNA, Neoplasm; Enzyme-Linked Immunosorbent Assay; Humans; Isoquinolines; Liver Neoplasms; Oncostatin M; Peptides; Phosphorylation; Piperazines; Receptors, Cell Surface; Receptors, Cytokine; Receptors, LDL; Receptors, Oncostatin M; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 1991 |
A role for protein kinase C activity in interleukin-1 (IL-1) induction of IL-2 gene expression but not in IL-1 signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Cycloheximide; Gene Expression; Humans; Interleukin-1; Interleukin-2; Isoquinolines; Kinetics; Mice; Nucleic Acid Hybridization; Piperazines; Plasmids; Promoter Regions, Genetic; Protein Kinase C; RNA; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1990 |
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C-mediated pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Fibroblast Growth Factor 1; Gene Expression; Humans; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Piperazines; Plasminogen Inactivators; Protein Kinase C; Signal Transduction; Tissue Plasminogen Activator; Transcription, Genetic | 1990 |
Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cycloheximide; DNA-Binding Proteins; Gene Expression Regulation; Genistein; Hybridomas; Immediate-Early Proteins; In Vitro Techniques; Interleukin-6; Isoflavones; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Tristetraprolin; Tyrosine | 1991 |
Anti-CD3 antibody-induced activated killer cells: cytokines as the additional signals for activation of killer cells in effector phase to mediate slow lysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cycloheximide; Cytokines; Cytotoxicity, Immunologic; Female; Interleukins; Isoquinolines; Killer Cells, Natural; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Piperazines; Protein Kinase C; Receptors, Antigen, T-Cell; Tumor Necrosis Factor-alpha | 1991 |
Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aphidicolin; Cell Line; Cell Nucleus; Cycloheximide; Cytarabine; Dactinomycin; Diterpenes; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Neoplasm; Sulfonamides; Transcription Factors; Transcription, Genetic | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Glyburide-stimulated glucose transport in cultured muscle cells via protein kinase C-mediated pathway requiring new protein synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Aminoquinolines; Animals; Biological Transport; Cells, Cultured; Cycloheximide; Glucose; Glyburide; Glycogen; Islets of Langerhans; Isoquinolines; Muscles; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbohydrates; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; Gene Expression Regulation, Enzymologic; Glucokinase; Hormones; Isoenzymes; Isoquinolines; Liver; Male; Piperazines; Protein Kinase C; Pyruvate Kinase; Rats; Rats, Inbred Strains; RNA, Messenger; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
Regulation of hsp70 mRNA levels during oocyte maturation and zygotic gene activation in the mouse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amanitins; Animals; Base Sequence; Cleavage Stage, Ovum; Cycloheximide; Gene Expression; Heat-Shock Proteins; Isoquinolines; Mice; Molecular Sequence Data; Oligonucleotides; Oocytes; Phosphoproteins; Piperazines; Polymerase Chain Reaction; Protein Kinase Inhibitors; RNA, Messenger | 1991 |
Protein kinase-C activation is required for oxytocin-induced prostaglandin production in human amnion cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Calcium; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Isoquinolines; Oxytocin; Phorbol Esters; Piperazines; Pregnancy; Protein Kinase C; RNA, Messenger; Staurosporine; Time Factors; Type C Phospholipases | 1991 |
Staurosporine-induced morphological differentiation of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Axons; Cell Differentiation; Colchicine; Cycloheximide; Humans; Isoquinolines; Microtubules; Neuroblastoma; Neurons; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1991 |
Inhibition by protein kinase-C inhibitor and cycloheximide of phorbol ester- and epidermal growth factor-induced arachidonic acid metabolism in cultured porcine thyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dinoprostone; Epidermal Growth Factor; Isoquinolines; Kinetics; Male; Mice; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1990 |
Swainsonine modulation of protein kinase C activity in murine peritoneal macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Cycloheximide; Dose-Response Relationship, Drug; Female; Immunoblotting; Isoquinolines; Macrophage Activation; Macrophages; Mannosidases; Mice; Phorbol Esters; Piperazines; Protein Kinase C; Sphingosine; Swainsonine | 1990 |
T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigen-Antibody Reactions; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Cell Survival; Cycloheximide; Dactinomycin; DNA Damage; Dose-Response Relationship, Immunologic; Hybridomas; In Vitro Techniques; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; Piperazines; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Time Factors | 1990 |
Induction of transcription from the long terminal repeat of Moloney murine sarcoma provirus by UV-irradiation, x-irradiation, and phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Line; Cells, Cultured; Cycloheximide; Gene Expression Regulation, Viral; Genes, Viral; Isoquinolines; Mice; Mice, Inbred Strains; Moloney murine sarcoma virus; Nucleic Acid Hybridization; Piperazines; Protein Kinase C; Proviruses; Repetitive Sequences, Nucleic Acid; RNA, Viral; Sarcoma Viruses, Murine; Tetradecanoylphorbol Acetate; Ultraviolet Rays; X-Rays | 1990 |
Rapid turnover of endogenous endonuclease activity in thymocytes: effects of inhibitors of macromolecular synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Nucleus; Cells, Cultured; Concanavalin A; Cycloheximide; Dactinomycin; Endonucleases; Interleukin-1; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Protease Inhibitors; Protein Biosynthesis; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; RNA, Messenger; Thymus Gland | 1990 |
cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Endothelium, Vascular; Gene Expression; In Vitro Techniques; Inflammation; Interleukin-1; Isoquinolines; Lymphocytes; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides | 1990 |
Modulation of c-myc gene expression by extracellular stimuli in rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Concanavalin A; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Gene Expression; Insulin; Insulin Antagonists; Isoquinolines; Liver Neoplasms, Experimental; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Effects of a phorbol ester, a calcium ionophore, and 3',5'-adenosine monophosphate production on hen granulosa cell plasminogen activator activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Chickens; Cyclic AMP; Cycloheximide; Dactinomycin; Female; Granulosa Cells; In Vitro Techniques; Isoquinolines; L-Lactate Dehydrogenase; Luteinizing Hormone; Piperazines; Plasminogen Activators; Progesterone; Protein Kinase C; Sheep; Tetradecanoylphorbol Acetate | 1988 |
Activators of protein kinase C up-regulate the cell surface expression of CD2 and CD5 T cell glycoproteins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; Calcium Channel Blockers; CD2 Antigens; CD5 Antigens; Cell Membrane; Cells, Cultured; Cycloheximide; Diglycerides; Dinoprostone; Enzyme Activation; Flow Cytometry; Humans; Isoquinolines; Membrane Glycoproteins; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Receptors, Immunologic; RNA, Messenger; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. Dependence on the elevation of messenger RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Cloning, Molecular; Colforsin; Cycloheximide; DNA; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1989 |
Diacylglycerol and calcium induce rapid enhancement of A-system amino acid transport by independent mechanisms in human T-lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; Biological Transport; Calcium; Cycloheximide; Cytoplasm; Diglycerides; Egtazic Acid; Ethers; Extracellular Space; Glycerides; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; T-Lymphocytes | 1989 |
Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cell Survival; Cycloheximide; Dactinomycin; DNA Damage; Isoquinolines; Lectins; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peanut Agglutinin; Phenotype; Piperazines; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Human melanogenesis is stimulated by diacylglycerol.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Cycloheximide; Dactinomycin; Diglycerides; Enzyme Activation; Glycerides; Humans; Isoquinolines; Melanins; Piperazines; Protein Kinase C; Skin Pigmentation; Sphingosine | 1989 |
Regulation of cell shape in the Cloudman melanoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-MSH; Animals; Axons; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Fluorescent Antibody Technique; Isoquinolines; Melanocyte-Stimulating Hormones; Melanoma; Mice; Microscopy, Electron; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1987 |
A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cycloheximide; Diglycerides; Enzyme Activation; Gene Expression Regulation; Half-Life; Humans; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors | 1988 |
Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Calcium; Cycloheximide; Deoxyadenosines; Deoxyguanosine; DNA; DNA Damage; Isoquinolines; Kinetics; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred BALB C; Piperazines; Poly Adenosine Diphosphate Ribose; Purine Nucleosides; T-Lymphocytes; Zinc | 1988 |
Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Catalase; Cell Line; Chlorobenzoates; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Ethanolamine; Ethanolamines; Free Radicals; Humans; Isoquinolines; Leukemia, Experimental; Nuclear Proteins; Phosphatidylserines; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Puromycin; Subcellular Fractions; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1987 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alprostadil; Animals; Base Sequence; Calcimycin; Cell Line; Cycloheximide; Dexamethasone; Enzyme Induction; Iloprost; Isoenzymes; Isoquinolines; Mice; Molecular Sequence Data; Piperazines; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1994 |
Role of protein kinase C in mediating NGF effect on neuropeptide Y expression in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Binding Sites; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Gene Expression; Isoquinolines; Kinetics; Molecular Sequence Data; Naphthalenes; Nerve Growth Factors; Neuropeptide Y; Oligodeoxyribonucleotides; PC12 Cells; Piperazines; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Synergistic effects of parathyroid hormone and 1,25-dihydroxyvitamin D3 on proliferation and vitamin D receptor expression of rat growth cartilage cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcitriol; Cell Division; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; DNA; Drug Synergism; Growth Plate; Isoquinolines; Parathyroid Hormone; Peptide Fragments; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Calcitriol; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
The use of ubiquitin as a marker of thyroxine-induced apoptosis in cultured Rana catesbeiana tail tips.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Biomarkers; Cells, Cultured; Cycloheximide; Dactinomycin; Fluorescence; Isoquinolines; Piperazines; Protein Kinase C; Rana catesbeiana; RNA; Tail; Thyroxine; Time Factors; Ubiquitins | 1994 |
Protein kinase C is a mediator of lipopolysaccharide-induced vascular suppression in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Cell Membrane; Citrulline; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoquinolines; Kinetics; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfonamides | 1994 |
Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amphiregulin; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bryostatins; Culture Media, Conditioned; Cycloheximide; Dose-Response Relationship, Drug; EGF Family of Proteins; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Isoquinolines; Lactones; Macrolides; Piperazines; Polyunsaturated Alkamides; Protein Kinase C; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Base Sequence; Cell Differentiation; Cycloheximide; Cytotoxicity, Immunologic; DNA Damage; Ethers, Cyclic; Gene Expression Regulation, Leukemic; Humans; Isoquinolines; Leukemia, Myeloid; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Okadaic Acid; Piperazines; Protease Inhibitors; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Phorbol ester stimulated cathepsin L expression in U937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cathepsin L; Cathepsins; Cell Differentiation; Cycloheximide; Cysteine Endopeptidases; Drug Interactions; Endopeptidases; Enzyme Induction; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Monocytes; Neoplasm Proteins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1995 |
Possible roles of protein kinases in neutrophil chemotactic factor production by leucocytes in allergic inflammation in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cells, Cultured; Chemotactic Factors; Culture Media, Conditioned; Cycloheximide; Depression, Chemical; Dexamethasone; Genistein; Hypersensitivity; Indole Alkaloids; Inflammation; Isoelectric Focusing; Isoflavones; Isoquinolines; Leukocytes; Male; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1994 |
Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Apoptosis; Cell Cycle; Cell Line; Cycloheximide; DNA, Neoplasm; Endodeoxyribonucleases; Fluoresceins; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Lovastatin; Mevalonic Acid; Piperazines; Protein Kinase C; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkylating Agents; Animals; Apoptosis; Cell Division; Cycloheximide; DNA; Etoposide; Isoquinolines; L Cells; Methylnitrosourea; Mice; Piperazines; Protein Biosynthesis; Protein Kinase C; Protein Synthesis Inhibitors; Topoisomerase II Inhibitors | 1994 |
Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Carrier Proteins; Cell Differentiation; Cell Division; Cycloheximide; Dactinomycin; Enzyme Activation; gamma-Glutamyltransferase; Gene Expression; Glucose; Isoquinolines; Kidney; Kinetics; LLC-PK1 Cells; Membrane Glycoproteins; Membrane Proteins; Monosaccharide Transport Proteins; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Sodium; Sodium-Glucose Transporter 1; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1994 |
Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bromodeoxyuridine; Cell Death; Cycloheximide; Isoquinolines; Leukemia, Lymphoid; Necrosis; Piperazines; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Regulation of parathyroid hormone gene expression and peptide secretion in human parathyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Alkaloids; Base Sequence; Blotting, Northern; Calcium; Cell Division; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hyperparathyroidism; Isoquinolines; Molecular Sequence Data; Oligonucleotide Probes; Parathyroid Hormone; Parathyroid Neoplasms; Piperazines; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Glucose-induced changes in Na+/H+ antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Gene Expression Regulation; Glucose; Hydrogen-Ion Concentration; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Hydrogen Exchangers | 1994 |
Inhibition and down-regulation of protein kinase C in cultured atrial myocytes: effects on distribution of specific granules and secretion of atrial natriuretic peptide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cells, Cultured; Culture Media; Cycloheximide; Cytoplasmic Granules; Down-Regulation; Fluorescent Antibody Technique; Isoquinolines; Microscopy, Electron; Microtubules; Myocardium; Piperazines; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'-monophosphate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amnion; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; Drug Synergism; Female; Isoquinolines; Oxytocin; Piperazines; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Receptors, Angiotensin; Receptors, Oxytocin; Tetradecanoylphorbol Acetate; Up-Regulation | 1993 |
Rapid induction of mouse virus-like (VL30) element transcripts by erythropoietin in murine erythroid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cloning, Molecular; Cycloheximide; DNA; DNA Transposable Elements; Erythroid Precursor Cells; Erythropoietin; Female; Friend murine leukemia virus; Gene Expression; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Staurosporine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Transforming growth factor-beta inhibits phosphate transport in renal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Isoquinolines; Kidney; Opossums; Phosphates; Piperazines; Protein Serine-Threonine Kinases; Signal Transduction; Time Factors; Transforming Growth Factor beta | 1993 |
Induction of early growth response-1 gene by interleukin-1 beta and tumor necrosis factor-alpha in normal human bone marrow stromal an osteoblastic cells: regulation by a protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Bone Marrow; Bone Marrow Cells; Cattle; Cells, Cultured; Connective Tissue; Culture Media; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Fetal Blood; Gene Expression Regulation; Genes, Immediate-Early; Humans; Immediate-Early Proteins; Interleukin-1; Isoquinolines; Molecular Sequence Data; Osteoblasts; Piperazines; Protein Kinase C; Protein Synthesis Inhibitors; Transcription Factors; Tumor Necrosis Factor-alpha | 1996 |
Prostaglandin production and ovulation during exposure of amphibian ovarian follicles to gonadotropin or phorbol ester in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Cells, Cultured; Cyclic AMP; Cycloheximide; Cyclooxygenase Inhibitors; Dactinomycin; Dinoprost; Enzyme Inhibitors; Female; Gonadotropins; Indomethacin; Ovulation; Phorbol Esters; Protein Synthesis Inhibitors; Radioimmunoassay; Ranidae | 1995 |
Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Arsenites; Cell Count; Chelating Agents; CHO Cells; Chromans; Cricetinae; Cycloheximide; DNA Damage; Electrophoresis, Agar Gel; Flow Cytometry; Fluoresceins; G1 Phase; G2 Phase; Hydrogen Peroxide; Reactive Oxygen Species | 1996 |
Molecular mechanisms underlying the regulation of proenkephalin gene expression in cultured spinal cord cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Mollusk Venoms; Nimodipine; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Signal Transduction; Spinal Cord; Tetradecanoylphorbol Acetate | 1996 |
Multiple pathways of Fas-induced apoptosis in primary culture of hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Caspase 1; Caspase 3; Caspases; Cells, Cultured; Ceramides; Cycloheximide; Cysteine Endopeptidases; Enzyme Induction; Enzyme Inhibitors; fas Receptor; Liver; Mice; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelins | 1996 |
Deoxycholic acid and SCFA-induced apoptosis in the human tumor cell-line HT-29 and possible mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Butyrates; Butyric Acid; Calcium; Chelating Agents; Colonic Neoplasms; Cycloheximide; Dactinomycin; Deoxycholic Acid; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Genistein; Humans; Isoflavones; Propionates; Protein Synthesis Inhibitors; Time Factors; Tumor Cells, Cultured | 1997 |
Regulation of thrombospondin-1 production by angiotensin II in rat heart endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Cell Line; Cycloheximide; Dactinomycin; Endothelium; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Losartan; Membrane Glycoproteins; Myocardium; Protein Kinase C; Pyridines; Rats; Tetrazoles; Thrombospondins | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Preincubation of thymocytes with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) induces apoptosis in non-stimulated thymocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Isoenzymes; Isoquinolines; Lactams, Macrocyclic; Male; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA; Sulfonamides; T-Lymphocytes; Thymus Gland | 1997 |
CTP:phosphocholine cytidylyltransferase activity in the preimplantation mouse embryo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amanitins; Animals; Blastocyst; Cell Division; Choline-Phosphate Cytidylyltransferase; Chromatography, Thin Layer; Cycloheximide; Enzyme Inhibitors; Mice; Mice, Mutant Strains; Nucleotidyltransferases; Oocytes; Protein Kinase C; Protein Synthesis Inhibitors; RNA Polymerase II; Zygote | 1997 |
Gamma radiation induces CD69 expression on lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; Bromodeoxyuridine; Cycloheximide; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Flow Cytometry; Gamma Rays; Humans; Kinetics; Lectins, C-Type; Lymphocyte Activation; Phytohemagglutinins; Protein Synthesis Inhibitors; T-Lymphocytes | 1997 |
Metal-induced metallothionein gene expression can be inactivated by protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adaptor Protein Complex 1; Adaptor Protein Complex alpha Subunits; Adaptor Proteins, Vesicular Transport; Alkaloids; Animals; Benzophenanthridines; Cadmium; CHO Cells; Cricetinae; Cycloheximide; DNA-Binding Proteins; Drug Resistance; Enzyme Inhibitors; Gene Expression Regulation; Membrane Proteins; Metallothionein; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Transcription Factor MTF-1; Transcription Factors; Zinc | 1997 |
Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Becaplermin; Benzoquinones; Calcium; Cells, Cultured; Collagenases; Culture Media, Serum-Free; Cyclic AMP; Cycloheximide; Endoplasmic Reticulum; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Gene Expression Regulation; Lactams, Macrocyclic; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Proto-Oncogene Proteins c-sis; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; RNA, Messenger; Transcription Factors; Transcription, Genetic | 1998 |
Apoptosis induced with different cycle-perturbing agents produces differential changes in the fluorescence lifetime of DNA-bound ethidium bromide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Camptothecin; Cell Cycle; Chromatin; Cycloheximide; DNA, Neoplasm; Enzyme Inhibitors; Ethidium; Flow Cytometry; Fluorescence; Fluorescent Dyes; Gamma Rays; Genistein; HL-60 Cells; Humans; Protein Synthesis Inhibitors | 1998 |
Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Northern; Cattle; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Immunoblotting; Losartan; Lymphokines; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Rats; RNA, Messenger; Transcription Factors; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasoconstrictor Agents | 1998 |
In vivo analysis of germ cell apoptosis reveals the existence of stage-specific 'social' control of germ cell death in the seminiferous epithelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cycloheximide; Enzyme Inhibitors; Fever; Male; Protein Kinase C; Rats; Rats, Wistar; Seminiferous Tubules; Spermatozoa; Zinc | 1997 |
12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Blast Crisis; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Half-Life; Humans; Ki-1 Antigen; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Prostaglandin E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic | 1998 |
Termination of growth hormone pulse-induced STAT5b signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cycloheximide; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Growth Hormone; Janus Kinase 2; Leupeptins; Liver; Milk Proteins; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Somatotropin; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Vanadates | 1999 |
Effect of TPA on aquaporin 4 mRNA expression in cultured rat astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Aquaporin 4; Aquaporins; Astrocytes; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate | 1999 |
Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; Electrophoresis; Female; Genistein; Growth Hormone; Growth Inhibitors; Janus Kinase 2; Leupeptins; Liver; Male; Milk Proteins; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1999 |
Interleukin-1beta regulates CFTR expression in human intestinal T84 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Benzoquinones; Cell Line; Colon; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Genistein; Humans; Indoles; Interleukin-1; Lactams, Macrocyclic; Maleimides; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2000 |
A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Antibodies, Monoclonal; Antibody Specificity; Calcium; Calmodulin; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Chelating Agents; Cycloheximide; Cytochalasin D; Edetic Acid; Endothelium, Vascular; Enzyme Inhibitors; Epitopes; Flow Cytometry; Genistein; HL-60 Cells; Humans; K562 Cells; Microtubules; Nocodazole; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins | 2000 |
Calmodulin-dependent and -independent apoptosis in cell of a Drosophila neuronal cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Calcimycin; Calcium; Calmodulin; Caspases; Cell Line; Chelating Agents; Cycloheximide; Dactinomycin; DNA Fragmentation; Drosophila melanogaster; Egtazic Acid; Enzyme Inhibitors; Ionophores; Neurons; Protein Synthesis Inhibitors; Sulfonamides | 2000 |
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1 | 2001 |
Differential influence of cAMP on the expression of the three subtypes (ATA1, ATA2, and ATA3) of the amino acid transport system A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adjuvants, Immunologic; Amino Acid Transport Systems; Amino Acids; Aminoisobutyric Acids; Blotting, Northern; Carrier Proteins; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Poly A; Protein Binding; Protein Synthesis Inhibitors; RNA, Messenger; Sodium; Substrate Specificity; Time Factors; Tumor Cells, Cultured | 2001 |
Induction of manganese superoxide dismutase by tumour necrosis factor-alpha in human endometrial stromal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Embryo Implantation; Endometrium; Enzyme Inhibitors; Female; Humans; Middle Aged; Protein Kinase C; Protein Synthesis Inhibitors; Stromal Cells; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Regulation of matrix metalloproteinase-2 production by cytokines and pharmacological agents in human pulp cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carbazoles; Cells, Cultured; Culture Media, Conditioned; Cycloheximide; Cytokines; Dental Pulp; Enzyme Inhibitors; Gelatinases; Humans; Indoles; Interleukin-1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pulpitis; Reproducibility of Results; Time Factors; Transforming Growth Factor beta | 2001 |
Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aggregatibacter actinomycetemcomitans; Cells, Cultured; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Matrix Metalloproteinase 2; Periodontal Diseases; Periodontal Ligament; Porphyromonas gingivalis; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2002 |
Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Membrane; Cells, Cultured; Culture Media; Cycloheximide; DNA-Binding Proteins; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; GTP-Binding Proteins; Imidazoles; Intercellular Adhesion Molecule-1; Interferon Regulatory Factor-1; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-1; Interleukin-13; Interleukin-4; NF-kappa B; Okadaic Acid; Osmosis; Phosphoproteins; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Staurosporine; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast; Breast Neoplasms; Concanavalin A; Cycloheximide; Dactinomycin; Enzyme Activation; Enzyme Activators; Female; Fibroadenoma; Gelatin; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Organ Culture Techniques; Protease Inhibitors; Protein Biosynthesis; Protein Kinase C; Protein Synthesis Inhibitors; Transcription, Genetic | 2004 |
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Butyrates; Cell Adhesion; Cell Differentiation; COS Cells; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoblotting; Isobutyrates; Membrane Proteins; Mice; Microfilament Proteins; Microscopy, Fluorescence; Protein Kinase Inhibitors; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions; Up-Regulation; Vorinostat | 2004 |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin | 2009 |