Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and cyclic gmp

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with cyclic gmp in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (17.07)	18.7374
1990's	28 (68.29)	18.2507
2000's	2 (4.88)	29.6817
2010's	4 (9.76)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jaiswal, RK	1
Inoue, T; Morita, T; Okuhama, R; Sera, M; Tominaga, N; Ueki, H	1
Andersson, KE; Belfrage, P; Degerman, E; López-Aparicio, P; Manganiello, VC; Rascón, A	1
Falk, G; Shiells, RA	1
Horio, T; Kohno, M; Murakawa, K; Takeda, T; Yasunari, K; Yokokawa, K	1
Hagiwara, M; Hidaka, H; Watanabe, Y	1
Haneda, M; Horide, N; Kajiwara, N; Kikkawa, R; Koya, D; Maeda, S; Shigeta, Y; Togawa, M	1
Asano, T; Koide, T; Matsui, T; Naitoh, S; Sugawa, M; Takato, M	1
Sancho-Tello, M; Terranova, PF	1
Kondratyev, AD; Posypanova, GA; Severin, SE	1
el-Fakahany, EE; Lai, WS; Rogers, TB	1
Rao, MC; Toskulkao, C	1
Mattila, P; Renkonen, R; Turunen, JP	1
Agopyan, N; Krnjević, K; Leblond, J	1
Chik, CL; Ho, AK; Klein, DC	1
Alger, BE; Doerner, D	1
Jaiswal, N; Jaiswal, RK; Sharma, RK	1
Jaiswal, RK; Sharma, RK	1
Hidaka, H; Kawakami, K; Ohmura, T; Onoue, K; Yamamoto, Y	1
el-Fakahany, EE; Lai, WS	1
Craven, PA; DeRubertis, FR; Studer, RK	1
Chik, CL; Ho, AK; Karpinski, E; Li, B; Liu, QY	1
Gukovskaya, AS; Pandol, SJ	1
Brunner, F	1
Burnside, B; Liepe, BA	1
Dreijer, AM; Kits, KS	1
Nishizawa, S; Uemura, K; Yamamoto, S	1
Sjöholm, A	1
Liu, H; Sperelakis, N; Xiong, Z	1
Ganguly, NK; Kaur, T; Singh, S; Verma, M	1
Delay, RJ; Dionne, VE; Dubin, AE	1
Copenhagen, DR; Dixon, DB	1
Braun, C; Plattner, H; Purvee, J; Van Houten, JL; Yang, WQ	1
Ayajiki, K; Okamura, T; Toda, N	1
Chik, CL; Ho, AK; Karpinski, E; Li, B	1
Allen, JC; Kahn, AM; Kone, BC; Yang, Y; Zhang, S	1
Newland, PL; Yates, P	1
Jin, LM; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z	1
Chai, CY; Chen, IC; Chen, IJ; Chou, SH; Dai, ZK; Tan, MS; Wu, BN; Wu, JR; Yeh, JL	1
Bieger, D; Burke, MM; Tabrizchi, R	1
Dimitriadis, F; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, K; Sejima, T; Shimizu, S; Tsounapi, P	1

Reviews

1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and cyclic gmp

Article	Year
[Trend in the development of new inhibitors of cyclic nucleotide metabolism and their clinical application]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cilostazol; Cyclic AMP; Cyclic GMP; Depression, Chemical; Isoquinolines; Nicardipine; Platelet Aggregation Inhibitors; Tetrazoles; Vasodilator Agents; Vinca Alkaloids	1991

Article

Year

[Trend in the development of new inhibitors of cyclic nucleotide metabolism and their clinical application].

Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:4

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cilostazol; Cyclic AMP; Cyclic GMP; Depression, Chemical; Isoquinolines; Nicardipine; Platelet Aggregation Inhibitors; Tetrazoles; Vasodilator Agents; Vinca Alkaloids

1991

Other Studies

40 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and cyclic gmp

Article	Year
Endothelin inhibits the atrial natriuretic factor stimulated cGMP production by activating the protein kinase C in rat aortic smooth muscle cells. Biochemical and biophysical research communications, 1992, Jan-15, Volume: 182, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Cytosol; Endothelins; Enzyme Activation; Isoquinolines; Kinetics; Male; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate	1992
Stimulatory effect of vanadate on 3',5'-cyclic guanosine monophosphate-inhibited low Michaelis-Menten constant 3',5'-cyclic adenosine monophosphate phosphodiesterase activity in isolated rat fat pads. Endocrinology, 1992, Volume: 131, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Alkaloids; Amiloride; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Insulin; Isoquinolines; Kinetics; Male; Microsomes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Staurosporine; Vanadates	1992
Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets. Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; In Vitro Techniques; Insulin; Isoquinolines; Kinetics; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin	1992
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive. Proceedings. Biological sciences, 1992, Jan-22, Volume: 247, Issue:1318 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylate Cyclase Toxin; Animals; Cholera Toxin; Cyclic GMP; Darkness; Dogfish; In Vitro Techniques; Isoquinolines; Macromolecular Substances; Membrane Potentials; Models, Neurological; NAD; Pertussis Toxin; Piperazines; Protein Kinase Inhibitors; Retina; Synapses; Virulence Factors, Bordetella	1992
Phorbol ester and atrial natriuretic peptide receptor response on vascular smooth muscle. Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Down-Regulation; Guanylate Cyclase; Isoquinolines; Muscle, Smooth, Vascular; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate	1992
Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation. Kidney international, 1991, Volume: 40, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Glomerular Mesangium; Guanylate Cyclase; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate	1991
Phorbol 12,13-diacetate-induced contraction of the canine basilar artery: role of protein kinase C. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1991, Volume: 11, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basilar Artery; Cyclic GMP; Dinoprost; Dogs; Endothelins; Enzyme Activation; Female; Imidazoles; Isoquinolines; Male; Muscle Contraction; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Quinacrine; Serotonin; Staurosporine	1991
Involvement of protein kinase C in regulating tumor necrosis factor alpha-stimulated progesterone production in rat preovulatory follicles in vitro. Endocrinology, 1991, Volume: 128, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; In Vitro Techniques; Isoquinolines; Ovarian Follicle; Ovulation; Piperazines; Progesterone; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha	1991
Effect of protein kinase modulators on the induction of morphological differentiation of pheochromocytoma PC12 cells by nerve and fibroblast growth factors. Biotechnology and applied biochemistry, 1990, Volume: 12, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Cell Differentiation; Cyclic AMP; Cyclic GMP; Drug Synergism; Fibroblast Growth Factors; Isoquinolines; Nerve Growth Factors; Pheochromocytoma; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Sulfonamides; Tumor Cells, Cultured	1990
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists. The Biochemical journal, 1990, Apr-01, Volume: 267, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cyclic GMP; Down-Regulation; Isoquinolines; Mice; N-Methylscopolamine; Neuroblastoma; Parasympathomimetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1990
Identification of a 50-kDa Ca-, cAMP-, and cGMP-dependent epithelial phosphoprotein as a cAMP regulatory protein. The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Cyclic AMP; Cyclic AMP Receptor Protein; Cyclic GMP; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epithelium; Flounder; Intestinal Mucosa; Isoquinolines; Kinetics; Molecular Weight; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Second Messenger Systems; Subcellular Fractions	1990
cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers. Journal of immunology (Baltimore, Md. : 1950), 1990, Dec-15, Volume: 145, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Endothelium, Vascular; Gene Expression; In Vitro Techniques; Inflammation; Interleukin-1; Isoquinolines; Lymphocytes; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides	1990
Mediation of acetylcholine's excitatory actions in central neurons. EXS, 1989, Volume: 57 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Cyclic GMP; Hippocampus; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Rats; Rats, Inbred Strains; Tetrodotoxin	1989
Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes. Biochemical pharmacology, 1988, Mar-15, Volume: 37, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Female; In Vitro Techniques; Isoproterenol; Isoquinolines; Norepinephrine; Pineal Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic	1988
Cyclic GMP depresses hippocampal Ca2+ current through a mechanism independent of cGMP-dependent protein kinase. Neuron, 1988, Volume: 1, Issue:8 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoquinolines; Membrane Potentials; Piperazines; Protein Kinases	1988
Negative regulation of atrial natriuretic factor receptor coupled membrane guanylate cyclase by phorbol ester. Potential protein kinase C regulation of cyclic GMP signal in isolated adrenocortical carcinoma cells of rat. FEBS letters, 1988, Jan-18, Volume: 227, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex Neoplasms; Animals; Atrial Natriuretic Factor; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate	1988
Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator. Biochemical and biophysical research communications, 1988, Oct-31, Volume: 156, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex Neoplasms; Animals; Carcinoma; Clonidine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1988
Induction and regulation of human interleukin 2 gene expression: significance of protein kinase C activation. Journal of biochemistry, 1986, Volume: 100, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Dinoprostone; Enzyme Activation; Gene Expression Regulation; Humans; Interleukin-2; Isoquinolines; Lymphocytes; Mitoguazone; Ornithine; Phytohemagglutinins; Piperazines; Prostaglandins E; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymidine	1986
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Histamine; Isoquinolines; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate	1987
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response. The Journal of clinical investigation, 1994, Volume: 93, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Amino Acid Oxidoreductases; Animals; Arginine; Calcimycin; Carbachol; Cyclic GMP; Diabetes Mellitus, Experimental; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kidney Glomerulus; Kinetics; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphates; Phosphorylation; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Staurosporine; Thromboxane A2	1994
cGMP inhibits L-type Ca2+ channel currents through protein phosphorylation in rat pinealocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Isoquinolines; Male; Nifedipine; Nitroprusside; Norepinephrine; Patch-Clamp Techniques; Phosphorylation; Pineal Gland; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thionucleotides	1995
Dual regulation of cGMP formation by calcium in pancreatic acinar cells. The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Oxidoreductases; Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Cyclic GMP; Cytosol; Guanylate Cyclase; Guinea Pigs; Homeostasis; Imidazoles; In Vitro Techniques; Isoquinolines; Kinetics; Nitric Oxide Synthase; Pancreas; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides; Trifluoperazine	1995
Dependence of endothelin-1 secretion on Ca2+. Biochemical pharmacology, 1995, Jun-16, Volume: 49, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcium; Cells, Cultured; Cyclic GMP; Endothelins; Endothelium, Vascular; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate	1995
Cyclic nucleotide regulation of teleost rod photoreceptor inner segment length. The Journal of general physiology, 1993, Volume: 102, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Actins; Animals; Cyclic AMP; Cyclic GMP; Cytoskeleton; Darkness; Ethers, Cyclic; In Vitro Techniques; Isoquinolines; Light; Okadaic Acid; Peptide Chain Elongation, Translational; Perciformes; Phosphoprotein Phosphatases; Photoreceptor Cells; Piperazines; Protein Kinase Inhibitors	1993
Multiple second messenger routes enhance two high-voltage-activated calcium currents in molluscan neuroendocrine cells. Neuroscience, 1995, Volume: 64, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channels; Cyclic AMP; Cyclic GMP; Electrophysiology; Isoquinolines; Lymnaea; Neurosecretory Systems; Nifedipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Piperazines; Protein Kinase C; Second Messenger Systems; Thionucleotides; Verapamil	1995
Interrelation between protein kinase C and nitric oxide in the development of vasospasm after subarachnoid hemorrhage. Neurological research, 1996, Volume: 18, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basilar Artery; Cyclic GMP; Dogs; Enzyme Inhibitors; Female; In Vitro Techniques; Ischemic Attack, Transient; Isometric Contraction; Isoquinolines; Male; Models, Cardiovascular; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Piperazines; Protein Kinase C; Staurosporine; Subarachnoid Hemorrhage	1996
Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms. Diabetes, 1997, Volume: 46, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium Channel Blockers; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gallopamil; Glucose; GTP-Binding Proteins; Insulin; Insulin Secretion; Ionomycin; Ionophores; Islets of Langerhans; Pertussis Toxin; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella	1997
Cyclic nucleotides regulate the activity of L-type calcium channels in smooth muscle cells from rat portal vein. Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cyclic GMP; Electrophysiology; Male; Muscle, Smooth, Vascular; Portal Vein; Rats; Rats, Sprague-Dawley	1997
Calcium and protein kinase C play a significant role in response to Shigella toxin in rabbit ileum both in vivo and in vitro. Biochimica et biophysica acta, 1997, Jul-10, Volume: 1361, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bacterial Toxins; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Electrolytes; Ileum; Indomethacin; Inositol Phosphates; Male; Neutralization Tests; Prostaglandins E; Protein Kinase C; Rabbits; Shiga Toxins; Tetradecanoylphorbol Acetate; Verapamil	1997
A cyclic nucleotide-dependent chloride conductance in olfactory receptor neurons. The Journal of membrane biology, 1997, Sep-01, Volume: 159, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Chloride Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Membrane Potentials; Necturus; Olfactory Receptor Neurons; Patch-Clamp Techniques; Photolysis; Sulfonamides	1997
Metabotropic glutamate receptor-mediated suppression of an inward rectifier current is linked via a cGMP cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Dec-01, Volume: 17, Issue:23 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Aminobutyrates; Animals; Atrial Natriuretic Factor; Benzoates; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Glycine; Ictaluridae; Ion Channel Gating; Isoquinolines; Models, Neurological; Patch-Clamp Techniques; Photoreceptor Cells; Potassium Channels; Receptors, Metabotropic Glutamate; Second Messenger Systems; Thionucleotides	1997
Cyclic nucleotides in glutamate chemosensory signal transduction of Paramecium. Journal of cell science, 1997, Volume: 110 ( Pt 20) Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Ammonium Chloride; Animals; Chemotactic Factors; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Inosine Monophosphate; Intracellular Fluid; Isoquinolines; Paramecium tetraurelia; Potassium Acetate; Quisqualic Acid; Second Messenger Systems; Signal Transduction	1997
Effect of Ca2+/calmodulin-dependent protein kinase II inhibitors on the neurogenic cerebroarterial relaxation. European journal of pharmacology, 1997, Dec-04, Volume: 340, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cerebral Arteries; Coronary Vessels; Cyclic GMP; Dinoprost; Dogs; Electric Stimulation; Enzyme Inhibitors; Female; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Norepinephrine; Oxytocics; Phosphorylation; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Tetrodotoxin; Vasoconstrictor Agents	1997
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylation. Journal of neurochemistry, 1999, Volume: 72, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Alkaloids; Animals; Antifungal Agents; Calcium Channels; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Indoles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Membrane Potentials; Nerve Tissue Proteins; Norepinephrine; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Pineal Gland; Protein Kinase C; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Sulfonamides; Sympathomimetics	1999
Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II. Circulation, 2003, Mar-25, Volume: 107, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Insulin; Ionomycin; Male; Muscle, Smooth, Vascular; Mutation; Phosphorylation; Rats; Rats, Sprague-Dawley; Threonine	2003
Nitrergic modulation of an oviposition digging rhythm in locusts. The Journal of experimental biology, 2007, Volume: 210, Issue:Pt 24 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Carbazoles; Cyclic GMP; Cyclic N-Oxides; Female; Grasshoppers; Guanylate Cyclase; Imidazoles; Indoles; Muscles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oviposition; Penicillamine; Protein Kinases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase	2007
Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Penis; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Species Specificity; Up-Regulation	2010
Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil. Pediatric pulmonology, 2011, Volume: 46, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterioles; Cyclic GMP; Endothelin-1; Hypertension, Pulmonary; Lung; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Wistar; rho-Associated Kinases; Treatment Outcome; Ventricular Dysfunction, Left	2011
Agonist-induced periodic vasomotion in rat isolated pulmonary artery. Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-1 Receptor Agonists; Animals; Benzophenanthridines; Calcium Channel Agonists; Calcium Signaling; Carbenoxolone; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Gap Junctions; In Vitro Techniques; Male; Methacholine Chloride; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Pinacidil; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Riluzole; Ryanodine; Tetraethylammonium; Vasomotor System	2011
Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacological research, 2012, Volume: 66, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic GMP; Erectile Dysfunction; Gene Expression Regulation; Hypertension; Male; Nitric Oxide Synthase Type III; Penis; Phosphorylation; Rats; Rats, Inbred SHR; Rats, Wistar; rho-Associated Kinases; RNA, Messenger	2012