1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with colforsin in 95 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (9.47) | 18.7374 |
1990's | 69 (72.63) | 18.2507 |
2000's | 15 (15.79) | 29.6817 |
2010's | 2 (2.11) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Castrén, E; Hartikka, J; Lindholm, D; Thoenen, H; Zafra, F | 1 |
Fox, LM; Funasaka, M; Goldenring, JR; Hidaka, H; Modlin, IM; Tsunoda, Y | 1 |
Hidaka, H; Li, G; Wollheim, CB | 1 |
Koyama, N; Morisaki, N; Saito, Y; Yoshida, S | 1 |
Beermann, ML; Leli, U; Nixon, RA; Shea, TB | 1 |
Amano, S; Hanazawa, S; Kitami, H; Kitano, S; Murakami, Y; Ohta, K; Takeshita, A | 1 |
Chang, KJ; Kwon, HB; Lee, CC; Schuetz, AW; Yoo, YR | 1 |
Nicholson, GC; Papadimitriou, JM; Wood, DJ; Zheng, MH | 1 |
Asano, K; Iizuka, H; Ito, F; Takahashi, H; Tamura, T; Tsutsui, M | 1 |
Hershman, JM; Murakami, S; Pang, XP; Sugawara, M; Urabe, M | 1 |
Chedrese, PJ; Ly, H; Murphy, BD; Rajkumar, K | 1 |
Kelly, MD; Kollros, PR; Konkle, BA | 1 |
Bryant, SH; Conte-Camerino, D | 1 |
Chang, F; Cohen, IS; DiFrancesco, D; Rosen, MR; Tromba, C | 1 |
Ashcroft, SJ; Niki, I | 1 |
Ishikawa, S; Saito, T | 1 |
Kajiyama, Y; Murayama, T; Nomura, Y; Takahashi, A | 1 |
Ribeiro, JA; Sebastião, AM | 1 |
Dinarello, CA; Morse, C; Zucali, JR | 1 |
Browning, MD; Dunwiddie, TV; Hahner, LD; Harris, RA; Leidenheimer, NJ | 1 |
Hurme, M; Ronni, T; Serkkola, E; Silvennoinen, O | 1 |
Mattila, P; Renkonen, R; Turunen, JP | 1 |
Larsson, R; Nygren, P | 1 |
Levin, EG; Marotti, KR; Santell, L | 1 |
Dorsett, JA; Parr, EL; Yau, WM | 1 |
Azhderian, EM; Conn, PJ; Greengard, P; Kaczmarek, LK; Nairn, AC; Strong, JA | 1 |
Iizuka, H; Sakai, H; Tamura, T | 1 |
Kabemura, M; Kimura, G; Matsuzaki, A; Ohtsu, M; Shimura, H | 1 |
Bollinger, DW; Toews, ML; Turner, JT | 1 |
Amiel, C; Friedlander, G | 1 |
Houchi, H; Misbahuddin, M; Morita, K; Nakanishi, A; Oka, M | 1 |
Koide, T; Niki, A; Niki, H; Niki, I; Sakamoto, N; Tamagawa, T | 1 |
Kelly, JS; Larkman, PM; Takahashi, T | 1 |
Cheung, HS; Mitchell, PG | 1 |
Carter, DA | 1 |
Keen, M; Krane, A; Malkhandi, J; Mercy, L | 1 |
Allen, JM; Balbi, D | 1 |
Fan, P | 1 |
Chik, CL; Ho, AK; Inukai, T | 1 |
Hinds, TR; Storm, DR; Wayman, GA | 1 |
DiBattista, JA; Iwata, K; Martel-Pelletier, J; Pelletier, JP; Zafarullah, M | 1 |
Reich, H; Sei, Y | 1 |
Nishida, A; Shimizu, M; Yamawaki, S | 1 |
Chang, JP; Jobin, RM; Neumann, CM; Van Goor, F; Wong, AO | 1 |
Erickson, RP; Gatlin, LA; Heiman, SA; Schiffman, SS; Stagner, WC; Suggs, MS | 1 |
Losee, ML; Schiffman, SS; Suggs, MS | 1 |
Itoh, M; Joh, T; Kato, T; Miyamoto, T; Okayama, N | 1 |
Kaku, K; Kaneko, T; Nagasaka, Y; Nakamura, K | 1 |
Gabrielian, K; Hinton, DR; Ryan, SJ; Sakamoto, H; Sakamoto, T; Sheu, SJ | 1 |
Arao, M; Chihara, K; Fukase, M; Sugimoto, T; Yamaguchi, T | 1 |
Kordon, C; L'Héritier, A; Leblanc, P; Rasolonjanahary, R | 1 |
Hertelendy, F; Jamaluddin, M; Marrone, BL; Molnár, M | 1 |
Brecher, P; Coats, WD | 1 |
Hinko, A; Soloff, MS | 1 |
Hidaka, H; Iguchi, A; Niki, A; Niki, H; Niki, I; Okazaki, K; Saitoh, M; Tamagawa, T | 1 |
Muroi, M; Suzuki, T | 1 |
Hashimoto, Y; Iizuka, H; Ishida-Yamamoto, A; Takahashi, H | 1 |
Malenka, RC; Rosahl, TW; Spillane, DM; Südhof, TC | 1 |
Rothstein, TL; Wang, Z; Xie, H | 1 |
Ericson, LE; Fagman, H; Nilsson, M | 1 |
Gubitz, AK; Kirkpatrick, KA; Kurokawa, M; Richardson, PJ; Widdowson, L | 1 |
Regan, JW; Stamer, WD; Yool, AJ | 1 |
Bernanke, DH; Hasui, K; Parent, AD; Shiota, T | 1 |
Hori, M; Ikuhara, T; Isogai, Y; Matsuzaki, K; Nakamura, I; Suda, T; Suzuki, H; Takahashi, N | 1 |
Hamada, M; Kannan, Y; Kimura, K; Moriyama, M; Musashi, M; Sakurada, K; Shiota, M; Sugano, T | 1 |
Ha, TS; Kim, YH; Song, DK; Suh, HW; Wie, MB | 1 |
Dobson, JG; Ethier, MF | 1 |
Katsube, Y; Sperelakis, N; Yokoshiki, H | 1 |
Casey, ML; Devora, GA; MacDonald, PC; Mibe, M; Morimoto, T | 1 |
Sjöholm, A | 1 |
Castrucci, AM; da Silva, MA; Josefsson, L; Nery, LE | 1 |
Alberi, S; Dreifuss, JJ; Raggenbass, M | 1 |
Braganza, JM; Jaran, AS; Quesnel, LB | 1 |
Doris, RA; Houslay, MD; Kilgour, E; Vernon, RG | 1 |
Bisht, D; Chakraborti, PK; Rana, S | 1 |
Konishi, S; Mitoma, H | 1 |
Baines, DL; Monaghan, AS; Muimo, R; Olver, RE | 1 |
Choi, MR; Huh, SO; Kim, YH; Lee, JK; Song, DK; Suh, HW | 1 |
Blandizzi, C; Colucci, R; Del Tacca, M; Tognetti, M | 1 |
Fukao, H; Matsuo, O | 1 |
Kubo, Y; Miyashita, T | 1 |
Baldelli, P; Carabelli, V; Carbone, E; Hernández-Guijo, JM | 1 |
Courjaret, R; Lapied, B | 1 |
Ganapathy, V; Hatanaka, T; Huang, W; Martindale, RG | 1 |
Esuvaranathan, K; Khoo, HE; Mahendran, R; Yap, LL; Zhang, Y | 1 |
Kaneishi, K; Kato, M; Kobayashi, H; Sakuma, Y | 1 |
Bigdai, EV; Samoilov, VO | 1 |
Carlson, RR; Dudman, JT; Konradi, C; Macías, W | 1 |
Johnson, SW; Shen, KZ | 1 |
Aikawa, T; Hirose, T; Matsumoto, I; Shimada, T | 1 |
Linsdell, P; McDonald, TF; Missan, S | 1 |
Tang, X; Zhang, C | 1 |
Mizoguchi, T; Noguchi, T; Okumura, S; Takahashi, N; Take, I; Udagawa, N; Yamamoto, Y; Yamauchi, H | 1 |
Cao, AL; Liu, HY; Zeng, WD; Zhang, CQ | 1 |
Chakrabarti, MK; Hoque, KM; Koley, H; Sheikh, IA | 1 |
95 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and colforsin
Article | Year |
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Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytokines; Glutamates; Glutamic Acid; Growth Substances; Hippocampus; Ionomycin; Isoquinolines; Kainic Acid; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Nifedipine; Norepinephrine; Piperazines; Potassium; Protein Kinase Inhibitors; Quisqualic Acid; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1992 |
An inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Separation; Colforsin; Gastric Acid; Isoquinolines; Parasympathomimetics; Parietal Cells, Gastric; Piperazines; Protein Kinase Inhibitors; Protein Kinases | 1992 |
Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Membrane Permeability; Colforsin; Cricetinae; Diphosphonates; Drug Synergism; Insulin; Insulin Secretion; Insulinoma; Ion Channel Gating; Isoquinolines; Manganese; Membrane Potentials; Mitochondria; Piperazines; Protein Kinase Inhibitors; Stimulation, Chemical; Tumor Cells, Cultured | 1992 |
Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta, Thoracic; Biological Factors; Bucladesine; Cell Division; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fibronectins; Isoquinolines; Kinetics; Macromolecular Substances; Muscle, Smooth, Vascular; Pertussis Toxin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Wistar; Recombinant Proteins; Second Messenger Systems; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Virulence Factors, Bordetella | 1992 |
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Colforsin; Humans; Immunohistochemistry; Isoquinolines; Nervous System Neoplasms; Neurites; Neuroblastoma; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tumor Cells, Cultured | 1992 |
Porphyromonas gingivalis fimbriae induce expression of the neutrophil chemotactic factor KC gene of mouse peritoneal macrophages: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Dose-Response Relationship, Drug; Fimbriae, Bacterial; Gene Expression Regulation, Bacterial; Interleukin-8; Isoquinolines; Macrophages; Mice; Mice, Inbred BALB C; Neutrophils; Piperazines; Porphyromonas gingivalis; Protein Kinase C; RNA; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Induction of ovulation and oocyte maturation of amphibian (Rana dybowskii) ovarian follicles by protein kinase C activation in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Colforsin; Cycloheximide; Enzyme Activation; Female; Isoquinolines; Oogenesis; Ovarian Follicle; Ovary; Ovulation Induction; Piperazines; Pituitary Gland; Progesterone; Protein Kinase C; Radioimmunoassay; Ranidae; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Evidence that protein kinase-A, calcium-calmodulin kinase and cytoskeletal proteins are involved in osteoclast retraction induced by calcitonin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Resorption; Calcitonin; Cells, Cultured; Colchicine; Colforsin; Cytoskeletal Proteins; In Vitro Techniques; Isoquinolines; Neomycin; Osteoclasts; Phospholipases A; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Quinacrine; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Verapamil | 1992 |
Desensitization of the epidermal adenylate cyclase system: agonists and phorbol esters desensitize by independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Epidermis; Epinephrine; Histamine; Isoquinolines; Pertussis Toxin; Piperazines; Receptors, Adrenergic, beta; Receptors, Histamine; Skin; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Effect of lithium on function and growth of thyroid cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Division; Cell Line; Colforsin; Cyclic AMP; Iodides; Isoquinolines; Lithium; Piperazines; Protein Kinase C; Rats; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Triiodothyronine | 1991 |
Protein kinase C, an endogenous regulator of hormone-induced cyclic AMP induction in porcine luteal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Colforsin; Colistin; Corpus Luteum; Cyclic AMP; Female; Isoquinolines; Luteinizing Hormone; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; Swine; Tetradecanoylphorbol Acetate | 1991 |
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C-mediated pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Fibroblast Growth Factor 1; Gene Expression; Humans; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Piperazines; Plasminogen Inactivators; Protein Kinase C; Signal Transduction; Tissue Plasminogen Activator; Transcription, Genetic | 1990 |
Chloride channel regulation in the skeletal muscle of normal and myotonic goats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Membrane Permeability; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Electric Conductivity; Female; Goats; Ion Channels; Isoquinolines; Male; Membrane Potentials; Muscles; Myotonia; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine; Tetrahydropapaveroline | 1991 |
Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Colforsin; Dogs; Electrophysiology; In Vitro Techniques; Ion Channel Gating; Isoproterenol; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Purkinje Fibers | 1991 |
Possible involvement of protein phosphorylation in the regulation of the sulphonylurea receptor of a pancreatic beta-cell line, HIT T15.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Colforsin; Diazoxide; Glyburide; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Phosphorylation; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Proteins; Receptors, Drug; Rubidium; Sulfonylurea Receptors; Tetradecanoylphorbol Acetate | 1991 |
Inhibition by phorbol ester of cellular adenosine 3',5'-monophosphate production and cellular free calcium mobilization in response to arginine vasopressin in rat renal papillary collecting tubule cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Isoquinolines; Kidney Medulla; Kidney Tubules, Collecting; Male; Osmolar Concentration; Piperazines; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Modes of inhibitory action of 4 beta-phorbol 12-myristate 13-acetate in thrombin-stimulated arachidonic acid release in intact and permeabilized platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Membrane Permeability; Chlorides; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Rabbits; Serotonin; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenylyl Cyclases; Animals; Colforsin; Enzyme Activation; Evoked Potentials; Imines; Isoquinolines; Lithium; Muscles; Neuromuscular Junction; Phorbol Esters; Piperazines; Polymyxin B; Protein Kinase C; Rana ridibunda; Synaptic Transmission | 1990 |
The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Bone Marrow Cells; Bucladesine; Calcium Channel Blockers; Calmodulin; Cell Line; Colforsin; Colony-Forming Units Assay; Colony-Stimulating Factors; Cyclic AMP; Fibroblasts; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Interleukin-1; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha | 1990 |
Phosphorylation-independent effects of second messenger system modulators on gamma-aminobutyric acidA receptor complex function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chlorides; Colforsin; Cyclic AMP; Edetic Acid; Isoquinolines; Mice; Mice, Inbred ICR; Muscimol; Phosphorylation; Piperazines; Protein Kinases; Pyridazines; Receptors, GABA-A; Second Messenger Systems | 1990 |
Control of interleukin-1 beta expression by protein kinase C and cyclic adenosine monophosphate in myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Activation; Gene Expression; Humans; Interleukin-1; Isoquinolines; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Endothelium, Vascular; Gene Expression; In Vitro Techniques; Inflammation; Interleukin-1; Isoquinolines; Lymphocytes; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides | 1990 |
Modulation of vincristine sensitivity of human kidney tumor cells by pharmacological agents interfering with intracellular signals. No apparent relationship to changes in cytoplasmic Ca2+ or pH.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Calcium; Colforsin; Cytoplasm; Humans; Hydrogen-Ion Concentration; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Sensitivity and Specificity; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vincristine | 1990 |
Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. Dependence on the elevation of messenger RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Cloning, Molecular; Colforsin; Cycloheximide; DNA; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1989 |
Characterization of acetylcholine release from enzyme-dissociated myenteric ganglia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium; Colforsin; Deoxyribonuclease I; Female; Guinea Pigs; Isoquinolines; L-Lactate Dehydrogenase; Microbial Collagenase; Microscopy, Electron; Microscopy, Electron, Scanning; Myenteric Plexus; Neuropeptides; Peptide Hydrolases; Piperazines; Potassium; Protein Kinase C; Serotonin; Tetrodotoxin; Veratrine | 1989 |
Protein kinase inhibitors selectively block phorbol ester- or forskolin-induced changes in excitability of Aplysia neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Aplysia; Calcium; Colforsin; Cyclic AMP; Isoquinolines; Neurons; Organelles; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Proteins | 1989 |
Effects of the tumor promoter, phorbol 12-myristate, 13-acetate, on the epidermal adenylate cyclase system: evidence for adenylate cyclase-regulation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Epidermis; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Cell Surface; Swine; Tetradecanoylphorbol Acetate | 1989 |
Induction of DNA synthesis by cholera toxin in the temperature-sensitive cell-cycle mutants of rat 3Y1 fibroblasts at a restrictive temperature.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Cell Cycle; Cholera Toxin; Colforsin; Cyclic AMP; DNA; Fibroblasts; Isoquinolines; Membrane Proteins; Mutation; Pertussis Toxin; Piperazines; Rats; Sulfonamides; Temperature; Verapamil; Virulence Factors, Bordetella | 1989 |
Vasoactive intestinal peptide receptor/adenylate cyclase system: differences between agonist- and protein kinase C-mediated desensitization and further evidence for receptor internalization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Isoquinolines; Peptide PHI; Piperazines; Protein Kinase C; Receptors, Gastrointestinal Hormone; Receptors, Vasoactive Intestinal Peptide; Staurosporine; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1988 |
Protein kinase C activators and bradykinin selectively inhibit vasopressin-stimulated cAMP synthesis in MDCK cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Cell Line; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Enzyme Activation; Glucagon; Isoquinolines; Piperazines; Prostaglandins E; Protein Kinase C; Tetradecanoylphorbol Acetate; Vasopressins | 1987 |
Stimulation by vasoactive intestinal polypeptide of catecholamine synthesis in isolated bovine adrenal chromaffin cells. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Dihydroxyphenylalanine; In Vitro Techniques; Isoquinolines; Piperazines; Tetradecanoylphorbol Acetate; Tyrosine; Vasoactive Intestinal Peptide | 1987 |
Possible involvement of diacylglycerol-activated, Ca2+-dependent protein kinase in glucose memory of the rat pancreatic B-cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colforsin; Enzyme Activation; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides; Tetradecanoylphorbol Acetate | 1988 |
Adenosine 3':5'-cyclic monophosphate mediates a 5-hydroxytryptamine-induced response in neonatal rat motoneurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Animals, Newborn; Brain Stem; Bucladesine; Cesium; Colforsin; Cyclic AMP; Enzyme Inhibitors; Ion Channels; Isoquinolines; Membrane Potentials; Motor Neurons; Piperazines; Protein Kinase C; Rats; Serotonin; Spinal Cord | 1995 |
Protein kinase regulation of tumor necrosis factor alpha stimulated collagenase and stromelysin message levels in chondrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cartilage, Articular; Cell Membrane; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Enzyme Induction; Gene Expression Regulation; Isoquinolines; Kinetics; Matrix Metalloproteinase 3; Metalloendopeptidases; Neoplasm Proteins; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Noradrenergic regulation of c-jun expression in the rat pineal gland in culture: positive and negative components.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Gene Expression Regulation; Isoquinolines; Male; Norepinephrine; Organ Culture Techniques; Phorbol 12,13-Dibutyrate; Pineal Gland; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; RNA, Messenger; Sulfonamides | 1993 |
The role of protein kinase A and protein kinase C in prostanoid IP receptor desensitization in NG108-15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Guanylyl Imidodiphosphate; Hybrid Cells; Iloprost; Isoquinolines; Mice; Piperazines; Protein Kinase C; Rats; Receptors, Prostaglandin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Role of protein kinase C in mediating NGF effect on neuropeptide Y expression in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Binding Sites; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Gene Expression; Isoquinolines; Kinetics; Molecular Sequence Data; Naphthalenes; Nerve Growth Factors; Neuropeptide Y; Oligodeoxyribonucleotides; PC12 Cells; Piperazines; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Antagonism by forskolin of the 5-HT3 receptor-mediated current in nodose ganglion neurons is independent of cyclic AMP.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colforsin; Cyclic AMP; Ion Channels; Isoquinolines; Neurons; Nodose Ganglion; Piperazines; Protein Kinase Inhibitors; Rats; Second Messenger Systems; Serotonin Antagonists | 1994 |
Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carcinogens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Enzyme Activation; Ionomycin; Isoquinolines; Kinetics; Mice; Neuroblastoma; Phorbol Esters; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1994 |
Hormone stimulation of type III adenylyl cyclase induces Ca2+ oscillations in HEK-293 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoproterenol; Isoquinolines; Kidney; Kinetics; Models, Biological; Oscillometry; Phosphatidylinositols; Piperazines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucagon; Signal Transduction; Time Factors | 1995 |
Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Glycoproteins; Humans; Immunoenzyme Techniques; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Staurosporine; Synovial Membrane; Tetradecanoylphorbol Acetate; Thionucleotides; Tissue Inhibitor of Metalloproteinases; Up-Regulation | 1995 |
Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Calcimycin; Calcium; Calcium-Transporting ATPases; Cholera Toxin; Colforsin; Drug Synergism; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Hydroquinones; Isoquinolines; Leukemia-Lymphoma, Adult T-Cell; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Piperazines; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Forskolin and phorbol myristate acetate inhibit intracellular Ca2+ mobilization induced by amitriptyline and bradykinin in rat frontocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Amitriptyline; Animals; Bradykinin; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Frontal Lobe; Imipramine; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Neurons; Piperazines; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate | 1993 |
Interactions of cyclic adenosine 3',5'-monophosphate, protein kinase-C, and calcium in dopamine- and gonadotropin-releasing hormone-stimulated growth hormone release in the goldfish.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine; Female; Goldfish; Gonadotropin-Releasing Hormone; Growth Hormone; Isoquinolines; Male; Piperazines; Pituitary Gland; Protein Kinase C; Sulfonamides; Verapamil | 1994 |
Modulators of the adenylate cyclase system can alter electrophysiological taste responses in gerbil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cell Membrane Permeability; Colforsin; Cyclic AMP; Electrophysiology; Female; Gerbillinae; GTP Phosphohydrolases; GTP-Binding Proteins; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Sodium Fluoride; Taste | 1994 |
Effect of modulators of the adenylate cyclase system on sweet electrophysiological taste responses in gerbil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Chorda Tympani Nerve; Colforsin; Dimethylformamide; Electrophysiology; Female; Gerbillinae; Isoquinolines; Ketamine; Piperazines; Protein Kinase C; Signal Transduction; Sodium Chloride; Taste; Tongue | 1994 |
Role of myosin light-chain kinase and protein kinase C in pepsinogen secretion from guinea pig gastric chief cells in monolayer culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Carbachol; Cells, Cultured; Colforsin; Gastric Mucosa; Guinea Pigs; Immunoenzyme Techniques; Ionomycin; Isoquinolines; Male; Microscopy, Electron; Myosin-Light-Chain Kinase; Pepsinogens; Piperazines; Protein Kinase C; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1994 |
cAMP inhibits the insulin-stimulated mitogen-activated protein kinase pathway in rat hepatoma H4EII cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Cyclic AMP; Enzyme Activation; Glycerophosphates; Insulin; Isoquinolines; Liver Neoplasms, Experimental; Manganese; Phosphorylation; Piperazines; Rats; Receptor, Insulin; Sodium Fluoride; Thionucleotides; Tumor Cells, Cultured | 1994 |
Intercellular gap formation induced by thrombin in confluent cultured bovine retinal pigment epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Cattle; Cells, Cultured; Colforsin; Cytoskeleton; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Gap Junctions; Isoquinolines; Pigment Epithelium of Eye; Piperazines; Protein Kinase Inhibitors; Staurosporine; Thrombin; Time Factors; Vinculin | 1994 |
Protein kinase C is crucial for the stimulation of sodium-dependent phosphate transport by parathyroid hormone-related peptide in osteoblast-like cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Biological Transport; Bone Neoplasms; Calcimycin; Calcium; Cell Line; Colforsin; Cytosol; Humans; Isoquinolines; Kinetics; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Phosphates; Piperazines; Protein Kinase C; Proteins; Rats; Sodium; Tetradecanoylphorbol Acetate | 1994 |
Neuropeptide Y enhances LHRH binding to rat gonadotrophs in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cells, Cultured; Colforsin; Cyclic AMP; Gonadotropin-Releasing Hormone; GTP-Binding Proteins; Isoquinolines; Male; Neuropeptide Y; Pertussis Toxin; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Signal transduction in avian granulosa cells: effects of protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Chickens; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Female; Granulosa Cells; Inositol Phosphates; Isoquinolines; Piperazines; Progesterone; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Cyclic AMP suppresses fibronectin expression in the rabbit aorta in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aorta; Blotting, Northern; Bucladesine; Calcium; Colforsin; Culture Media; Cyclic AMP; Fibronectins; Gene Expression; Isoquinolines; Kinetics; Male; Organ Culture Techniques; Piperazines; Protein Biosynthesis; Protein Kinase Inhibitors; Rabbits; RNA, Messenger | 1993 |
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'-monophosphate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amnion; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; Drug Synergism; Female; Isoquinolines; Oxytocin; Piperazines; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Receptors, Angiotensin; Receptors, Oxytocin; Tetradecanoylphorbol Acetate; Up-Regulation | 1993 |
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Immunoblotting; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Kinetics; Male; Myosin-Light-Chain Kinase; Myosins; Phosphates; Phosphorus Radioisotopes; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Role of protein kinase A in LPS-induced activation of NF-kappa B proteins of a mouse macrophage-like cell line, J774.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Bucladesine; Cholera Toxin; Colforsin; Consensus Sequence; Cyclic AMP; Dinoprostone; Female; Gene Expression Regulation, Neoplastic; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Phosphorylation; Piperazines; Protein Kinases; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factor RelB; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Activators of protein kinase C but not of phospholipase C modulate adenylate cyclase-responses of normal pig epidermis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenylyl Cyclases; Animals; Bradykinin; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; Epinephrine; Histamine; Isoquinolines; Keratinocytes; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1995 |
Long-term potentiation in mice lacking synapsins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Colforsin; Hippocampus; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Mice; Mice, Knockout; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyramidal Cells; Synapsins; Synaptic Transmission | 1995 |
Signaling pathways for antigen receptor-mediated induction of transcription factor CREB in B lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Anti-Idiotypic; Antigens, CD; B-Lymphocytes; B7-2 Antigen; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Immunoglobulins; Ionomycin; Isoquinolines; Lymphoma, B-Cell; Membrane Glycoproteins; Mice; Molecular Sequence Data; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Antigen, B-Cell; Signal Transduction; Staurosporine; Sulfonamides | 1996 |
Ca2+-dependent and Ca2+-independent regulation of the thyroid epithelial junction complex by protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Epithelium; Isoquinolines; Membrane Proteins; Phosphoproteins; Piperazines; Staurosporine; Swine; Thyroid Gland; Thyrotropin; Tight Junctions; Trypsin; Zonula Occludens-1 Protein | 1996 |
Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine; Agatoxins; Alkaloids; Animals; Antihypertensive Agents; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cholera Toxin; Cholinergic Fibers; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GTP-Binding Proteins; Isoquinolines; Neostriatum; Neurons; Phenanthridines; Phenethylamines; Piperazines; Potassium; Presynaptic Terminals; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Purinergic P1; Signal Transduction; Spider Venoms; Stereoisomerism; Sulfonamides; Tritium; Xanthines | 1996 |
Forskolin stimulation of water and cation permeability in aquaporin 1 water channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aquaporin 1; Aquaporins; Cations; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ion Channels; Isoquinolines; Mercuric Chloride; Oocytes; Patch-Clamp Techniques; Phosphorylation; Piperazines; RNA, Complementary; Water; Xenopus | 1996 |
Protein kinase C has two different major roles in lattice compaction enhanced by cerebrospinal fluid from patients with subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Cerebrospinal Fluid; Colforsin; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Humans; Protein Kinase C; Subarachnoid Hemorrhage | 1996 |
Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Animals, Newborn; Bucladesine; Calcitonin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Dentin; Enzyme Activation; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred Strains; Osteoblasts; Phorbol 12,13-Dibutyrate; Protein Kinase C; Signal Transduction; Skull; Tetradecanoylphorbol Acetate; Thionucleotides | 1996 |
Phorbol ester, but not endotoxin, desensitizes mannan-induced glycogenolysis in the perfused rat liver.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aprotinin; Calcimycin; Colforsin; Enzyme Inhibitors; Escherichia coli; Leupeptins; Lipopolysaccharides; Liver; Liver Glycogen; Male; Mannans; Norepinephrine; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1996 |
Molecular mechanisms underlying the regulation of proenkephalin gene expression in cultured spinal cord cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Mollusk Venoms; Nimodipine; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Signal Transduction; Spinal Cord; Tetradecanoylphorbol Acetate | 1996 |
Adenosine stimulation of DNA synthesis in human endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Endothelium, Vascular; Humans; Kinetics; Poly A; Purinergic P1 Receptor Antagonists; Quinazolines; Tetradecanoylphorbol Acetate; Thioinosine; Thionucleotides; Thymidine; Triazoles; Umbilical Veins | 1997 |
Regulation of Ca2+ channel currents by intracellular ATP in smooth muscle cells of rat mesenteric artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Barium; Calcium Channels; Colforsin; Electric Conductivity; Enzyme Inhibitors; Intracellular Membranes; Mesenteric Arteries; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Protein Kinase Inhibitors; Rats | 1997 |
Parathyroid hormone-related protein and human myometrial cells: action and regulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Chorionic Gonadotropin; Colforsin; Corticotropin-Releasing Hormone; Female; Gene Expression Regulation; Humans; Muscle Relaxation; Myometrium; Okadaic Acid; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Pregnancy; Proteins; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1997 |
Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium Channel Blockers; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gallopamil; Glucose; GTP-Binding Proteins; Insulin; Insulin Secretion; Ionomycin; Ionophores; Islets of Langerhans; Pertussis Toxin; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1997 |
Cellular signalling of PCH-induced pigment aggregation in the crustacean Macrobrachium potiuna erythrophores.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chromatophores; Colforsin; Cyclosporine; In Vitro Techniques; Invertebrate Hormones; Neomycin; Okadaic Acid; Oligopeptides; Palaemonidae; Pigments, Biological; Pyrrolidonecarboxylic Acid; Signal Transduction; Trifluoperazine | 1997 |
The oxytocin-induced inward current in vagal neurons of the rat is mediated by G protein activation but not by an increase in the intracellular calcium concentration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brain Stem; Buffers; Calcium; Colforsin; Cyclic AMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; N-Methylaspartate; Neurons; Oxytocin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Thionucleotides; Vagus Nerve | 1997 |
Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Adult; Cell Membrane; Child; Child, Preschool; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Energy Metabolism; Female; Fluorescein-5-isothiocyanate; Gentamicins; Humans; Male; Middle Aged; Nasal Polyps; Thionucleotides | 1998 |
Regulation of the GTP-binding protein-based antilipolytic system of sheep adipocytes by growth hormone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adrenergic beta-Agonists; Analysis of Variance; Animals; Cell Membrane; Colforsin; Culture Techniques; Enzyme Inhibitors; Growth Hormone; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Isomerism; Isoproterenol; Lipolysis; Male; Models, Biological; Okadaic Acid; Pertussis Toxin; Phenylisopropyladenosine; Protein Binding; Receptors, Purinergic P1; Sheep; Stimulation, Chemical; Virulence Factors, Bordetella | 1998 |
Synergistic activation of yeast-expressed rat androgen receptor by modulators of protein kinase-A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Androgens; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyproterone; Dihydrotestosterone; Enzyme Inhibitors; Flutamide; Gene Expression Regulation; Genes, Reporter; Metribolone; Okadaic Acid; Rats; Receptors, Androgen; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Saccharomyces cerevisiae; Signal Transduction; Transcriptional Activation; Transformation, Genetic | 1999 |
Monoaminergic long-term facilitation of GABA-mediated inhibitory transmission at cerebellar synapses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cerebellum; Colforsin; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Methiothepin; Neuronal Plasticity; Norepinephrine; Propranolol; Protein Kinase Inhibitors; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA; Serotonin; Sulfonamides; Synapses; Synaptic Transmission; Tetrodotoxin; Thionucleotides | 1999 |
Inwardly rectifying K+ currents in fetal alveolar type II cells: regulation by protein kinase A and protein phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Potassium Channels; Pregnancy; Protein Kinase Inhibitors; Protein Phosphatase 1; Pulmonary Alveoli | 1999 |
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Calcium Channel Blockers; Calmodulin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glioma; Imidazoles; Isoquinolines; Nimodipine; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured | 1999 |
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Calcium; Colforsin; Dose-Response Relationship, Drug; Ethylmaleimide; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Ileum; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle, Smooth; Myenteric Plexus; Nifedipine; Norepinephrine; omega-Conotoxins; Pertussis Toxin; Phenols; Receptors, Histamine H3; Rolipram; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetrodotoxin; Virulence Factors, Bordetella; Yohimbine | 2000 |
Antithrombotic regulation in human endothelial cells by fibrinolytic factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Autocrine Communication; Blood Coagulation; Blotting, Northern; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Fibrin; Fibrinolysis; Gene Expression Regulation; Hot Temperature; Humans; Plasminogen Activator Inhibitor 1; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Umbilical Veins; Urokinase-Type Plasminogen Activator | 2000 |
Extracellular Ca2+ sensitivity of mGluR1alpha induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Cell Size; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Fluorescent Dyes; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Isoquinolines; MAP Kinase Signaling System; Protein Kinase C; Receptors, Metabotropic Glutamate; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases | 2000 |
Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Autocrine Communication; Calcium; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; GABA Antagonists; Isoquinolines; Kinetics; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Kinase Inhibitors; Sulfonamides; Suramin | 2001 |
Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adenylyl Imidodiphosphate; Animals; Bungarotoxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Electrophysiology; Enzyme Inhibitors; Imidazoles; Insecta; Insecticides; Isoquinolines; Median Nerve; Neonicotinoids; Neurons; Niacin; Nitro Compounds; Okadaic Acid; Permeability; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Nicotinic; Signal Transduction; Sulfonamides | 2001 |
Differential influence of cAMP on the expression of the three subtypes (ATA1, ATA2, and ATA3) of the amino acid transport system A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adjuvants, Immunologic; Amino Acid Transport Systems; Amino Acids; Aminoisobutyric Acids; Blotting, Northern; Carrier Proteins; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Poly A; Protein Binding; Protein Synthesis Inhibitors; RNA, Messenger; Sodium; Substrate Specificity; Time Factors; Tumor Cells, Cultured | 2001 |
The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Antibodies; BCG Vaccine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-6; Isoquinolines; Phosphodiesterase Inhibitors; Protein Denaturation; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2002 |
3',5'-cyclic adenosine monophosphate augments intracellular Ca2+ concentration and gonadotropin-releasing hormone (GnRH) release in immortalized GnRH neurons in an Na+ -dependent manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Calcium; Cell Line, Transformed; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Isoquinolines; Neurons; Protein Kinase C; Sodium; Sulfonamides; Tetrodotoxin | 2002 |
Components of the intracellular cAMP system supporting the olfactory reception of amyl alcohol.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Aluminum Compounds; Animals; Antimetabolites; Caffeine; Calcium Channel Blockers; Calcium Chloride; Chelating Agents; Chlortetracycline; Colforsin; Cyclic AMP; Dideoxyadenosine; Egtazic Acid; Fluorides; In Vitro Techniques; Ionomycin; Ionophores; Microscopy, Fluorescence; Nifedipine; Olfactory Mucosa; Pentanols; Phosphodiesterase Inhibitors; Rana temporaria; Reaction Time; Signal Transduction; Smell | 2003 |
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; Embryo, Mammalian; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoquinolines; Neurons; Nifedipine; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 2003 |
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclase Inhibitors; Amino Acids; Amino Acids, Dicarboxylic; Animals; Colforsin; Cyclopropanes; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Imines; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Subthalamic Nucleus; Sulfonamides; Synaptic Transmission; Tetradecanoylphorbol Acetate; Xanthenes | 2003 |
Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Calcimycin; Calcium; Colforsin; Corticosterone; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Drug Synergism; Enzyme Activation; Guinea Pigs; Hydrocortisone; Ionophores; Isoquinolines; Male; Perfusion; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyridinium Compounds; Receptors, G-Protein-Coupled; Secretory Rate | 2005 |
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cytochalasin D; Cytoskeleton; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoquinolines; KCNQ1 Potassium Channel; Maleimides; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins | 2006 |
Activation of protein kinases A and C promoted proliferation of chicken primordial germ cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Proliferation; Chick Embryo; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Germ Cells; Isoquinolines; Phorbol Esters; Protein Kinase C; Sulfonamides | 2007 |
Effects of calcitonin on the function of human osteoclast-like cells formed from CD14-positive monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Calcitonin; Cell Differentiation; Cells, Cultured; Colforsin; DNA Primers; Humans; Intracellular Signaling Peptides and Proteins; Lipopolysaccharide Receptors; Macrophage Colony-Stimulating Factor; Membrane Proteins; Monocytes; Osteoclasts; Phorbol Esters; Receptor Activity-Modifying Protein 2; Receptor Activity-Modifying Protein 3; Receptor Activity-Modifying Proteins; Receptors, Calcitonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Follicle-stimulating hormone promotes proliferation of cultured chicken ovarian germ cells through protein kinases A and C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Proliferation; Cells, Cultured; Chickens; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Follicle Stimulating Hormone; Isoquinolines; Ovum; Protein Kinase C; Receptors, FSH; Sulfonamides; Tetradecanoylphorbol Acetate | 2010 |
The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Line, Tumor; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Diarrhea; Epithelial Cells; Guanine Nucleotide Exchange Factors; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels; Intestinal Mucosa; Mice; Microscopy, Confocal; Potassium Channel Blockers; Pyrazoles; rap GTP-Binding Proteins; rap1 GTP-Binding Proteins; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; Signal Transduction | 2013 |