Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and chelerythrine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with chelerythrine in 44 studies

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	27 (61.36)	18.2507
2000's	12 (27.27)	29.6817
2010's	5 (11.36)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Augereau, JM; Gleye, J; Herbert, JM; Maffrand, JP	1
Grant, S; Jarvis, WD; Povirk, LF; Traylor, RS; Turner, AJ	1
Glembotski, CC; McDonough, PM; Stella, SL	1
Campenot, RB; Draker, DD; Senger, DL	1
Moffat, MP; Ward, CA	1
Brunner, F	1
Vietor, I; Vilcek, J	1
Hoffmann, EK; Jensen, BS; Larsen, AK	1
Terranova, PF; Zachow, RJ	1
Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB	1
Maurer, JA; McKay, DB; Wenger, BW	1
Gubitz, AK; Kirkpatrick, KA; Kurokawa, M; Richardson, PJ; Widdowson, L	1
Chalfant, ML; Civan, JM; Civan, MM; DiBona, DR; O'Brien, TG; Peterson-Yantorno, K	1
Jarvis, WD; Spangelo, BL	1
Amaral, J; Behar, J; Biancani, P; Chen, Q; De Petris, G; Yu, P	1
Lochter, A; Schachner, M	1
Conn, CA; Klir, JJ; Kluger, MJ; Kozak, W	1
Chapman, BM; Soares, MJ; Yamamoto, T	1
Grillner, S; Parker, D; Svensson, E	1
Bertaglia, A; Cervo, L; Mukherjee, S; Samanin, R	1
Chen, JH; Lin, LY; Yu, CW	1
Green, CB; Whalen, MM	1
Allshire, AP; Fuchsbauer, CM; Stapleton, MT	1
Adler, MR; Botsford, SA; Gronau, RT; Light, DB; Ter Beest, JK	1
Krnjević, K; Liu, PL; McArdle, JJ; Ren, J; Ye, JH	1
Hiruma, H; Hoka, S; Katakura, T; Kawakami, T; Maruyama, H; Nishida, S; Simada, ZB; Takenaka, T	1
Boyan, BD; Dean, DD; Gilley, RM; Schwartz, Z; Sylvia, VL	1
Fernandez, MC; Marucha, PT; Rojas, IG; Walters, JD	1
Caivano, M; Cohen, P; Davies, SP; Reddy, H	1
Beales, IL; Calam, J	1
Chung, SW; Kang, SN; Kim, TS	1
Douglas, RM; Gu, XQ; Haddad, GG; Yao, H	1
Alpini, G; Alvaro, D; Barbaro, B; Francis, H; Glaser, S; LeSage, G; Mancino, MG; Marzioni, M; Mauldin, J; Phinizy, JL; Rashid, S; Roskams, T; Stoica, G; Ueno, Y	1
De Groat, WC; Ishiura, Y; Nakamura, Y; Namiki, M; Yokoyama, O	1
Blanquet, PR; Derer, P; Mariani, J	1
Kim, SH; Kim, TS; Oh, SM	1
Jarajapu, YP; Knot, HJ	1
Chrones, T; Preiksaitis, HG; Sims, SM	1
Gok, S; Izanli-Paksoy, A; Vural, K	1
Blanco, CE; Villamor, E; Zoer, B	1
Johnson, CD; Kizub, IV; Pavlova, OO; Soloviev, AI; Zholos, AV	1
Bailey, SR; Berhane, Y; Elliott, J; Woodcock, H; Zerpa, H	1
Bieger, D; Burke, MM; Tabrizchi, R	1
Balezina, OP; Bogatcheva, PO; Ezhova, EV	1

Other Studies

44 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and chelerythrine

Article	Year
Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochemical and biophysical research communications, 1990, Nov-15, Volume: 172, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibiotics, Antineoplastic; Benzophenanthridines; Binding, Competitive; Brain; Cell Transformation, Neoplastic; Isoquinolines; Kinetics; Leukemia L1210; Lymphoma; Phenanthridines; Piperazines; Protein Kinase C; Rats; Staurosporine; Tumor Cells, Cultured	1990
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer research, 1994, Apr-01, Volume: 54, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Gossypol; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Naphthalenes; Perylene; Phenanthridines; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Time Factors; Tumor Cells, Cultured	1994
Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial natriuretic factor secretion by contraction rate and endothelin. The Journal of biological chemistry, 1994, Apr-01, Volume: 269, Issue:13 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Analysis of Variance; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzophenanthridines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytoplasm; Endothelins; Fluorescent Dyes; Heart; Heart Atria; Indoles; Isoquinolines; Kinetics; Myocardial Contraction; Myocardium; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Phosphoproteins; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence	1994
Evidence that protein kinase C activities involved in regulating neurite growth are localized to distal neurites. Journal of neurochemistry, 1994, Volume: 63, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies; Benzophenanthridines; Calcium; Cells, Cultured; Isoquinolines; Naphthalenes; Nerve Growth Factors; Neurites; Phenanthridines; Phosphorylation; Piperazines; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate	1994
Role of protein kinase C in mediating effects of hydrogen peroxide in guinea-pig ventricular myocytes. Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Size; Enzyme Activation; Guinea Pigs; Heart Ventricles; Homeostasis; Hydrogen Peroxide; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardium; Phenanthridines; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Time Factors	1995
Dependence of endothelin-1 secretion on Ca2+. Biochemical pharmacology, 1995, Jun-16, Volume: 49, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcium; Cells, Cultured; Cyclic GMP; Endothelins; Endothelium, Vascular; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate	1995
Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts. Lymphokine and cytokine research, 1994, Volume: 13, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arsenites; Benzophenanthridines; Cell Line; Fibroblasts; Heat-Shock Proteins; Humans; Interleukin-1; Isoquinolines; Phenanthridines; Phosphorylation; Phosphotransferases; Piperazines; Sodium Compounds; Staurosporine; Tumor Necrosis Factor-alpha; Tyrosine	1994
Activation of protein kinase C during cell volume regulation in Ehrlich mouse ascites tumor cells. Biochimica et biophysica acta, 1994, Jul-21, Volume: 1222, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Carcinoma, Ehrlich Tumor; Carrier Proteins; Cell Size; Chloride Channels; Enzyme Activation; Hypertonic Solutions; Hypotonic Solutions; Isoquinolines; Mice; Phenanthridines; Piperazines; Potassium Channels; Protein Kinase C; Sodium-Potassium-Chloride Symporters; Tumor Cells, Cultured	1994
Involvement of protein kinase C and protein tyrosine kinase pathways in tumor necrosis factor-alpha-induced clustering of ovarian theca-interstitial cells. Molecular and cellular endocrinology, 1993, Volume: 97, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstenedione; Animals; Benzophenanthridines; Benzylidene Compounds; Catechols; Cell Adhesion; Diglycerides; Enzyme Activation; Female; Hypophysectomy; Isoquinolines; Luteinizing Hormone; Nitriles; Phenanthridines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Theca Cells; Tumor Necrosis Factor-alpha; Tyrphostins	1993
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release. Molecular and cellular endocrinology, 1993, Volume: 94, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium	1993
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry. Journal of neurochemistry, 1996, Volume: 66, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity	1996
Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals. Journal of neurochemistry, 1996, Volume: 67, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine; Agatoxins; Alkaloids; Animals; Antihypertensive Agents; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cholera Toxin; Cholinergic Fibers; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GTP-Binding Proteins; Isoquinolines; Neostriatum; Neurons; Phenanthridines; Phenethylamines; Piperazines; Potassium; Presynaptic Terminals; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Purinergic P1; Signal Transduction; Spider Venoms; Stereoisomerism; Sulfonamides; Tritium; Xanthines	1996
Regulation of epithelial Na+ permeability by protein kinase C is tissue specific. The Journal of membrane biology, 1996, Volume: 152, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Amiloride; Animals; Benzophenanthridines; Biological Transport; Bufo marinus; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Organ Specificity; Phenanthridines; Piperazines; Protein Kinase C; Rana catesbeiana; Rana pipiens; Skin; Skin Physiological Phenomena; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Urinary Bladder	1996
Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. Endocrinology, 1996, Volume: 137, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Cells, Cultured; Enzyme Inhibitors; Interleukin-1; Interleukin-6; Lysophosphatidylcholines; Male; Phenanthridines; Phosphorylcholine; Pituitary Gland, Anterior; Platelet Activating Factor; Prolactin; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine	1996
Different pathways mediate cholecystokinin actions in cholelithiasis. The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzimidazoles; Benzophenanthridines; Biological Transport; Calmodulin; Cholecystokinin; Cholelithiasis; Enzyme Inhibitors; Gallbladder; Humans; Male; Muscle Contraction; Muscle, Smooth; Phenanthridines; Protein Kinase C; Reference Values; Sciuridae; Sincalide	1997
Inhibitors of protein kinases abolish ECM-mediated promotion of neuronal polarity. Experimental cell research, 1997, Aug-25, Volume: 235, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Benzophenanthridines; Bucladesine; Cell Polarity; Cells, Cultured; Cyclic AMP; Dibutyryl Cyclic GMP; Embryo, Mammalian; Enzyme Inhibitors; Extracellular Matrix; Extracellular Matrix Proteins; Hippocampus; Neurites; Neurons; Phenanthridines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Vanadates	1997
Attenuation of lipopolysaccharide fever in rats by protein kinase C inhibitors. The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Benzophenanthridines; Body Temperature Regulation; Dexamethasone; Enzyme Inhibitors; Escherichia coli; Fever; Interleukin-6; Lipopolysaccharides; Male; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Time Factors	1997
Protein kinase C dependent and independent mechanisms controlling rat trophoblast cell DNA synthesis and differentiation. Journal of reproduction and fertility, 1997, Volume: 111, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Blotting, Northern; Blotting, Western; Cell Differentiation; Cholesterol Side-Chain Cleavage Enzyme; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Isoquinolines; Male; Phenanthridines; Pregnancy; Progesterone; Protein Kinase C; Rats; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Trophoblasts; Tumor Cells, Cultured	1997
Substance P modulates sensory action potentials in the lamprey via a protein kinase C-mediated reduction of a 4-aminopyridine-sensitive potassium conductance. The European journal of neuroscience, 1997, Volume: 9, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Adenylate Cyclase Toxin; Alkaloids; Animals; Benzophenanthridines; Cadmium Chloride; Electric Stimulation; Enzyme Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lampreys; Male; Neurons; Notochord; Peptides; Pertussis Toxin; Phenanthridines; Phorbol 12,13-Dibutyrate; Potassium Channels; Protein Kinase C; Protein Kinases; Spinal Cord; Substance P; Tetraethylammonium; Thionucleotides; Virulence Factors, Bordetella; Wasp Venoms	1997
Protein kinases A and C are involved in the mechanisms underlying consolidation of cocaine place conditioning. Brain research, 1997, Nov-14, Volume: 775, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Cocaine; Conditioning, Operant; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Injections, Intraventricular; Isoquinolines; Male; Motor Activity; Narcotics; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides	1997
Metal-induced metallothionein gene expression can be inactivated by protein kinase C inhibitor. FEBS letters, 1997, Dec-22, Volume: 420, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adaptor Protein Complex 1; Adaptor Protein Complex alpha Subunits; Adaptor Proteins, Vesicular Transport; Alkaloids; Animals; Benzophenanthridines; Cadmium; CHO Cells; Cricetinae; Cycloheximide; DNA-Binding Proteins; Drug Resistance; Enzyme Inhibitors; Gene Expression Regulation; Membrane Proteins; Metallothionein; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Transcription Factor MTF-1; Transcription Factors; Zinc	1997
Lysis-sensitive targets stimulate an elevation of cAMP in human natural killer cells. Immunology, 1998, Volume: 93, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Antineoplastic Agents; Benzophenanthridines; Cyclic AMP; Enzyme Inhibitors; Genistein; Humans; Killer Cells, Natural; Neoplasms; Phenanthridines; Phosphodiesterase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Tumor Cells, Cultured	1998
BDM drives protein dephosphorylation and inhibits adenine nucleotide exchange in cardiomyocytes. The American journal of physiology, 1998, Volume: 275, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Adhesion; Cell Membrane Permeability; Cells, Cultured; Diacetyl; Enzyme Inhibitors; Genistein; Heart; Male; Myocardial Contraction; Myocardium; Myofibrils; Phenanthridines; Protein Kinases; Rats; Rats, Wistar; Uncoupling Agents	1998
Protein kinase C and regulatory volume decrease in mudpuppy red blood cells. The Journal of membrane biology, 1998, Nov-15, Volume: 166, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Size; Enzyme Inhibitors; Erythrocytes; Gramicidin; Hematocrit; Hypotonic Solutions; Indoles; Ion Channel Gating; Ion Transport; Isoquinolines; Maleimides; Models, Biological; Necturus; Osmotic Fragility; Osmotic Pressure; Patch-Clamp Techniques; Phenanthridines; Potassium Channels; Protein Kinase C; Sulfonamides	1998
Cocaine decreases the glycine-induced Cl- current of acutely dissociated rat hippocampal neurons. European journal of pharmacology, 1999, Feb-12, Volume: 367, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anesthetics, Local; Animals; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Glycine Agents; Hippocampus; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Strychnine; Sulfonamides; Tetrodotoxin	1999
Axonal transport is inhibited by a protein kinase C inhibitor in cultured isolated mouse dorsal root ganglion cells. Brain research, 1999, Apr-24, Volume: 826, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Axonal Transport; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Ganglia, Spinal; Male; Mice; Mice, Inbred C57BL; Neurites; Neurons, Afferent; Phenanthridines; Protein Kinase C	1999
Prostaglandins mediate the effects of 1,25-(OH)2D3 and 24,25-(OH)2D3 on growth plate chondrocytes in a metabolite-specific and cell maturation-dependent manner. Bone, 1999, Volume: 24, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 24,25-Dihydroxyvitamin D 3; Alkaline Phosphatase; Alkaloids; Animals; Benzophenanthridines; Calcitriol; Cells, Cultured; Chondrocytes; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Plate; Indomethacin; Male; Phenanthridines; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley	1999
The role of protein kinase C and calcium in induction of human polymorphonuclear leukocyte IL-1 beta gene expression by GM-CSF. Cytokine, 2000, Volume: 12, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzophenanthridines; Calcium; Cells, Cultured; Enzyme Inhibitors; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-1; Intracellular Fluid; Isoquinolines; Neutrophils; Phenanthridines; Protein Kinase C; Recombinant Proteins; Sulfonamides; Transcription, Genetic	2000
Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides	2000
Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C. Gut, 2001, Volume: 48, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Carbachol; Carcinogens; Cell Communication; Cells, Cultured; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Acid; Interleukin-1; Parietal Cells, Gastric; Phenanthridines; Protein Kinase C; Rabbits; Sphingomyelin Phosphodiesterase; Staurosporine; Tetradecanoylphorbol Acetate	2001
Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells. European journal of pharmacology, 2001, May-25, Volume: 420, Issue:2-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzophenanthridines; Calcitriol; Capsaicin; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Maleimides; Phenanthridines; Protein Kinase C; Signal Transduction; Tretinoin	2001
Role of Na(+)/H(+) exchanger during O(2) deprivation in mouse CA1 neurons. American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acids; Alkaloids; Animals; Benzophenanthridines; Cell Hypoxia; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Guanidines; Hippocampus; Hydrogen-Ion Concentration; Hypoxia, Brain; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Neurologic Mutants; Neurons; Oxygen; Phenanthridines; Protein Kinase C; Sodium; Sodium-Hydrogen Exchangers; Sulfonamides; Sulfones	2001
Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 284, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Bicarbonates; Bile; Bile Ducts, Intrahepatic; Chelating Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agonists; Down-Regulation; Egtazic Acid; Enzyme Inhibitors; Epithelium; Liver; Male; Phenanthridines; Protein Kinase C; Quinolines; Rats; Rats, Inbred F344; Receptors, Dopamine D2; Secretin	2003
Role of protein kinase C in central muscarinic inhibitory mechanisms regulating voiding in rats. Neuroscience, 2003, Volume: 116, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Enzyme Inhibitors; Female; Injections, Intraventricular; Membrane Potentials; Muscarinic Agonists; Neural Inhibition; Oxotremorine; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urination	2003
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. Neuroscience, 2003, Volume: 118, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin	2003
Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone. European journal of pharmacology, 2005, Mar-28, Volume: 511, Issue:2-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstadienes; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Cell Differentiation; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HL-60 Cells; Humans; Indoles; Lactones; Maleimides; Models, Biological; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Wortmannin	2005
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amides; Animals; Benzophenanthridines; Blood Pressure; Calcium; Calcium Signaling; Cerebral Arteries; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Tonus; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases	2005
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Benzophenanthridines; Calcium; Electric Stimulation; Esophageal Sphincter, Lower; Humans; In Vitro Techniques; Muscle Contraction; Naphthalenes; Protein Kinase C; Pyridines; rhoA GTP-Binding Protein	2008
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis. Archives of pharmacal research, 2009, Volume: 32, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Benzophenanthridines; Bronchodilator Agents; Carbachol; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; KATP Channels; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Pinacidil; Protein Kinase C; rhoA GTP-Binding Protein; Trachea	2009
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2010, Volume: 180, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzophenanthridines; Body Weight; Calcium; Chick Embryo; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Femoral Artery; Hypoxia; NG-Nitroarginine Methyl Ester; Oxadiazoles; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Quinoxalines; rho-Associated Kinases; Vasoconstriction	2010
Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats. British journal of pharmacology, 2010, Volume: 159, Issue:8 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Benzophenanthridines; Calcium; Diabetes Mellitus, Experimental; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Streptozocin	2010
Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins. Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Animals; Antioxidants; Benzophenanthridines; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Cyclic N-Oxides; Cytoskeletal Proteins; Female; Horses; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Reactive Oxygen Species; rho-Associated Kinases; Rotenone; Spin Labels; Vasoconstriction; Vasodilator Agents; Veins	2010
Agonist-induced periodic vasomotion in rat isolated pulmonary artery. Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-1 Receptor Agonists; Animals; Benzophenanthridines; Calcium Channel Agonists; Calcium Signaling; Carbenoxolone; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Gap Junctions; In Vitro Techniques; Male; Methacholine Chloride; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Pinacidil; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Riluzole; Ryanodine; Tetraethylammonium; Vasomotor System	2011
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels. Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Animals; Benzophenanthridines; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Imidazoles; Indoles; Maleimides; Mice; Muscle, Skeletal; Nifedipine; Potassium Channels, Voltage-Gated; Protein Kinase C; Synapses	2010