1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with carbachol in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (14.52) | 18.7374 |
| 1990's | 37 (59.68) | 18.2507 |
| 2000's | 12 (19.35) | 29.6817 |
| 2010's | 4 (6.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fox, LM; Funasaka, M; Goldenring, JR; Hidaka, H; Modlin, IM; Tsunoda, Y | 1 |
| Chase, HS; Lindeman, RP; Luo, H | 1 |
| Obara, K; Usuki, T; Yabu, H | 1 |
| Easom, RA; Hidaka, H; Landt, M; Walters, SM; Wenham, RM | 1 |
| Ikeda, K; Machida, J; Nishi, K; Sakiyama, H; Ueda, S; Yoshida, M | 1 |
| Cotman, CW; Koh, JY; Palmer, E | 1 |
| Blanchard, LM; Larose, L; Morisset, J; Paquette, B | 1 |
| Arita, Y; Kimura, T; Nawata, H; Ogami, Y | 1 |
| Bahrami, LH; Lenhard, LW; Pandol, SJ; Perkins, PS | 1 |
| Izawa, T; Komabayashi, T; Rubin, RP; Suda, K; Tsuboi, M; Yakata, A | 1 |
| Chung, OY; Louie, DS | 1 |
| Francis, J; Pon, DJ; Qu, Y; Sen, AK; Torchia, J | 1 |
| Balda, MS; Cereijido, M; Contreras, RG; García-Sáinz, JA; González-Mariscal, L; Macias-Silva, M; Torres-Marquez, ME | 1 |
| Manganel, M; Turner, RJ | 1 |
| el-Fakahany, EE; Lai, WS; Rogers, TB | 1 |
| Gnegy, ME; Mangels, LA | 1 |
| Pandol, SJ; Schoeffield, MS | 1 |
| Ari, IL; Atlas, D; Schwarz, L | 1 |
| Agopyan, N; Krnjević, K; Leblond, J | 1 |
| De Pont, JJ; Van den Broek, BA; Van Os, CH; Willems, PH | 1 |
| Myers, LM; Sumners, C | 1 |
| Dandona, P; Jeremy, JY | 1 |
| el-Fakahany, EE; Lai, WS | 1 |
| Houchi, H; Misbahuddin, M; Morita, K; Nakanishi, A; Oka, M | 1 |
| Ishii, K; Kato, R; Sasakawa, N; Yamamoto, S | 1 |
| Craven, PA; DeRubertis, FR; Studer, RK | 1 |
| Hinds, TR; Storm, DR; Wayman, GA | 1 |
| Sanderson, MJ; Schweitzer, ES; Wasterlain, CG | 1 |
| Itoh, M; Joh, T; Kato, T; Miyamoto, T; Moriyama, A; Okayama, N; Suzuki, T; Takeuchi, T | 1 |
| Dehaye, JP; Turner, RJ; Valdez, IH | 1 |
| Chopra, LC; Twort, CH; Ward, JP | 1 |
| Gardner, JD; Huang, SC; Pandya, PK; Talkad, VD; Wank, SA | 1 |
| Itoh, M; Joh, T; Kato, T; Miyamoto, T; Okayama, N | 1 |
| Garg, LC; Mohuczy-Dominiak, D; Saha, PK | 1 |
| DelValle, J; Osburn, J; Wang, L; Wilson, EJ | 1 |
| Fukunaga, K; Izumi, F; Kuroiwa, A; Minami, K; Miyamoto, E; Nakashima, Y; Tsutsui, M; Yanagihara, N | 1 |
| Benz, D; Möller, K; Perrin, D; Söling, HD | 1 |
| Honda, K; Kamiya, H; Takano, Y | 1 |
| Aronstam, RS; Puhl, HL; Raman, PS; Williams, CL | 1 |
| Almazan, G; Larocca, JN | 1 |
| Hayasaka, M; Horiuchi, K; Satoh, M; Takayanagi, I | 1 |
| Ebihara, T; Kumahara, E; Saffen, D | 1 |
| Alroy, G; Su, H; Yaari, Y | 1 |
| Diener, M; Heinke, B; Ribeiro, R | 1 |
| Jope, RS; Pacheco, MA | 1 |
| Bechrakis, NE; Nass, JU; Nuskovski, M; Strauss, O; Stumpff, F; Thieme, H; Wiederholt, M | 1 |
| Dreja, K; Hartshorne, DJ; Hellstrand, P; Susnjar, M; Swärd, K; Walsh, MP | 1 |
| Mikoshiba, K; Muto, Y; Nagao, T; Urushidani, T; Yamada, M | 1 |
| Beales, IL; Calam, J | 1 |
| Honda, Y; Honjo, M; Inatani, M; Kido, N; Sawamura, T; Tanihara, H; Yue, BY | 1 |
| Fährmann, M; Heinzmann, A; Seidler, U | 1 |
| Eddinger, TJ; Meehl, JT; Ratz, PH | 1 |
| Büyükafşar, K; Levent, A | 2 |
| Babül, A; Celik, A; Demiryürek, AT; Demiryürek, S; Kara, AF; Tarakçioglu, M | 1 |
| Dehaye, JP; Garcia-Marcos, M; Marino, A; Otto, A; Pochet, S; Seil, M | 1 |
| Gok, S; Izanli-Paksoy, A; Vural, K | 1 |
| Kamai, T; Masuda, A; Mizuno, T; Tatsumiya, K; Watanabe, M; Yamanishi, T; Yoshida, K | 1 |
| Dimitriadis, F; Kinoshita, Y; Ohiwa, H; Ohmasa, F; Saito, M; Satoh, K; Shimizu, S; Shomori, K; Tsounapi, P | 1 |
| Henderson, S; Klausner, AP; Ratz, PH; Southern, JB; Speich, JE; Wilson, CW | 1 |
| Al-Qudah, M; Anderson, CD; Grider, JR; Kendig, DM; Mahavadi, S; Murthy, KS | 1 |
| Carbonetto, S; Tremblay, M; Vezina-Audette, R | 1 |
62 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and carbachol
| Article | Year |
|---|---|
An inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Separation; Colforsin; Gastric Acid; Isoquinolines; Parasympathomimetics; Parietal Cells, Gastric; Piperazines; Protein Kinase Inhibitors; Protein Kinases | 1992 |
Participation of protein kinase C in desensitization to bradykinin and to carbachol in MDCK cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Calcium; Carbachol; Cell Line; Cell Membrane; Dogs; Epithelium; Isoquinolines; Kidney; Kinetics; Microscopy, Fluorescence; Piperazines; Protein Kinase C; Receptors, Cell Surface; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Calcium and potassium channel regulation by protein phosphorylation in smooth muscle cells of guinea pig taenia coli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Atropine; Calcium Channels; Carbachol; Colon; Guinea Pigs; In Vitro Techniques; Isoquinolines; Marine Toxins; Membrane Potentials; Models, Biological; Muscle, Smooth; Nifedipine; Oxazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Potassium Channels; Protein Kinase C | 1992 |
Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Kinetics; Myosin-Light-Chain Kinase; Phosphorylation; Piperazines; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Rats | 1992 |
Effects of phorbol ester on lower urinary tract smooth muscles in rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Drug Interactions; Female; Isoquinolines; Muscle Contraction; Muscle, Smooth; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rabbits; Urethra; Urinary Bladder | 1992 |
Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Carbachol; Cells, Cultured; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Isoquinolines; Mice; N-Methylaspartate; Neurons; Neurotoxins; Piperazines; Protein Kinase C; Receptors, Glutamate; Receptors, Neurotransmitter; Sulfonamides | 1991 |
Carbamylcholine and phorbol esters desensitize muscarinic receptors by different mechanisms in rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Calcimycin; Carbachol; Dose-Response Relationship, Drug; Down-Regulation; Gallic Acid; Isoquinolines; Male; Pancreas; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Secretory Rate; Tetradecanoylphorbol Acetate | 1990 |
Effects of H7 and staurosporine on cytosolic free calcium and amylase secretion in rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Carbachol; Cytosol; Isoquinolines; Kinetics; Male; Pancreas; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcimycin; Carbachol; DNA Probes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzymes; Isoquinolines; Lipase; Nucleic Acid Hybridization; Pancreas; Pancreatic Elastase; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C-dependent diacylglycerol formation is mediated via Ca2+/calmodulin in parotid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Calmodulin; Carbachol; Diglycerides; Isoquinolines; Lanthanum; Male; Parotid Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Verapamil | 1991 |
Carbachol acts through protein kinase C to modulate cholecystokinin receptors on pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Carbachol; Down-Regulation; Enzyme Activation; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Male; Pancreas; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1991 |
Carbachol-stimulated phosphorylation of a 170-kDa endogenous protein in avian salt gland cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atropine; Carbachol; Ducks; Ionomycin; Isoquinolines; Kinetics; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Proteins; Salt Gland; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylate Cyclase Toxin; Animals; Calcium; Calmodulin; Carbachol; Cells, Cultured; Electric Conductivity; Epithelial Cells; Epithelium; GTP-Binding Proteins; Intercellular Junctions; Isoquinolines; Kidney; Membrane Potentials; Neomycin; Pertussis Toxin; Piperazines; Polymyxin B; Protein Kinase C; Trifluoperazine; Type C Phospholipases; Virulence Factors, Bordetella | 1991 |
Agonist-induced activation of Na+/H+ exchange in rat parotid acinar cells is dependent on calcium but not on protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Carbachol; Carrier Proteins; Diglycerides; Epinephrine; Isoquinolines; Male; Parotid Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium-Hydrogen Exchangers; Sulfonamides; Trifluoperazine | 1990 |
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cyclic GMP; Down-Regulation; Isoquinolines; Mice; N-Methylscopolamine; Neuroblastoma; Parasympathomimetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Muscarinic receptor-mediated translocation of calmodulin in SK-N-SH human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Biological Transport; Calcium; Calmodulin; Carbachol; Humans; Ionomycin; Isoquinolines; Kinetics; Neuroblastoma; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1990 |
1,2-Diacylglycerol, protein kinase C, and pancreatic enzyme secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcimycin; Carbachol; Dibutyryl Cyclic GMP; Diglycerides; Glycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Kinetics; Pancreas; Piperazines; Protein Kinase C; Sincalide; Tetradecanoylphorbol Acetate; Tetragastrin | 1986 |
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Carbazoles; Cerebral Cortex; Cholera Toxin; GTP-Binding Proteins; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Male; Neurosecretion; Norepinephrine; Ouabain; Pertussis Toxin; Phenylephrine; Piperazines; Polymyxin B; Potassium Chloride; Protein Kinase C; Rats; Veratridine; Virulence Factors, Bordetella | 1989 |
Mediation of acetylcholine's excitatory actions in central neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Cyclic GMP; Hippocampus; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Rats; Rats, Inbred Strains; Tetrodotoxin | 1989 |
Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ release in permeabilized pancreatic acinar cells by hormonal and phorbol ester pretreatment.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Cell Membrane Permeability; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Kinetics; Pancreas; Piperazines; Protein Kinase Inhibitors; Rabbits; Sincalide; Sugar Phosphates; Tetradecanoylphorbol Acetate | 1989 |
Regulation of angiotensin II binding sites in neuronal cultures by catecholamines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Animals, Newborn; Brain; Carbachol; Cells, Cultured; Isoquinolines; Kinetics; Neurons; Norepinephrine; Phosphatidylinositols; Piperazines; Propranolol; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Yohimbine | 1989 |
Fluoride but not phorbol esters stimulate rat urinary bladder prostanoid synthesis: investigations into the roles of G proteins and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atropine; Bucladesine; Calcimycin; Carbachol; Fluorides; GTP-Binding Proteins; Isoquinolines; Nifedipine; Phorbol Esters; Piperazines; Prostaglandins; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Urinary Bladder; Verapamil | 1987 |
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Histamine; Isoquinolines; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1987 |
Stimulation by vasoactive intestinal polypeptide of catecholamine synthesis in isolated bovine adrenal chromaffin cells. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Dihydroxyphenylalanine; In Vitro Techniques; Isoquinolines; Piperazines; Tetradecanoylphorbol Acetate; Tyrosine; Vasoactive Intestinal Peptide | 1987 |
Differential effects of protein kinase C activators on carbamylcholine- and high K+-induced rises in intracellular free calcium concentration in cultured adrenal chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Glands; Animals; Calcium; Carbachol; Cattle; Chromaffin Granules; Chromaffin System; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Piperazines; Potassium; Potassium Chloride; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Amino Acid Oxidoreductases; Animals; Arginine; Calcimycin; Carbachol; Cyclic GMP; Diabetes Mellitus, Experimental; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kidney Glomerulus; Kinetics; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphates; Phosphorylation; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Staurosporine; Thromboxane A2 | 1994 |
Hormone stimulation of type III adenylyl cyclase induces Ca2+ oscillations in HEK-293 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoproterenol; Isoquinolines; Kidney; Kinetics; Models, Biological; Oscillometry; Phosphatidylinositols; Piperazines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucagon; Signal Transduction; Time Factors | 1995 |
Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/calmodulin kinase II inhibitor KN-62.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Dopamine Antagonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Isoquinolines; Kinetics; Membrane Potentials; Norepinephrine; PC12 Cells; Piperazines; Protein Kinase C; Rats; Trifluoperazine | 1995 |
Mediation of pepsinogen secretion from guinea pig chief cells by Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Gastric Mucosa; Guinea Pigs; Immunohistochemistry; Ionomycin; Isoquinolines; Male; Pepsinogens; Phosphorylation; Piperazines | 1995 |
Beta-adrenergic stimulation and cAMP mobilize Ca2+ from an IP3-insensitive pool in rat submandibular granular ducts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Alkaloids; Animals; Atenolol; Atropine; Calcium; Carbachol; Cyclic AMP; Epinephrine; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoproterenol; Isoquinolines; Kinetics; Male; Phentolamine; Piperazines; Propanolamines; Propranolol; Protein Kinase C; Protein Kinase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Staurosporine; Submandibular Gland | 1993 |
Differences in sensitivity to the specific protein kinase C inhibitor Ro31-8220 between small and large bronchioles of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bronchi; Bronchoconstriction; Carbachol; In Vitro Techniques; Indoles; Isoquinolines; Male; Maleimides; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Serotonin | 1994 |
Biochemical regulation of the three different states of the cholecystokinin (CCK) receptor in pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzodiazepinones; Bombesin; Carbachol; Cholecystokinin; Devazepide; GTP-Binding Proteins; In Vitro Techniques; Isoquinolines; Pancreas; Phosphorylation; Piperazines; Rats; Receptors, Cholecystokinin; Secretin; Sincalide; Sodium Fluoride; Tetradecanoylphorbol Acetate | 1994 |
Role of myosin light-chain kinase and protein kinase C in pepsinogen secretion from guinea pig gastric chief cells in monolayer culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Carbachol; Cells, Cultured; Colforsin; Gastric Mucosa; Guinea Pigs; Immunoenzyme Techniques; Ionomycin; Isoquinolines; Male; Microscopy, Electron; Myosin-Light-Chain Kinase; Pepsinogens; Piperazines; Protein Kinase C; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1994 |
Cholinergic inhibition of Na-K-ATPase via activation of protein kinase C in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atropine; Carbachol; Cells, Cultured; Dogs; Enzyme Activation; Epithelium; Inositol Phosphates; Isoquinolines; Kidney; Naphthalenes; Parasympathomimetics; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Staurosporine; Sulfonamides | 1993 |
Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminopyrine; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Acid; Inositol 1,4,5-Trisphosphate; Isoquinolines; Parasympathomimetics; Parietal Cells, Gastric; Piperazines; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Sulfonamides | 1996 |
Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Adrenal Medulla; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Catecholamines; Cattle; Chromaffin System; Enzyme Inhibitors; Humans; Ion Channels; Isoquinolines; Nicotinic Agonists; Piperazines; Sodium; Tyrosine 3-Monooxygenase | 1996 |
The role of protein kinase C in carbachol-induced and of cAMP-dependent protein kinase in isoproterenol-induced secretion in primary cultured guinea pig parotid acinar cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amylases; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Inhibitors; Exocytosis; Guinea Pigs; Immunoblotting; Isoproterenol; Isoquinolines; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Piperazines; Protein Binding; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1996 |
Involvement of protein kinase C in muscarinic agonist-induced contractions of guinea pig ileal longitudinal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Diglycerides; Guinea Pigs; Ileum; In Vitro Techniques; Inositol Phosphates; Muscarinic Agonists; Muscle Contraction; Protein Kinase C; Sulfonamides | 1996 |
Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpipe
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Inhibitors; Humans; Neuroblastoma; Piperidines; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Tumor Cells, Cultured | 1997 |
Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by muscarinic receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Atropine; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Cholinergic Agents; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate | 1997 |
Protein kinase C mediates increase of Ca2+ sensitivity for contraction by cholinoceptor partial agonist in ileal longitudinal muscle of guinea pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agents; Coloring Agents; Enzyme Inhibitors; Fura-2; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Maleimides; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pilocarpine; Propylbenzilylcholine Mustard; Protein Kinase C; Receptors, Cholinergic; Sensitivity and Specificity | 1998 |
Protein kinase inhibitor H7 blocks the induction of immediate-early genes zif268 and c-fos by a mechanism unrelated to inhibition of protein kinase C but possibly related to inhibition of phosphorylation of RNA polymerase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; Nerve Growth Factors; PC12 Cells; Phorbol Esters; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Rats; RNA Polymerase II; RNA, Messenger; Transcription Factors; Transcription, Genetic; Zinc Fingers | 1999 |
Protein kinase C mediates muscarinic block of intrinsic bursting in rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Atropine; Carbachol; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyramidal Cells; Rats; Receptors, Muscarinic; Signal Transduction; Tetraethylammonium; Tetrodotoxin | 1999 |
Involvement of calmodulin and protein kinase C in the regulation of K+ transport by carbachol across the rat distal colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbachol; Cholinergic Agonists; Colon; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Transport; Potassium; Protein Kinase C; Rats; Rats, Wistar; Rubidium Radioisotopes; Staurosporine | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Signaling; Carbachol; Carbamazepine; Chelating Agents; DNA; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Gene Expression Regulation; Humans; Indoles; Ionomycin; Ionophores; Lithium; Muscarinic Agonists; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphatidylinositols; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1999 |
The effects of protein kinase C on trabecular meshwork and ciliary muscle contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Animals; Blotting, Western; Carbachol; Cattle; Cells, Cultured; Ciliary Body; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Isoenzymes; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Tetradecanoylphorbol Acetate; Trabecular Meshwork | 1999 |
Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Cholinergic Agonists; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Myosins; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein | 2000 |
A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Aminopyrine; Animals; Bucladesine; Calcium; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbon Radioisotopes; Cyclic AMP; Cytochalasin D; Cytoskeleton; Drug Interactions; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Parietal Cells, Gastric; Protein Kinase C; Rabbits; Receptors, Cytoplasmic and Nuclear; Stomach | 2001 |
Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Carbachol; Carcinogens; Cell Communication; Cells, Cultured; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Acid; Interleukin-1; Parietal Cells, Gastric; Phenanthridines; Protein Kinase C; Rabbits; Sphingomyelin Phosphodiesterase; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aqueous Humor; Blotting, Western; Carbachol; Cells, Cultured; Ciliary Body; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Intraocular Pressure; Muscle Contraction; Muscle, Smooth; Myosins; Ophthalmic Solutions; Protein Kinase Inhibitors; Rabbits; Trabecular Meshwork; Vinculin | 2001 |
CaMKII is activated and translocated to the secretory apical membrane during cholinergically conveyed gastric acid secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminopyrine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Membrane; Cell Polarity; Cells, Cultured; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Gastric Acid; H(+)-K(+)-Exchanging ATPase; Male; Parietal Cells, Gastric; Protein Transport; Rabbits; Rats; Rats, Wistar; Secretory Vesicles | 2002 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder | 2002 |
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2003 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthesia; Animals; Blood Pressure; Carbachol; Cardiotonic Agents; Coronary Vessels; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Intracellular Signaling Peptides and Proteins; Ischemic Preconditioning, Myocardial; Lactates; Male; Malondialdehyde; Myocardial Infarction; Neutrophils; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; rho-Associated Kinases; Tachycardia, Ventricular; Vasodilation; Ventricular Premature Complexes | 2005 |
Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Biological Transport; Calcium; Carbachol; Ethidium; Interleukin-1beta; Mice; Mice, Knockout; Phospholipases A2; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Saliva; Submandibular Gland | 2007 |
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Benzophenanthridines; Bronchodilator Agents; Carbachol; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; KATP Channels; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Pinacidil; Protein Kinase C; rhoA GTP-Binding Protein; Trachea | 2009 |
Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Chloride; Protein Kinase Inhibitors; rho-Associated Kinases; Swine; Urinary Bladder; Urothelium | 2009 |
Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Prostate; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases | 2011 |
Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dinoprostone; Enzyme Inhibitors; Female; Male; Mice; Muscle Contraction; Muscle, Smooth; Potassium Chloride; rho-Associated Kinases; Urinary Bladder; Urinary Bladder Neck Obstruction | 2012 |
Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Benzimidazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cholinergic Neurons; Colon; Enzyme Inhibitors; In Vitro Techniques; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Myosin-Light-Chain Kinase; Naphthalimides; Peptide Fragments; Pyridines; Rats, Sprague-Dawley; Receptor, Muscarinic M3; rho-Associated Kinases | 2014 |
Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Agrin; Animals; Benzoquinones; Bungarotoxins; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cell Line; Gene Expression; Lactams, Macrocyclic; Laminin; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Protein Aggregates; Receptors, Cholinergic; Sodium Channel Blockers; Sodium Channels; Staining and Labeling; Tetrodotoxin; Verapamil | 2017 |