1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with bisindolylmaleimide i in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (45.10) | 18.2507 |
| 2000's | 25 (49.02) | 29.6817 |
| 2010's | 3 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clegg, RA; Johnson, MS; Mitchell, R; Simpson, J | 2 |
| Black, JL; Yang, KX | 1 |
| Giebisch, G; Kubokawa, M; McNicholas, CM; Wang, W | 1 |
| Dautrevaux, M; Formstecher, P; Lefebvre, P; Tahayato, A | 1 |
| Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB | 1 |
| Babior, BM; el-Benna, J; Park, JW; Ruedi, JM | 1 |
| Carpentier, G; Lagord, C; Leibovitch, MP; Leibovitch, SA; Martelly, I | 1 |
| Ikeuchi, Y; Nishizaki, T; Okada, Y | 1 |
| Artemenko, IP; Hokin, LE; Los, GV | 1 |
| Ikeuchi, Y; Matsuoka, T; Nishizaki, T; Sumikawa, K | 1 |
| Bavister, BD; Rose-Hellekant, TA | 1 |
| Almazan, G; Larocca, JN | 1 |
| Hayasaka, M; Horiuchi, K; Satoh, M; Takayanagi, I | 1 |
| Nishizaki, T; Nomura, T | 1 |
| Barnes, PJ; Dupont, LJ; Mak, JC; Pype, JL; Verleden, GM | 1 |
| Chow, SC; Jondal, M; Osorio, LM; Rottenberg, M | 1 |
| Adler, MR; Botsford, SA; Gronau, RT; Light, DB; Ter Beest, JK | 1 |
| Ghofrani, HA; Grimminger, F; Hardebusch, T; Rosseau, S; Schermuly, R; Seeger, W; Voswinckel, R; Weissmann, N | 1 |
| Abe, N; Habu, S; Iwakabe, K; Kitamura, H; Matsuki, N; Nakui, M; Nishimura, T; Ohmi, Y; Ohta, A; Sato, M; Yagita, H; Yahata, C; Yahata, T | 1 |
| Akamatsu, N; Higaki, T; Imamura, H; Komatsu, S; Kono, Y; Nakagawa, M; Sato, T; Sawada, S; Tada, Y; Tamagaki, T; Toratani, A; Tsuda, Y; Tsuji, H; Yamasaki, S | 1 |
| Balaban, CD; Freilino, M; Romero, GG | 1 |
| Muraki, T; Ogawa, A; Ohba, K; Uchida, Y; Wada, K; Yoshioka, T | 1 |
| Cafferata, EG; Giordano, L; González-Guerrico, AM; Pivetta, OH; Santa-Coloma, TA | 1 |
| Chaudhuri, S; Raha, S | 1 |
| Fujimoto, S; Hayakawa, T; Kawakami, N; Kita, K; Yamaguchi, T | 1 |
| Anesini, C; Borda, T; Cazaux, CA; Cremaschi, GA; Genaro, AM; Sterin-Borda, L; Wald, M | 1 |
| Chen, H; Fetscher, C; Heusch, G; Michel, MC; Schäfers, RF; Wambach, G | 1 |
| Boland, R; Buitrago, C; de Boland, AR; Morelli, S | 1 |
| Leopoldt, D; Rozengurt, E; Yee, HF | 1 |
| Chung, SW; Kang, SN; Kim, TS | 1 |
| Hirata, I; Katsu, K; Kayazawa, M; Kojima, K; Matsuse, R; Nakagawa, K; Saitoh, O; Sugi, K; Tabata, K; Tanaka, S; Teranishi, T; Uchida, K | 1 |
| Nakajima, Y; Nakanishi, S; Shinohara, Y | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Eddinger, TJ; Meehl, JT; Ratz, PH | 1 |
| Dutia, MB; Johnston, AR; Seckl, JR | 1 |
| Barros, F; de la Pena, P; Dupuy, SG; Garcia-Manso, D; Giraldez, T; Gomez-Varela, D | 1 |
| Abe, K; Misawa, M | 1 |
| Hescheler, J; Klöckner, U; Krieger, A; Leroy, J; Malécot, CO; Pereverzev, A; Pfitzer, G; Schneider, T; Vajna, R | 1 |
| Kim, SH; Kim, TS; Oh, SM | 1 |
| Cameron, P; Kanke, T; Macfarlane, SR; McKenzie, RC; Plevin, R; Sloss, CM | 1 |
| Jarajapu, YP; Knot, HJ | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Gong, MC; Guo, Z; Pang, H; Post, SR; Su, W; Xie, Z | 1 |
| Craveiro, RB; Ferreira, AT; França, JP; Oshiro, ME; Paredes-Gamero, EJ; Pesquero, JB | 1 |
| Linsdell, P; McDonald, TF; Missan, S | 1 |
| Gao, C; Gao, N; Hu, HZ; Liu, S; Wood, JD; Xia, Y | 1 |
| Kojo, T; Komagiri, Y; Kubokawa, M; Nakamura, K | 1 |
| Balezina, OP; Bogatcheva, PO; Ezhova, EV | 1 |
| Alvarez, SM; Browne, BM; Clelland, LJ; Miner, AS; Ratz, PH | 1 |
| Holloway, AC; Nurse, CA; Salman, S | 1 |
51 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and bisindolylmaleimide i
| Article | Year |
|---|---|
The properties of protein kinase C zeta purified from alpha T3-1 cells using hydroxyapatite chromatography.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Line; Chromatography; Chromatography, DEAE-Cellulose; Durapatite; Indoles; Isoenzymes; Isoquinolines; Kinetics; Maleimides; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats | 1995 |
The involvement of protein kinase C in the contraction of human airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techniques; Indoles; Isoquinolines; Maleimides; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine | 1995 |
Role of Ca2+/CaMK II in Ca(2+)-induced K+ channel inhibition in rat CCD principal cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electrophysiology; Female; Indoles; Isoquinolines; Kidney Cortex; Kidney Tubules, Collecting; Male; Maleimides; Piperazines; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1995 |
A protein kinase C-dependent activity modulates retinoic acid-induced transcription.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cell Line; Cell Nucleus; Chlorocebus aethiops; DNA; Enzyme Induction; Humans; Indoles; Isoenzymes; Isoquinolines; Maleimides; Molecular Sequence Data; Phosphorylation; Piperazines; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin | 1993 |
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium | 1993 |
Separation of H7-resistant protein kinase C isoforms from gonadotroph-derived alpha T3-1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Isoquinolines; Maleimides; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C | 1996 |
Cell-free activation of the respiratory burst oxidase by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Catalase; Cattle; Cell-Free System; Cytosol; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Isoquinolines; Maleimides; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Rats; Respiratory Burst; Superoxide Dismutase | 1995 |
The kinase inhibitor iso-H7 stimulates rat satellite cell differentiation through a non-protein kinase C pathway by increasing myogenin expression level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Differentiation; Creatine Kinase; Enzyme Inhibitors; Indoles; Isoquinolines; Maleimides; Muscle, Skeletal; Myogenin; Myosin Light Chains; Protein Kinase C; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1996 |
Repetitive applications of ATP potentiate potassium current by Ca2+/calmodulin kinase in cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Hippocampus; Indoles; Ion Channel Gating; Isoquinolines; Maleimides; Neurons; Patch-Clamp Techniques; Potassium; Protein Kinase C; Rats; Signal Transduction; Sulfonamides | 1996 |
Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Atropine; Calcium; Egtazic Acid; Enzyme Inhibitors; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Maleimides; Neuroblastoma; Nickel; Phosphatidylinositols; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Kinetics; Macromolecular Substances; Maleimides; Mutagenesis, Site-Directed; Oleic Acid; Oocytes; Point Mutation; Protein Kinase C; Receptors, Nicotinic; Recombinant Proteins; Serine; Torpedo; Xenopus laevis | 1997 |
Precocious oocyte maturation is induced by an inhibitor of cAMP-dependent protein kinase in the intact golden hamster.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Female; Indoles; Isoquinolines; Maleimides; Mesocricetus; Oocytes; Phorbol Esters; Protein Kinase C; Signal Transduction; Sulfonamides | 1996 |
Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by muscarinic receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Atropine; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Cholinergic Agents; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate | 1997 |
Protein kinase C mediates increase of Ca2+ sensitivity for contraction by cholinoceptor partial agonist in ileal longitudinal muscle of guinea pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agents; Coloring Agents; Enzyme Inhibitors; Fura-2; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Maleimides; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pilocarpine; Propylbenzilylcholine Mustard; Protein Kinase C; Receptors, Cholinergic; Sensitivity and Specificity | 1998 |
Methamphetamine modulates ACh-evoked currents in Xenopus occytes expressing the rat alpha7 receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Isoquinolines; Maleimides; Methamphetamine; Oocytes; Protein Kinase C; Rats; Receptors, Nicotinic; RNA, Messenger; Sulfonamides; Xenopus | 1997 |
Regulation of H1-receptor coupling and H1-receptor mRNA by histamine in bovine tracheal smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cattle; Cimetidine; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Indoles; Indomethacin; Maleimides; Muscle, Smooth; Pyrilamine; Receptors, Histamine H1; RNA, Messenger; Trachea | 1998 |
Simultaneous cross-linking of CD6 and CD28 induces cell proliferation in resting T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antibodies, Monoclonal; Antigens, CD; Carcinogens; CD28 Antigens; CD3 Complex; Cell Division; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Indoles; Interleukin-2; Lymphocyte Activation; Maleimides; Protein Kinase C; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase C and regulatory volume decrease in mudpuppy red blood cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Size; Enzyme Inhibitors; Erythrocytes; Gramicidin; Hematocrit; Hypotonic Solutions; Indoles; Ion Channel Gating; Ion Transport; Isoquinolines; Maleimides; Models, Biological; Necturus; Osmotic Fragility; Osmotic Pressure; Patch-Clamp Techniques; Phenanthridines; Potassium Channels; Protein Kinase C; Sulfonamides | 1998 |
Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Farnesol; Hypoxia; In Vitro Techniques; Indoles; Maleimides; Nitric Oxide; Prostaglandin Antagonists; Protein Kinase C; Pulmonary Artery; Pulmonary Circulation; Rabbits; Triazoles; Vasoconstriction | 1999 |
The essential role of phorbol ester-sensitive protein kinase C isoforms in activation-induced cell death of Th1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Indoles; Isoenzymes; Maleimides; Membrane Glycoproteins; Mice; Mice, Transgenic; Mitogens; Protein Kinase C; Tetradecanoylphorbol Acetate; Th1 Cells; Th2 Cells | 1999 |
A role of protein kinase C in the regulation of cytosolic phospholipase A(2) in bradykinin-induced PGI(2) synthesis by human vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Bradykinin; Calcium; Cells, Cultured; Cytosol; DNA Primers; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Kinetics; Maleimides; Mutagenesis, Site-Directed; Phospholipases A; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate | 1999 |
Protein kinase C inhibition blocks the early appearance of vestibular compensation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Ear, Inner; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Male; Maleimides; Nystagmus, Pathologic; Protein Kinase C; Purkinje Cells; Rats; Rats, Long-Evans; Signal Transduction | 1999 |
Protein kinase C mediates tumor necrosis factor-alpha-induced inhibition of obese gene expression and leptin secretion in brown adipocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipocytes; Adipose Tissue, Brown; Animals; Cell Differentiation; Cell Membrane; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation; Glycerolphosphate Dehydrogenase; Indoles; Leptin; Male; Maleimides; Mice; Mice, Inbred ICR; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 1999 |
Interleukin-1beta regulates CFTR expression in human intestinal T84 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Benzoquinones; Cell Line; Colon; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Genistein; Humans; Indoles; Interleukin-1; Lactams, Macrocyclic; Maleimides; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2000 |
Inhibition and stimulation of growth of Entamoeba histolytica in culture: association with PKC activity and protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Culture Media; Down-Regulation; Entamoeba histolytica; Enzyme Inhibitors; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Threonine | 2000 |
Phorbor myristate acetate induces NADPH oxidase activity of cytochalasin B-primed neutrophils through the protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Androstadienes; Cytochalasin B; Ethanol; Granulocyte Colony-Stimulating Factor; Humans; Indoles; Maleimides; NADPH Oxidases; Neutrophils; Phosphatidylinositol 3-Kinases; Phospholipase D; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Altered beta-adrenoceptor function associated to protein kinase C activation in hyperproliferative T lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adrenergic beta-Agonists; Cell Division; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Isoproterenol; Lymphoma, T-Cell; Maleimides; Neuroimmunomodulation; Protein Kinase C; Receptors, Adrenergic, beta; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured | 2000 |
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction | 2001 |
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcitriol; Calcium; Calmodulin; Chick Embryo; Egtazic Acid; Enzyme Activation; Fluphenazine; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Naphthalenes; Neomycin; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin; Type C Phospholipases; Verapamil | 2001 |
Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bombesin; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunoblotting; Indoles; Maleimides; Marine Toxins; Mice; Microscopy, Fluorescence; Myosin-Light-Chain Phosphatase; Nucleic Acid Synthesis Inhibitors; Oxazoles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Thiazoles; Thiazolidines; Time Factors | 2001 |
Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzophenanthridines; Calcitriol; Capsaicin; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Maleimides; Phenanthridines; Protein Kinase C; Signal Transduction; Tretinoin | 2001 |
Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Caco-2 Cells; Decanoic Acids; Docosahexaenoic Acids; Eicosapentaenoic Acid; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fatty Acids; Humans; Indoles; Interleukin-8; Intestinal Mucosa; Maleimides; Naphthalenes; Oleic Acid; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger | 2001 |
Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cytoskeleton; Edetic Acid; Egtazic Acid; Enzyme Inhibitors; Estrenes; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Glutamic Acid; Indoles; Kinetics; Maleimides; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Transfection; Type C Phospholipases | 2001 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder | 2002 |
Role of the flocculus in mediating vestibular nucleus neuron plasticity during vestibular compensation in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adaptation, Physiological; Animals; Cerebellum; Denervation; Drug Administration Schedule; Enzyme Inhibitors; In Vitro Techniques; Indans; Indoles; Maleimides; Neuronal Plasticity; Neurons; Neurons, Afferent; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Vestibular Nuclei | 2002 |
Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cells, Cultured; Enzyme Inhibitors; ERG1 Potassium Channel; Estrenes; Ether-A-Go-Go Potassium Channels; Hydrolysis; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Potentials; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Pyridines; Pyrrolidinones; Rats; rho-Associated Kinases; Signal Transduction; Thyrotropin-Releasing Hormone | 2003 |
Astrocyte stellation induced by Rho kinase inhibitors in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Astrocytes; Carbazoles; Cell Size; Cells, Cultured; Cerebral Cortex; Colchicine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gout Suppressants; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Phalloidine; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; rho-Associated Kinases | 2003 |
The cytosolic II-III loop of Cav2.3 provides an essential determinant for the phorbol ester-mediated stimulation of E-type Ca2+ channel activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Barium; Calcium; Calcium Channels; Cell Line; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Humans; Indoles; Ion Channel Gating; Kidney; Maleimides; Membrane Potentials; Patch-Clamp Techniques; Phorbol Esters; Protein Kinase C; Protein Structure, Tertiary; Protein Subunits; Time Factors; Transfection | 2004 |
Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstadienes; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Cell Differentiation; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HL-60 Cells; Humans; Indoles; Lactones; Maleimides; Models, Biological; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Wortmannin | 2005 |
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; I-kappa B Kinase; Indoles; Keratinocytes; Maleimides; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotides; Phosphodiesterase Inhibitors; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrrolidinones; Receptor, PAR-2; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases | 2005 |
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amides; Animals; Benzophenanthridines; Blood Pressure; Calcium; Calcium Signaling; Cerebral Arteries; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Tonus; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Immunoblotting; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Up-Regulation | 2006 |
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bone Marrow Cells; Boron Compounds; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Erythroblasts; Female; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Mice; Mice, Inbred C57BL; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; RNA, Messenger | 2006 |
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cytochalasin D; Cytoskeleton; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoquinolines; KCNQ1 Potassium Channel; Maleimides; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins | 2006 |
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Boron Compounds; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Guinea Pigs; Ileum; Indoles; Male; Maleimides; Norepinephrine; Phenethylamines; Pyrrolidinones; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction; Submucous Plexus; Synaptic Transmission; Tetrodotoxin; Theophylline; Triazines; Triazoles | 2007 |
Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cyclosporine; Humans; Indoles; Kidney Tubules, Proximal; Maleimides; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Inwardly Rectifying; Protein Kinase C | 2009 |
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Animals; Benzophenanthridines; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Imidazoles; Indoles; Maleimides; Mice; Muscle, Skeletal; Nifedipine; Potassium Channels, Voltage-Gated; Protein Kinase C; Synapses | 2010 |
Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cardiovascular Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escin; Female; Femoral Artery; Indoles; Male; Maleimides; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Octoxynol; Organ Culture Techniques; Permeability; Potassium Chloride; Rabbits; rho-Associated Kinases; Surface-Active Agents | 2011 |
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinases; Carbonic Anhydrase I; Carbonic Anhydrase II; Cell Hypoxia; Cell Line; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Female; Hypercapnia; Indoles; Isoquinolines; KATP Channels; Maleimides; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Oligopeptides; Potassium Channels, Inwardly Rectifying; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2014 |