1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with atorvastatin in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, JO; Kofler, S; Methe, H; Nabauer, M; Weis, M | 1 |
| Shah, DI; Singh, M | 1 |
| Favre, G; Leveque, K; Sarrabayrouse, G; Synaeve, C; Tilkin-Mariamé, AF | 1 |
| Fukumoto, Y; Rashid, M; Seto, M; Shimokawa, H; Tawara, S; Yano, K | 1 |
| Hui, L; Xiao-Ping, G; Yi, R | 1 |
| Alzayed, Z; Büyükafşar, K; İlhan, E; Seçilmiş, MA; Tiftik, RN | 1 |
2 trial(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and atorvastatin
| Article | Year |
|---|---|
Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Atorvastatin; B7-1 Antigen; Bacterial Proteins; Bacterial Toxins; Cells, Cultured; Cytokines; Drug Interactions; Female; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1 Receptor-Associated Kinases; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Middle Aged; Monocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Prenylation; Pyrroles; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4 | 2005 |
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Cross-Over Studies; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Leukocytes; Male; Pravastatin; Pyrroles; Quinolines; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2009 |
4 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and atorvastatin
| Article | Year |
|---|---|
Involvement of Rho-kinase in experimental vascular endothelial dysfunction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Antibiotics, Antineoplastic; Aorta, Thoracic; Atorvastatin; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Endothelium, Vascular; Heptanoic Acids; Homocysteine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Intracellular Signaling Peptides and Proteins; Male; Nitrates; Nitrites; Oxidative Stress; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Streptozocin; Thiobarbituric Acid Reactive Substances; Vasodilation | 2006 |
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Benzamides; Botulinum Toxins; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Lymphoma; Melanoma, Experimental; Membrane Proteins; Methionine; Mevalonic Acid; Mice; Pyrroles; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering | 2007 |
Atorvastatin prevents angiotensin II-induced high permeability of human arterial endothelial cell monolayers via ROCK signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Arteries; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Lim Kinases; Permeability; Phosphorylation; Pyrroles; rho-Associated Kinases; Signal Transduction; Zonula Occludens-1 Protein | 2015 |
Effects of the Rho/Rho-Kinase Pathway on Perfusion Pressure in the Isolated-Perfused Rat Hind Limb Vascular Bed.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Atorvastatin; Muscle Relaxants, Central; Perfusion; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasodilation; Vasodilator Agents | 2021 |