Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and arachidonic acid

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with arachidonic acid in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (30.00)	18.7374
1990's	39 (65.00)	18.2507
2000's	3 (5.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Akimaru, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T; Yoshioka, T	1
Fujii, T; Hashizume, T; Sato, T	1
Kojo, T	1
Sekino, H; Suzuki-Nishimura, T; Uchida, MK; Yoshino, Y	1
Beraud, M; Cambon, C; Didier, A; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC; Vandaele, J	1
Mattila, P; Renkonen, R	1
Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ	1
Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC	1
Ganguly, NK; Khullar, M; Khurana, S; Panigrahi, D; Walia, BN	1
el Touny, S; Hannun, YA; Khan, W	1
Conquer, J; Mahadevappa, VG	1
Emoto, T; Hattori, Y; Hiraiwa, M; Kasai, K; Kuroda, H; Shimoda, S; Yamazaki, A	1
Kitaoka, M; Kojima, I; Ogata, E	1
Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S	1
Ballou, LR; Barker, SC; Kang, AH; Postlethwaite, AE	1
Kajiyama, Y; Murayama, T; Nomura, Y; Takahashi, A	1
AbuBakar, S; Albrecht, T; Boldogh, I	1
Franke, T; Glusa, E; Markwardt, F; Nilius, B	1
Pandol, SJ; Schoeffield, MS	1
Hansen, HS; Jensen, B; Linnebjerg, H	1
Fuse, I; Iwanaga, T; Tai, HH	1
Boscá, L; Díaz-Guerra, MJ; Mojena, M	1
McMorris, FA; Shin, ML; Shirazi, Y	1
Insel, PA; Slivka, SR; Weiss, BA	1
Anderson, R; Beyers, AD; Nel, AE; Savage, JE	1
Ida, E; Onoue, K; Sakata, A; Tominaga, M; Yamasaki, H	1
Maridonneau-Parini, I; Tauber, AI	1
Maridonneau-Parini, I; Tauber, AI; Tringale, SM	1
Ida, E; Onoue, K; Sakata, A; Tominaga, M	1
Daniel, LW; Parker, J; Waite, M	1
Halenda, SP; Rehm, AG	1
Matsumoto, T; Sha'afi, RI; Tao, W	1
Bertrand, W; Mordhorst, M; Morrison, AR; Portilla, D	1
Craven, PA; DeRubertis, FR	1
Fuse, I; Tai, HH	1
Christensen, SB; Fujiki, H; Hirasawa, N; Ohuchi, K; Sugawara, T; Sugimura, T; Tsurufuji, S; Watanabe, M	1
Coderre, TJ; Yashpal, K	1
Arreola, J; Dirksen, RT; Perez-Cornejo, P; Piech, KM; Sheu, SS	1
Chang, JP; Neumann, CM; Van Goor, F	1
Mitchell, R; Thomson, FJ	1
Schrier, RW; Williams, B	1
Mitchell, MD; Pollard, JK	1
Bertrand, N; McCarron, R; Spatz, M; Stanimirovic, DB	1
Beraud, M; Bessieres, MH; Frisach, MF; M'Rini, C; Pipy, B; Seguela, JP; Thardin, JF; Vandaele, J	1
Duty, L; Gorelik, E; Kim, M; Prezioso, JA; Tweardy, DJ; Wang, J	1
Goracci, G; Gresele, P; Iorio, P; Nenci, GG; Nucciarelli, F; Stasi, M; Vezza, R	1
Gerritsen, ME; Moatter, T	1
Galkina, SI; Margolis, LB; Sud'ina, GF	1
Hashizume, T; Nakao, M; Sato, T	1
Aussel, C; Breittmayer, JP; Dumaurier, MJ; Marhaba, R; Pelassy, C	1
Matsuoka, I; Nakahata, N; Nakanishi, H	1
Bever, CT; Li, Q; Milo, R; Panitch, H	1
Hartfield, PJ; Robinson, JM	1
Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M	1
Geertsma, MF; Nibbering, PH; Van Den Barselaar, MT; Van Furth, R; Zheng, L; Zomerdijk, TP	1
Oriji, GK	1
Perkinton, MS; Sihra, TS; Williams, RJ	1
Habibi, HR; Pati, D	1
Cui, YF; Guo, HS; Jin, H; Li, L; Xu, WX; Yu, YC	1
Imai, H; Kitahara, J; Nakagawa, Y; Sakamoto, H; Tosaki, T	1

Other Studies

60 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and arachidonic acid

Article	Year
Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors. Physiological chemistry and physics and medical NMR, 1992, Volume: 24, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Calcium; Dose-Response Relationship, Drug; Genistein; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Zymosan	1992
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism. The Biochemical journal, 1992, Feb-15, Volume: 282 ( Pt 1) Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases	1992
[A pharmacological study on the mechanism of the endothelin-induced contraction of the bovine cerebral artery]. Nihon seirigaku zasshi. Journal of the Physiological Society of Japan, 1991, Volume: 53, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Cerebral Arteries; Endothelins; Female; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Quinacrine; Sarcoplasmic Reticulum; Sodium Channels; Tetrodotoxin; Vasoconstriction	1991
Characteristics of activation of rat mast cells by polyethylenimines and a polyallylamine: effects on the release of histamine and of arachidonate and its metabolites. General pharmacology, 1990, Volume: 21, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Histamine Release; Isoquinolines; Male; Mast Cells; Molecular Weight; Peritoneum; Piperazines; Polyamines; Polyethyleneimine; Rats; Rats, Inbred Strains	1990
Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis, 1991, Volume: 12, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cell Survival; Culture Media; Cyclooxygenase Inhibitors; Diethylnitrosamine; Dose-Response Relationship, Drug; Extracellular Space; Female; Indomethacin; Intracellular Fluid; Isoquinolines; Kinetics; Leukotrienes; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Oxygen; Peritoneal Cavity; Phospholipids; Piperazines; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tritium	1991
Protein kinase C regulates MHC-class II expression on endothelial cells. Scandinavian journal of immunology, 1991, Volume: 34, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Dose-Response Relationship, Drug; Endothelium; Histocompatibility Antigens Class II; Interferon-gamma; Isoquinolines; Myocardium; Piperazines; Protein Kinase C; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Time Factors	1991
Protein kinase C-dependent and -independent actions of arachidonic acid in GH3 cells. Biochemical Society transactions, 1991, Volume: 19, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Cytosol; Enzyme Activation; Isoquinolines; Kinetics; Masoprocol; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Neoplasms; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Rats	1991
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. Biochimica et biophysica acta, 1991, Aug-20, Volume: 1085, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2	1991
Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhoea. Biochimica et biophysica acta, 1991, Oct-21, Volume: 1097, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcimycin; Calcium; Chlorides; Diarrhea; Enterotoxins; Indomethacin; Intestinal Mucosa; Intestine, Small; Isoquinolines; Male; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium; Tetradecanoylphorbol Acetate; Verapamil; Water-Electrolyte Balance	1991
Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C. FEBS letters, 1991, Nov-04, Volume: 292, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Blood Platelets; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Isoquinolines; Peptide Mapping; Phosphorylation; Piperazines; Precipitin Tests; Protein Kinase C; Substrate Specificity	1991
Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. Biochemical and biophysical research communications, 1990, Feb-28, Volume: 167, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Fatty Acids; Humans; Isoquinolines; Linoleic Acid; Linoleic Acids; Neutrophils; Oleic Acid; Oleic Acids; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate	1990
Inhibition by protein kinase-C inhibitor and cycloheximide of phorbol ester- and epidermal growth factor-induced arachidonic acid metabolism in cultured porcine thyroid cells. Metabolism: clinical and experimental, 1990, Volume: 39, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dinoprostone; Epidermal Growth Factor; Isoquinolines; Kinetics; Male; Mice; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland	1990
Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells. The Journal of biological chemistry, 1990, Oct-05, Volume: 265, Issue:28 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Diglycerides; Glucose; Glycerol; Inositol; Insecticides; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Phosphates; Piperazines; Protein Kinase Inhibitors; Pyrethrins; Sphingosine; Tetradecanoylphorbol Acetate	1990
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells. Biochemical pharmacology, 1990, Oct-01, Volume: 40, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate	1990
Sphingosine potentiates IL-1-mediated prostaglandin E2 production in human fibroblasts. Journal of immunology (Baltimore, Md. : 1950), 1990, Dec-15, Volume: 145, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Drug Synergism; Enzyme Activation; Fibroblasts; Humans; In Vitro Techniques; Interleukin-1; Isoquinolines; Phorbol Esters; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Time Factors	1990
Modes of inhibitory action of 4 beta-phorbol 12-myristate 13-acetate in thrombin-stimulated arachidonic acid release in intact and permeabilized platelets. Archives of biochemistry and biophysics, 1990, Volume: 276, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Membrane Permeability; Chlorides; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Rabbits; Serotonin; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thrombin	1990
Human cytomegalovirus stimulates arachidonic acid metabolism through pathways that are affected by inhibitors of phospholipase A2 and protein kinase C. Biochemical and biophysical research communications, 1990, Jan-30, Volume: 166, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Diacylglycerol Kinase; Humans; In Vitro Techniques; Isoquinolines; Lipase; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Piperazines; Protein Kinase C; Quinacrine; Tetracaine; Tetradecanoylphorbol Acetate	1990
Pharmacological modification of mechanical and electrical responses of frog heart to thrombin. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 341, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Barium; Barium Compounds; Calcium Channels; Chlorides; Electrophysiology; Enzyme Activation; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Piperazines; Protein Kinase C; Rana esculenta; Tetradecanoylphorbol Acetate; Thrombin; Vasoconstriction	1990
1,2-Diacylglycerol, protein kinase C, and pancreatic enzyme secretion. The Journal of biological chemistry, 1986, Apr-05, Volume: 261, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcimycin; Carbachol; Dibutyryl Cyclic GMP; Diglycerides; Glycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Kinetics; Pancreas; Piperazines; Protein Kinase C; Sincalide; Tetradecanoylphorbol Acetate; Tetragastrin	1986
Inhibition by amiloride and by Na+-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells. FEBS letters, 1988, Nov-21, Volume: 240, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Carrier Proteins; Histamine Release; In Vitro Techniques; Isoquinolines; Mast Cells; Piperazines; Protein Kinase C; Rats; Sodium; Sodium-Hydrogen Exchangers; Sphingosine	1988
Phorbol ester, 1,2-diacylglycerol, and collagen induce inhibition of arachidonic acid incorporation into phospholipids in human platelets. The Journal of biological chemistry, 1989, Mar-05, Volume: 264, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Acylglycerophosphocholine O-Acyltransferase; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Coenzyme A Ligases; Collagen; Diglycerides; Enzyme Activation; Glycerides; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane B2	1989
Oleate-induced translocation of protein kinase C to hepatic microsomal membranes. Biochemical and biophysical research communications, 1989, May-15, Volume: 160, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Brain; Calcium; Fatty Acids; Intracellular Membranes; Isoenzymes; Isoquinolines; Leupeptins; Microsomes, Liver; Oleic Acid; Oleic Acids; Phorbol 12,13-Dibutyrate; Phosphatidate Phosphatase; Piperazines; Protein Kinase C; Rats; Spermine	1989
Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids. Journal of immunology (Baltimore, Md. : 1950), 1989, Jun-15, Volume: 142, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Clone Cells; Complement Membrane Attack Complex; Complement System Proteins; Glioma; Humans; Hybrid Cells; Isoquinolines; Neuroglia; Oligodendroglia; Phosphatidylinositols; Piperazines; Protein Kinase C; Quinacrine; Rats	1989
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells. Molecular pharmacology, 1989, Volume: 36, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate	1989
Apparent involvement of phospholipase A2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes. Biochemical pharmacology, 1988, Dec-15, Volume: 37, Issue:24 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Arachidonic Acid; Arachidonic Acids; Clofazimine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Superoxides	1988
Arachidonic acid release is closely related to the Fc gamma receptor-mediated superoxide generation in macrophages. Microbiology and immunology, 1988, Volume: 32, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Glucose; Guinea Pigs; In Vitro Techniques; Indomethacin; Isoquinolines; Macrophages; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Quinones; Receptors, Fc; Superoxides; Tetradecanoylphorbol Acetate	1988
Activation of NADPH-oxidase by arachidonic acid involves phospholipase A2 in intact human neutrophils but not in the cell-free system. Biochemical and biophysical research communications, 1986, Aug-14, Volume: 138, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cell-Free System; Cyclooxygenase Inhibitors; Enzyme Activation; Humans; Isoquinolines; Lipoxygenase Inhibitors; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oleic Acid; Oleic Acids; Phospholipases A; Phospholipases A2; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Quinacrine; Superoxides; Tretoquinol	1986
Identification of distinct activation pathways of the human neutrophil NADPH-oxidase. Journal of immunology (Baltimore, Md. : 1950), 1986, Nov-01, Volume: 137, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Enzyme Activation; Humans; Indomethacin; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Piperazines; Pyrazoles; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan	1986
Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages. Journal of immunology (Baltimore, Md. : 1950), 1987, Jun-15, Volume: 138, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Guinea Pigs; Isoquinolines; Macrophages; NADH, NADPH Oxidoreductases; NADPH Oxidases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate	1987
Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis. The Journal of biological chemistry, 1987, Apr-15, Volume: 262, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Indomethacin; Isoquinolines; Kidney; Lysophosphatidylcholines; Molecular Weight; Phospholipid Ethers; Phosphorylation; Piperazines; Prostaglandins; Protein Kinase C; Tetradecanoylphorbol Acetate	1987
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets. The Biochemical journal, 1987, Dec-01, Volume: 248, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diglycerides; Diterpenes; Drug Synergism; Humans; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin	1987
Demonstration of calcium-dependent phospholipase A2 activity in membrane preparation of rabbit neutrophils. Absence of activation by fMet-Leu-Phe, phorbol 12-myristate 13-acetate and A-kinase. The Biochemical journal, 1988, Mar-01, Volume: 250, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Membrane; Enzyme Activation; In Vitro Techniques; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Tetradecanoylphorbol Acetate	1988
Protein kinase C modulates phospholipase C and increases arachidonic acid release in bradykinin stimulated MDCK cells. Biochemical and biophysical research communications, 1988, May-31, Volume: 153, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dogs; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Type C Phospholipases	1988
Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. Gastroenterology, 1988, Volume: 95, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Colon; Diglycerides; DNA; Enzyme Activation; Epithelial Cells; Fatty Acids, Unsaturated; Female; Inositol Phosphates; Isoquinolines; Linoleic Acid; Linoleic Acids; Oleic Acid; Oleic Acids; Ornithine Decarboxylase; Palmitic Acid; Palmitic Acids; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Thymidine	1988
Does protein kinase C activation mediate thrombin-induced arachidonate release in human platelets? Biochimica et biophysica acta, 1988, Oct-28, Volume: 972, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Enzyme Activation; Gallic Acid; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2	1988
Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages. British journal of pharmacology, 1988, Volume: 94, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Cytoplasm; In Vitro Techniques; Isoquinolines; Lyngbya Toxins; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Piperazines; Plant Extracts; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thapsigargin	1988
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model. The European journal of neuroscience, 1994, Aug-01, Volume: 6, Issue:8 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P	1994
Autonomic modulation of action potential and tension in guinea pig papillary muscles. European journal of pharmacology, 1994, Dec-27, Volume: 271, Issue:2-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Action Potentials; Animals; Arachidonic Acid; Guinea Pigs; In Vitro Techniques; Indomethacin; Isoquinolines; Myocardial Contraction; Papillary Muscles; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha-1; Receptors, Muscarinic	1994
Interactions between protein kinase C and arachidonic acid in the gonadotropin response to salmon and chicken gonadotropin-releasing hormone-II in goldfish. General and comparative endocrinology, 1994, Volume: 93, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Cells, Cultured; Enzyme Activation; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Isoquinolines; Lipoprotein Lipase; Masoprocol; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate	1994
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue. Molecular and cellular endocrinology, 1993, Volume: 95, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine	1993
Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells. The Journal of clinical investigation, 1993, Volume: 92, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Arachidonic Acid; Cells, Cultured; Culture Media; Eicosanoids; Glomerular Mesangium; Glucose; Isoquinolines; Kinetics; Mannitol; Molecular Sequence Data; Oligopeptides; Phospholipases A; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Substrate Specificity; Thromboxane B2; Tritium	1993
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase. Prostaglandins, 1993, Volume: 46, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha	1993
Endothelins release 51Cr from cultured human cerebromicrovascular endothelium. Biochemical and biophysical research communications, 1993, Feb-26, Volume: 191, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cerebrovascular Circulation; Chromium Radioisotopes; Dexamethasone; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Humans; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; L-Lactate Dehydrogenase; Microcirculation; Piperazines; Protein Kinase Inhibitors; Ryanodine; Tetradecanoylphorbol Acetate; Verapamil	1993
Eicosanoid production by mouse peritoneal macrophages during Toxoplasma gondii penetration: role of parasite and host cell phospholipases. Infection and immunity, 1993, Volume: 61, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Calcium; Cyclooxygenase Inhibitors; Eicosanoids; Female; Indomethacin; Isoquinolines; Lipoxygenase; Macrophages; Mice; Peritoneal Cavity; Phospholipases; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Quinacrine; Toxoplasma; Toxoplasmosis, Animal	1993
Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase. Cytokine, 1995, Volume: 7, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antineoplastic Agents; Arachidonic Acid; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Mice; Naphthalenes; Piperazines; Protein Kinase C; Staurosporine; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1995
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets. FEBS letters, 1996, Mar-04, Volume: 381, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin	1996
Acidic fibroblast factor induction of cyclooxygenase II in rabbit cardiac muscle microvessel endothelial cells: mediation by protein kinase C. Microcirculation (New York, N.Y. : 1994), 1994, Volume: 1, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Blotting, Northern; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblast Growth Factor 1; Inositol Phosphates; Isoenzymes; Isoquinolines; Microcirculation; Myocardium; Naphthalenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Sulfonamides	1994
Regulation of intracellular pH by phospholipase A2 and protein kinase C upon neutrophil adhesion to solid substrata. FEBS letters, 1996, Sep-09, Volume: 393, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Albumins; Arachidonic Acid; Cell Adhesion; Fibronectins; Humans; Hydrogen-Ion Concentration; Lysophosphatidylcholines; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Terpenes; Tetradecanoylphorbol Acetate	1996
Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets. Journal of biochemistry, 1996, Volume: 120, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Arachidonic Acid; Blood Platelets; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lysophospholipids; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Wortmannin	1996
Regulation of phospholipid biosynthesis by Ca(2+)-calmodulin-dependent protein kinase inhibitors. Journal of lipid mediators and cell signalling, 1997, Volume: 16, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acid; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Indoles; Jurkat Cells; Myosin-Light-Chain Kinase; Naphthalenes; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Phospholipids	1997
Selective inhibition of collagen-induced arachidonic acid liberation by 1-(5-iodonaphthalene-1-sulphonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), a myosin light chain kinase inhibitor, in washed rabbit platelets. Biochemical pharmacology, 1997, Nov-01, Volume: 54, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcium; Collagen; Enzyme Inhibitors; Myosin-Light-Chain Kinase; Naphthalenes; Phosphorylation; Platelet Aggregation; Rabbits; Tyrosine	1997
Effect of propranolol and IFN-beta on the induction of MHC class II expression and cytokine production by IFN-gamma IN THP-1 human monocytic cells. Immunopharmacology and immunotoxicology, 1998, Volume: 20, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Cell Line; Cytokines; Diglycerides; HLA-DQ Antigens; HLA-DR Antigens; Humans; Interferon-beta; Interferon-gamma; Monocytes; Propranolol; Protein Kinase C	1998
Arachidonic acid activates NADPH oxidase by a direct, calmodulin-regulated mechanism. Prostaglandins & other lipid mediators, 1998, Volume: 56, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; NADPH Oxidases; Neutrophils; Nitric Oxide Synthase; Onium Compounds; Spectrophotometry; Staurosporine; Sulfonamides; Superoxides; Vasodilator Agents	1998
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner. Archives of biochemistry and biophysics, 1999, Mar-01, Volume: 363, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine	1999
Arachidonic acid, but not its metabolites, is essential for FcgammaR-stimulated intracellular killing of Staphylococcus aureus by human monocytes. Immunology, 1999, Volume: 96, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Immunoglobulin G; Indomethacin; Lipoxygenase Inhibitors; Monocytes; Oxygen; Phagocytosis; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Staphylococcus aureus; Sulfonamides	1999
Endothelin-induced prostacyclin production in rat aortic endothelial cells is mediated by protein kinase C. Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 60, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Arachidonic Acid; Cells, Cultured; Eicosanoids; Endothelins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Indomethacin; Male; Protein Kinase C; Rats; Staurosporine	1999
Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Jul-15, Volume: 19, Issue:14 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Arachidonic Acid; Benzodiazepines; Benzothiadiazines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Genistein; GTP-Binding Proteins; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, AMPA; Signal Transduction; Virulence Factors, Bordetella; Wortmannin	1999
Involvement of protein kinase C and arachidonic acid pathways in the gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis in the goldfish ovary. Biology of reproduction, 2002, Volume: 66, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Meiosis; Oocytes; Ovarian Follicle; Protein Kinase C; Receptors, LHRH; Testosterone; Tetradecanoylphorbol Acetate	2002
Effect of unsaturated fatty acid on muscarinic current in guinea pig gastric antral circular myocytes. Acta pharmacologica Sinica, 2003, Volume: 24, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Cell Separation; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Guinea Pigs; Indomethacin; Linoleic Acid; Male; Membrane Potentials; Myocytes, Smooth Muscle; Oleic Acid; Patch-Clamp Techniques; Pyloric Antrum	2003
Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Antioxidants; Arachidonic Acid; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Endothelial Cells; Genistein; Glutathione; Humans; Hydrogen Peroxide; Maleates; Oxidants; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Umbilical Veins	2007