Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and angiotensin ii

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with angiotensin ii in 52 studies

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19904 (7.69)18.7374
1990's24 (46.15)18.2507
2000's16 (30.77)29.6817
2010's7 (13.46)24.3611
2020's1 (1.92)2.80

Authors

AuthorsStudies
Franki, N; Gibbons, N; Hays, RM; Singhal, PC1
Sumners, C1
Schrier, RW; Williams, B1
Cinotti, GA; Menè, P; Pugliese, F1
Haneda, M; Horide, N; Kajiwara, N; Kikkawa, R; Koya, D; Maeda, S; Shigeta, Y; Togawa, M1
Awazu, M; Harvie, BR; Ichikawa, I; Kon, V; Parker, RE1
Kojima, I; Shibata, H1
Chiou, S; Davis, JS; Fineberg, NS; Ganguly, A1
Chan, YL; Wang, T1
Elliott, ME; Goodfriend, TL; Jones, HM; Tomasko, S1
Eguchi, S; Emori, T; Hirata, Y; Imai, T; Kanno, K; Marumo, F; Ohta, K; Shichiri, M1
Iwasaki, T; Miyata, S; Morita, S; Nagai, K; Shibata, R1
Kalberg, CJ; Sumners, C1
Kurtz, A; Scholz, H1
Myers, LM; Sumners, C1
Craven, PA; DeRubertis, FR; Patterson, MC1
Caramelo, C; Schrier, RW; Tsai, P1
García-Sáinz, JA; Hernández-Sotomayor, SM1
Avantaggiati, ML; Balsano, C; Burgio, VL; Chirillo, P; Collepardo, D; Levrero, M; Natoli, G; Puri, PL1
Distler, A; Haller, H; Lindschau, C; Luft, FC; Quass, P1
Ganguly, A; Haxton, M; Li, L1
Jimi, N; Minami, K; Sata, T; Segawa, K; Shigematsu, A1
Chua, BH; Chua, CC; Hamdy, RC2
Keiser, HR; Oriji, GK1
Chan, JS; Wang, TT; Wu, XH; Zhang, SL1
Nakamura, M; Seki, T; Sperelakis, N; Sunagawa, M; Yokoshiki, H1
Guimarães, S; Nunes, JP1
Carmines, PK; Hall, DA; Ma, R; Sansom, SC1
Hui, J; Jiang, W; Yang, X1
Fan, YP; Puri, RN; Rattan, S1
Bauer, J; Parekh, N1
Hattori, T; Higashi, M; Hiroki, J; Ichiki, T; Morikawa, K; Mukai, Y; Shimokawa, H; Takahashi, S; Takeshita, A1
Deng, P; Epstein, DL; Rao, PV; Sasaki, Y1
Hasegawa, K; Hayashi, K; Homma, K; Kanda, T; Mitsuhashi, T; Saruta, T; Sugano, N; Takamatsu, I; Tatematsu, S; Wakino, S; Yoshioka, K1
Choy, DF; da Cunha, V; Dole, WP; Halks-Miller, M; Johns, A; Li, W; Light, DR; Mahmoudi, M; Martin-McNulty, B; Schroeder, M; Vincelette, J; Wang, YX1
da Cunha, V; Deng, GD; Dole, WP; Feng, Q; Halks-Miller, M; Johns, A; Kauser, K; Light, DR; Lu, X; Mahmoudi, M; Martin-McNulty, B; Schirm, S; Schroeder, M; Subramanyam, B; Tseng, JL; Vincelette, J; Wang, YX1
Hayashi, K; Homma, K; Kanda, T; Saruta, T; Sugano, N; Wakino, S1
Kost, CK; Martin, DS; Song, J1
Jalil, JE; Lavandero, S; Ocaranza, MP; Rivera, P1
Badejo, AM; Casey, DB; Dhaliwal, JS; Gallen, TB; Greco, AJ; Kadowitz, PJ1
Fukumoto, Y; Rashid, M; Seto, M; Shimokawa, H; Tawara, S; Yano, K1
Brook, RD; Chen, LC; Mikolaj, M; Rajagopalan, S; Sun, Q; Wang, A; Xu, X; Ying, Z; Yue, P; Zhong, M1
Alfarano, C; Cerbai, E; Failli, P; Franchi-Micheli, S; Mannucci, E; Mugelli, A; Raimondi, L1
Caldwell, RB; Caldwell, RW; Chandra, S; Iddings, JA; Romero, MJ; Shatanawi, A; Umapathy, NS; Verin, AD1
Burger, D; Carter, A; He, Y; Montezano, AC; Nishigaki, N; Touyz, RM1
Eguchi, S; Fujigaki, Y; Hishida, A; Suzuki, H; Yamamoto, T1
Alexander, BT; Ojeda, NB; Royals, TP1
Hui, L; Xiao-Ping, G; Yi, R1
Chen, YC; Du, GH; Fang, LH; Li, L; Niu, ZR; Wang, DS; Yuan, TY; Zhang, HF1
Gómez, GI; Sáez, JC; Velarde, V1
Dai, F; Guan, H; Liang, X; Qi, Y; Sun, J; Yao, W1

Reviews

1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and angiotensin ii

ArticleYear
Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.
    Journal of pharmacological sciences, 2006, Volume: 100, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Fibrosis; Glomerulosclerosis, Focal Segmental; Hypertension; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Diseases; Microcirculation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents

2006

Trials

1 trial(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and angiotensin ii

ArticleYear
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
    Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Cross-Over Studies; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Leukocytes; Male; Pravastatin; Pyrroles; Quinolines; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2009

Other Studies

50 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and angiotensin ii

ArticleYear
Effects of angiotensin II and arginine vasopressin on F-actin content of cultured mesangial cells.
    Journal of the American Society of Nephrology : JASN, 1992, Volume: 3, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Angiotensin II; Animals; Arginine Vasopressin; Bucladesine; Calcium; Cells, Cultured; Cytochalasin B; Extracellular Space; Glomerular Mesangium; Isoquinolines; Piperazines; Protein Kinase C; Proteins; Rats

1992
Norepinephrine increases angiotensin II binding in rat brain synaptosomes.
    Brain research bulletin, 1992, Volume: 28, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Brain Stem; Hypothalamus; In Vitro Techniques; Isoquinolines; Male; Norepinephrine; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Synaptosomes

1992
Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells.
    Diabetes, 1992, Volume: 41, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analysis of Variance; Angiotensin II; Animals; Aorta; Arginine Vasopressin; Cell Membrane Permeability; Cells, Cultured; Digitonin; Diglycerides; Enzyme Activation; Glucose; Isoquinolines; Kinetics; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligopeptides; Phosphorylation; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate

1992
Regulation of Na(+)-Ca2+ exchange in cultured human mesangial cells.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Calcium; Cell Line; Culture Media; Endothelins; Fura-2; Glomerular Mesangium; Gramicidin; Homeostasis; Humans; Insulin; Ionophores; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Sodium; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents

1991
Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation.
    Kidney international, 1991, Volume: 40, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Glomerular Mesangium; Guanylate Cyclase; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate

1991
Down-regulation of endothelin-1 receptors by protein kinase C in streptozotocin diabetic rats.
    Journal of cardiovascular pharmacology, 1991, Volume: 17 Suppl 7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Down-Regulation; Endothelins; Isoquinolines; Kidney Glomerulus; Piperazines; Protein Kinase C; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, Endothelin

1991
Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells.
    Endocrinologia japonica, 1991, Volume: 38, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Angiotensin II; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Hydroxyeicosatetraenoic Acids; Isoquinolines; Piperazines; Protein Kinase C; Radioimmunoassay; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Zona Glomerulosa

1991
Greater importance of Ca(2+)-calmodulin in maintenance of ang II- and K(+)-mediated aldosterone secretion: lesser role of protein kinase C.
    Biochemical and biophysical research communications, 1992, Jan-15, Volume: 182, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Angiotensin II; Animals; Calcium; Calmodulin; Cattle; Diglycerides; Dose-Response Relationship, Drug; Egtazic Acid; Imidazoles; In Vitro Techniques; Isoquinolines; Kinetics; Nitrendipine; Piperazines; Potassium; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Zona Glomerulosa

1992
The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Bicarbonates; Biological Transport; Calcium Channel Blockers; Dose-Response Relationship, Drug; Gallic Acid; Isoquinolines; Kidney Tubules, Proximal; Male; Perfusion; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sodium; Tetradecanoylphorbol Acetate

1991
Sphingosine inhibits angiotensin-stimulated aldosterone synthesis.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 38, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Angiotensin II; Animals; Bucladesine; Cattle; Cells, Cultured; Isoquinolines; Ouabain; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Zona Glomerulosa

1991
Cellular mechanism of endothelin-1 release by angiotensin and vasopressin.
    Hypertension (Dallas, Tex. : 1979), 1991, Volume: 18, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Endothelins; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoquinolines; Neomycin; Nicardipine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine

1991
Effects of H-7 (protein kinase inhibitor) and phorbol ester on aortic strips from spontaneously hypertensive rats.
    European journal of pharmacology, 1990, Jan-17, Volume: 175, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Calcimycin; Calcium; Dinoprost; Hypertension; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY

1990
Regulation of angiotensin II binding sites in neuronal cultures by protein kinase C.
    The American journal of physiology, 1990, Volume: 258, Issue:4 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Animals, Newborn; Brain Stem; Cells, Cultured; Homeostasis; Hypothalamus; Isoquinolines; Kinetics; Neurons; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetradecanoylphorbol Acetate

1990
Role of protein kinase C in renal vasoconstriction caused by angiotensin II.
    The American journal of physiology, 1990, Volume: 259, Issue:3 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Cobalt; Enzyme Inhibitors; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil

1990
Regulation of angiotensin II binding sites in neuronal cultures by catecholamines.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Animals, Newborn; Brain; Carbachol; Cells, Cultured; Isoquinolines; Kinetics; Neurons; Norepinephrine; Phosphatidylinositols; Piperazines; Propranolol; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Yohimbine

1989
Role for protein kinase C in the modulation of glomerular PGE2 production by angiotensin II.
    Biochemical and biophysical research communications, 1988, May-16, Volume: 152, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Dinoprostone; Female; Isoquinolines; Kidney Glomerulus; Phorbol Esters; Phorbols; Piperazines; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate

1988
Mechanism of cellular effect of phorbol esters on action of arginine vasopressin and angiotensin II on rat vascular smooth muscle cells in culture.
    The Biochemical journal, 1988, Sep-15, Volume: 254, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Depression, Chemical; Ethers; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate

1988
Phorbol esters and calcium-mobilizing hormones increase membrane-associated protein kinase C activity in rat hepatocytes.
    Biochimica et biophysica acta, 1988, Jan-18, Volume: 968, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Arginine Vasopressin; Cell Membrane; Cells, Cultured; Enzyme Activation; Epinephrine; Isoquinolines; Kinetics; Liver; Piperazines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate

1988
Reactive oxygen intermediates mediate angiotensin II-induced c-Jun.c-Fos heterodimer DNA binding activity and proliferative hypertrophic responses in myogenic cells.
    The Journal of biological chemistry, 1995, Sep-22, Volume: 270, Issue:38

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Angiotensin II; Animals; Base Sequence; Cell Differentiation; Cell Division; DNA; DNA-Binding Proteins; Gene Expression; Isoquinolines; Mice; Molecular Sequence Data; Muscles; Oligodeoxyribonucleotides; Piperazines; Protein Biosynthesis; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transcription Factor AP-1

1995
Nuclear calcium signaling is initiated by cytosolic calcium surges in vascular smooth muscle cells.
    Kidney international, 1994, Volume: 46, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Calcium; Cell Nucleus; Cells, Cultured; Cytosol; Ionomycin; Isoquinolines; Kinetics; Microscopy, Confocal; Muscle, Smooth, Vascular; Piperazines; Potassium Chloride; Protein Kinase C; Rats; Second Messenger Systems; Signal Transduction; Staurosporine; Terpenes; Thapsigargin

1994
Inhibition of angiotensin II- and potassium-mediated aldosterone secretion by KN-62 suggests involvement of Ca(2+)-calmodulin dependent protein kinase II in aldosterone secretion.
    Biochemical and biophysical research communications, 1995, Apr-26, Volume: 209, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Isoquinolines; Kinetics; Piperazines; Potassium; Sulfonamides; Zona Glomerulosa

1995
Inhibitory effect of the intravenous anesthetic, ketamine, on rat mesangial cell proliferation.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthetics, Intravenous; Angiotensin II; Animals; Cell Count; Cell Division; Cells, Cultured; Cyclic AMP; Cytokines; Depression, Chemical; Glomerular Mesangium; Ketamine; Male; Propofol; Protein Kinase Inhibitors; Rats; Rats, Wistar; Thymidine

1997
Regulation of thrombospondin-1 production by angiotensin II in rat heart endothelial cells.
    Biochimica et biophysica acta, 1997, Jun-27, Volume: 1357, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Cell Line; Cycloheximide; Dactinomycin; Endothelium; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Losartan; Membrane Glycoproteins; Myocardium; Protein Kinase C; Pyridines; Rats; Tetrazoles; Thrombospondins

1997
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 57, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Epoprostenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Osmolar Concentration; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Vasoconstrictor Agents

1997
Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells.
    Kidney international, 1998, Volume: 53, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antimetabolites; Carcinogens; Cells, Cultured; Cyclic AMP; Deoxyglucose; Diuretics, Osmotic; Enzyme Inhibitors; Estrenes; Gene Expression; Glucose; Growth Hormone; Kidney; Mannitol; Opossums; Phosphodiesterase Inhibitors; Phospholipases A; Pyrrolidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases

1998
Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells.
    Biochimica et biophysica acta, 1998, Feb-04, Volume: 1401, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Northern; Cattle; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Immunoblotting; Losartan; Lymphokines; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Rats; RNA, Messenger; Transcription Factors; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasoconstrictor Agents

1998
Angiotensin II stimulation of Ca2+-channel current in vascular smooth muscle cells is inhibited by lavendustin-A and LY-294002.
    Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta; Calcium Channels; Cell Line; Chromones; Electric Conductivity; Enzyme Inhibitors; Kinetics; Morpholines; Phenols; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats

1999
The influence of the wall tension on the contractile responses of arteries.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Arteries; Endothelium, Vascular; Enzyme Inhibitors; Gadolinium; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Protein Kinase C; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents

1999
Regulation of Ca(2+)-activated K(+) channels by multifunctional Ca(2+)/calmodulin-dependent protein kinase.
    American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Feedback; Glomerular Mesangium; Humans; Large-Conductance Calcium-Activated Potassium Channels; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated

2000
Angiotensin II type 1 receptor modulation of L-type calcium currents in guinea-pig ventricular cells.
    Chinese medical journal, 2001, Volume: 114, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Ventricles; Losartan; Membrane Potentials; Patch-Clamp Techniques; Protein Kinase C; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Ventricular Function

2001
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
    Life sciences, 2002, Mar-22, Volume: 70, Issue:18

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Angiotensin II; Animals; Dose-Response Relationship, Drug; Drug Combinations; Esophagus; Female; Flavonoids; Genistein; Imidazoles; Losartan; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Opossums; Pyridines; Rabbits; Species Specificity; Tyrphostins

2002
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
    Kidney international, 2003, Volume: 63, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents

2003
Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system.
    Circulation research, 2003, Oct-17, Volume: 93, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Cardiomegaly; Cell Movement; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Macrophages; Male; NADPH Oxidases; Organ Culture Techniques; Protein Serine-Threonine Kinases; Rats; Rats, Inbred WKY; rho-Associated Kinases; Superoxides; Vasoconstrictor Agents; Vasodilation

2003
Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
    Experimental eye research, 2005, Volume: 80, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Aqueous Humor; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Intracellular Signaling Peptides and Proteins; Muscle Proteins; Myosin Light Chains; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; rho-Associated Kinases; Trabecular Meshwork

2005
Role of Rho-kinase and p27 in angiotensin II-induced vascular injury.
    Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Abdominal; Blood Pressure; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Intracellular Signaling Peptides and Proteins; Macrophages; Male; Mice; Mice, Knockout; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases; Tumor Suppressor Proteins; Tunica Media

2005
Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
    European journal of pharmacology, 2005, Apr-11, Volume: 512, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Apolipoproteins E; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Collagen Type III; Coronary Vessels; Dose-Response Relationship, Drug; Fibrosis; Gene Expression; Heart Rate; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Myocardium; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger; Up-Regulation

2005
Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.
    Circulation, 2005, May-03, Volume: 111, Issue:17

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Endothelium, Vascular; Extracellular Matrix; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases

2005
Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway.
    Cardiovascular research, 2006, Dec-01, Volume: 72, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blotting, Western; Carrier Proteins; Enalapril; Enzyme Activation; Hypertension, Renal; Intracellular Signaling Peptides and Proteins; Kidney; Male; Orchiectomy; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Rats; Rats, Mutant Strains; Renal Veins; rho-Associated Kinases; Signal Transduction; Testosterone; Vascular Resistance

2006
Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta; Blood Pressure; Chemokine CCL2; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; Male; Oxidative Stress; Peptidyl-Dipeptidase A; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Rats; Rats, Inbred BN; Rats, Inbred Lew; rho-Associated Kinases; RNA, Messenger; Transforming Growth Factor beta1; Ventricular Remodeling

2007
Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 295, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthesia; Angiotensin II; Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Heart Rate; Hypoxia; Injections, Intravenous; Isradipine; Lung; Male; NG-Nitroarginine Methyl Ester; Protein Kinase Inhibitors; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Resistance; Vasodilator Agents

2008
Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Atmosphere Exposure Chambers; Blood Pressure; Cardiomegaly; Collagen; Disease Models, Animal; Guanine Nucleotide Exchange Factors; Hypertension; Infusion Pumps; Inhalation Exposure; Injections, Intraperitoneal; Male; Matrix Metalloproteinases, Secreted; Mice; Mice, Inbred C57BL; Myocardium; Particulate Matter; Protein Kinase Inhibitors; rho GTP-Binding Proteins; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vasoconstriction; Vasodilation; Ventricular Remodeling

2009
Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.
    Cardiovascular diabetology, 2009, Jun-22, Volume: 8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Biphenyl Compounds; Diabetes Mellitus, Experimental; In Vitro Techniques; Irbesartan; Losartan; Male; Rats; Rats, Wistar; rho-Associated Kinases; Tetrazoles; Up-Regulation; Vasoconstriction

2009
Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway.
    American journal of physiology. Cell physiology, 2011, Volume: 300, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginase; Boronic Acids; Cattle; Cell Line; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Simvastatin

2011
Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Adaptor Proteins, Signal Transducing; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apolipoproteins E; Biphenyl Compounds; Blood Pressure; Cell-Derived Microparticles; Cells, Cultured; Endothelial Cells; Hypertrophy, Left Ventricular; Irbesartan; Male; Membrane Microdomains; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; NADPH Oxidases; Platelet Endothelial Cell Adhesion Molecule-1; Protein Kinase Inhibitors; Reactive Oxygen Species; rho-Associated Kinases; Signal Transduction; Tetrazoles; Vascular Cell Adhesion Molecule-1

2011
Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats.
    Renal failure, 2011, Volume: 33, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Disease Progression; ErbB Receptors; Gefitinib; Kidney Diseases; Kidney Glomerulus; Male; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; rho-Associated Kinases; Signal Transduction

2011
Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: role of fasudil, a Rho kinase inhibitor.
    American journal of physiology. Renal physiology, 2013, Apr-01, Volume: 304, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Blood Pressure; Castration; Enalapril; Female; Fetal Growth Retardation; Glomerular Filtration Rate; Hemodynamics; Kidney; Male; Placental Insufficiency; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Renal Circulation; Renin-Angiotensin System; rho-Associated Kinases; Sex Characteristics; Vascular Resistance

2013
Atorvastatin prevents angiotensin II-induced high permeability of human arterial endothelial cell monolayers via ROCK signaling pathway.
    Biochemical and biophysical research communications, 2015, Mar-27, Volume: 459, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Arteries; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Lim Kinases; Permeability; Phosphorylation; Pyrroles; rho-Associated Kinases; Signal Transduction; Zonula Occludens-1 Protein

2015
Fasudil evokes vasodilatation of rat mesenteric vascular bed via Ca(2+) channels and Rho/ROCK pathway.
    European journal of pharmacology, 2016, Oct-05, Volume: 788

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Calcium Channels; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mesenteric Arteries; Myosin Light Chains; Phosphorylation; Potassium Chloride; Protein Phosphatase 1; Rats; rho-Associated Kinases; Vasodilation

2016
Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage.
    International journal of molecular sciences, 2019, Sep-07, Volume: 20, Issue:18

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Connexin 43; Creatinine; Disease Models, Animal; Gene Expression Regulation; Kidney Diseases; Male; Oxidative Stress; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Time Factors

2019
RhoA/ROCK Pathway Activation is Regulated by AT1 Receptor and Participates in Smooth Muscle Migration and Dedifferentiation via Promoting Actin Cytoskeleton Polymerization.
    International journal of molecular sciences, 2020, Jul-29, Volume: 21, Issue:15

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Dedifferentiation; Cell Line; Cell Movement; Gene Expression Regulation; Humans; Irbesartan; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polymerization; Protein Kinase Inhibitors; Receptor, Angiotensin, Type 1; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Vasodilator Agents

2020