Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and alpha-synuclein

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with alpha-synuclein in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Guo, SS; He, Q; Li, YH; Lin, W; Ma, CG; Wang, J; Wang, Y; Xiao, BG; Zhang, Q1
Li, S; Liu, FT; Liu, W; Liu, ZY; Tang, YL; Wang, J; Wu, JJ; Xiao, BG; Yang, YJ; Zhao, J; Zuo, J1
Bähr, M; Becker, S; Dambeck, V; Eckermann, K; Fonseca-Ornelas, L; Koch, JC; Lingor, P; Lopes da Fonseca, T; Outeiro, TF; Tatenhorst, L; Tönges, L; Walle, H; Zweckstetter, M1
Becker, S; Campbell-Bezat, C; Giordanetto, F; Ibanez-de-Opakua, A; Pan, AC; Robustelli, P; Shaw, DE; Zweckstetter, M1

Other Studies

4 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and alpha-synuclein

ArticleYear
Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model.
    The European journal of neuroscience, 2016, Volume: 43, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Intranasal; alpha-Synuclein; Animals; Dopaminergic Neurons; Encephalitis; Female; Inflammation Mediators; Lipopolysaccharides; Mice, Inbred C57BL; Microglia; Motor Activity; Neuroprotective Agents; NF-kappa B; Olfactory Bulb; Parkinsonian Disorders; rho-Associated Kinases; Signal Transduction; Substantia Nigra

2016
Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway.
    Brain research, 2016, Feb-01, Volume: 1632

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Synuclein; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Humans; Membrane Proteins; Mitogen-Activated Protein Kinase 8; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; rho-Associated Kinases; Signal Transduction

2016
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.
    Acta neuropathologica communications, 2016, Apr-22, Volume: 4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Synuclein; Amides; Animals; Brain; Carrier Proteins; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Aggregates; Protein Kinase Inhibitors; Psychomotor Performance; Pyridines; Recognition, Psychology; Time Factors; Tyrosine 3-Monooxygenase

2016
Molecular Basis of Small-Molecule Binding to α-Synuclein.
    Journal of the American Chemical Society, 2022, 02-16, Volume: 144, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Synuclein; Amino Acid Sequence; Hydrogen Bonding; Intrinsically Disordered Proteins; Ligands; Molecular Conformation; Molecular Dynamics Simulation; Protein Binding; Small Molecule Libraries

2022