1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with 1-(5-isoquinolinylsulfonyl)-3-methylpiperazine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 24 (85.71) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goishi, K; Higashiyama, S; Ishikawa, M; Klagsbrun, M; Mekada, E; Nakano, N; Taniguchi, N; Umata, T | 1 |
| Krieger, C; Lanius, RA; Shaw, CA; Wagey, R | 1 |
| Enger, MD; Tang, N | 1 |
| Carpentier, G; Climent, F; Lagord, C; Martelly, I; Moraczewski, J; Pons, G | 1 |
| Arden, J; Sadée, W; Wang, Z | 1 |
| Carpentier, G; Lagord, C; Leibovitch, MP; Leibovitch, SA; Martelly, I | 1 |
| Bossemeyer, D; Engh, RA; Girod, A; Huber, R; Kinzel, V | 1 |
| Denger, S; Jahn, L; Kreuzer, J; Merten, M; Schmidts, A; von Hodenberg, E | 1 |
| Keiser, HR; Oriji, GK | 1 |
| Eby, J; Fink, JS; Gearan, T; Symes, A | 1 |
| Hayashi, M; Kaiho, F; Shibasaki, T; Takahashi, H; Takeshita, K | 1 |
| Chorváth, B; Duraj, J; Rauko, P; Sedlák, J | 1 |
| Crissman, HA; Sailer, BL; Steinkamp, JA; Valdez, JG | 1 |
| Chua, BH; Chua, CC; Hamdy, RC | 1 |
| Braganza, JM; Jaran, AS; Quesnel, LB | 1 |
| Aguirre Ghiso, JA; Bal de Kier Joffé, E; Ladeda, V | 1 |
| Hunzicker-Dunn, M; Lamm, ML; Rajagopalan-Gupta, RM | 1 |
| Gebert, CA; Park, SH; Waxman, DJ | 1 |
| Ebihara, T; Kumahara, E; Saffen, D | 1 |
| Boyan, BD; Dean, DD; Gilley, RM; Schwartz, Z; Sylvia, VL | 1 |
| Oriji, GK | 1 |
| Boudouresque, F; Delfino, C; Fraboulet, S; Girard, B; Oliver, C; Ouafik, L | 1 |
| Hochegger, K; Marian, B; Partik, G; Schörkhuber, M | 1 |
| Balaban, CD; Freilino, M; Romero, GG | 1 |
| Arima, K; Fujisawa, K; Miyakawa, I; Narahara, H; Nasu, K; Sugano, T | 1 |
| Kubo, Y; Miyashita, T | 1 |
| Broberg, A; Heino, J; Nissinen, L; Potila, M | 1 |
| Li, MH; Yang, ZQ; Yin, WZ | 1 |
28 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and 1-(5-isoquinolinylsulfonyl)-3-methylpiperazine
| Article | Year |
|---|---|
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acids; Animals; Anti-Bacterial Agents; Cell Membrane; Chlorocebus aethiops; Diphtheria Toxin; DNA; Endosomes; Enzyme Inhibitors; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Macrolides; Molecular Weight; Piperazines; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Staurosporine; Tetradecanoylphorbol Acetate; Vero Cells | 1995 |
Characterization, distribution, and protein kinase C-mediated regulation of [35S]glutathione binding sites in mouse and human spinal cord.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Animals; Binding Sites; Enzyme Activation; Glutathione; Glycine; Humans; Isoquinolines; Mice; Mice, Inbred C57BL; Middle Aged; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Peptide; Spinal Cord; Sulfur Radioisotopes | 1994 |
Cd(2+)-induced c-myc mRNA accumulation in NRK-49F cells is blocked by the protein kinase inhibitor H7 but not by HA1004, indicating that protein kinase C is a mediator of the response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cadmium; Cell Line; DNA Probes; Gene Expression; Genes, fos; Genes, jun; Genes, myc; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; RNA, Messenger; Sulfonamides | 1993 |
Satellite cell myogenesis is highly stimulated by the kinase inhibitor iso-H7: comparison with HA1004 and staurosporine effects.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Differentiation; Cell Fusion; Cells, Cultured; Creatine Kinase; In Vitro Techniques; Isoquinolines; Muscles; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Staurosporine; Sulfonamides | 1993 |
Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Opioid, mu | 1996 |
The kinase inhibitor iso-H7 stimulates rat satellite cell differentiation through a non-protein kinase C pathway by increasing myogenin expression level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Differentiation; Creatine Kinase; Enzyme Inhibitors; Indoles; Isoquinolines; Maleimides; Muscle, Skeletal; Myogenin; Myosin Light Chains; Protein Kinase C; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1996 |
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding Sites; Casein Kinase II; Casein Kinases; Cattle; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glycine; Isoquinolines; Myosin-Light-Chain Kinase; Protein Conformation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Sulfonamides | 1996 |
Fibrinogen promotes monocyte adhesion via a protein kinase C dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Alkaloids; Cell Adhesion; Cells, Cultured; Fibrin; Fibrinogen; Humans; Isoquinolines; Monocytes; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin | 1997 |
Integration of Jak-Stat and AP-1 signaling pathways at the vasoactive intestinal peptide cytokine response element regulates ciliary neurotrophic factor-dependent transcription.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Ciliary Neurotrophic Factor; Cytokines; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Nuclear Proteins; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Trans-Activators; Transcription Factor AP-1; Transcription, Genetic; Vasoactive Intestinal Peptide | 1997 |
The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absorption through a paracellular pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Rectal; Animals; Cefoxitin; Cephamycins; Decanoic Acids; Intestinal Absorption; Male; Myosin-Light-Chain Kinase; Protein Kinase C; Rats; Rats, Wistar; Rectum; Sulfonamides; Suppositories | 1997 |
The leukocyte common antigen (CD45) on human pre-B leukemia cells: variant glycoprotein form expression during the cell exposure to phorbol ester is blocked by a nonselective protein kinase inhibitor H7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Electrophoresis, Polyacrylamide Gel; Epitopes; Humans; Leukocyte Common Antigens; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Apoptosis induced with different cycle-perturbing agents produces differential changes in the fluorescence lifetime of DNA-bound ethidium bromide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Camptothecin; Cell Cycle; Chromatin; Cycloheximide; DNA, Neoplasm; Enzyme Inhibitors; Ethidium; Flow Cytometry; Fluorescence; Fluorescent Dyes; Gamma Rays; Genistein; HL-60 Cells; Humans; Protein Synthesis Inhibitors | 1998 |
Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Northern; Cattle; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Immunoblotting; Losartan; Lymphokines; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Rats; RNA, Messenger; Transcription Factors; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasoconstrictor Agents | 1998 |
Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Adult; Cell Membrane; Child; Child, Preschool; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Energy Metabolism; Female; Fluorescein-5-isothiocyanate; Gentamicins; Humans; Male; Middle Aged; Nasal Polyps; Thionucleotides | 1998 |
Function and expression of CD44 during spreading, migration, and invasion of murine carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Carcinogens; Cell Adhesion; Cell Division; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; Hyaluronan Receptors; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mice; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1998 |
Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cell-Free System; Chorionic Gonadotropin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Proteins; Ovary; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Receptors, LH; Time Factors; Tyrosine; Virulence Factors, Bordetella | 1999 |
Termination of growth hormone pulse-induced STAT5b signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cycloheximide; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Growth Hormone; Janus Kinase 2; Leupeptins; Liver; Milk Proteins; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Somatotropin; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Vanadates | 1999 |
Protein kinase inhibitor H7 blocks the induction of immediate-early genes zif268 and c-fos by a mechanism unrelated to inhibition of protein kinase C but possibly related to inhibition of phosphorylation of RNA polymerase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; Nerve Growth Factors; PC12 Cells; Phorbol Esters; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Rats; RNA Polymerase II; RNA, Messenger; Transcription Factors; Transcription, Genetic; Zinc Fingers | 1999 |
Prostaglandins mediate the effects of 1,25-(OH)2D3 and 24,25-(OH)2D3 on growth plate chondrocytes in a metabolite-specific and cell maturation-dependent manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 24,25-Dihydroxyvitamin D 3; Alkaline Phosphatase; Alkaloids; Animals; Benzophenanthridines; Calcitriol; Cells, Cultured; Chondrocytes; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Plate; Indomethacin; Male; Phenanthridines; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1999 |
Endothelin-induced prostacyclin production in rat aortic endothelial cells is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Arachidonic Acid; Cells, Cultured; Eicosanoids; Endothelins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Indomethacin; Male; Protein Kinase C; Rats; Staurosporine | 1999 |
Alpha1-adrenergic regulation of peptidylglycine alpha-amidating monooxygenase gene expression in cultured rat cardiac myocytes: transcriptional studies and messenger ribonucleic acid stability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Agonists; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Mixed Function Oxygenases; Multienzyme Complexes; Myocardium; Phenylephrine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; RNA Stability; RNA, Messenger; Sulfonamides; Transcription, Genetic | 1999 |
Protein-kinase-C iso-enzymes support DNA synthesis and cell survival in colorectal-tumor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Carcinogens; Cell Division; Cell Survival; DNA, Neoplasm; Enzyme Inhibitors; HT29 Cells; Humans; Isoenzymes; Membrane Proteins; Naphthalenes; Neoplasm Proteins; Oligonucleotides, Antisense; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Protein kinase C inhibition blocks the early appearance of vestibular compensation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Ear, Inner; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Male; Maleimides; Nystagmus, Pathologic; Protein Kinase C; Purkinje Cells; Rats; Rats, Long-Evans; Signal Transduction | 1999 |
Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Blotting, Northern; Choriocarcinoma; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Pregnancy; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uterine Neoplasms | 2000 |
Extracellular Ca2+ sensitivity of mGluR1alpha induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Cell Size; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Fluorescent Dyes; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Isoquinolines; MAP Kinase Signaling System; Protein Kinase C; Receptors, Metabotropic Glutamate; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases | 2000 |
Three-dimensional collagen regulates collagen gene expression by a mechanism that requires serine/threonine kinases and is independent of mechanical contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Bone Neoplasms; Cell Adhesion; Collagen; Feedback; Gene Expression Regulation, Enzymologic; Humans; Integrin alpha2; Kinetics; Matrix Metalloproteinase 1; Osteosarcoma; Protein Serine-Threonine Kinases; Signal Transduction; Tissue Inhibitor of Metalloproteinase-2; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
[The influence of protein kinase C inhibitor in eosinophil apoptosis of nasal polyps].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Eosinophils; Female; Humans; Male; Middle Aged; Nasal Polyps; Protein Kinase C | 2004 |