1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride and carbostyril

1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride has been researched along with carbostyril in 14 studies

Compound Research Comparison

Studies (1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride)	Trials (1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride)	Recent Studies (post-2010) (1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride)	Studies (carbostyril)	Trials (carbostyril)	Recent Studies (post-2010) (carbostyril)
15	2	0	12,855	1,323	5,611

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (50.00)	18.2507
2000's	7 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lee, DK	1
Chung, SJ; Lee, MH; Shim, CK; Yu, IL	1
Choi, EC; Choi, KH; Hong, JS; Kim, SK; Lee, DK; Yoon, SJ	1
Chung, BC; Jung, BH; Mitoma, C; Park, J; Park, YH	1
Choi, MS; Chung, YH; Dilger, C; Lee, CW; Lee, DK; Meyerhoff, C; Pabst, G; Reh, C; Ryu, JM; Yoon, SJ	1
Baek, MC; Choi, EC; Choi, KH; Kim, BK	1
Choi, CH; Chung, YH; Lee, DK; Moon, EY; Pyo, S; Yoon, SJ	1
Choi, MH; Chung, BC; Jung, BH	1
Chung, MK; Han, SS; Kim, JC; Shin, HC; Yun, HI	1
Ahn, TH; Chung, MK; Jang, BS; Kang, SS; Kim, CY; Kim, JC; Kim, SH; Shin, DH	1
Ahn, TH; Chung, MK; Ha, CS; Han, J; Kang, SS; Kim, CY; Kim, JC; Shin, DH; Song, SW	1
Bae, CS; Chung, MK; Han, J; Kim, JC; Kim, SH; Park, SC; Shin, HC; Yun, HI	1
Amidon, GL; Chung, MK; Jung, YH; Kim, JC; Kim, JS; Lee, MK; Shin, HC	1
Chung, MK; Jung, YH; Kim, JC; Kim, SH; Kwon, HJ; Oh, KS; Shin, DH; Shin, HC; Yun, HI	1

Trials

2 trial(s) available for 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride and carbostyril

Article	Year
Safety, tolerability and pharmacokinetics of the new long-acting quinolone DW-116 after single and multiple dosing in healthy subjects. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:3 Topics: Adult; Anti-Infective Agents; Delayed-Action Preparations; Double-Blind Method; Fluoroquinolones; Food-Drug Interactions; Humans; Male; Piperazines; Quinolones; Saliva	1998
Pharmacokinetics and urinary excretion of DW116, a new fluoroquinolone antibacterial agent, in humans as a phase I study. Drug development and industrial pharmacy, 2000, Volume: 26, Issue:1 Topics: Adult; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Fluoroquinolones; Half-Life; Humans; Male; Piperazines; Quinolones	2000

Other Studies

12 other study(ies) available for 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride and carbostyril

Article	Year
Pharmacokinetic study of a new quinolone, DW-116. Drugs, 1995, Volume: 49 Suppl 2 Topics: Animals; Anti-Infective Agents; Bacterial Infections; Dogs; Fluoroquinolones; Half-Life; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley	1995
Pharmacokinetics of 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1- piperazinyl)-1,4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride (DW-116), a new quinolone antibiotic in rats. Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:5 Topics: Animals; Anti-Infective Agents; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Fluoroquinolones; Male; Piperazines; Quinolones; Rats; Rats, Wistar	1997
In-vitro and in-vivo activities of DW-116, a new fluoroquinolone. The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:4 Topics: Animals; Anti-Infective Agents; Bacterial Infections; Ciprofloxacin; Dose-Response Relationship, Drug; Enterococcus faecalis; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Male; Methicillin Resistance; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Ofloxacin; Piperazines; Pseudomonas aeruginosa; Quinolones; Staphylococcus aureus	1997
Metabolic disposition of the new fluoroquinolone antibacterial agent DW116 in rats. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:9 Topics: Administration, Oral; Animals; Anti-Infective Agents; Area Under Curve; Bile; Fluoroquinolones; Half-Life; Injections, Intravenous; Male; Metabolic Clearance Rate; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley; Tissue Distribution	1997
Resistance mechanism of Acinetobacter spp. strains resistant to DW-116, a new quinolone. Archives of pharmacal research, 1998, Volume: 21, Issue:3 Topics: Acinetobacter; Acinetobacter Infections; Anti-Infective Agents; Base Sequence; Electrophoresis, Polyacrylamide Gel; Fluoroquinolones; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Piperazines; Polymerase Chain Reaction; Quinolones; Topoisomerase II Inhibitors	1998
Immunomodulating activity of DW-116, a new quinolone antibiotic. Archives of pharmacal research, 1998, Volume: 21, Issue:5 Topics: Adjuvants, Immunologic; Animals; Anti-Infective Agents; Bacteria; Cell Division; Fluoroquinolones; Hemolytic Plaque Technique; Hypersensitivity, Delayed; Immunoglobulin M; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Piperazines; Quinolones; Spleen	1998
Embryo lethality and teratogenicity of a new fluoroquinolone antibacterial DW-116 in rats. Archives of toxicology, 2000, Volume: 74, Issue:2 Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Infective Agents; Body Weight; Bone and Bones; Eating; Female; Fetal Death; Fluoroquinolones; Male; Maternal-Fetal Exchange; Piperazines; Pregnancy; Quinolones; Rats; Rats, Sprague-Dawley; Teratogens	2000
Developmental toxicity evaluation of the new fluoroquinolone antibacterial DW-116 in rats. Teratogenesis, carcinogenesis, and mutagenesis, 2003, Volume: Suppl 1 Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Infective Agents; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Female; Fetal Weight; Fetus; Fluoroquinolones; Gestational Age; Maternal-Fetal Exchange; Molecular Structure; Organ Size; Piperazines; Placenta; Pregnancy; Quinolones; Rats; Rats, Sprague-Dawley	2003
26-Week repeated oral dose toxicity study of the new quinolone antibacterial DW-116 in Sprague-Dawley rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2003, Volume: 41, Issue:5 Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Infective Agents; Bilirubin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluoroquinolones; Leukocyte Count; Liver; Male; No-Observed-Adverse-Effect Level; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley; Sex Factors	2003
Transplacental pharmacokinetics of the new fluoroquinolone DW-116 in pregnant rats. Toxicology letters, 2003, Apr-30, Volume: 142, Issue:1-2 Topics: Amniotic Fluid; Animals; Anti-Infective Agents; Area Under Curve; Embryonic and Fetal Development; Female; Fetus; Fluoroquinolones; Half-Life; Male; Maternal-Fetal Exchange; Piperazines; Placenta; Pregnancy; Quinolones; Rats; Rats, Sprague-Dawley	2003
Fetal and maternal tissue distribution of the new fluoroquinolone DW-116 in pregnant rats. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2003, Volume: 136, Issue:1 Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Bacterial Agents; Area Under Curve; Carbon Radioisotopes; Female; Fetus; Fluoroquinolones; Lactation; Maternal-Fetal Exchange; Piperazines; Pregnancy; Quinolones; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Tissue Distribution	2003
Peri- and postnatal developmental toxicity of the fluoroquinolone antibacterial DW-116 in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2004, Volume: 42, Issue:3 Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Bacterial Agents; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fluoroquinolones; Longevity; Male; Maternal Exposure; No-Observed-Adverse-Effect Level; Piperazines; Pregnancy; Quinolones; Rats; Rats, Sprague-Dawley; Reproduction; Sexual Maturation; Specific Pathogen-Free Organisms	2004