Page last updated: 2024-09-03

1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene and resveratrol

1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene has been researched along with resveratrol in 16 studies

Compound Research Comparison

Studies
(1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene)
Trials
(1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene)
Recent Studies (post-2010)
(1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene)
Studies
(resveratrol)
Trials
(resveratrol)
Recent Studies (post-2010) (resveratrol)
3002310,9312417,998
110210,9312417,998

Protein Interaction Comparison

ProteinTaxonomy1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene (IC50)resveratrol (IC50)
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
Chain A, Leukotriene A-4 hydrolaseHomo sapiens (human)212
M18 aspartyl aminopeptidasePlasmodium falciparum 3D72.242
VifHuman immunodeficiency virus 125.31
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)25.31
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)0.75
Amyloid-beta precursor proteinHomo sapiens (human)2.6
Cytochrome P450 1A2Homo sapiens (human)3
Prostaglandin G/H synthase 1Ovis aries (sheep)2.025
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.312
Luciferin 4-monooxygenasePhotinus pyralis (common eastern firefly)0.0589
Cytochrome P450 3A4Homo sapiens (human)0.6
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.685
DNA polymerase alpha catalytic subunitHomo sapiens (human)3.3
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)4.9
AromataseHomo sapiens (human)0.96
Cytochrome P450 2C9 Homo sapiens (human)7
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.685
TyrosinaseHomo sapiens (human)5.35
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)1.3972
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)2.5
Amine oxidase [flavin-containing] AHomo sapiens (human)2.4945
Prostaglandin G/H synthase 1Homo sapiens (human)0.8517
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.312
Amine oxidase [flavin-containing] BHomo sapiens (human)5.01
Dipeptidyl peptidase 4Homo sapiens (human)0.0006
Cytochrome P450 2C19Homo sapiens (human)3
Prostaglandin G/H synthase 2Homo sapiens (human)1.672
Prostaglandin G/H synthase 2Ovis aries (sheep)3.49
Nuclear factor NF-kappa-B p100 subunit Homo sapiens (human)2.5
Transcription factor p65Homo sapiens (human)2.5
Cytochrome P450 1B1Homo sapiens (human)1.4
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)1.63
large T antigenBetapolyomavirus macacae26.2

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (31.25)29.6817
2010's8 (50.00)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Boocock, D; Farmer, PB; Gescher, AJ; Jones, DJ; Potter, GA; Ruparelia, KC; Sale, S; Steward, WP; Verschoyle, RD; Wilsher, N1
Chen, KY; Chen, M; Gosslau, A; Ho, CT1
Gescher, AJ; Potter, GA; Ruparelia, KC; Sale, S; Steward, WP; Tunstall, RG1
Gossage, RA; Haddadi, A; Lai, R; Lavasanifar, A; Ma, Z; Molavi, O1
Chen, LK; Dai, F; Qiang, PF; Xu, QP; Zhang, L; Zhao, YH1
Amarowicz, R; Jodynis-Liebert, J; Kulcenty, K; Murias, M; Myszkowski, K; Piotrowska, H; Wierzchowski, M1
Crooks, PA; Penthala, NR; Thakkar, S1
Ignatowicz, E; Jodynis-Liebert, J; Krajka-Kuźniak, V; Kujawska, M; Murias, M; Nowicki, M; Petzke, E; Piotrowska, H; Wierzchowski, M; Zawierucha, P1
Borys, S; Jodynis-Liebert, J; Kaczmarek, M; Kucińska, M; Murias, M; Piotrowska-Kempisty, H; Ruciński, M; Wierzchowski, M; Zawierucha, P; Łażewski, D1
Bachleda, P; Dvořák, Z; Pastorková, B; Vrzalová, A1
Jodynis-Liebert, J; Jozkowiak, M; Krajka-Kuzniak, V; Nowicki, A; Piotrowska-Kempisty, H; Ramlau, P; Rucinski, M; Skupin-Mrugalska, P; Wierzchowski, M1
Czajkowski, M; Józkowiak, M; Nowicki, A; Pawlak, M; Piotrowska-Kempisty, H; Rolle, K; Skupin-Mrugalska, P; Wawrzyniak, D; Wierzchowski, M1
Bryja, A; Czajkowski, M; Gogola-Mruk, J; Józkowiak, M; Kempisty, B; Kobylarek, D; Piotrowska-Kempisty, H; Skupin-Mrugalska, P; Spaczyński, RZ1
Go, ML; Zhang, W2
Alam, MS; Ismail, T; Khazir, J; Kumar, HM; Qurishi, Y; Sarkar, D; Shafi, S; Srinivas, J1

Other Studies

16 other study(ies) available for 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene and resveratrol

ArticleYear
Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene.
    British journal of cancer, 2004, Feb-09, Volume: 90, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Chemoprevention; Colorectal Neoplasms; Drug Design; Hydroxylation; Isomerism; Mice; Resveratrol; Stilbenes; Tissue Distribution

2004
A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts.
    British journal of cancer, 2005, Feb-14, Volume: 92, Issue:3

    Topics: Apoptosis; Cell Division; Cell Line, Transformed; Fibroblasts; Humans; Mitochondria; Resveratrol; Stilbenes; Tumor Cells, Cultured

2005
Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells.
    International journal of cancer, 2005, Jun-10, Volume: 115, Issue:2

    Topics: Adenoma; Animals; Antineoplastic Agents, Phytogenic; Chemoprevention; Colonic Neoplasms; Cyclooxygenase 2; Diet; Dinoprostone; Female; Genes, APC; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Resveratrol; Ribonucleotide Reductases; Stilbenes; Tissue Distribution

2005
Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol.
    Cancer chemotherapy and pharmacology, 2008, Volume: 63, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biopolymers; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Estrogens; Female; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Resveratrol; STAT3 Transcription Factor; Stilbenes; Tubulin

2008
Trans-3,4,5,4'-tetramethoxystilbene, a resveratrol analog, potently inhibits angiogenesis in vitro and in vivo.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Chick Embryo; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Resveratrol; Stilbenes

2013
Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue.
    Toxicology in vitro : an international journal published in association with BIBRA, 2013, Volume: 27, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Aryl Hydrocarbon Hydroxylases; Caspases; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Humans; Resveratrol; Stilbenes

2013
Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
    Bioorganic & medicinal chemistry letters, 2015, Jul-15, Volume: 25, Issue:14

    Topics: Antineoplastic Agents; Benzofurans; Benzothiazoles; Binding Sites; Cell Line, Tumor; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Resveratrol; Stilbenes; Thiophenes; Tubulin

2015
Effect of resveratrol analogue, DMU-212, on antioxidant status and apoptosis-related genes in rat model of hepatocarcinogenesis.
    Human & experimental toxicology, 2017, Volume: 36, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Liver Neoplasms, Experimental; Male; Oxidative Stress; Rats; Rats, Wistar; Resveratrol; Stilbenes

2017
3'-hydroxy-3,4,5,4'-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model.
    Scientific reports, 2016, 09-02, Volume: 6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Genome, Human; Humans; Metabolome; Mice; Mice, SCID; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Real-Time Polymerase Chain Reaction; Resveratrol; Signal Transduction; Stilbenes; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2016
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 103

    Topics: Adult; Aged; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inducers; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Isomerism; Male; Middle Aged; Receptors, Aryl Hydrocarbon; Resveratrol; Stilbenes

2017
The Effect of 3'-Hydroxy-3,4,5,4'-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells.
    International journal of molecular sciences, 2020, Feb-07, Volume: 21, Issue:3

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Kruppel-Like Factor 4; Ovarian Neoplasms; Resveratrol; Stilbenes; Transcriptome

2020
Enhanced biological activity of liposomal methylated resveratrol analog 3'-hydroxy-3,4,5,4'-tetramethoxystilbene (DMU-214) in 3D patient-derived ovarian cancer model.
    Drug delivery, 2022, Volume: 29, Issue:1

    Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Liposomes; Ovarian Neoplasms; Resveratrol; Stilbenes

2022
Steroidogenic activity of liposomal methylated resveratrol analog 3,4,5,4'-tetramethoxystilbene (DMU-212) in human luteinized granulosa cells in a primary three-dimensional in vitro model.
    Endocrine, 2023, Volume: 82, Issue:3

    Topics: Cholesterol Side-Chain Cleavage Enzyme; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Humans; Liposomes; Multienzyme Complexes; Progesterone; Resveratrol; Stilbenes

2023
Quinone reductase induction activity of methoxylated analogues of resveratrol.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:6

    Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers; Cell Line, Tumor; Enzyme Induction; Mice; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Resveratrol; Stilbenes

2007
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
    Bioorganic & medicinal chemistry letters, 2011, Feb-01, Volume: 21, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Humans; Mice; NAD(P)H Dehydrogenase (Quinone); Resveratrol; Stilbenes; Structure-Activity Relationship

2011
Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives.
    Bioorganic chemistry, 2016, Volume: 64

    Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Mice; Monophenol Monooxygenase; Resveratrol; Stilbenes; Structure-Activity Relationship

2016