Compounds > 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol
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1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and rb 6145

1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol has been researched along with rb 6145 in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (84.21)18.2507
2000's2 (10.53)29.6817
2010's1 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adams, GE; Cole, S; Fielden, EM; Naylor, MA; O'Neill, P; Stephens, MA; Stratford, IJ; Threadgill, MD; Webb, P1
Adams, GE; Cole, S; Fielden, EM; Naylor, MA; O'Neill, P; Stephens, MA; Stratford, IJ; Threadgill, MD1
Adams, GE; Cole, S; Fielden, EM; Jenkins, TC; Naylor, MA; O'Neill, P; Stier, MA; Stratford, IJ; Suto, MJ; Threadgill, MD1
Stratford, IJ1
Adams, GE; Bedwell, J; Bown, SG; Bremner, JC; MacRobert, AJ; Pearson, JK; Phillips, D; Sansom, JM; Stratford, IJ1
Beningo, KA; Elliott, WL; Heffner, TG; Leopold, WR; Sebolt-Leopold, JS; Stier, MA; Suto, MJ; Vincent, PW; Wiley, JN1
Chaplin, DJ1
Adams, GE; Bremner, JC; Cole, S; Edwards, HS; Stratford, IJ1
Adams, GE; Cole, S; Elliott, W; Fielden, EM; Leopold, W; Sebolt-Leopold, J; Stratford, IJ; Suto, M1
Binger, M; Workman, P1
Adams, GE; Bremner, JC; Edwards, HS; Fielden, EM; Stratford, IJ1
Adams, GE; Bowler, J; Cole, S; Lorimore, SA; Nolan, J; Stratford, IJ; Wright, EG1
Adams, GE; Bradley, JK; Bremner, JC; Naylor, MA; Sansom, JM; Stratford, IJ1
Adams, GE; Fielden, EM; Naylor, MA; Showalter, HD; Stephens, MA; Stratford, IJ; Threadgill, MD1
Bremner, JC1
Adams, GE; Horsman, MR; Khalil, AA; Overgaard, J; Steinberg, F; Stratford, IJ; Streffer, C; Wood, PJ1
Airley, R; Cowen, RL; Honess, D; Jaffar, M; Patterson, AV; Saunders, M; Stratford, IJ; Telfer, BA; van der Kogel, AJ; Williams, KJ; Wolf, CR1
Banáth, JP; Durand, RE; Olive, PL1
Elliott, W; Leopold, J; Leopold, W; Sercel, A; Showalter, H; Suto, C; Winters, T1

Reviews

2 review(s) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and rb 6145

ArticleYear
Bioreductive drugs in cancer therapy.
    BJR supplement, 1992, Volume: 24

    Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Hypoxia; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines

1992
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation.
    Cancer metastasis reviews, 1993, Volume: 12, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Humans; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents

1993

Other Studies

17 other study(ies) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and rb 6145

ArticleYear
Synthesis of a series of nitrothiophenes with basic or electrophilic substituents and evaluation as radiosensitizers and as bioreductively activated cytotoxins.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:7

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Mice; Nitro Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental; Structure-Activity Relationship; Thiophenes

1991
Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Amides; Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Cytotoxins; Mice; Mice, Inbred C3H; Nitrofurans; Radiation-Sensitizing Agents; Structure-Activity Relationship

1990
Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activate
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytotoxins; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Prodrugs; Radiation-Sensitizing Agents

1990
Increasing the effect of photodynamic therapy on the RIF-1 murine sarcoma, using the bioreductive drugs RSU1069 and RB6145.
    British journal of cancer, 1992, Volume: 66, Issue:6

    Topics: Animals; Indoles; Mice; Misonidazole; Nitroimidazoles; Organometallic Compounds; Photochemotherapy; Sarcoma; Tumor Cells, Cultured

1992
Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3

    Topics: Animals; Antiemetics; Dogs; Drug Evaluation; Imidazoles; Mice; Misonidazole; Nitroimidazoles; Ondansetron; Radiation-Sensitizing Agents; Vomiting

1992
Bioreductive therapy.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4

    Topics: Antineoplastic Agents; Cell Hypoxia; Humans; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines

1992
Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4

    Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prodrugs; Tirapazamine; Triazines

1992
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3

    Topics: Animals; Cell Hypoxia; Combined Modality Therapy; Drug Evaluation; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental

1992
Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069).
    Cancer chemotherapy and pharmacology, 1991, Volume: 29, Issue:1

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Female; Half-Life; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Sarcoma, Experimental

1991
Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1991, Volume: 20 Suppl 1

    Topics: Antineoplastic Agents; Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1991
Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice.
    International journal of radiation oncology, biology, physics, 1991, Volume: 21, Issue:2

    Topics: Administration, Oral; Animals; Combined Modality Therapy; Injections, Intraperitoneal; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental

1991
Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT).
    International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2

    Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Nitroimidazoles; Photochemotherapy; Sarcoma, Experimental

1994
Synthesis of the enantiomers of the bioreductively-activated cytotoxin RSU-1069 and its prodrug RB6145 and lack of stereoselectivity in their cytotoxicity and radiosensitization in vitro.
    Drug design and discovery, 1993, Volume: 10, Issue:3

    Topics: Antineoplastic Agents; Misonidazole; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

1993
A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour.
    Acta oncologica (Stockholm, Sweden), 1996, Volume: 35, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Misonidazole; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Phosphorus Radioisotopes

1996
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours.
    Gene therapy, 2002, Volume: 9, Issue:14

    Topics: Animals; Combined Modality Therapy; Female; Fibrosarcoma; Genetic Therapy; Genetic Vectors; Humans; Hypoxia; Mice; Mice, Nude; Misonidazole; NADPH-Ferrihemoprotein Reductase; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Cells, Cultured

2002
The range of oxygenation in SiHa tumor xenografts.
    Radiation research, 2002, Volume: 158, Issue:2

    Topics: Animals; Carcinoma; Cell Survival; Comet Assay; DNA Damage; Female; Humans; In Vitro Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Misonidazole; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Transplantation, Heterologous; Uterine Cervical Neoplasms

2002
Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality.
    Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:3

    Topics: Acylation; Alkylating Agents; Animals; Drug Design; Drug Screening Assays, Antitumor; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship

2014