1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and misonidazole

1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol has been researched along with misonidazole in 100 studies

Research

Studies (100)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (49.00)	18.7374
1990's	48 (48.00)	18.2507
2000's	2 (2.00)	29.6817
2010's	1 (1.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adams, GE; Cole, S; Fielden, EM; Naylor, MA; O'Neill, P; Stephens, MA; Stratford, IJ; Threadgill, MD; Webb, P	1
Adams, GE; Cole, S; Fielden, EM; Naylor, MA; O'Neill, P; Stephens, MA; Stratford, IJ; Threadgill, MD	1
Adams, GE; Bremner, JC; Stratford, IJ; Wood, PJ	1
Stratford, IJ	1
Siemann, DW; Sutherland, RM	1
Jenner, TJ; Maggi, A; O'Neill, P; Paone, A; Sapora, O	1
Adams, GE; Bedwell, J; Bown, SG; Bremner, JC; MacRobert, AJ; Pearson, JK; Phillips, D; Sansom, JM; Stratford, IJ	1
Beningo, KA; Elliott, WL; Heffner, TG; Leopold, WR; Sebolt-Leopold, JS; Stier, MA; Suto, MJ; Vincent, PW; Wiley, JN	1
Scavone, SV; Sebolt-Leopold, JS	1
Lafleur, MV; Loman, H; Retel, J; Soetekouw, R; Visser, OJ; Wagenaar, N; Westmijze, EJ	2
Chaplin, DJ	4
Durand, RE; Olive, PL	1
Siemann, DW	1
Adams, GE; Bremner, JC; Cole, S; Edwards, HS; Stratford, IJ	1
Hall, EJ; He, ZY; Hei, TK; Piao, CQ	2
Bridges, JM; Lappin, TR; MacManus, MP; McAleer, JJ; McKeown, SR	1
Chaplin, DJ; Horsman, MR	1
Adams, GE; Cole, S; Elliott, W; Fielden, EM; Leopold, W; Sebolt-Leopold, J; Stratford, IJ; Suto, M	1
Binger, M; Workman, P	1
Arundel-Suto, CM; Elliott, WE; Leopold, WR; Sebolt-Leopold, JS; Stier, MA; Suto, MJ; Werbel, LM	1
Herman, TS; Holden, SA; Rudolph, MB; Teicher, BA	1
Crump, PW; Fielden, EM; Jenner, TJ; O'Neill, P; Santodonato, L; Sapora, O	1
Edwards, DI; Widdick, DA	1
Adams, GE; Bremner, JC; Edwards, HS; Fielden, EM; Stratford, IJ	1
Koch, CJ; Wallen, CA; Wheeler, KT; Wong, KH	1
Adams, GE; Bowler, J; Cole, S; Lorimore, SA; Nolan, J; Stratford, IJ; Wright, EG	1
Adams, GE; Bowler, J; Bremner, JC; Stratford, IJ	1
Adams, GE; Godden, J; Keohane, A; Stratford, IJ	1
Adams, GE; Cole, S; Fielden, EM; Jenkins, TC; Stratford, IJ	1
Hall, EJ; Pirro, JP; Roizin-Towle, L	1
Butler, SA; Cobb, LM; Nolan, J	1
Crump, PW; Fielden, EM; Jenner, TJ; O'Neill, P	1
Adams, GE; Cole, S; Fielden, EM; Jenkins, TC; Naylor, MA; O'Neill, P; Stier, MA; Stratford, IJ; Suto, MJ; Threadgill, MD	1
Hall, EJ; Hei, TK	1
Hickson, ID; Robson, CN; Stephens, M; Stratford, IJ	1
Deacon, J; Holliday, S; Stratford, IJ; Walling, JM	1
Adams, GE; Godden, J; Howells, N; Stratford, IJ	1
Adams, GE; Cole, S; Stratford, IJ	1
Cole, S; Robbins, L	1
Cunniffe, SM; O'Neill, P	1
Biol, GI; Dale, LD; Edwards, DI; Widdick, DA	1
Gulyas, S; Hill, RP; Whitmore, GF	2
Chapman, JD; Kanclerz, A	1
Brown, JM	1
Bush, C; Delic, JI; Schlappack, OK; Stanley, JA; Steel, GG	1
Kennedy, KA	1
Dische, S	1
Walton, MI; Workman, P	2
Fielden, EM; Jenner, TJ; O'Neill, P; Sapora, O	1
Dale, LD; Edwards, DI; Tocher, JH	1
Chaplin, DJ; Horsman, MR; Overgaard, J	1
Adams, GE; Stephens, MA; Stratford, IJ; Walling, J	1
Adams, GE; Ahmed, I; Fielden, EM; Jenkins, TC; McNeil, SS; O'Neill, P; Silver, AR; Stratford, IJ	1
Austen, KR; Fielden, EM; Jenner, TJ; O'Neill, P	1
Deacon, JM; Holliday, SB; Horwich, A; Peckham, MJ	1
Acker, B; Chaplin, DJ	1
Jenkins, TC; McNeil, SS; O'Neill, P	1
Chaplin, DJ; Durand, RE; Olive, PL	1
Adams, GE; O'Neill, P; Sheldon, PW; Silver, AR; Stratford, IJ; Walling, JM	1
O'Neill, P; Silver, AR	1
Silver, AR; Stratford, IJ; Walling, JM	1
Workman, P	1
Adams, GE; Ahmed, I; Fielden, EM; Jenkins, TC; Sheldon, PW; Stratford, IJ; Walling, JM	1
Adams, GE; Ahmed, I; Fielden, EM; Jenkins, TC; Silver, AR; Stratford, IJ; Walling, JM	1
Ahmed, I; Deacon, JM; Holliday, SB; Jenkins, TC	1
Chaplin, DJ; Durand, RE; Jenkins, TC; Stratford, IJ	1
Jenkins, TC; McNeil, SS; O'Neill, P; Silver, AR	1
Gulyas, S; Whitmore, GF	1
Ahmed, I; Jenkins, TC; McNeil, SS; O'Neill, P; Silver, AR	1
Geard, CR; Hall, EJ; Hei, TK; Osmak, RS	1
Alliet, K; Maddison, K; Siemann, DW; Wolf, K	1
Jenkins, TC; O'Neill, P; Silver, AR	1
Adams, GE	1
Adams, GE; Ahmed, I; Sheldon, PW; Stratford, IJ	2
Edwards, DI; Knight, RC; Knox, RJ; Skolimowski, IM; Zahoor, A	1
Maddison, K; Siemann, DW; Wolf, K	1
Olive, PL	2
Adams, GE; Bradley, JK; Bremner, JC; Naylor, MA; Sansom, JM; Stratford, IJ	1
Adams, GE; Fielden, EM; Naylor, MA; Showalter, HD; Stephens, MA; Stratford, IJ; Threadgill, MD	1
Koch, CJ	1
Bremner, JC	1
Stratford, IJ; Workman, P	1
Bengmark, S; Persson, BG; Wang, LQ	1
Adams, GE; Horsman, MR; Khalil, AA; Overgaard, J; Steinberg, F; Stratford, IJ; Streffer, C; Wood, PJ	1
Olive, PL; Zheng, H	1
Dachs, GU; Firth, JD; Harris, AL; Patterson, AV; Ratcliffe, PJ; Stratford, IJ; Townsend, KM	1
Chinje, EC; Harris, AL; Patterson, AV; Saunders, MP; Strafford, IJ; Talbot, DC	1
Melo, T; Misra, V; Rauth, AM	1
Airley, R; Cowen, RL; Honess, D; Jaffar, M; Patterson, AV; Saunders, M; Stratford, IJ; Telfer, BA; van der Kogel, AJ; Williams, KJ; Wolf, CR	1
Banáth, JP; Durand, RE; Olive, PL	1
Elliott, W; Leopold, J; Leopold, W; Sercel, A; Showalter, H; Suto, C; Winters, T	1

Reviews

6 review(s) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and misonidazole

Article	Year
Bioreductive drugs in cancer therapy. BJR supplement, 1992, Volume: 24 Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Hypoxia; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1992
Sensitizers and protectors in radiotherapy. Cancer, 1985, May-01, Volume: 55, Issue:9 Suppl Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy	1985
Hypoxic cells as specific drug targets for chemotherapy. Anti-cancer drug design, 1987, Volume: 2, Issue:2 Topics: Animals; Antineoplastic Agents; DNA Damage; DNA Repair; Humans; Misonidazole; Mitomycin; Mitomycins; Oxygen; Tirapazamine; Triazines	1987
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation. Cancer metastasis reviews, 1993, Volume: 12, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Humans; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents	1993
The experimental development of bioreductive drugs and their role in cancer therapy. Cancer metastasis reviews, 1993, Volume: 12, Issue:2 Topics: Animals; Antineoplastic Agents; Aziridines; Combined Modality Therapy; DNA Damage; Humans; Indolequinones; Indoles; Misonidazole; Neoplasms; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1993

Trials

3 trial(s) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and misonidazole

Article	Year
Sensitizers and protectors in radiotherapy. Cancer, 1985, May-01, Volume: 55, Issue:9 Suppl Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy	1985
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985
A toxicity and pharmacokinetic study in man of the hypoxic-cell radiosensitiser RSU-1069. The British journal of radiology, 1986, Volume: 59, Issue:708 Topics: Adult; Aged; Clinical Trials as Topic; Humans; Kinetics; Middle Aged; Misonidazole; Nausea; Radiation-Sensitizing Agents; Vomiting	1986

Other Studies

93 other study(ies) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and misonidazole

Article	Year
Synthesis of a series of nitrothiophenes with basic or electrophilic substituents and evaluation as radiosensitizers and as bioreductively activated cytotoxins. Journal of medicinal chemistry, 1991, Volume: 34, Issue:7 Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Mice; Nitro Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental; Structure-Activity Relationship; Thiophenes	1991
Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins. Journal of medicinal chemistry, 1990, Volume: 33, Issue:9 Topics: Amides; Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Cytotoxins; Mice; Mice, Inbred C3H; Nitrofurans; Radiation-Sensitizing Agents; Structure-Activity Relationship	1990
Can 31P magnetic resonance spectroscopy measurements of changes in experimental tumour metabolism be related to modification of oxygenation status? BJR supplement, 1992, Volume: 24 Topics: Animals; Cell Hypoxia; Magnetic Resonance Spectroscopy; Mice; Misonidazole; Neoplasms, Experimental; Phosphorus; Radiation-Sensitizing Agents; Time Factors	1992
Potentiation of alkylating chemotherapy by dual function nitrofurans in multi-cell spheroids and solid tumors. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1992, Volume: 24, Issue:4 Topics: Animals; Antineoplastic Agents; Aziridines; Bone Marrow; Carcinoma; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Lomustine; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Misonidazole; Nitrofurans; Radiation-Sensitizing Agents; Sarcoma, Experimental; Stem Cells; Tumor Cells, Cultured	1992
Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione. Biochemical pharmacology, 1992, Oct-06, Volume: 44, Issue:7 Topics: Animals; Aziridines; Buthionine Sulfoximine; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutathione; Methionine Sulfoximine; Misonidazole; Mutagenicity Tests; Mutation; Oxidation-Reduction; Oxygen; Thioguanine	1992
Increasing the effect of photodynamic therapy on the RIF-1 murine sarcoma, using the bioreductive drugs RSU1069 and RB6145. British journal of cancer, 1992, Volume: 66, Issue:6 Topics: Animals; Indoles; Mice; Misonidazole; Nitroimidazoles; Organometallic Compounds; Photochemotherapy; Sarcoma; Tumor Cells, Cultured	1992
Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Animals; Antiemetics; Dogs; Drug Evaluation; Imidazoles; Mice; Misonidazole; Nitroimidazoles; Ondansetron; Radiation-Sensitizing Agents; Vomiting	1992
Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Alkylating Agents; Animals; Carmustine; Drug Synergism; In Vitro Techniques; Isoquinolines; Leukemia L1210; Misonidazole; Poly(ADP-ribose) Polymerase Inhibitors; Streptozocin; Tumor Cells, Cultured	1992
Inactivation and repair of double-stranded DNA damaged by the aziridinyl nitroimidazole RSU 1069. Chemico-biological interactions, 1992, Volume: 82, Issue:1 Topics: Alkalies; Antineoplastic Agents; Bacteriophage phi X 174; DNA; DNA Damage; DNA Repair; DNA, Viral; Electrolytes; Hydrogen-Ion Concentration; Misonidazole; Radiation-Sensitizing Agents	1992
Bioreductive therapy. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Antineoplastic Agents; Cell Hypoxia; Humans; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1992
Evaluation of bioreductive drugs in multicell spheroids. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Animals; Antineoplastic Agents; Cell Aggregation; Cell Hypoxia; Cell Survival; Cricetinae; Evaluation Studies as Topic; In Vitro Techniques; Misonidazole; Mitomycin; Models, Biological; Nitrofurans; Porfiromycin; Prodrugs; Tirapazamine; Triazines	1992
Cytotoxicity of dual function nitrofurans in rodent and human tumor cells. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Survival; Dose-Response Relationship, Drug; Humans; Mice; Misonidazole; Nitrofurans; Prodrugs; Radiation-Sensitizing Agents; Tumor Cells, Cultured	1992
Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prodrugs; Tirapazamine; Triazines	1992
Mechanism of oncogenicity for bioreductive drugs. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Line; Cell Transformation, Neoplastic; Mice; Misonidazole; Neoplasms, Second Primary; Nitrofurans; Prodrugs; Radiation-Sensitizing Agents; Risk; Tirapazamine; Triazines	1992
Hypobaric hypoxia: a method for testing bioreductive drugs in vivo. International journal of radiation oncology, biology, physics, 1992, Volume: 23, Issue:3 Topics: Animals; Biotransformation; Cell Hypoxia; Dose-Response Relationship, Drug; Mammary Neoplasms, Experimental; Mechlorethamine; Mice; Mice, Inbred Strains; Misonidazole; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1992
Tumor blood flow changes induced by chemical modifiers of radiation response. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Animals; Antineoplastic Agents; Blood Flow Velocity; Cisplatin; Doxorubicin; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents	1992
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Animals; Cell Hypoxia; Combined Modality Therapy; Drug Evaluation; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental	1992
Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069). Cancer chemotherapy and pharmacology, 1991, Volume: 29, Issue:1 Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Female; Half-Life; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Sarcoma, Experimental	1991
Interaction of RSU 1069 and 1137 with DNA in vitro. Biological implications and mechanistic aspects. Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11 Topics: Alkalies; Aziridines; Bacteriophage phi X 174; DNA; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Misonidazole; Temperature	1991
A new class of analogues of the bifunctional radiosensitizer alpha-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines. Journal of medicinal chemistry, 1991, Volume: 34, Issue:8 Topics: Animals; Aziridines; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Cricetinae; Fibrosarcoma; Mice; Misonidazole; Molecular Structure; Nitroimidazoles; Oxygen; Pyrans; Radiation-Sensitizing Agents; Structure-Activity Relationship	1991
Effect of oxygenation, pH and hyperthermia on RSU-1069 in vitro and in vivo with radiation in the FSaIIC murine fibrosarcoma. Cancer letters, 1991, Volume: 59, Issue:2 Topics: Animals; Benzimidazoles; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Radiation; Fibrosarcoma; Fluorescent Dyes; Hydrogen-Ion Concentration; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured	1991
The repair of DNA damage induced in V79 mammalian cells by the nitroimidazole-aziridine, RSU-1069. Implications for radiosensitization. Biochemical pharmacology, 1991, Oct-09, Volume: 42, Issue:9 Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Kinetics; Misonidazole; Radiation-Sensitizing Agents; Temperature	1991
A comparison of the relative activities of 8 radiosensitizers in the SOS chromotest. Mutation research, 1991, Volume: 259, Issue:1 Topics: Cell Hypoxia; Escherichia coli; Misonidazole; Radiation-Sensitizing Agents; SOS Response, Genetics	1991
Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1991, Volume: 20 Suppl 1 Topics: Antineoplastic Agents; Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents	1991
Pharmacokinetics and cytotoxicity of RSU-1069 in subcutaneous 9L tumours under oxic and hypoxic conditions. British journal of cancer, 1991, Volume: 63, Issue:4 Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Injections, Subcutaneous; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Oxygen; Rats; Rats, Inbred F344; Tumor Stem Cell Assay	1991
Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. International journal of radiation oncology, biology, physics, 1991, Volume: 21, Issue:2 Topics: Administration, Oral; Animals; Combined Modality Therapy; Injections, Intraperitoneal; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental	1991
Bioreductive drugs and the selective induction of tumour hypoxia. British journal of cancer, 1990, Volume: 61, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Constriction; Hydralazine; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Mitomycins; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tirapazamine; Triazines	1990
The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation. British journal of cancer, 1990, Volume: 61, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Misonidazole; Mitomycin; Mitomycins; Radiation Tolerance; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1990
Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas. Radiation research, 1990, Volume: 124, Issue:1 Suppl Topics: Animals; Antineoplastic Agents; Female; Mice; Mice, Inbred C3H; Misonidazole; Prodrugs; Radiation-Sensitizing Agents; Sarcoma, Experimental	1990
Studies with bifunctional bioreductive drugs. I. In vitro oncogenic transforming potential. Radiation research, 1990, Volume: 124, Issue:1 Suppl Topics: Animals; Antineoplastic Agents; Aziridines; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Mice, Inbred Strains; Misonidazole; Nitrofurans; Radiation-Sensitizing Agents	1990
Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin. Radiation research, 1990, Volume: 124, Issue:1 Suppl Topics: Antineoplastic Agents; Aziridines; Cell Line; Cell Survival; Humans; In Vitro Techniques; Lung Neoplasms; Misonidazole; Nitrofurans; Radiation-Sensitizing Agents	1990
Distribution of pimonidazole and RSU 1069 in tumour and normal tissues. British journal of cancer, 1990, Volume: 62, Issue:6 Topics: Animals; Antineoplastic Agents; Autoradiography; Male; Melanins; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution	1990
A comparison of the techniques of alkaline filter elution and alkaline sucrose sedimentation used to assess DNA damage induced by 2-nitroimidazoles. Biochemical pharmacology, 1990, Aug-01, Volume: 40, Issue:3 Topics: Animals; Cell Line; Centrifugation, Density Gradient; Cricetinae; DNA; DNA Damage; Fibroblasts; Filtration; Hydrogen-Ion Concentration; Misonidazole; Oxygen	1990
Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activate Journal of medicinal chemistry, 1990, Volume: 33, Issue:9 Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytotoxins; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Prodrugs; Radiation-Sensitizing Agents	1990
Oncogenic transforming potential of nitroimidazole radiosensitizers. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Etanidazole; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents	1989
Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione Transferase; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1989
High uptake of RSU 1069 and its analogues melanotic melanomas. Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:1 Topics: Animals; Cell Line; Cell Membrane Permeability; Deoxyribonucleases; Drug Evaluation, Preclinical; Half-Life; Humans; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred Strains; Microbial Collagenase; Misonidazole; Sarcoma, Experimental; Tissue Distribution; Trypsin; Tumor Cells, Cultured	1989
Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo. International journal of radiation biology, 1989, Volume: 55, Issue:3 Topics: Animals; Combined Modality Therapy; Female; Hydralazine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents	1989
Manipulation of radiobiological hypoxia in a human melanoma xenograft to exploit the bioreductive cytotoxicity of RSU-1069. International journal of radiation biology, 1989, Volume: 56, Issue:5 Topics: Animals; Cell Hypoxia; Combined Modality Therapy; Constriction; Female; Hydralazine; Melanoma; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Radiation-Sensitizing Agents; Transplantation, Heterologous	1989
Manipulation of oxygenation in a human tumour xenograft with BW12C or hydralazine: effects on responses to radiation and to the bioreductive cytotoxicity of misonidazole or RSU-1069. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1989, Volume: 16, Issue:3 Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzaldehydes; Colonic Neoplasms; Combined Modality Therapy; Female; Humans; Hydralazine; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Oxidation-Reduction; Oxygen; Radiation-Sensitizing Agents; Radiotherapy; Transplantation, Heterologous	1989
Assessment of the repair and damage of DNA induced by parent and reduced RSU-1069, a 2-nitroimidazole-aziridine. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4 Topics: Aerobiosis; Antineoplastic Agents; DNA Damage; DNA Repair; Escherichia coli; Misonidazole; Oxidation-Reduction; Plasmids; Radiation-Sensitizing Agents; Transcription, Genetic	1989
Comparative DNA damage and repair induced by misonidazole, CB 1954 and RSU 1069. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4 Topics: Antineoplastic Agents; Aziridines; Azirines; Coliphages; DNA Damage; DNA Repair; DNA, Bacterial; DNA, Single-Stranded; DNA, Viral; Escherichia coli; Misonidazole; Radiation-Sensitizing Agents	1989
Toxicity of RSU-1069 for KHT cells treated in vivo or in vitro: evidence for a diffusible toxic product. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4 Topics: Animals; Cell Count; Cell Survival; Diffusion; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tumor Cells, Cultured	1989
Hydralazine-induced tumor hypoxia: a potential target for cancer chemotherapy. Journal of the National Cancer Institute, 1989, Apr-19, Volume: 81, Issue:8 Topics: Animals; Antineoplastic Agents; Aziridines; Drug Synergism; Female; Hydralazine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Misonidazole; Mitomycins; Neoplasms, Experimental; Regional Blood Flow	1989
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice. International journal of radiation oncology, biology, physics, 1988, Volume: 14, Issue:2 Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Metastasis; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents; Radiation-Sensitizing Agents	1988
The response of murine stem spermatogonia to radiation combined with 3-aminobenzamide. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1987, Volume: 52, Issue:1 Topics: Animals; Benzamides; Colony-Forming Units Assay; DNA Repair; Gamma Rays; Male; Mice; Mice, Inbred CBA; Misonidazole; Oxygen; Poly(ADP-ribose) Polymerase Inhibitors; Radiation Tolerance; Radiation-Sensitizing Agents; Spermatogenesis; Spermatogonia; Spermatozoa; Stem Cells	1987
Pharmacokinetics and metabolism of the mixed-function hypoxic cell sensitizer prototype RSU 1069 in mice. Cancer chemotherapy and pharmacology, 1988, Volume: 22, Issue:4 Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Female; Fibrosarcoma; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Radiation-Sensitizing Agents	1988
Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochemical pharmacology, 1988, Oct-15, Volume: 37, Issue:20 Topics: Antineoplastic Agents; Cell Survival; Cells, Cultured; Cross-Linking Reagents; DNA; DNA Damage; Misonidazole; Oxidation-Reduction; Oxygen; Radiation-Sensitizing Agents	1988
Comparative DNA damage induced by nitroimidazole-aziridine drugs: 1. Effects of methyl substitution on drug action. Anti-cancer drug design, 1988, Volume: 3, Issue:3 Topics: Coliphages; DNA Damage; DNA, Single-Stranded; DNA, Viral; Misonidazole; Molecular Structure; Oxidation-Reduction; Polarography; Structure-Activity Relationship	1988
The interaction between RSU-1069, hydralazine and hyperthermia in a C3H mammary carcinoma as assessed by tumour growth delay. Acta oncologica (Stockholm, Sweden), 1988, Volume: 27, Issue:6b Topics: Animals; Combined Modality Therapy; Female; Hydralazine; Hyperthermia, Induced; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Misonidazole	1988
Dual-function radiation sensitizers and bioreductive drugs: factors affecting cellular uptake and sensitizing efficiency in analogues of RSU 1069. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1988, Volume: 53, Issue:4 Topics: Animals; Cell Line; Cricetinae; Misonidazole; Radiation-Sensitizing Agents	1988
Postirradiation modification of tumor blood flow: a method to increase the effectiveness of chemical radiosensitizers. Radiation research, 1988, Volume: 115, Issue:2 Topics: Animals; Cell Survival; Combined Modality Therapy; Female; Hydralazine; Lung Neoplasms; Mice; Mice, Inbred C57BL; Misonidazole; Radiation-Sensitizing Agents; Regional Blood Flow; Vasodilator Agents	1988
Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage. Anti-cancer drug design, 1987, Volume: 1, Issue:4 Topics: Antineoplastic Agents; Cell Line; Cell Survival; DNA; DNA Damage; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Plasmids; Radiation-Sensitizing Agents; Structure-Activity Relationship	1987
Variation of the radiosensitizing efficiency of RSU-1069 with pre-irradiation contact times: a rapid mix study. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1987, Volume: 52, Issue:2 Topics: Animals; Cell Line; Cell Survival; Cricetinae; In Vitro Techniques; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Time Factors	1987
The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: evidence for therapeutic gain. International journal of radiation oncology, biology, physics, 1987, Volume: 13, Issue:4 Topics: Animals; Cell Survival; Cells, Cultured; Female; Hydralazine; Lung Neoplasms; Mice; Mice, Inbred C57BL; Misonidazole; Radiation-Sensitizing Agents	1987
Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochemical pharmacology, 1987, Jun-01, Volume: 36, Issue:11 Topics: Deoxyribonucleotides; DNA; DNA Damage; Kinetics; Misonidazole; Plasmids; Radiation-Sensitizing Agents; Structure-Activity Relationship	1987
Cytotoxicity of RSU 1069 in spheroids and murine tumors. International journal of radiation oncology, biology, physics, 1987, Volume: 13, Issue:9 Topics: Animals; Cell Survival; Cricetinae; In Vitro Techniques; Mice; Misonidazole; Models, Biological; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents	1987
RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions. Biochemical pharmacology, 1986, Jan-01, Volume: 35, Issue:1 Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; DNA; Female; Glutathione; Hydrolysis; Hypoxia; Kinetics; Misonidazole; Oxidation-Reduction; Radiation-Sensitizing Agents; Structure-Activity Relationship; X-Rays	1986
Interaction of the aziridine moiety of RSU-1069 with nucleotides and inorganic phosphate. Implications for alkylation of DNA. Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7 Topics: Adamantane; Alkylation; Animals; Chromatography, Liquid; Deoxyguanine Nucleotides; DNA; Hydrogen-Ion Concentration; Kinetics; Mathematics; Misonidazole; Nucleotides; Osmolar Concentration; Phosphates	1986
The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action. British journal of cancer, 1986, Volume: 53, Issue:3 Topics: Animals; Benzamides; Bromodeoxyuridine; Cell Survival; Cells, Cultured; Cricetinae; DNA; Dose-Response Relationship, Drug; Glutathione; Misonidazole; NAD; Oxygen; Radiation-Sensitizing Agents	1986
Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069. British journal of cancer, 1986, Volume: 53, Issue:6 Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; HeLa Cells; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Oxygen; Radiation Tolerance	1986
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069. Cancer treatment reports, 1986, Volume: 70, Issue:9 Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental	1986
Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Animals; Cell Line; Cell Survival; Combined Modality Therapy; Cricetinae; In Vitro Techniques; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Radiation-Sensitizing Agents	1986
Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Animals; Cell Line; Cell Survival; Cricetinae; In Vitro Techniques; Misonidazole; Radiation-Sensitizing Agents	1986
Experimental pharmacokinetics of RSU-1069 and its analogues: high tumor/plasma ratios. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Animals; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Transplantation; Radiation-Sensitizing Agents	1986
The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Animals; Cell Survival; Combined Modality Therapy; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents	1986
The phosphate-group of DNA as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: DNA, Bacterial; Misonidazole; Plasmids; Radiation-Sensitizing Agents	1986
Studies on the toxicity of RSU-1069. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Aerobiosis; Anaerobiosis; Animals; Cell Line; Cell Survival; Cricetinae; In Vitro Techniques; Misonidazole; Mutation; Radiation-Sensitizing Agents	1986
Induction of DNA strand breaks by reduced nitroimidazoles. Implications for DNA base damage. Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22 Topics: Deoxyguanosine; DNA; DNA Damage; Glyoxal; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship	1986
Potentiation of RSU-1069 tumour cytotoxicity by 5-hydroxytryptamine (5-HT). British journal of cancer, 1986, Volume: 54, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Lung Neoplasms; Mice; Mice, Inbred C57BL; Misonidazole; Serotonin	1986
In vitro assessment of the oncogenic potential of nitroimidazole radiosensitizers. International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:9 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sister Chromatid Exchange; Time Factors	1985
Enhancement of the antitumor efficacy of lomustine by the radiosensitizer RSU 1069. Cancer treatment reports, 1985, Volume: 69, Issue:12 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Lethal Dose 50; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Radiation-Protective Agents; Sarcoma	1985
Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer. Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro. Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Acetates; Animals; Buffers; Cattle; DNA; DNA, Bacterial; Drug Stability; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Misonidazole; Oxidation-Reduction; Phosphates; Plasmids; Radiation-Protective Agents; Spectrophotometry; Thymus Gland	1985
Radiosensitizers: a conference preview. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents	1984
Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo. British journal of cancer, 1984, Volume: 49, Issue:5 Topics: Animals; Aziridines; Azirines; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Drug Synergism; Female; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents	1984
Pharmacology of the mixed-function radio- and chemosensitizers CB 1954 and RSU 1069. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Aziridines; Azirines; Brain; Drug Synergism; Female; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Radiation-Sensitizing Agents; Time Factors	1984
Photosensitive interaction of RSU 1069 with DNA. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Aziridines; Azirines; Darkness; DNA; Light; Misonidazole; Radiation-Sensitizing Agents	1984
RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Aziridines; Azirines; Cell Line; Cell Survival; Combined Modality Therapy; Cricetinae; Cricetulus; Drug Synergism; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasms, Experimental; Radiation-Sensitizing Agents	1984
Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Aziridines; Azirines; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors	1984
Use of the comet assay to detect hypoxic cells in murine tumours and normal tissues exposed to bioreductive drugs. Acta oncologica (Stockholm, Sweden), 1995, Volume: 34, Issue:3 Topics: Aerobiosis; Animals; Antineoplastic Agents; Bone Marrow; Carcinoma, Squamous Cell; Cell Hypoxia; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Radiation; Electrophoresis, Agar Gel; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred C3H; Misonidazole; Organ Specificity; Oxidation-Reduction; Radiation-Sensitizing Agents; Spleen; Tirapazamine; Triazines	1995
Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. II. RSU 1069. British journal of cancer, 1995, Volume: 71, Issue:3 Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; DNA, Neoplasm; Fibroblasts; Flow Cytometry; Kinetics; Male; Mice; Mice, Inbred C3H; Misonidazole	1995
Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT). International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2 Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Nitroimidazoles; Photochemotherapy; Sarcoma, Experimental	1994
Synthesis of the enantiomers of the bioreductively-activated cytotoxin RSU-1069 and its prodrug RB6145 and lack of stereoselectivity in their cytotoxicity and radiosensitization in vitro. Drug design and discovery, 1993, Volume: 10, Issue:3 Topics: Antineoplastic Agents; Misonidazole; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	1993
Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer research, 1993, Sep-01, Volume: 53, Issue:17 Topics: Animals; Cell Hypoxia; Cell Line; Cricetinae; Cricetulus; Fibroblasts; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1993
Bioreduction of RSU 1069 and mitomycin C after dearterialization. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1993, Volume: 19, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Chemotherapy, Adjuvant; Hepatic Artery; Humans; Ligation; Liver Neoplasms, Experimental; Male; Misonidazole; Mitomycin; Rats; Rats, Inbred WF	1993
A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour. Acta oncologica (Stockholm, Sweden), 1996, Volume: 35, Issue:8 Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Misonidazole; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Phosphorus Radioisotopes	1996
Influence of oxygen on radiation-induced DNA damage in testicular cells of C3H mice. International journal of radiation biology, 1997, Volume: 71, Issue:3 Topics: Animals; DNA; DNA Damage; DNA Repair; Hypoxia; Male; Mice; Mice, Inbred C3H; Misonidazole; Oxygen; Sertoli Cells; Spermatids; Spermatocytes; Spleen; Testis; Tumor Cells, Cultured	1997
Targeting gene expression to hypoxic tumor cells. Nature medicine, 1997, Volume: 3, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Cell Hypoxia; Cytosine Deaminase; DNA-Binding Proteins; Fibrosarcoma; Flucytosine; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Nuclear Proteins; Nucleoside Deaminases; Oxygen; Phosphoglycerate Kinase; Prodrugs; Promoter Regions, Genetic; Recombinant Fusion Proteins; Transcription Factors; Tumor Cells, Cultured	1997
Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069. British journal of cancer, 1997, Volume: 76, Issue:10 Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Misonidazole; NADPH-Ferrihemoprotein Reductase; Radiation-Sensitizing Agents; Tirapazamine; Transfection; Triazines; Tumor Cells, Cultured	1997
Bioreductive therapies: an overview of drugs and their mechanisms of action. International journal of radiation oncology, biology, physics, 1998, Nov-01, Volume: 42, Issue:4 Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; DNA, Neoplasm; Forecasting; Humans; Indolequinones; Indoles; Misonidazole; Mitomycin; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1998
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours. Gene therapy, 2002, Volume: 9, Issue:14 Topics: Animals; Combined Modality Therapy; Female; Fibrosarcoma; Genetic Therapy; Genetic Vectors; Humans; Hypoxia; Mice; Mice, Nude; Misonidazole; NADPH-Ferrihemoprotein Reductase; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Cells, Cultured	2002
The range of oxygenation in SiHa tumor xenografts. Radiation research, 2002, Volume: 158, Issue:2 Topics: Animals; Carcinoma; Cell Survival; Comet Assay; DNA Damage; Female; Humans; In Vitro Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Misonidazole; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Transplantation, Heterologous; Uterine Cervical Neoplasms	2002
Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality. Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:3 Topics: Acylation; Alkylating Agents; Animals; Drug Design; Drug Screening Assays, Antitumor; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship	2014