1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and azomycin

1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol has been researched along with azomycin in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (34.38)	18.7374
1990's	18 (56.25)	18.2507
2000's	2 (6.25)	29.6817
2010's	1 (3.13)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adams, GE; Fielden, EM; Naylor, MA; Stephens, MA; Stratford, IJ; Threadgill, MD; Webb, P	1
Stratford, IJ	1
Adams, GE; Bedwell, J; Bown, SG; Bremner, JC; MacRobert, AJ; Pearson, JK; Phillips, D; Sansom, JM; Stratford, IJ	1
Beningo, KA; Elliott, WL; Heffner, TG; Leopold, WR; Sebolt-Leopold, JS; Stier, MA; Suto, MJ; Vincent, PW; Wiley, JN	1
Chaplin, DJ	1
Adams, GE; Bremner, JC; Cole, S; Edwards, HS; Stratford, IJ	1
Chaplin, DJ; Horsman, MR	1
Adams, GE; Cole, S; Elliott, W; Fielden, EM; Leopold, W; Sebolt-Leopold, J; Stratford, IJ; Suto, M	1
Binger, M; Workman, P	1
Arundel-Suto, CM; Elliott, WE; Leopold, WR; Sebolt-Leopold, JS; Stier, MA; Suto, MJ; Werbel, LM	1
Adams, GE; Bremner, JC; Edwards, HS; Fielden, EM; Stratford, IJ	1
Adams, GE; Bowler, J; Cole, S; Lorimore, SA; Nolan, J; Stratford, IJ; Wright, EG	1
Butler, SA; Cobb, LM; Nolan, J	1
Hall, EJ; Hei, TK	1
Hickson, ID; Robson, CN; Stephens, M; Stratford, IJ	1
Chapman, JD; Kanclerz, A	1
Brown, JM	1
Dische, S	1
Adams, GE; Ahmed, I; Fielden, EM; Jenkins, TC; McNeil, SS; O'Neill, P; Silver, AR; Stratford, IJ	1
Workman, P	1
Ahmed, I; Jenkins, TC; McNeil, SS; O'Neill, P; Silver, AR	1
Geard, CR; Hall, EJ; Hei, TK; Osmak, RS	1
Adams, GE	1
Maddison, K; Siemann, DW; Wolf, K	1
Adams, GE; Bradley, JK; Bremner, JC; Naylor, MA; Sansom, JM; Stratford, IJ	1
Adams, GE; Fielden, EM; Naylor, MA; Showalter, HD; Stephens, MA; Stratford, IJ; Threadgill, MD	1
Bremner, JC	1
Adams, GE; Horsman, MR; Khalil, AA; Overgaard, J; Steinberg, F; Stratford, IJ; Streffer, C; Wood, PJ	1
Melo, T; Misra, V; Rauth, AM	1
Airley, R; Cowen, RL; Honess, D; Jaffar, M; Patterson, AV; Saunders, M; Stratford, IJ; Telfer, BA; van der Kogel, AJ; Williams, KJ; Wolf, CR	1
Banáth, JP; Durand, RE; Olive, PL	1
Elliott, W; Leopold, J; Leopold, W; Sercel, A; Showalter, H; Suto, C; Winters, T	1

Reviews

4 review(s) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and azomycin

Article	Year
Bioreductive drugs in cancer therapy. BJR supplement, 1992, Volume: 24 Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Hypoxia; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1992
Sensitizers and protectors in radiotherapy. Cancer, 1985, May-01, Volume: 55, Issue:9 Suppl Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy	1985
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation. Cancer metastasis reviews, 1993, Volume: 12, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Humans; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents	1993

Trials

2 trial(s) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and azomycin

Article	Year
Sensitizers and protectors in radiotherapy. Cancer, 1985, May-01, Volume: 55, Issue:9 Suppl Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy	1985
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1985

Article

Year

Sensitizers and protectors in radiotherapy.

Cancer, 1985, May-01, Volume: 55, Issue:9 Suppl

Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy

1985

Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2

Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1985

Other Studies

28 other study(ies) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and azomycin

Article	Year
2-Nitroimidazole dual-function bioreductive drugs: studies on the effects of regioisomerism and side-chain structural modifications on differential cytotoxicity and radiosensitization by aziridinyl and oxiranyl derivatives. Journal of medicinal chemistry, 1992, Sep-18, Volume: 35, Issue:19 Topics: Antibiotics, Antineoplastic; Aziridines; Isomerism; Nitroimidazoles; Radiation Tolerance; Structure-Activity Relationship; Tumor Cells, Cultured	1992
Increasing the effect of photodynamic therapy on the RIF-1 murine sarcoma, using the bioreductive drugs RSU1069 and RB6145. British journal of cancer, 1992, Volume: 66, Issue:6 Topics: Animals; Indoles; Mice; Misonidazole; Nitroimidazoles; Organometallic Compounds; Photochemotherapy; Sarcoma; Tumor Cells, Cultured	1992
Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Animals; Antiemetics; Dogs; Drug Evaluation; Imidazoles; Mice; Misonidazole; Nitroimidazoles; Ondansetron; Radiation-Sensitizing Agents; Vomiting	1992
Bioreductive therapy. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Antineoplastic Agents; Cell Hypoxia; Humans; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1992
Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:4 Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prodrugs; Tirapazamine; Triazines	1992
Tumor blood flow changes induced by chemical modifiers of radiation response. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Animals; Antineoplastic Agents; Blood Flow Velocity; Cisplatin; Doxorubicin; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents	1992
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908. International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3 Topics: Animals; Cell Hypoxia; Combined Modality Therapy; Drug Evaluation; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental	1992
Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069). Cancer chemotherapy and pharmacology, 1991, Volume: 29, Issue:1 Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Female; Half-Life; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Sarcoma, Experimental	1991
A new class of analogues of the bifunctional radiosensitizer alpha-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines. Journal of medicinal chemistry, 1991, Volume: 34, Issue:8 Topics: Animals; Aziridines; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Cricetinae; Fibrosarcoma; Mice; Misonidazole; Molecular Structure; Nitroimidazoles; Oxygen; Pyrans; Radiation-Sensitizing Agents; Structure-Activity Relationship	1991
Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1991, Volume: 20 Suppl 1 Topics: Antineoplastic Agents; Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents	1991
Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. International journal of radiation oncology, biology, physics, 1991, Volume: 21, Issue:2 Topics: Administration, Oral; Animals; Combined Modality Therapy; Injections, Intraperitoneal; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental	1991
Distribution of pimonidazole and RSU 1069 in tumour and normal tissues. British journal of cancer, 1990, Volume: 62, Issue:6 Topics: Animals; Antineoplastic Agents; Autoradiography; Male; Melanins; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution	1990
Oncogenic transforming potential of nitroimidazole radiosensitizers. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Etanidazole; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents	1989
Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione Transferase; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents	1989
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice. International journal of radiation oncology, biology, physics, 1988, Volume: 14, Issue:2 Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Metastasis; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents; Radiation-Sensitizing Agents	1988
Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage. Anti-cancer drug design, 1987, Volume: 1, Issue:4 Topics: Antineoplastic Agents; Cell Line; Cell Survival; DNA; DNA Damage; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Plasmids; Radiation-Sensitizing Agents; Structure-Activity Relationship	1987
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069. Cancer treatment reports, 1986, Volume: 70, Issue:9 Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental	1986
Induction of DNA strand breaks by reduced nitroimidazoles. Implications for DNA base damage. Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22 Topics: Deoxyguanosine; DNA; DNA Damage; Glyoxal; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship	1986
In vitro assessment of the oncogenic potential of nitroimidazole radiosensitizers. International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:9 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sister Chromatid Exchange; Time Factors	1985
Radiosensitizers: a conference preview. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents	1984
Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Aziridines; Azirines; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors	1984
Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT). International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2 Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Nitroimidazoles; Photochemotherapy; Sarcoma, Experimental	1994
Synthesis of the enantiomers of the bioreductively-activated cytotoxin RSU-1069 and its prodrug RB6145 and lack of stereoselectivity in their cytotoxicity and radiosensitization in vitro. Drug design and discovery, 1993, Volume: 10, Issue:3 Topics: Antineoplastic Agents; Misonidazole; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	1993
A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour. Acta oncologica (Stockholm, Sweden), 1996, Volume: 35, Issue:8 Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Misonidazole; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Phosphorus Radioisotopes	1996
Bioreductive therapies: an overview of drugs and their mechanisms of action. International journal of radiation oncology, biology, physics, 1998, Nov-01, Volume: 42, Issue:4 Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; DNA, Neoplasm; Forecasting; Humans; Indolequinones; Indoles; Misonidazole; Mitomycin; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines	1998
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours. Gene therapy, 2002, Volume: 9, Issue:14 Topics: Animals; Combined Modality Therapy; Female; Fibrosarcoma; Genetic Therapy; Genetic Vectors; Humans; Hypoxia; Mice; Mice, Nude; Misonidazole; NADPH-Ferrihemoprotein Reductase; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Cells, Cultured	2002
The range of oxygenation in SiHa tumor xenografts. Radiation research, 2002, Volume: 158, Issue:2 Topics: Animals; Carcinoma; Cell Survival; Comet Assay; DNA Damage; Female; Humans; In Vitro Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Misonidazole; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Transplantation, Heterologous; Uterine Cervical Neoplasms	2002
Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality. Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:3 Topics: Acylation; Alkylating Agents; Animals; Drug Design; Drug Screening Assays, Antitumor; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship	2014