1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole has been researched along with metronidazole in 27 studies
*Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. [MeSH]
*Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. [MeSH]
| Studies (1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole) | Trials (1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole) | Recent Studies (post-2010) (1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole) | Studies (metronidazole) | Trials (metronidazole) | Recent Studies (post-2010) (metronidazole) |
|---|---|---|---|---|---|
| 29 | 2 | 4 | 13,983 | 2,489 | 3,725 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (59.26) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Lambert, B; Lindblad, A; Ringborg, U | 1 |
| de Graaff, J; Pavicić, MJ; van Winkelhoff, AJ | 1 |
| Andreasen, PB; Døssing, M; Egsmose, C; Loft, S; Poulsen, HE; Sonne, J | 1 |
| D'Arcy, PF; McElnay, JC; Passmore, CM; Rainey, EA | 1 |
| Asikainen, S; Jousimies-Somer, H; Summanen, P; Suomala, P | 1 |
| Fredricsson, B; Hagström, B; Nord, CE; Rane, A | 1 |
| Bolton, RP; Culshaw, MA | 1 |
| Bergan, T | 1 |
| Baldson, MJ; Jackson, D | 1 |
| Bergan, T; Leinebo, O; Salvesen, B | 1 |
| Laudage, G; Riemann, JF; Schneider, MU | 1 |
| Aase, S; Bergan, T; Harbitz, T; Leinebo, O; Liavag, I; Olsen, A | 1 |
| Ralph, ED | 1 |
| Krasemann, C; Schädler, G; Werner, H | 1 |
| Gibson, RA; Lattanzio, L; McGee, H | 1 |
| Baxter, H; Guay, DR; Jacyk, WR; Meatherall, RC; Penner, B | 1 |
| Hall, P; Kaye, CM; McIntosh, N; Steele, J | 1 |
| Dawson, SG; Easmon, CS; Ison, CA; Kaye, CM; Timewell, RM | 1 |
| Danziger, LH; Pendland, SL; Piscitelli, SC; Schreckenberger, PC | 1 |
| De Nucci, G; Ferraz, JG; Hofstätter, E; Leite, G; Leonardi, S; Magalhães, AF; Miranda, EL; Muscará, MN; Pedrazzoli, J | 1 |
| Barrett, DA; Jessa, MJ; Shaw, PN; Spiller, RC | 1 |
| Barrett, DA; Goddard, AF; Jessa, MJ; Shaw, PN; Spiller, RC | 1 |
| Da Silva, CM; David, FL; De Nucci, G; Ferraz, JG; Muscará, MN; Pedrazzoli, J; Polimeno, NC; Sousa, SS | 1 |
| Cohen-Wolkowiez, M; Kearns, GL; Pearce, RE; Sampson, MR | 1 |
| Chellman, GJ; McNerney, ME; Moffat, GJ; Newcomb, DL; Thompson, KE; Zalikowski, J | 1 |
| Abdel-Rahman, S; Pearce, RE; Stancil, SL; van Haandel, L | 1 |
| Anzenbacher, P; Anzenbacherová, E; Hudcovic, T; Zemanová, N | 1 |
2 trial(s) available for 1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole and metronidazole
| Article | Year |
|---|---|
Plasma hydroxy-metronidazole/metronidazole ratio in patients with liver disease and in healthy volunteers.
Topics: Adult; Biotransformation; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Metronidazole; Middle Aged; Schistosomiasis mansoni | 1995 |
The effect of omeprazole on the pharmacokinetics of metronidazole and hydroxymetronidazole in human plasma, saliva and gastric juice.
Topics: Adult; Anti-Ulcer Agents; Antitrichomonal Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Double-Blind Method; Gastric Juice; Half-Life; Humans; Male; Metabolic Clearance Rate; Metronidazole; Omeprazole; Saliva | 1997 |
25 other study(ies) available for 1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole and metronidazole
| Article | Year |
|---|---|
Absence of genotoxic effects of metronidazole and two of its urinary metabolites on human lymphocytes in vitro.
Topics: Chromatids; Chromosome Aberrations; DNA Repair; Dose-Response Relationship, Drug; Humans; Lymphocytes; Metronidazole; Structure-Activity Relationship | 1979 |
Synergistic effects between amoxicillin, metronidazole, and the hydroxymetabolite of metronidazole against Actinobacillus actinomycetemcomitans.
Topics: Actinobacillus; Amoxicillin; Drug Synergism; Metronidazole; Microbial Sensitivity Tests | 1991 |
Metronidazole elimination is preserved in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Male; Metronidazole | 1990 |
Metronidazole excretion in human milk and its effect on the suckling neonate.
Topics: Adult; Body Weight; Female; Humans; Infant; Infant, Newborn; Male; Metronidazole; Milk, Human | 1988 |
Activity of metronidazole and its hydroxy metabolite against clinical isolates of Actinobacillus actinomycetemcomitans.
Topics: Actinobacillus; Humans; Metronidazole; Microbial Sensitivity Tests; Periodontitis | 1988 |
Systemic concentrations of metronidazole and its main metabolites after intravenous oral and vaginal administration.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Biological Availability; Female; Humans; Injections, Intravenous; Metronidazole | 1987 |
Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile.
Topics: Administration, Oral; Adult; Aged; Enterocolitis, Pseudomembranous; Feces; Female; Humans; Injections, Intravenous; Male; Metronidazole; Middle Aged | 1986 |
Antibacterial activity and pharmacokinetics of nitroimidazoles. A review.
Topics: Bacteria, Anaerobic; Biotransformation; Humans; Kinetics; Metronidazole; Microbial Sensitivity Tests; Nitroimidazoles; Structure-Activity Relationship; Tinidazole; Tissue Distribution | 1985 |
Metronidazole metabolite and Gardnerella vaginalis (Corynebacterium vaginale)
Topics: Drug Resistance, Microbial; Gardnerella vaginalis; Haemophilus; Humans; Metronidazole | 1981 |
Assay of metronidazole by HPLC compared with microbial method.
Topics: Bacteriological Techniques; Chromatography, High Pressure Liquid; Metronidazole; Tinidazole | 1984 |
Serum concentrations of metronidazole and its main metabolite in patients with active Crohn's disease: correlation with disease activity and therapeutic efficacy?
Topics: Adult; Crohn Disease; Female; Humans; Male; Metronidazole; Middle Aged; Time Factors | 1984 |
Pharmacokinetics of metronidazole and its major metabolite after a high intravenous dose.
Topics: Drug Evaluation; Female; Humans; Infusions, Parenteral; Kinetics; Male; Metronidazole; Time Factors | 1984 |
Comparative antimicrobial activity of metronidazole and the hydroxy metabolite against Gardnerella vaginalis.
Topics: Anti-Bacterial Agents; Culture Media; Drug Resistance, Microbial; Female; Gardnerella vaginalis; Haemophilus; Haemophilus Infections; Humans; In Vitro Techniques; Metronidazole; Microbial Sensitivity Tests; Time Factors; Vaginitis | 1983 |
In vitro activity of azlocillin, metronidazole and its hydroxy metabolite against anaerobes. Bacteriostatic synergism studies.
Topics: Anaerobiosis; Azlocillin; Bacteria; Drug Synergism; Metronidazole; Microbial Sensitivity Tests; Penicillins | 1983 |
Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.
Topics: Chromatography, High Pressure Liquid; Female; Humans; Metronidazole; Tinidazole | 1984 |
Pharmacokinetics of metronidazole in patients undergoing continuous ambulatory peritoneal dialysis.
Topics: Adult; Aged; Female; Humans; Kinetics; Male; Metronidazole; Middle Aged; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 1984 |
Intravenous metronidazole in the newborn.
Topics: Bacterial Infections; Female; Half-Life; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Injections, Intravenous; Kinetics; Metronidazole | 1983 |
Pharmacokinetics of metronidazole and its principal metabolites and their activity against Gardnerella vaginalis.
Topics: Blood Bactericidal Activity; Female; Gardnerella vaginalis; Haemophilus; Humans; Kinetics; Metronidazole; Microbial Sensitivity Tests | 1982 |
In vitro activities of metronidazole and its hydroxy metabolite against Bacteroides spp.
Topics: Bacteroides; Drug Synergism; Metronidazole; Microbial Sensitivity Tests | 1994 |
Rapid and selective high-performance liquid chromatographic method for the determination of metronidazole and its active metabolite in human plasma, saliva and gastric juice.
Topics: Anti-Infective Agents; Chromatography, High Pressure Liquid; Gastric Juice; Humans; Metronidazole; Reference Standards; Reproducibility of Results; Saliva; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tinidazole | 1996 |
Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Anti-Infective Agents; Chromatography, High Pressure Liquid; Humans; Liver Cirrhosis, Alcoholic; Liver Diseases; Liver Function Tests; Male; Metronidazole; Middle Aged | 1999 |
The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst.
Topics: Biotransformation; Catalysis; Cytochrome P-450 CYP3A; Female; Humans; Kinetics; Male; Metronidazole; Microsomes, Liver | 2013 |
Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys.
Topics: Administration, Intravaginal; Amniotic Fluid; Animals; Anti-Infective Agents; Biotransformation; Female; Fetus; Macaca fascicularis; Maternal Exposure; Metronidazole; Permeability; Pregnancy; Risk Assessment; Vagina | 2016 |
Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Drug Stability; Humans; Limit of Detection; Linear Models; Metronidazole; Middle Aged; Reproducibility of Results; Tandem Mass Spectrometry; Young Adult | 2018 |
Rapid Determination of Metronidazole and 2-Hydroxymetronidazole in Murine Blood Plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Metronidazole; Mice; Plasma | 2022 |