1-(2-chloroethyl)-1-nitrosourea has been researched along with ethylnitrosourea in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (51.81) | 18.7374 |
| 1990's | 29 (34.94) | 18.2507 |
| 2000's | 8 (9.64) | 29.6817 |
| 2010's | 3 (3.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joshua, AV; Lown, JW; McLaughlin, LW | 1 |
| Kann, HE | 1 |
| Brent, TP; Gonzaga, PE; Ludlum, DB; Margison, GP; Niu, TQ; Potter, PM; Rafferty, JA; Yu, D | 1 |
| Tokuda, K | 1 |
| de Castiglione, R; Gozzini, L; Lucietto, P | 1 |
| Filippeschi, S; Spinelli, L; Ubezio, P | 1 |
| Bresnick, E; Chan, CL; Eastman, A; Wu, ZN | 1 |
| Bigner, DD; Bigner, SH; Brent, TP; Mitra, S; Ostrowski, LE; Rasheed, A; Schold, SC; von Wronski, MA | 1 |
| Ings, RM; Lemoine, A; Lucas, C | 1 |
| McCormick, JE; McElhinney, RS | 2 |
| Chen, FX; Church, KM; Gold, B; Wurdeman, RL; Zhang, Y | 1 |
| Benabib, AL; Chatel, M; Darcel, F; de Certaines, JD; François, A; Le Moyec, L; Le Rumeur, E; Lotito, S; Remy, C | 1 |
| Dykes, DJ; Griswold, DP; Harrison, SD; Laster, WR; Montgomery, JA; Shealy, YF; Waud, WR | 1 |
| Barascut, JL; Carminati, A; Imbach, JL; Lown, JW; Naghipur, A | 1 |
| Atassi, G; Bibby, MC; Double, JA; Dumont, P; McCormick, JE; McElhinney, RS; Pratesi, G; Radacic, M | 1 |
| Dolan, ME; Erickson, LC; Hora, NK; Pegg, AE | 1 |
| Eisenbrand, G; Krauth-Siegel, RL; Schirmer, RH; Stahl, W | 1 |
| Gibson, NW; Hartley, JA; Kohn, KW; Mattes, WB | 1 |
| Bresnick, E; Ding, R; Eastman, A; Ghosh, K | 1 |
| Gibson, NW; Kohn, KW | 1 |
| D'Incalci, M; Day, R; Erickson, LC; Kohn, KW; Kornblith, PL; Laurent, G; Sariban, E; Smith, BH; Zlotogorski, C | 1 |
| Ducore, JM | 1 |
| Carter, CA; Kirk, MC; Ludlum, DB | 1 |
| Barascut, JL; Carminati, A; Imbach, JL; Mulcahy, RT | 1 |
| Babich, MA; Day, RS | 1 |
| Bodell, WJ; Ludlum, DB; Tokuda, K | 1 |
| Berger, MR; Kaufmann, M; Petru, E; Zeller, WJ | 1 |
| Bibby, MC; Double, JA; McCormick, JE; McElhinney, RS | 1 |
| Denkel, E; Eisenbrand, G; Müller, N; Sterzel, W | 1 |
| Berger, MR; Eisenbrand, G; Fiebig, H; Müller, N; Schreiber, J; Stahl, W; Sterzel, W; Zeller, WJ | 1 |
| Kirk, MC; Ludlum, DB; Parker, S | 1 |
| Barnes, D; Erickson, LC; Yarosh, DB | 1 |
| Kacinski, BM; Ludlum, DB; Rupp, WD | 1 |
| Babich, MA; Day, RS; Hurst-Calderone, S; Yarosh, DB | 1 |
| Erickson, LC; Gibson, NW; Zlotogorski, C | 1 |
| Ducore, JM; Rosenstein, BS | 2 |
| D'Incalci, M; Erickson, LC; Hartley, JA; Kohn, KW; Szmigiero, L | 1 |
| Arcioni, A; Borrello, S; Cavatorta, P; Galeotti, T; Masotti, L; Minotti, G; Palombini, G; Sartor, G; Zannoni, C | 1 |
| Dolan, ME; Weinkam, RJ | 1 |
| Bodell, WJ; Gerosa, MA; Rosenblum, ML; Talcott, RL | 1 |
| Deen, DF; Tofilon, PJ | 1 |
| Eisenbrand, G | 1 |
| Brent, TP | 1 |
| Erickson, LC; Zlotogorski, C | 2 |
| Erickson, LC; Kohn, KW; Sariban, E | 1 |
| Erickson, LC; Gibson, NW; Hickman, JA | 1 |
| Osorio, L; Sapse, AM; Snyder, G | 1 |
| Erickson, LC; Kohn, KW; Laurent, G; Sharkey, NA | 1 |
| Eisenbrand, G; Zeller, WJ | 1 |
| Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME | 1 |
| Izumu, I; Kowada, M; Mineura, K; Watanabe, K | 1 |
| Boosalis, M; Ludlum, DB; Mackay, W; Matijasevic, Z; Samson, L | 1 |
| Bodell, WJ; Chen, FX; Church, KM; Gold, B; Zhang, Y | 1 |
| Bibby, MC; Loadman, PM; Matthew, AM; McCormick, JE; McElhinney, RS | 1 |
| Fukuchi, M; Hitomi, K; Kohda, K; Kowada, M; Mineura, K; Terashima, I | 1 |
| Bibby, MC; Double, JA; Dumont, P; McCormick, JE; McElhinney, RS; Radacic, M | 1 |
| Abril, N; Ferrezuelo, F; Margison, GP; Prieto-Alamo, MJ; Pueyo, C; Rafferty, JA | 1 |
| Abdaoui, M; Aouf, N; Dewynter, G; Favre, G; Montero, JL; Morère, A | 1 |
| Bodell, WJ; Ye, Q | 1 |
| Buchdahl, C; Debiton, E; Gardette, D; Gramain, JC; Madelmont, JC; Maurizis, JC; Mounetou, E; Veyre, A | 1 |
| Ludlum, DB | 1 |
| Kohda, K; Terashima, I | 1 |
| Bailey, JA; Cooper, DP; Deans, B; Elder, RH; Heeran, MC; Jansen, JG; Margison, GP; Mynett, KJ; Rafferty, JA; van Zeeland, AA; Watson, AJ; Weeks, RJ; Wijnhoven, SW; Willington, MA | 1 |
| Abbondandolo, A; Aprile, A; Campomenosi, P; Chen, FX; Fronza, G; Gold, B; Inga, A; Menichini, P; Monti, P; Ottaggio, L; Viaggi, S | 1 |
| Bibby, MC; Margison, GP; McElhinney, RS; Rafferty, JA; Thompson, MJ | 1 |
| Gerson, SL; Phillips, WP | 1 |
| Erickson, LC; Kurpad, C; Maze, R; Pegg, AE; Williams, DA | 1 |
| Bodell, WJ | 3 |
| Li, Q; Ludlum, DB; Matijasevic, Z | 1 |
| Brozmanová, J; Chovanec, M; Farkasová, E; Margison, GP; Vlasáková, D; Vlcková, V | 1 |
| Debiton, E; Glasser, AL; Madelmont, JC; Marchenay, C; Maurizis, JC; Rolhion, C | 1 |
| Guliaev, AB; Hang, B; Singer, B | 1 |
| Demidem, A; Madelmont, JC; Morvan, D | 1 |
| Caillaud, D; Demidem, A; Madelmont, JC; Merle, P; Morvan, D | 1 |
| Chevrollier, A; Demidem, A; Douay, O; Loiseau, D; Morvan, D; Reynier, P; Stepien, G | 1 |
| Behzadi, M; Demidem, A; Morvan, D; Schwartz, L; Stepien, G; Steyaert, JM | 1 |
| Li, L; Li, S; Peng, R; Sun, G; Zhao, L; Zhong, R | 1 |
| Baral, R; Goswami, KK; Mallick, A; Sanyal, U; Saxena, AK; Sen, A | 1 |
5 review(s) available for 1-(2-chloroethyl)-1-nitrosourea and ethylnitrosourea
| Article | Year |
|---|---|
Metabolism of the chloroethylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Biotransformation; Ethylnitrosourea; Microsomes, Liver; Molecular Structure; Nitrosourea Compounds | 1991 |
Nitrosoureas from chemist to physician: classification and recent approaches to drug design.
Topics: Antineoplastic Agents; Drug Design; Ethylnitrosourea | 1990 |
DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds.
Topics: Alkylation; Animals; Antineoplastic Agents; Carcinogens; Carmustine; Chemical Phenomena; Chemistry; DNA; Ethylnitrosourea; Liver Neoplasms; Lomustine; Mammary Neoplasms, Experimental; Nitrosourea Compounds; Nucleic Acid Conformation | 1986 |
Tumor cell resistance.
Topics: Alkylation; Animals; Antineoplastic Agents; Biotransformation; Brain; Brain Neoplasms; Catalase; Cell Survival; Dihydrolipoamide Dehydrogenase; DNA; DNA Repair; Drug Resistance; Ethylnitrosourea; Glutathione Peroxidase; Humans; NADPH-Ferrihemoprotein Reductase; Superoxide Dismutase | 1984 |
The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular level.
Topics: Alkyl and Aryl Transferases; Alkylation; Animals; Antineoplastic Agents; Cross-Linking Reagents; DNA; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Ethylnitrosourea; Humans; Methylnitronitrosoguanidine; Nitrosourea Compounds | 1997 |
78 other study(ies) available for 1-(2-chloroethyl)-1-nitrosourea and ethylnitrosourea
| Article | Year |
|---|---|
Noval antitumor nitrosoureas and related compounds and their reactions with DNA.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cross-Linking Reagents; DNA; Leukemia L1210; Mice; Nitrosourea Compounds; Structure-Activity Relationship | 1980 |
Comparison of biochemical and biological effects of four nitrosoureas with differing carbamoylating activities.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; DNA, Neoplasm; Ethylnitrosourea; Leukemia L1210; Lomustine; Neoplasm Proteins; Nitrosourea Compounds; RNA, Neoplasm; Streptozocin; Time Factors | 1978 |
Identification of the cross-link between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA.
Topics: Antineoplastic Agents; Base Sequence; Chromatography, High Pressure Liquid; DNA; Electrophoresis, Polyacrylamide Gel; Ethylnitrosourea; Guanine; Humans; Kinetics; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase | 1992 |
[Effect of pretreatment with N-methyl-N-nitrosourea or streptozotocin on the cytotoxicity and the induction of sister chromatid exchanges in human and rodent brain tumor cells treated with chloroethylnitrosourea].
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Drug Resistance; Drug Synergism; Ethylnitrosourea; Glioma; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Sister Chromatid Exchange; Streptozocin; Tumor Cells, Cultured | 1992 |
Bombesin receptor antagonists. 4. Chloromethylketone and chloroethylnitrosourea derivatives.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Bombesin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Ethylnitrosourea; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; Receptors, Bombesin; Receptors, Neurotransmitter; Spectrometry, Mass, Fast Atom Bombardment; Thymidine | 1991 |
Method for kinetic analysis of drug-induced cell cycle perturbations.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Cycle; DNA; Ethylnitrosourea; Flow Cytometry; Kinetics; Leukemia L1210; Mice; Staining and Labeling; Tumor Cells, Cultured | 1991 |
Expression of human O6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese hamster ovary cell line and its response to certain alkylating agents.
Topics: Animals; Cell Line; CHO Cells; Cricetinae; DNA; DNA Repair; Ethylnitrosourea; Humans; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Transfection | 1992 |
Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.
Topics: Blotting, Northern; Blotting, Southern; Blotting, Western; DNA; Ethylnitrosourea; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunohistochemistry; Methyltransferases; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Tumor Cells, Cultured | 1991 |
N-(2-chloroethyl)-N-nitrosoureas covalently bound to nonionic and monocationic lexitropsin dipeptides. Synthesis, DNA affinity binding characteristics, and reactions with 32P-end-labeled DNA.
Topics: Alkylation; Base Sequence; Binding Sites; Cations; Distamycins; DNA; DNA Restriction Enzymes; Ethylnitrosourea; Guanidines; Guanine; Molecular Sequence Data; Molecular Structure; Netropsin | 1990 |
Limits of tumour treatment follow up by surface coil 31P magnetic resonance spectroscopy. The case of sarcosinamide-CNU treated ependymoblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ependymoma; Ethylnitrosourea; Follow-Up Studies; Magnetic Resonance Spectroscopy; Mice; Sarcosine | 1989 |
Antitumor activity of 2-chloroethyl (methylsulfonyl)methanesulfonate (clomesone, NSC 33847) against selected tumor systems in mice.
Topics: Animals; Antineoplastic Agents; DNA Damage; Drug Resistance; Ethylnitrosourea; Mesylates; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 1989 |
Pathways and kinetics of aqueous decomposition and carbamoylating activity of new anticancer nitroimidazole-linked 2-chloroethylnitrosoureas.
Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry; Ethylnitrosourea; Kinetics; Nitroimidazoles | 1989 |
Nucleoside analogues: 8. Some isomers of B.3839, the original 5-fluorouracil/nitrosourea molecular combination, and their effect on colon, breast and lung tumours in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Screening Assays, Antitumor; Ethylnitrosourea; Fluorouracil; Isomerism; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Nitrosourea Compounds | 1989 |
Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
Topics: Cell Division; Cell Survival; Cross-Linking Reagents; DNA Damage; DNA Repair; Ethylnitrosourea; Guanine; Humans; Lomustine; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1988 |
A method to determine the carbamoylating potential of 1-(2-chloroethyl)-1-nitrosoureas.
Topics: Alkylating Agents; Carbamates; Carmustine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dithionitrobenzoic Acid; Ethylnitrosourea; Glutathione; Humans; Nitrosourea Compounds; Semustine; Streptozocin | 1987 |
DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents.
Topics: Alkylating Agents; Alkylation; Antineoplastic Agents; Autoradiography; Base Sequence; DNA; Ethylnitrosourea; Guanine; Hydrogen-Ion Concentration; Lomustine; Mesylates; Nitrogen Mustard Compounds | 1986 |
DNA-mediated transfer and expression of a human DNA repair gene that demethylates O6-methylguanine.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; DNA Restriction Enzymes; Drug Resistance; Ethylnitrosourea; Female; Genes; Guanine; Humans; Liver; Methyltransferases; Mycophenolic Acid; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transformation, Genetic | 1985 |
DNA cross-linking by chloroethylating agents.
Topics: Alkylating Agents; Cell Survival; Cells, Cultured; Cross-Linking Reagents; DNA Damage; Ethylnitrosourea; Humans; Mesylates | 1986 |
DNA cross-linking responses of human malignant glioma cell strains to chloroethylnitrosoureas, cisplatin, and diaziquone.
Topics: Aziridines; Benzoquinones; Brain Neoplasms; Carmustine; Cells, Cultured; Cisplatin; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Drug Resistance; Ethylnitrosourea; Glioblastoma; Humans; Neoplasm Proteins; Nitrosourea Compounds | 1987 |
alpha-Difluoromethylornithine effects on nitrosourea-induced cytotoxicity and crosslinking in a methylation excision repair positive (MER+) human cell line.
Topics: Burkitt Lymphoma; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Eflornithine; Ethylnitrosourea; Humans; Methylation; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1987 |
Phosphotriester formation by the haloethylnitrosoureas and repair of these lesions by E. coli BS21 extracts.
Topics: Alkylation; Dinucleoside Phosphates; DNA Damage; DNA Repair; Escherichia coli; Ethylnitrosourea; Lomustine; Poly A; Poly T; Polydeoxyribonucleotides; Thymine Nucleotides | 1988 |
Aerobic and hypoxic toxicity of a new class of mixed-function drugs associating nitroimidazoles and chloroethylnitrosourea in nitrosourea-sensitive (Mer-) and -resistant (Mer+) human tumor cells.
Topics: Aerobiosis; Anaerobiosis; Antineoplastic Agents; Cell Survival; Drug Resistance; Ethylnitrosourea; HeLa Cells; Humans; Nitroimidazoles; Nitrosourea Compounds; Structure-Activity Relationship | 1988 |
Potentiation of cytotoxicity by 3-aminobenzamide in DNA repair-deficient human tumor cell lines following exposure to methylating agents or anti-neoplastic drugs.
Topics: Antineoplastic Agents; Benzamides; Busulfan; Cell Line; Cell Survival; DNA Repair; Drug Synergism; Ethylnitrosourea; Humans; Kinetics; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1988 |
Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N-(2-chloroethyl)-N-nitrosourea.
Topics: Alkylation; DNA; DNA Repair; Drug Resistance; Ethylnitrosourea; Glioma; Humans; Tumor Cells, Cultured | 1988 |
In vitro evaluation of an estradiol-linked nitrosourea in mammary carcinomas of mouse, rat and man.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Estradiol; Ethylnitrosourea; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred Strains; Middle Aged; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1988 |
Nucleoside analogues. 4. Molecular combinations of anti-tumour drugs: synthesis of 5-fluorouracil seco-nucleosides with N-(2-chloroethyl)-N-nitrosourea residues by using aryl N-nitrosocarbamates.
Topics: Antineoplastic Agents; Ethylnitrosourea; Fluorouracil; Nucleosides | 1986 |
Nucleoside analogues. 5. Molecular combination of anti-cancer drugs: activity of 5-fluorouracil/nitrosourea combinations against mouse colon tumours.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Ethylnitrosourea; Fluorouracil; Mice; Nucleosides; Structure-Activity Relationship | 1986 |
Drug design: nitrosoureas.
Topics: Alkylating Agents; Animals; Chemical Phenomena; Chemistry; Estradiol; Ethylnitrosourea; Glutathione; Leukemia, Experimental; Mice; Rats; Structure-Activity Relationship | 1986 |
Synthesis and characterization of O6-(2-chloroethyl)guanine: a putative intermediate in the cytotoxic reaction of chloroethylnitrosoureas with DNA.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; DNA Damage; Ethylnitrosourea; Guanine; Hydrogen-Ion Concentration; Spectrophotometry, Ultraviolet; Time Factors | 1987 |
Transfection of DNA from a chloroethylnitrosourea-resistant tumor cell line (MER+) to a sensitive tumor cell line (MER-) results in a tumor cell line resistant to MNNG and CNU that has increased O-6-methylguanine-DNA methyltransferase levels and reduced l
Topics: Cell Line; Cell Survival; DNA Repair; DNA, Neoplasm; Drug Resistance; Ethylnitrosourea; Humans; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1986 |
Repair of haloethylnitrosourea-induced DNA damage in mutant and adapted bacteria.
Topics: Alkylation; Carmustine; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli; Ethylnitrosourea; Methylnitronitrosoguanidine; Mutation; Rec A Recombinases; Recombination, Genetic | 1985 |
Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.
Topics: Cell Survival; DNA Repair; Ethylnitrosourea; Fibroblasts; Guanine; Humans; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity | 1986 |
Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents.
Topics: Alkylating Agents; Antineoplastic Agents; Cell Line; Cell Survival; Cross-Linking Reagents; DNA; DNA Repair; Ethylnitrosourea; Humans; Methylnitronitrosoguanidine; Neoplasms; Nitrosourea Compounds | 1985 |
Theophylline release of replicon initiation inhibition by nitrosoureas correlates with the synergistic killing in L1210 leukemia in vitro.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; DNA, Neoplasm; Drug Synergism; Ethylnitrosourea; Leukemia L1210; Mice; Replicon; Theophylline | 1985 |
A filter incubation method for the determination of potentially crosslinkable sites in DNA in mammalian cells.
Topics: Binding Sites; Cell Line; Cisplatin; Cross-Linking Reagents; DNA; Ethylnitrosourea; Filtration; Humans; Hydrogen-Ion Concentration; Time Factors | 1985 |
Lipid composition, physical state, and lipid peroxidation of tumor membranes.
Topics: Adenosine Diphosphate; Animals; Cell Membrane; Ditiocarb; Ethylnitrosourea; Glutathione Reductase; Iron; Lipid Peroxides; Liver Neoplasms, Experimental; Male; Membrane Fluidity; Membrane Lipids; Microsomes, Liver; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Superoxide Dismutase; Time Factors; Xanthine Oxidase | 1984 |
An analysis of 1-(2-chloroethyl)-1-nitrosourea activity at the cellular level.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Drug Evaluation, Preclinical; Ethylnitrosourea; Leukemia L1210; Leukemia P388; Lomustine; Mice; Nitrosourea Compounds; Streptozocin; Structure-Activity Relationship | 1983 |
Combined effects of drugs and radiation against tumor cells.
Topics: Animals; Brain Neoplasms; Cell Survival; Cells, Cultured; Combined Modality Therapy; Disease Models, Animal; Ethylnitrosourea; Humans; Nitrosourea Compounds; Rats; X-Rays | 1984 |
Anticancer nitrosoureas: investigations on antineoplastic, toxic and neoplastic activities.
Topics: Animals; Antineoplastic Agents; Carcinogens; Ethylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1984 |
Theophylline does not reverse DNA replicon initiation inhibition in human cells resistant to alkylating agent-theophylline killing synergism.
Topics: Alkylating Agents; Burkitt Lymphoma; Carmustine; Cell Line; Cell Survival; Cisplatin; Cross-Linking Reagents; DNA, Neoplasm; Drug Resistance; Drug Synergism; Ethylnitrosourea; Humans; Melphalan; Replicon; Theophylline | 1984 |
Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.
Topics: Antineoplastic Agents; Cell Line; DNA, Neoplasm; Ethylnitrosourea; Guanine; Humans; Kinetics; Leukemia, Lymphoid; Methylnitrosourea; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1984 |
Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts.
Topics: Alkylating Agents; Cell Survival; Cells, Cultured; Cross-Linking Reagents; DNA; DNA Repair; Ethylnitrosourea; Humans; Methylation; Methylnitronitrosoguanidine; Nitrosourea Compounds | 1984 |
Effects of carbamoylation on cell survival and DNA repair in normal human embryo cells (IMR-90) treated with various 1-(2-chloroethyl)-1-nitrosoureas.
Topics: Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; DNA Replication; Ethylnitrosourea; Female; Humans; Lomustine; Lung; Nitrosourea Compounds; Pregnancy; Structure-Activity Relationship | 1984 |
Effects of the antitumor agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one on the DNA of mouse L1210 cells.
Topics: Animals; Cell Division; Dacarbazine; DNA, Neoplasm; Ethylnitrosourea; Imidazoles; Kinetics; Leukemia L1210; Mice; Neoplasm Proteins; Nitrogen Mustard Compounds; Protein Binding | 1984 |
Self-consistent-field comparative studies of some nitrosoureas and nitrosamides.
Topics: Chemical Phenomena; Chemistry; Ethylnitrosourea; Methylnitrosourea; Models, Molecular; Nitroso Compounds; Nitrosourea Compounds; Structure-Activity Relationship | 1984 |
Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; DNA; Ethylnitrosourea; Female; Fibroblasts; Humans; Methylnitronitrosoguanidine; Nitrosourea Compounds; Pregnancy; Time Factors | 1983 |
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
Topics: Cell Line; Cell Transformation, Neoplastic; Cross-Linking Reagents; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylation; Mutation; Nitrosourea Compounds; Peptide Hydrolases | 1980 |
Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.
Topics: Animals; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Leukemia, Experimental; Male; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1981 |
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1994 |
Characterization and chemosensitivity of two cell lines derived from human glioblastomas.
Topics: Animals; Brain Neoplasms; Drug Resistance; Ethylnitrosourea; Female; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Karyotyping; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasm Transplantation; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Occipital Lobe; Parietal Lobe; S100 Proteins; Tumor Cells, Cultured | 1993 |
Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.
Topics: Animals; Cattle; Cell Survival; DNA; DNA Glycosylases; DNA Repair; Drug Resistance; Ethylnitrosourea; Genes, Fungal; Kinetics; Mammals; N-Glycosyl Hydrolases; Saccharomyces cerevisiae | 1993 |
DNA crosslinking, sister chromatid exchange and cytotoxicity of N-2-chloroethylnitrosoureas tethered to minor groove binding peptides.
Topics: Alkylation; Animals; Base Sequence; Carcinogens; Carmustine; Cell Survival; Dipeptides; DNA; Ethylnitrosourea; Kinetics; Leukemia L1210; Mice; Molecular Sequence Data; Plasmids; Sister Chromatid Exchange; Time Factors; Tumor Cells, Cultured | 1993 |
Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Ethylnitrosourea; Fluorouracil; Male; Mice | 1996 |
Enhancement effect of O6-fluorobenzylguanines on chloroethylnitrosourea cytotoxicity in tumor cells.
Topics: Antineoplastic Agents; Cell Division; Drug Synergism; Ethylnitrosourea; Guanine; HeLa Cells; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1996 |
Nucleoside analogs. 14. The synthesis of antitumor activity in mice of molecular combinations of 5-fluorouracil and N-(2-Chloroethyl)-N-nitrosourea moieties separated by a three-carbon chain.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Ethylnitrosourea; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Nucleosides | 1996 |
Contribution of ogt-encoded alkyltransferase to resistance to chloroethylnitrosoureas in nucleotide excision repair-deficient Escherichia coli.
Topics: Bacterial Proteins; DNA Repair; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors | 1996 |
A new family of potential oncostatics: 2-chloroethylnitrososulfamides (CENS)--I. Synthesis, structure, and pharmacological evaluation (preliminary results).
Topics: Antineoplastic Agents, Alkylating; Cell Survival; Dimethyl Sulfoxide; Ethylnitrosourea; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nitrosation; Sulfonic Acids; Tumor Cells, Cultured | 1996 |
Detection of N7-(2-hydroxyethyl)guanine adducts in DNA and 9L cells treated with 1-(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Antineoplastic Agents; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Electrochemistry; Ethylnitrosourea; Guanine; L Cells; Mice; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1997 |
O6-(alkyl/aralkyl)guanosine and 2'-deoxyguanosine derivatives: synthesis and ability to enhance chloroethylnitrosourea antitumor action.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Survival; Computer Simulation; Deoxyguanosine; Drug Synergism; Ethylnitrosourea; Guanosine; Hydrogen Bonding; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Static Electricity; Structure-Activity Relationship | 1997 |
Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues.
Topics: Cell Survival; Cloning, Molecular; Drug Synergism; Enzyme Inhibitors; Ethylnitrosourea; HeLa Cells; Humans; Indicators and Reagents; Kinetics; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship | 1998 |
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Dacarbazine; DNA Glycosylases; Erythrocytes; Ethylnitrosourea; Female; Fibroblasts; Guanine; Hypoxanthine Phosphoribosyltransferase; Leukocyte Count; Liver; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mutagens; Mutation; N-Glycosyl Hydrolases; Temozolomide | 1998 |
N-(2-chloroethyl)-N-nitrosourea tethered to lexitropsin induces minor groove lesions at the p53 cDNA that are more cytotoxic than mutagenic.
Topics: Alkylation; Antineoplastic Agents; Base Sequence; DNA, Complementary; Ethylnitrosourea; Genes, p53; Humans; Molecular Sequence Data; Mutagens; Netropsin; Structure-Activity Relationship; Transfection | 1999 |
Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Colony-Forming Units Assay; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Ethylnitrosourea; Fluorouracil; Guanine; Humans; Male; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Tumor Stem Cell Assay | 1999 |
Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carmustine; Drug Resistance, Neoplasm; Drug Synergism; Ethylnitrosourea; Glutathione; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1999 |
Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.
Topics: Animals; Antineoplastic Agents; Carcinoma; Ethylnitrosourea; Female; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Leukemia L1210; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Tumor Cells, Cultured | 1999 |
Effect of cations on the formation of DNA alkylation products in DNA reacted with 1-(2-Chloroethyl)-1-nitrosourea.
Topics: Alkylating Agents; Alkylation; Animals; Brain Neoplasms; Cations; Cattle; Chromatography, High Pressure Liquid; DNA Adducts; DNA, Neoplasm; Ethylnitrosourea; Magnesium Chloride; Rats; Sodium Chloride; Spermine; Tumor Cells, Cultured | 1999 |
Role of base excision repair in protecting cells from the toxicity of chloroethylnitrosoureas.
Topics: Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA Adducts; DNA Glycosylases; DNA Repair; Escherichia coli; Ethylnitrosourea; Models, Chemical; N-Glycosyl Hydrolases; Substrate Specificity | 1999 |
Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents.
Topics: Alkylating Agents; Bacterial Proteins; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Transcription Factors | 2000 |
Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells.
Topics: Animals; Apoptosis; Carmustine; Cattle; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylnitrosourea; Guanosine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Time Factors; Tumor Cells, Cultured | 2002 |
Repair of DNA alkylation products formed in 9L cell lines treated with 1-(2-chloroethyl)-1-nitrosourea.
Topics: Alkylation; Animals; Cell Line; Cell Survival; DNA; DNA Repair; Ethylnitrosourea; Glioma; Rats; Tumor Cells, Cultured | 2003 |
Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts.
Topics: Adenine; Base Pair Mismatch; Binding Sites; Cytosine; Deoxyribonuclease IV (Phage T4-Induced); DNA Adducts; DNA Glycosylases; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Exodeoxyribonucleases; Models, Molecular; Nucleic Acid Conformation; Protein Conformation; Substrate Specificity; Thymine DNA Glycosylase; Uracil-DNA Glycosidase | 2004 |
Bystander effects are induced by CENU treatment and associated with altered protein secretory activity of treated tumor cells: a relay for chemotherapy?
Topics: Actins; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Bystander Effect; Cell Proliferation; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Ethylnitrosourea; Flow Cytometry; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Intracellular Signaling Peptides and Proteins; Magnetic Resonance Spectroscopy; Male; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Phosphatidylethanolamine Binding Protein; Protein Serine-Threonine Kinases; rho-Associated Kinases; Up-Regulation | 2006 |
CENU treatment induced bystander effects which are effective on parental and non-parental tumors and have a phospholipid metabolism proton NMR spectroscopy signature.
Topics: Animals; Bystander Effect; Carcinoma, Lewis Lung; Cell Differentiation; Ethylnitrosourea; Lung Neoplasms; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nitroso Compounds; Phospholipids; Protons | 2006 |
DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response.
Topics: Alkylation; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; DNA Adducts; DNA Modification Methylases; DNA Repair Enzymes; Ethylnitrosourea; Glioma; Humans; Statistics as Topic; Tumor Suppressor Proteins | 2009 |
Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Differentiation; Cell Proliferation; Cell Respiration; Cell Survival; Energy Metabolism; Ethylnitrosourea; Glucose; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Membrane Potential, Mitochondrial; Mitochondria; Osteosarcoma; Oxidative Phosphorylation; Pyruvic Acid; Tumor Cells, Cultured | 2009 |
A model of phospholipid biosynthesis in tumor in response to an anticancer agent in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Ethylnitrosourea; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Neoplasms; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids | 2010 |
Influence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry.
Topics: Animals; Cell Line, Tumor; Cross-Linking Reagents; DNA Damage; Ethylnitrosourea; Gas Chromatography-Mass Spectrometry; Humans; Mice; O(6)-Methylguanine-DNA Methyltransferase | 2015 |
In vitro and in vivo evaluation of 2-chloroethylnitrosourea derivatives as antitumor agents.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; CD4 Antigens; CD8 Antigens; Cell Line, Tumor; Ethylnitrosourea; Humans; Interleukin-2 Receptor alpha Subunit; Kidney; Liver; Male; Mice; Naphthalimides; Neoplasms; Sarcoma 180 | 2015 |