Compounds > 1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine

Page last updated: 2024-09-03

1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine and ipsapirone

1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine has been researched along with ipsapirone in 4 studies

Compound Research Comparison

Studies (1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine)	Trials (1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine)	Recent Studies (post-2010) (1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine)	Studies (ipsapirone)	Trials (ipsapirone)	Recent Studies (post-2010) (ipsapirone)
53	0	15	373	58	14

Protein Interaction Comparison

Protein	Taxonomy	1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine (IC50)	ipsapirone (IC50)
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)		10
Alpha-2A adrenergic receptor	Homo sapiens (human)		1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)		10
Alpha-2B adrenergic receptor	Homo sapiens (human)		1
Alpha-2C adrenergic receptor	Homo sapiens (human)		1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)		0.0082
D(4) dopamine receptor	Homo sapiens (human)		1.8
Alpha-1D adrenergic receptor	Homo sapiens (human)		0.5
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)		10
Alpha-1A adrenergic receptor	Homo sapiens (human)		0.5
Alpha-1B adrenergic receptor	Homo sapiens (human)		0.5
D(3) dopamine receptor	Homo sapiens (human)		1.2
D(2) dopamine receptor	Rattus norvegicus (Norway rat)		2.9

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (75.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L	1
Azmitia, EC; Segal, M; Whitaker-Azmitia, PM	1
Aghajanian, GK; Sprouse, JS	2

Other Studies

4 other study(ies) available for 1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine and ipsapirone

Article	Year
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3 Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes	1998
Physiological effects of selective 5-HT1a and 5-HT1b ligands in rat hippocampus: comparison to 5-HT. Brain research, 1989, Nov-13, Volume: 502, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes	1989
Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology, 1988, Volume: 27, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Anti-Anxiety Agents; Hippocampus; Male; Piperazines; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes	1988
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.), 1987, Volume: 1, Issue:1 Topics: Animals; Lysergic Acid Diethylamide; Male; Neurons; Piperazines; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists	1987