1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine has been researched along with indomethacin in 5 studies
| Studies (1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine) | Trials (1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine) | Recent Studies (post-2010) (1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine) | Studies (indomethacin) | Trials (indomethacin) | Recent Studies (post-2010) (indomethacin) |
|---|---|---|---|---|---|
| 15 | 0 | 6 | 29,527 | 1,838 | 3,396 |
| Protein | Taxonomy | 1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine (IC50) | indomethacin (IC50) |
|---|---|---|---|
| Chain A, membrane-associated prostaglandin E synthase-2 | Macaca fascicularis (crab-eating macaque) | 1000 | |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | 1.1 | |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | 5.8 | |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 0.9994 | |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 0.7764 | |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | 0.34 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.5605 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.004 | |
| Interleukin-8 | Homo sapiens (human) | 0.05 | |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.004 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 6 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 5 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 0.011 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.4848 | |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | 0.2 | |
| Thromboxane-A synthase | Homo sapiens (human) | 0.1 | |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | 0.082 | |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | 4.5 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 5.7 | |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | 0.2 | |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | 0.2 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 1.5128 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 0.5504 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 3.4486 | |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | 0.2 | |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | 0.05 | |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | 8.97 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 3.4647 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.4233 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 3 | |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | 0.49 | |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | 7.7 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 0.5461 | |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | 0.96 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goto, T; Motoyama, Y; Ochi, T | 1 |
| Edwards, RM; Evans, C; Hieble, JP; McCafferty, GP; Wibberley, A | 1 |
| Borda, E; Busch, L; Miozza, V; S-Borda, L | 1 |
| Jansson, L; Sandberg, M | 1 |
| Aalkjaer, C; Chen, H; Simonsen, U | 1 |
5 other study(ies) available for 1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine and indomethacin
| Article | Year |
|---|---|
The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Formaldehyde; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Nitrobenzenes; Pain Measurement; Piperazines; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles | 2000 |
Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.
Topics: Acetic Acid; Anesthesia; Animals; Cats; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Ketoprofen; Male; Nitrobenzenes; Piperazines; Reflex, Abnormal; Sodium Chloride; Sulfonamides; Thiazoles; Urinary Bladder Diseases | 2006 |
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Guanidines; Indazoles; Indomethacin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Organ Size; Ornithine; Parotid Gland; Periodontitis; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salivary Proteins and Peptides; Thiazoles | 2010 |
Effects of cyclooxygenase inhibition on insulin release and pancreatic islet blood flow in rats.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Duodenum; Glucose; Indomethacin; Insulin; Islets of Langerhans; Lactones; Male; Membrane Proteins; Piperazines; Pyrazoles; Rats; Rats, Wistar; Regional Blood Flow; Sulfones; Thiazoles | 2014 |
A sex-specific, COX-derived/thromboxane receptor activator causes depolarization and vasoconstriction in male mice mesenteric resistance arteries.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Mice; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Obesity; Piperazines; Receptors, Thromboxane; Sex Characteristics; Thiazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 2020 |