Compounds > 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

Page last updated: 2024-09-03

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and valproic acid

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone has been researched along with valproic acid in 13 studies

Compound Research Comparison

Studies (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Trials (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Recent Studies (post-2010) (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Studies (valproic acid)	Trials (valproic acid)	Recent Studies (post-2010) (valproic acid)
7,666	0	1,658	14,155	1,256	5,108

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (7.69)	18.2507
2000's	5 (38.46)	29.6817
2010's	6 (46.15)	24.3611
2020's	1 (7.69)	2.80

Authors

Authors	Studies
Dingermann, T; Tillner, J; Winckler, T	1
Cheng, L; Harwood, AJ; Mudge, AW; Williams, RS	1
Adley, K; Boeckeler, K; Jenkins, A; Jin, T; Williams, RS; Xu, X	1
Bialer, M; Dalton, EC; Ewan, K; Eyal, S; Harwood, AJ; Jenkins, A; Pessah, N; Shimshoni, JA; Williams, RS; Yagen, B	1
Adley, KE; Jin, T; Lee, VW; Maniak, M; Müller-Taubenberger, A; Pawolleck, N; Sihra, TS; Wiedemann, C; Williams, RS; Xu, X	1
Pawolleck, N; Williams, RS	1
Brown, NA; Gordienko, D; Kelemen, R; Klein, PS; Shah, R; Terbach, N; Wilkinson, CJ; Williams, RS	1
Bialer, M; Chang, P; Deranieh, RM; Dham, M; Greenberg, ML; Hoeller, O; Orabi, B; Shimshoni, JA; Walker, MC; Williams, RS; Yagen, B	1
Chaieb, L; Eikel, D; Elphick, LM; Guschina, IA; Harwood, JL; Nau, H; Pawolleck, N; Plant, NJ; Williams, RS	1
Walker, MC; Williams, RS	2
Kelly, E; Sharma, D; Wilkinson, CJ; Williams, RSB	1
Baines, RP; Thompson, CRL; Wolton, K	1

Reviews

2 review(s) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and valproic acid

Article	Year
The search for better epilepsy treatments: from slime mould to coconuts. Biochemical Society transactions, 2013, Volume: 41, Issue:6 Topics: Animals; Anticonvulsants; Cocos; Dictyostelium; Drug Discovery; Epilepsy; Humans; Valproic Acid	2013
New experimental therapies for status epilepticus in preclinical development. Epilepsy & behavior : E&B, 2015, Volume: 49 Topics: Animals; Anticonvulsants; Dictyostelium; Diet, Ketogenic; Drug Evaluation, Preclinical; Humans; Phosphatidylinositols; Signal Transduction; Status Epilepticus; Therapies, Investigational; Valproic Acid	2015

Other Studies

11 other study(ies) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and valproic acid

Article	Year
Developmentally regulated promoters from Dictyostelium discoideum as molecular markers for testing potential teratogens. Die Pharmazie, 1996, Volume: 51, Issue:11 Topics: Animals; Anticonvulsants; beta-Galactosidase; Biomarkers; Dictyostelium; Genes, Bacterial; Teratogens; Toxicity Tests; Transformation, Genetic; Valproic Acid	1996
A common mechanism of action for three mood-stabilizing drugs. Nature, 2002, May-16, Volume: 417, Issue:6886 Topics: Animals; Animals, Newborn; Antimanic Agents; Bipolar Disorder; Calcium-Calmodulin-Dependent Protein Kinases; Carbamazepine; Cell Aggregation; Chemotaxis; Dictyostelium; Ganglia, Spinal; Genes, Protozoan; Glycogen Synthase Kinases; Growth Cones; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Inositol 1,4,5-Trisphosphate; Lithium; Mice; Mutation; Neurons, Afferent; Rats; Signal Transduction; Valproic Acid	2002
The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum. European journal of cell biology, 2006, Volume: 85, Issue:9-10 Topics: Animals; Anticonvulsants; Cyclic AMP-Dependent Protein Kinases; Dictyostelium; Enzyme Activation; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Glycogen Synthase Kinases; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Neuroprotective Agents; Protozoan Proteins; Receptors, Cyclic AMP; Valproic Acid	2006
The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Molecular pharmacology, 2007, Volume: 71, Issue:3 Topics: Animals; Anticonvulsants; Cells, Cultured; Dictyostelium; Ganglia, Spinal; Growth Cones; Inositol 1,4,5-Trisphosphate; Rats; Rats, Sprague-Dawley; Signal Transduction; Valproic Acid; Wnt Proteins	2007
Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid. Eukaryotic cell, 2007, Volume: 6, Issue:6 Topics: Animals; Anticonvulsants; Chemotaxis; Dictyostelium; Endocytosis; Enzyme Inhibitors; Exocytosis; Humans; Inositol 1,4,5-Trisphosphate; Phosphatidylinositol 3-Kinases; Phospholipids; Protozoan Proteins; Rats; Recombinant Fusion Proteins; Signal Transduction; Valproic Acid	2007
Quantifying in vivo phosphoinositide turnover in chemotactically competent Dictyostelium cells. Methods in molecular biology (Clifton, N.J.), 2009, Volume: 571 Topics: Chemotaxis; Chromatography, Thin Layer; Dictyostelium; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Valproic Acid	2009
Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium. Journal of cell science, 2011, Jul-01, Volume: 124, Issue:Pt 13 Topics: Animals; Biological Transport, Active; Cells, Cultured; Dictyostelium; Hydrogen-Ion Concentration; Membrane Transport Proteins; Substrate Specificity; Valproic Acid; Xenopus laevis; Zebrafish	2011
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Disease models & mechanisms, 2012, Volume: 5, Issue:1 Topics: Animals; Anticonvulsants; Dictyostelium; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Inositol; Models, Biological; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Rats; Signal Transduction; Time Factors; Valproic Acid	2012
Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Disease models & mechanisms, 2012, Volume: 5, Issue:2 Topics: Cell Line; Dictyostelium; Fatty Acids; Fatty Liver; Hepatocytes; Humans; Inositol; Kinetics; Lipid Metabolism; Models, Biological; Species Specificity; Teratogens; Valproic Acid	2012
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Disease models & mechanisms, 2018, 08-21, Volume: 11, Issue:9 Topics: Amino Acid Sequence; Anticonvulsants; Bipolar Disorder; Diacylglycerol Kinase; Dictyostelium; Diglycerides; Epilepsy; Green Fluorescent Proteins; Lithium; Models, Biological; Mutation; Valproic Acid	2018
Dictyostelium discoideum: An Alternative Nonanimal Model for Developmental Toxicity Testing. Toxicological sciences : an official journal of the Society of Toxicology, 2021, 09-28, Volume: 183, Issue:2 Topics: Animals; Dictyostelium; Mutation; Reproduction; Toxicity Tests; Valproic Acid	2021