1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and inositol 1,4,5-trisphosphate

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone has been researched along with inositol 1,4,5-trisphosphate in 53 studies

Compound Research Comparison

Studies (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Trials (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Recent Studies (post-2010) (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Studies (inositol 1,4,5-trisphosphate)	Trials (inositol 1,4,5-trisphosphate)	Recent Studies (post-2010) (inositol 1,4,5-trisphosphate)
7,666	0	1,658	6,600	1	589

Protein Interaction Comparison

Protein	Taxonomy	inositol 1,4,5-trisphosphate (IC50)
Inositol-trisphosphate 3-kinase A	Rattus norvegicus (Norway rat)	4.45
Inositol 1,4,5-trisphosphate receptor type 2	Homo sapiens (human)	0.03
Inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens (human)	0.03
Inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens (human)	0.03

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (26.42)	18.7374
1990's	29 (54.72)	18.2507
2000's	9 (16.98)	29.6817
2010's	1 (1.89)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cubitt, AB; Firtel, RA	1
Drayer, AL; van Haastert, PJ	1
Peters, DJ; Schaap, P; Snaar-Jagalska, BE; Van Haastert, PJ	1
Bominaar, AA; Draijer, R; Van Dijken, P; Van Haastert, PJ	1
Bominaar, AA; van der Kaay, J; van Haastert, PJ	1
Bumann, J; Jaworski, E; Malchow, D; Menz, S	1
Europe-Finner, GN; Newell, PC; Wood, CA	1
Kesbeke, F; Schenk, PW; Snaar-Jagalska, BE; Van Es, S	1
Europe-Finner, GN; Gammon, B; Liu, G; Newell, PC; Wood, CA	1
Bominaar, AA; Kesbeke, F; Snaar-Jagalska, BE; Van der Kaay, J; Van Haastert, PJ	1
De Vries, MJ; Erneux, C; Penning, LC; Roovers, E; Van der Kaay, J; Van Haastert, PJ; Van Lookeren Campagne, MM	1
Van Haastert, PJ	2
Ginsburg, G; Kimmel, AR	1
Europe-Finner, GN; Gammon, B; Newell, PC; Wood, CA	1
Peters, DJ; Schaap, P; Spek, W; Van Haastert, PJ; Van Lookeren Campagne, MM	1
De Jong, CC; Janssens, PM; Van Haastert, PJ; Vink, AA	1
Europe-Finner, GN; Newell, PC	5
Erneux, C; Van Eijk, R; Van Haastert, PJ; Van Lookeren Campagne, MM	1
Europe-Finner, GN; Newell, PC; Small, NV	1
Eisen, M; Kimmel, AR	1
Bozzaro, S; Malchow, D; Schaloske, R; Sordano, C	1
Cotter, DA; Lydan, MA	1
Irvine, RF	1
Van der Kaay, J; Van Haastert, PJ	1
Bominaar, AA; Van Haastert, PJ	3
Ishida, S; Kuwayama, H; Van Haastert, PJ	1
Snaar-Jagalska, BE; Van Haastert, PJ	1
Drayer, AL; Mayr, GW; Van der Kaay, J; Van Haastert, PJ	1
Bominaar, AA; Kesbeke, F; Van Haastert, PJ	1
Craxton, A; de Haas, JR; Erneux, C; Shears, SB; Van Dijken, P; Van Haastert, PJ	1
Van der Kaay, J; Van Haastert, PJ; Wesseling, J	1
Arents, JC; Schoen, CD; Schulkes, CC; van Driel, R	1
Bergsma, JC; Van Dijken, P; Van Haastert, PJ	1
Brearley, CA; Hanke, DE; Parmar, PN	1
Kuwayama, H; Van Haastert, PJ	1
Eames, M; Harwood, AJ; Ryves, WJ; Viggars, J; Williams, RS	1
Deery, WJ; Gomer, RH	1
Malchow, D; Schaloske, R; Schlatterer, C	1
Harwood, AJ	1
Van Dijken, P; Van Haastert, PJ	1
Cheng, L; Harwood, AJ; Mudge, AW; Williams, RS	1
Adley, KE; Keim, M; Williams, RS	1
Bialer, M; Dalton, EC; Ewan, K; Eyal, S; Harwood, AJ; Jenkins, A; Pessah, N; Shimshoni, JA; Williams, RS; Yagen, B	1
Adley, KE; Jin, T; Lee, VW; Maniak, M; Müller-Taubenberger, A; Pawolleck, N; Sihra, TS; Wiedemann, C; Williams, RS; Xu, X	1
Bates, DG; Heslop-Harrison, JS; Kim, JS; Kotov, NV; Postlethwaite, I; Valeyev, NV	1
Bolourani, P; Keizer-Gunnink, I; Kortholt, A; Rehmann, H; Van Haastert, PJ; Weeks, G; Wittinghofer, A	1

Reviews

3 review(s) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and inositol 1,4,5-trisphosphate

Article	Year
Dynamics and function of the inositolcycle in Dictyostelium discoideum. Developmental genetics, 1991, Volume: 12, Issue:1-2 Topics: Cell Membrane Permeability; Cyclic AMP; Dictyostelium; Guanosine 5'-O-(3-Thiotriphosphate); Inositol; Inositol 1,4,5-Trisphosphate; Phosphorylation	1991
Signal transduction for chemotaxis in Dictyostelium amoebae. Seminars in cell biology, 1990, Volume: 1, Issue:2 Topics: Calcium; Chemotaxis; Cytoskeleton; Dictyostelium; Inositol 1,4,5-Trisphosphate; Signal Transduction	1990
Inositide evolution: what can it tell us about functions? Biochemical Society transactions, 1995, Volume: 23, Issue:1 Topics: Animals; Biological Evolution; Dictyostelium; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Molecular Conformation; Phosphatidylinositols	1995

Other Studies

50 other study(ies) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and inositol 1,4,5-trisphosphate

Article	Year
Characterization of phospholipase activity in Dictyostelium discoideum. Identification of a Ca(2+)-dependent polyphosphoinositide-specific phospholipase C. The Biochemical journal, 1992, Apr-15, Volume: 283 ( Pt 2) Topics: Animals; Calcium; Cell Membrane; Chromatography, High Pressure Liquid; Dictyostelium; Guanosine 5'-O-(3-Thiotriphosphate); Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Membrane Lipids; Palmitic Acid; Palmitic Acids; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases	1992
Molecular cloning and expression of a phosphoinositide-specific phospholipase C of Dictyostelium discoideum. The Journal of biological chemistry, 1992, Sep-15, Volume: 267, Issue:26 Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Dictyostelium; DNA; Gene Expression; Inositol 1,4,5-Trisphosphate; Molecular Sequence Data; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Polymerase Chain Reaction; Sequence Homology, Nucleic Acid; Transcription, Genetic	1992
Lithium, an inhibitor of cAMP-induced inositol 1,4,5-trisphosphate accumulation in Dictyostelium discoideum, inhibits activation of guanine-nucleotide-binding regulatory proteins, reduces activation of adenylylcyclase, but potentiates activation of guanyl European journal of biochemistry, 1992, Oct-01, Volume: 209, Issue:1 Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic GMP; Dictyostelium; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylate Cyclase; Inositol 1,4,5-Trisphosphate; Lithium; Second Messenger Systems; Signal Transduction	1992
Developmental regulation of the inositol 1,4,5-trisphosphate phosphatases in Dictyostelium discoideum. Differentiation; research in biological diversity, 1991, Volume: 46, Issue:1 Topics: Chromatography, Ion Exchange; Dictyostelium; Inositol 1,4,5-Trisphosphate; Kinetics; Models, Biological; Phosphoric Monoester Hydrolases; Second Messenger Systems	1991
Mutant analysis suggests that cyclic GMP mediates the cyclic AMP-induced Ca2+ uptake in Dictyostelium. Journal of cell science, 1991, Volume: 99 ( Pt 1) Topics: Animals; Calcium; Cyclic AMP; Cyclic GMP; Dictyostelium; Inositol 1,4,5-Trisphosphate; Mutation	1991
Effects of normal and mutant ras genes on inositol lipid metabolism in Dictyostelium. Cellular signalling, 1991, Volume: 3, Issue:5 Topics: Aluminum; Aluminum Compounds; Animals; Cyclic AMP; Dictyostelium; Fluorides; Fluorine; Genes, ras; Inositol 1,4,5-Trisphosphate; Kinetics; Mutation; Phosphatidylinositols; Signal Transduction	1991
Involvement of cyclic AMP cell surface receptors and G-proteins in signal transduction during slug migration of Dictyostelium discoideum. Developmental biology, 1991, Volume: 145, Issue:1 Topics: Adenylyl Cyclases; Binding, Competitive; Cell Membrane; Cell Movement; Cyclic AMP; Dictyostelium; GTP Phosphohydrolases; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Kinetics; Receptors, Cyclic AMP; Signal Transduction	1991
G-proteins and the inositol cycle in Dictyostelium discoideum. Biochemical Society symposium, 1990, Volume: 56 Topics: Cyclic AMP; Dictyostelium; Fungal Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Mutation	1990
Chemoattractant and guanosine 5'-[gamma-thio]triphosphate induce the accumulation of inositol 1,4,5-trisphosphate in Dictyostelium cells that are labelled with [3H]inositol by electroporation. The Biochemical journal, 1989, Mar-01, Volume: 258, Issue:2 Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclic AMP; Dictyostelium; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Phospholipids; Rats; Stimulation, Chemical; Sugar Phosphates; Thionucleotides	1989
Determination of inositol 1,4,5-trisphosphate levels in Dictyostelium by isotope dilution assay. Analytical biochemistry, 1989, Feb-15, Volume: 177, Issue:1 Topics: Chromatography, High Pressure Liquid; Cyclic AMP; Dictyostelium; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Radioisotope Dilution Technique; Sugar Phosphates	1989
Inositol trisphosphate and diacylglycerol can differentially modulate gene expression in Dictyostelium. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:23 Topics: Cyclic AMP; Dictyostelium; Diglycerides; Gene Expression; Gene Expression Regulation, Fungal; Genes, Fungal; Glycerides; Inositol 1,4,5-Trisphosphate; RNA, Fungal	1989
Inositol tris- and polyphosphate formation during chemotaxis of Dictyostelium. Journal of cell science, 1989, Volume: 93 ( Pt 4) Topics: Animals; Chemotaxis; Chromatography, High Pressure Liquid; Cyclic AMP; Dictyostelium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Permeability; Solubility; Thionucleotides; Time Factors	1989
Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum. Journal of cell science, 1989, Volume: 93 ( Pt 1) Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Chlorides; Cyclic AMP; Dictyostelium; Gene Expression; Genes, Fungal; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium; Lithium Chloride; RNA, Messenger; Spores, Fungal; Transcription, Genetic	1989
Regulatory properties of magnesium-dependent guanylate cyclase in Dictyostelium discoideum membranes. The Journal of biological chemistry, 1989, Mar-15, Volume: 264, Issue:8 Topics: Adenine Nucleotides; Calcium; Cell Membrane; Cyclic GMP; Dictyostelium; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylate Cyclase; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Magnesium; Thionucleotides	1989
Cyclic AMP stimulates accumulation of inositol trisphosphate in Dictyostelium. Journal of cell science, 1987, Volume: 87 ( Pt 2) Topics: Chemotaxis; Chromatography, Ion Exchange; Cyclic AMP; Dictyostelium; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Stimulation, Chemical; Sugar Phosphates	1987
GTP analogues stimulate inositol trisphosphate formation transiently in Dictyostelium. Journal of cell science, 1987, Volume: 87 ( Pt 4) Topics: Chemotaxis; Cyclic AMP; Dictyostelium; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Receptors, Cyclic AMP; Saponins; Stimulation, Chemical; Sugar Phosphates; Thionucleotides; Time Factors	1987
Two dephosphorylation pathways of inositol 1,4,5-trisphosphate in homogenates of the cellular slime mould Dictyostelium discoideum. The Biochemical journal, 1988, Sep-01, Volume: 254, Issue:2 Topics: 2,3-Diphosphoglycerate; Cell Fractionation; Chromatography, High Pressure Liquid; Dictyostelium; Diphosphoglyceric Acids; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Phosphoric Monoester Hydrolases; Sugar Phosphates	1988
Adaptation to chemotactic cyclic AMP signals in Dictyostelium involves the G-protein. Journal of cell science, 1987, Volume: 88 ( Pt 4) Topics: Adaptation, Physiological; Calcium; Chemotaxis; Cyclic AMP; Cyclic GMP; Dictyostelium; Inosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates	1987
Inositol 1,4,5-trisphosphate induces cyclic GMP formation in Dictyostelium discoideum. Biochemical and biophysical research communications, 1985, Aug-15, Volume: 130, Issue:3 Topics: Calcium; Cell Membrane Permeability; Chemotaxis; Cyclic AMP; Cyclic GMP; Dictyostelium; Folic Acid; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Models, Biological; Sugar Phosphates	1985
Inositol 1,4,5-triphosphate induces calcium release from a non- mitochondrial pool in amoebae of Dictyostelium. Biochimica et biophysica acta, 1986, Aug-01, Volume: 887, Issue:3 Topics: Actins; Adenosine Triphosphate; Animals; Calcium; Cell Compartmentation; Cell Membrane Permeability; Cyclic GMP; Dictyostelium; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Mitochondria; Receptors, Cell Surface; Sugar Phosphates	1986
Inositol 1,4,5-trisphosphate and calcium stimulate actin polymerization in Dictyostelium discoideum. Journal of cell science, 1986, Volume: 82 Topics: Actins; Calcium; Cyclic AMP; Cytoskeletal Proteins; Cytoskeleton; Dictyostelium; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Sugar Phosphates	1986
Regulation of gene expression by the intracellular second messengers IP3 and diacylglycerol. Developmental genetics, 1988, Volume: 9, Issue:4-5 Topics: Dictyostelium; Diglycerides; Gene Expression Regulation; Genes, Fungal; Glycerides; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Second Messenger Systems; Sugar Phosphates	1988
Stimulation of calcium influx by platelet activating factor in Dictyostelium. Journal of cell science, 1995, Volume: 108 ( Pt 4) Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Calcium; Cell Membrane; Cyclic AMP; Dictyostelium; Diterpenes; Dose-Response Relationship, Drug; Estrenes; Ginkgolides; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Kinetics; Lactones; Platelet Activating Factor; Pyrrolidinones; Species Specificity; Time Factors	1995
The role of Ca2+ during spore germination in Dictyostelium: autoactivation is mediated by the mobilization of Ca2+ while amoebal emergence requires entry of external Ca2+. Journal of cell science, 1995, Volume: 108 ( Pt 5) Topics: Animals; Calcium; Cell Compartmentation; Dictyostelium; Estrenes; Fungal Proteins; Gallic Acid; Inositol 1,4,5-Trisphosphate; Lanthanum; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Protozoan Proteins; Pyrrolidinones; Signal Transduction; Spores, Fungal	1995
Desalting inositolpolyphosphates by dialysis. Analytical biochemistry, 1995, Feb-10, Volume: 225, Issue:1 Topics: Adenosine Triphosphate; Animals; Dialysis; Dictyostelium; Glucose-6-Phosphate; Glucosephosphates; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Osmolar Concentration; Phosphorus Radioisotopes; Phytic Acid; Radioisotope Dilution Technique; Salts; Tritium	1995
Phospholipase C activity in Dictyostelium discoideum using endogenous nonradioactive phosphatidylinositol 4,5-bisphosphate as substrate. Methods in enzymology, 1994, Volume: 238 Topics: Animals; Calcium Channels; Cattle; Chromatography, High Pressure Liquid; Dictyostelium; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Liver; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Radioisotope Dilution Technique; Receptors, Cytoplasmic and Nuclear; Substrate Specificity; Tritium; Type C Phospholipases	1994
Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction. The Journal of cell biology, 1993, Volume: 123, Issue:6 Pt 1 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Chemotaxis; Cyclic GMP; Dictyostelium; Folic Acid; Genes, Fungal; Genetic Linkage; GTP-Binding Proteins; Guanylate Cyclase; Inositol 1,4,5-Trisphosphate; Mutation; Second Messenger Systems; Signal Transduction	1993
G-protein assays in Dictyostelium. Methods in enzymology, 1994, Volume: 237 Topics: Animals; Cell Membrane; Cyclic AMP; Cyclic GMP; Dictyostelium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylate Cyclase; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Kinetics; Phosphorus Radioisotopes; Protein Binding; Radioisotope Dilution Technique; Sulfur Radioisotopes; Tritium; Type C Phospholipases	1994
Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity. The EMBO journal, 1994, Apr-01, Volume: 13, Issue:7 Topics: Animals; Cell Differentiation; Chemotaxis; Cyclic AMP; Dictyostelium; Dose-Response Relationship, Drug; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Mutation; Second Messenger Systems; Signal Transduction; Type C Phospholipases	1994
Phospholipase C in Dictyostelium discoideum. Cyclic AMP surface receptor and G-protein-regulated activity in vitro. The Biochemical journal, 1994, Jan-01, Volume: 297 ( Pt 1) Topics: Animals; Calcium; Cyclic AMP; Dictyostelium; Egtazic Acid; Enzyme Activation; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Inositol 1,4,5-Trisphosphate; Kinetics; Phosphatidylinositols; Receptors, Cyclic AMP; Thionucleotides; Tritium; Type C Phospholipases	1994
Phospholipase C in Dictyostelium discoideum. Identification of stimulatory and inhibitory surface receptors and G-proteins. The Biochemical journal, 1994, Jan-01, Volume: 297 ( Pt 1) Topics: Animals; Cyclic AMP; Dictyostelium; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Inositol Polyphosphate 5-Phosphatases; Mutation; Phosphoric Monoester Hydrolases; Receptors, Cyclic AMP; Type C Phospholipases	1994
Chemotactic antagonists of cAMP inhibit Dictyostelium phospholipase C. Journal of cell science, 1993, Volume: 104 ( Pt 1) Topics: Animals; Chemotaxis; Cyclic AMP; Dictyostelium; Fungal Proteins; Inositol 1,4,5-Trisphosphate; Nucleotides, Cyclic; Signal Transduction; Thionucleotides; Type C Phospholipases	1993
A novel, phospholipase C-independent pathway of inositol 1,4,5-trisphosphate formation in Dictyostelium and rat liver. The Journal of biological chemistry, 1995, Dec-15, Volume: 270, Issue:50 Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Dictyostelium; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Models, Biological; Molecular Conformation; Molecular Structure; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Rats; Subcellular Fractions; Type C Phospholipases	1995
Nucleus-associated phosphorylation of Ins(1,4,5)P3 to InsP6 in Dictyostelium. The Biochemical journal, 1995, Dec-15, Volume: 312 ( Pt 3) Topics: Adenosine Triphosphate; Animals; Cell Nucleus; Chromatography, High Pressure Liquid; Cytosol; Dictyostelium; Inositol; Inositol 1,4,5-Trisphosphate; Kinetics; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phytic Acid; Tritium	1995
Guanylate cyclase activity in permeabilized Dictyostelium discoideum cells. Journal of cellular biochemistry, 1996, Mar-01, Volume: 60, Issue:3 Topics: Animals; Calcium; Cell Fractionation; Cell Membrane Permeability; Cyclic GMP; Dictyostelium; Electroporation; Enzyme Activation; Enzyme Reactivators; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylate Cyclase; Half-Life; Inositol 1,4,5-Trisphosphate; Solubility	1996
Phospholipase-C-independent inositol 1,4,5-trisphosphate formation in Dictyostelium cells. Activation of a plasma-membrane-bound phosphatase by receptor-stimulated Ca2+ influx. European journal of biochemistry, 1997, Feb-15, Volume: 244, Issue:1 Topics: Animals; Calcium; Cell Membrane; Dictyostelium; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Phosphoric Monoester Hydrolases; Receptors, Cyclic AMP; Solubility; Subcellular Fractions; Type C Phospholipases	1997
Metabolic evidence for PtdIns(4,5)P2-directed phospholipase C in permeabilized plant protoplasts. The Biochemical journal, 1997, May-15, Volume: 324 ( Pt 1) Topics: Animals; Chromatography, High Pressure Liquid; Dictyostelium; Electroporation; Erythrocyte Membrane; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Liver; Mammals; Phosphoinositide Phospholipase C; Phospholipase C delta; Phosphoric Diester Hydrolases; Plants; Protein Kinase C; Protoplasts; Rats	1997
Chemotactic and osmotic signals share a cGMP transduction pathway in Dictyostelium discoideum. FEBS letters, 1998, Mar-13, Volume: 424, Issue:3 Topics: Animals; Carrier Proteins; Chemotaxis; Cyclic GMP; Dictyostelium; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Intracellular Signaling Peptides and Proteins; Mutation; Osmosis; Receptors, Cyclic AMP; Signal Transduction	1998
Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate. The EMBO journal, 1999, May-17, Volume: 18, Issue:10 Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Aggregation; Cloning, Molecular; Dictyostelium; Drug Resistance; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Lithium; Molecular Sequence Data; Mutation; Phosphorylation; Prolyl Oligopeptidases; Sequence Alignment; Serine Endopeptidases; Signal Transduction	1999
A putative receptor mediating cell-density sensing in Dictyostelium. The Journal of biological chemistry, 1999, Nov-26, Volume: 274, Issue:48 Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Adhesion; Cell Adhesion Molecules; Cyclic AMP; Dictyostelium; DNA, Complementary; Gene Expression Regulation; Glutathione Transferase; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Membrane Proteins; Molecular Sequence Data; Mutation; Protein Binding; Protozoan Proteins; Receptors, Cell Surface; Recombinant Fusion Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Signal Transduction; Trypsin	1999
A Xestospongin C-sensitive Ca(2+) store is required for cAMP-induced Ca(2+) influx and cAMP oscillations in Dictyostelium. The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12 Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Chemotaxis; Cyclic AMP; Dictyostelium; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Oxazoles; Periodicity; Receptors, Cytoplasmic and Nuclear; Thapsigargin	2000
Signal transduction and Dictyostelium development. Protist, 2001, Volume: 152, Issue:1 Topics: Animals; Chemotaxis; Cyclic AMP; Dictyostelium; Inositol 1,4,5-Trisphosphate; Signal Transduction	2001
Phospholipase Cdelta regulates germination of Dictyostelium spores. BMC cell biology, 2001, Volume: 2 Topics: Animals; Cell Differentiation; Cells, Cultured; Dictyostelium; Gene Deletion; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Osmotic Pressure; Phospholipase C delta; Spores, Protozoan; Temperature; Type C Phospholipases	2001
A common mechanism of action for three mood-stabilizing drugs. Nature, 2002, May-16, Volume: 417, Issue:6886 Topics: Animals; Animals, Newborn; Antimanic Agents; Bipolar Disorder; Calcium-Calmodulin-Dependent Protein Kinases; Carbamazepine; Cell Aggregation; Chemotaxis; Dictyostelium; Ganglia, Spinal; Genes, Protozoan; Glycogen Synthase Kinases; Growth Cones; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Inositol 1,4,5-Trisphosphate; Lithium; Mice; Mutation; Neurons, Afferent; Rats; Signal Transduction; Valproic Acid	2002
Analysis of signal transduction: formation of cAMP, cGMP, and Ins(1,4,5)P3 in vivo and in vitro. Methods in molecular biology (Clifton, N.J.), 2006, Volume: 346 Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic GMP; Dictyostelium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylate Cyclase; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Receptors, Cyclic AMP; Signal Transduction; Type C Phospholipases	2006
Pharmacogenetics: defining the genetic basis of drug action and inositol trisphosphate analysis. Methods in molecular biology (Clifton, N.J.), 2006, Volume: 346 Topics: Animals; Antimanic Agents; Bipolar Disorder; Dictyostelium; Disease Models, Animal; DNA Transposable Elements; Drug Evaluation, Preclinical; Drug Resistance; Gene Deletion; Gene Targeting; Humans; Inositol 1,4,5-Trisphosphate; Pharmacogenetics; Restriction Mapping	2006
The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Molecular pharmacology, 2007, Volume: 71, Issue:3 Topics: Animals; Anticonvulsants; Cells, Cultured; Dictyostelium; Ganglia, Spinal; Growth Cones; Inositol 1,4,5-Trisphosphate; Rats; Rats, Sprague-Dawley; Signal Transduction; Valproic Acid; Wnt Proteins	2007
Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid. Eukaryotic cell, 2007, Volume: 6, Issue:6 Topics: Animals; Anticonvulsants; Chemotaxis; Dictyostelium; Endocytosis; Enzyme Inhibitors; Exocytosis; Humans; Inositol 1,4,5-Trisphosphate; Phosphatidylinositol 3-Kinases; Phospholipids; Protozoan Proteins; Rats; Recombinant Fusion Proteins; Signal Transduction; Valproic Acid	2007
Computational modelling suggests dynamic interactions between Ca2+, IP3 and G protein-coupled modules are key to robust Dictyostelium aggregation. Molecular bioSystems, 2009, Volume: 5, Issue:6 Topics: Algorithms; Animals; Calcium; Calmodulin; Cell Aggregation; Chemotaxis; Computer Simulation; Cyclic AMP; Dictyostelium; Enzyme Inhibitors; GTP-Binding Proteins; Imidazoles; Inositol 1,4,5-Trisphosphate; Models, Biological; Protozoan Proteins	2009
A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]. Molecular biology of the cell, 2010, Mar-15, Volume: 21, Issue:6 Topics: Animals; Cells, Cultured; Chemotaxis; Dictyostelium; Enzyme Activation; Gene Knockdown Techniques; Guanine Nucleotide Exchange Factors; Inositol 1,4,5-Trisphosphate; Phosphatidylinositol 3-Kinases; Protozoan Proteins; Pseudopodia; rap1 GTP-Binding Proteins; ras Proteins; Recombinant Fusion Proteins; Signal Transduction	2010