Page last updated: 2024-09-03

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and chloroquine

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone has been researched along with chloroquine in 9 studies

Compound Research Comparison

Studies
(1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Trials
(1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Recent Studies (post-2010)
(1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Studies
(chloroquine)
Trials
(chloroquine)
Recent Studies (post-2010) (chloroquine)
7,66601,65816,4057634,029

Protein Interaction Comparison

ProteinTaxonomy1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone (IC50)chloroquine (IC50)
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium berghei43
Spike glycoproteinBetacoronavirus England 15.47
Replicase polyprotein 1abBetacoronavirus England 15.47
Transmembrane protease serine 2Homo sapiens (human)5.47
Dihydrofolate reductase Bos taurus (cattle)0.0301
Amyloid-beta precursor proteinHomo sapiens (human)7
Histidine-rich protein PFHRP-IIPlasmodium falciparum (malaria parasite P. falciparum)0.2383
Procathepsin LHomo sapiens (human)5.47
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus5.47
Replicase polyprotein 1abHuman coronavirus 229E5.47
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus5.47
Spike glycoproteinSevere acute respiratory syndrome coronavirus 23.58
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 26.375
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)1.5
Serine/threonine-protein kinase mTORHomo sapiens (human)0.27
Beta-secretase 1Homo sapiens (human)7
Spike glycoproteinSevere acute respiratory syndrome-related coronavirus5.47
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.503
Angiotensin-converting enzyme 2 Homo sapiens (human)6.235
Cysteine proteinase falcipain 2a Plasmodium falciparum (malaria parasite P. falciparum)0.02
Cysteine proteinase falcipain 2a Plasmodium falciparum (malaria parasite P. falciparum)0.2

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's2 (22.22)18.2507
2000's3 (33.33)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bonner, JT; Fong, D1
Bush, JM; Cardelli, JA; Ebert, D; Freeze, HH1
Cardelli, JA; Miears, D; Richardson, J1
Favard-Séréno, C; Ludosky, MA; Ryter, A1
Davies, L; Gross, JD; Martin, JB; Satre, M1
Baird, JK; Carlton, JM; Collins, WE; del Portillo, HA; Fidock, DA; Fryauff, DJ; McCutchan, TF; Nomura, T; Rathore, D; Su , X; Wellems, TE; Wootton, JC1
Brzostowski, JA; Kimmel, AR; Naudé, B; Wellems, TE1
de Azevedo, MF; Del Portillo, HA; Fernandez-Becerra, C; Naudé, B; Papakrivos, J; Sá, JM; Wellems, TE; Yamamoto, MM1
Papakrivos, J; Sá, JM; Wellems, TE1

Other Studies

9 other study(ies) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and chloroquine

ArticleYear
Proteases in cellular slime mold development: evidence for their involvement.
    Proceedings of the National Academy of Sciences of the United States of America, 1979, Volume: 76, Issue:12

    Topics: Amino Acids; Animals; Antipain; Cell Differentiation; Chloroquine; Dictyostelium; Energy Metabolism; Leupeptins; Pepstatins; Peptide Hydrolases; Protease Inhibitors

1979
Sulfated N-linked oligosaccharides affect secretion but are not essential for the transport, proteolytic processing, and sorting of lysosomal enzymes in Dictyostelium discoideum.
    The Journal of biological chemistry, 1990, May-25, Volume: 265, Issue:15

    Topics: Acetylglucosaminidase; alpha-Mannosidase; beta-Glucosidase; Biological Transport; Chloroquine; Chromatography, Ion Exchange; Dictyostelium; Glucosidases; Kinetics; Lysosomes; Mannosidases; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Oligosaccharides; Protein Processing, Post-Translational; Sulfuric Acids

1990
Role of acidic intracellular compartments in the biosynthesis of Dictyostelium lysosomal enzymes. The weak bases ammonium chloride and chloroquine differentially affect proteolytic processing and sorting.
    The Journal of biological chemistry, 1989, Feb-25, Volume: 264, Issue:6

    Topics: Acetylglucosaminidase; alpha-Mannosidase; Ammonium Chloride; beta-Glucosidase; Biological Transport; Cell Fractionation; Centrifugation, Density Gradient; Chloroquine; Dictyostelium; Enzyme Precursors; Glucosidases; Golgi Apparatus; Hydrogen-Ion Concentration; Lysosomes; Mannosidases; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Organelles; Peptide Hydrolases; Vacuoles

1989
Freeze-fracture study of phagocytosis in Dictyostelium discoideum.
    Journal of cell science, 1981, Volume: 51

    Topics: Cell Membrane; Chloroquine; Concanavalin A; Dictyostelium; Freeze Fracturing; Hydrogen-Ion Concentration; Microscopy, Electron; Microspheres; Phagocytosis; Saccharomyces cerevisiae; Sterols

1981
The target of ammonia action in dictyostelium.
    Cell, 1993, Oct-22, Volume: 75, Issue:2

    Topics: Alkalies; Amines; Ammonia; Animals; Cell Compartmentation; Chloroquine; Cytoplasm; Dictyostelium; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Morphogenesis; Vacuoles

1993
Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.
    The Journal of infectious diseases, 2001, Jun-01, Volume: 183, Issue:11

    Topics: Amino Acid Sequence; Animals; Chloroquine; Codon; Dictyostelium; Drug Resistance; Humans; Molecular Chaperones; Molecular Sequence Data; Mutation; Parasitic Sensitivity Tests; Plasmodium; Sequence Alignment

2001
Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.
    The Journal of biological chemistry, 2005, Jul-08, Volume: 280, Issue:27

    Topics: Acids; Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Cytoplasmic Vesicles; Dictyostelium; Drug Resistance, Bacterial; Gene Expression; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Phenotype; Phylogeny; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinidine; Quinine; Quinolines; Transfection

2005
Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum.
    Molecular and biochemical parasitology, 2006, Volume: 150, Issue:2

    Topics: Animals; Antimalarials; Chloroquine; Dictyostelium; Drug Resistance; Endosomes; Erythrocytes; Gene Expression; Genes, Protozoan; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Plasmodium falciparum; Plasmodium vivax; Promoter Regions, Genetic; Protozoan Proteins; Transfection; Vacuoles

2006
Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Adenosine Triphosphate; Ammonia; Animals; Antimalarials; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Transformed; Chloroquine; Cytoplasmic Vesicles; Dictyostelium; Hydrogen-Ion Concentration; Ionophores; Macrolides; Membrane Potentials; Membrane Transport Proteins; Phenotype; Plasmodium falciparum; Potassium; Protozoan Proteins; Valinomycin; Verapamil

2012