1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and alendronate

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone has been researched along with alendronate in 2 studies

Compound Research Comparison

Studies (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Trials (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Recent Studies (post-2010) (1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)	Studies (alendronate)	Trials (alendronate)	Recent Studies (post-2010) (alendronate)
7,666	0	1,658	4,096	731	1,724

Protein Interaction Comparison

Protein	Taxonomy	1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone (IC50)	alendronate (IC50)
Chain A, farnesyl pyrophosphate synthase	Trypanosoma cruzi		147
Farnesyl pyrophosphate synthase	Homo sapiens (human)		0.7523

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brown, RJ; Grove, JE; Watts, DJ	1
Hettema, EH; Nuttall, JM; Watts, DJ	1

Other Studies

2 other study(ies) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and alendronate

Article	Year
The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2000, Volume: 15, Issue:5 Topics: Alendronate; Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Base Sequence; Bone Resorption; Dictyostelium; Diphosphonates; DNA Primers; Etidronic Acid; Farnesyl-Diphosphate Farnesyltransferase; Geranyltranstransferase; Molecular Sequence Data; Risedronic Acid; RNA, Messenger; Sequence Homology, Amino Acid	2000
Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum. The Biochemical journal, 2012, Nov-01, Volume: 447, Issue:3 Topics: Alendronate; Amino Acid Sequence; Consensus Sequence; Dictyostelium; Diphosphonates; Drug Resistance; Geranyltranstransferase; Green Fluorescent Proteins; Mutagenesis, Site-Directed; Mutation; Peroxisomal Targeting Signal 2 Receptor; Peroxisome-Targeting Signal 1 Receptor; Peroxisomes; Protein Transport; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Signal Transduction	2012

Article

Year

The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2000, Volume: 15, Issue:5

Topics: Alendronate; Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Base Sequence; Bone Resorption; Dictyostelium; Diphosphonates; DNA Primers; Etidronic Acid; Farnesyl-Diphosphate Farnesyltransferase; Geranyltranstransferase; Molecular Sequence Data; Risedronic Acid; RNA, Messenger; Sequence Homology, Amino Acid

2000

Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum.

The Biochemical journal, 2012, Nov-01, Volume: 447, Issue:3

Topics: Alendronate; Amino Acid Sequence; Consensus Sequence; Dictyostelium; Diphosphonates; Drug Resistance; Geranyltranstransferase; Green Fluorescent Proteins; Mutagenesis, Site-Directed; Mutation; Peroxisomal Targeting Signal 2 Receptor; Peroxisome-Targeting Signal 1 Receptor; Peroxisomes; Protein Transport; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Signal Transduction

2012