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1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone has been researched along with 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone in 12 studies

Compound Research Comparison

Studies
(1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Trials
(1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Recent Studies (post-2010)
(1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Studies
(1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Trials
(1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
Recent Studies (post-2010) (1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone)
7,66601,6582007

Protein Interaction Comparison

ProteinTaxonomy1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone (IC50)1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone (IC50)
Serine/threonine-protein kinase PAK 1Homo sapiens (human)2.5

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's3 (25.00)18.2507
2000's3 (25.00)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Katou, Y; Kikuchi, H; Kubohara, Y; Nguyen, VH; Oshima, Y; Takahashi, K1
Roelfsema, JH; Schaap, P; Wang, M; Williams, JG1
Kay, RR; Wurster, B1
Williams, JG1
Sobolewski, A; Weeks, G1
Bloom, L; Kay, RR1
Johnson, SJ; Kay, RR; Masento, MS; Morris, HR; Skapski, AC; Taylor, GW1
Kubohara, Y1
Kay, RR; Thompson, CR1
Hirata, M; Kubohara, Y; Miwa, Y; Morimoto, S; Sasaguri, T; Taba, Y; Takahashi-Yanaga, F; Watanabe, Y1
Kay, RR; Maeda, M; Thompson, CR; Tsujioka, M; Yamamoto, T1
Arioka, M; Igawa, K; Kitazono, T; Kubokura, N; Matsumoto, T; Morimoto, S; Nakabeppu, Y; Nakatsu, Y; Sasaguri, T; Takahashi-Yanaga, F; Tomooka, K; Tsuzuki, T; Yoshihara, T1

Reviews

2 review(s) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

ArticleYear
Extracellular signals and intracellular transduction pathways regulating Dictyostelium development.
    Current opinion in cell biology, 1989, Volume: 1, Issue:6

    Topics: Cell Differentiation; Chemotaxis; Cyclic AMP; Dictyostelium; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Hexanones; Pentanones; ras Proteins; Signal Transduction; Transcription Factors

1989
The search for morphogens in Dictyostelium.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 1988, Volume: 9, Issue:6

    Topics: Adenosine; Ammonia; Cyclic AMP; Dictyostelium; Hexanones; Morphogenesis; Pentanones

1988

Other Studies

10 other study(ies) available for 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone and 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

ArticleYear
Development of novel DIF-1 derivatives that selectively suppress innate immune responses.
    Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

    Topics: Animals; Animals, Genetically Modified; Benzene; Chemistry Techniques, Synthetic; Dictyostelium; Drosophila; Drug Discovery; Drug Evaluation, Preclinical; Hexanones; Humans; Immunity, Innate; Immunosuppressive Agents; Insect Proteins; Interleukin-2; Jurkat Cells

2015
Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum.
    Developmental biology, 1990, Volume: 140, Issue:1

    Topics: Cyclic AMP; Dictyostelium; Dimethadione; Gene Expression Regulation, Fungal; Hexanones; Hydrogen-Ion Concentration; Methylamines; Pentanones; RNA, Messenger

1990
New roles for DIF? Effects on early development in Dictyostelium.
    Developmental biology, 1990, Volume: 140, Issue:1

    Topics: Cell Adhesion; Cell Aggregation; Cyclic AMP; Cyclic GMP; Dictyostelium; Dose-Response Relationship, Drug; Hexanones; Ketones; Pentanones

1990
The requirement for DIF for prestalk and stalk cell formation in Dictyostelium discoideum: a comparison of in vivo and in vitro differentiation conditions.
    Developmental biology, 1988, Volume: 127, Issue:2

    Topics: Acid Phosphatase; Antigens, Fungal; Cell Differentiation; Cyclic AMP; Dictyostelium; Hexanones; Isoenzymes; Ketones; Morphogenesis; Pentanones; Time Factors

1988
Differentiation-inducing factor from the slime mould Dictyostelium discoideum and its analogues. Synthesis, structure and biological activity.
    The Biochemical journal, 1988, Nov-15, Volume: 256, Issue:1

    Topics: Cell Differentiation; Chromatography, High Pressure Liquid; Dictyostelium; Hexanones; Ketones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Pentanones

1988
Effects of differentiation-inducing factors of Dictyostelium discoideum on human leukemia K562 cells: DIF-3 is the most potent anti-leukemic agent.
    European journal of pharmacology, 1999, Sep-17, Volume: 381, Issue:1

    Topics: Animals; Antineoplastic Agents; Calcium; Cell Count; Cell Differentiation; Cell Division; Dictyostelium; DNA; Dose-Response Relationship, Drug; Hexanones; Humans; K562 Cells; Leukemia; Pentanones; Phenols; Resorcinols

1999
Cell-fate choice in Dictyostelium: intrinsic biases modulate sensitivity to DIF signaling.
    Developmental biology, 2000, Nov-01, Volume: 227, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biomarkers; Cell Cycle; Cell Differentiation; Cell Lineage; Dictyostelium; Enzyme Induction; Gene Expression Regulation, Developmental; Glucose; Green Fluorescent Proteins; Hexanones; Luminescent Proteins; Lyases; Oxidoreductases; Pentanones; Signal Transduction; Spores

2000
Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells.
    The Journal of biological chemistry, 2003, Mar-14, Volume: 278, Issue:11

    Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cells, Cultured; Cyclin D1; Cyclin D2; Cyclin D3; Cyclins; Cysteine Endopeptidases; Dictyostelium; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; G1 Phase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HeLa Cells; Hexanones; Humans; Leupeptins; Lithium Chloride; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Resting Phase, Cell Cycle; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Umbilical Veins

2003
Novel development rescuing factors (DRFs) secreted by the developing Dictyostelium cells, that are involved in the restoration of a mutant lacking MAP-kinase ERK2.
    Zoological science, 2004, Volume: 21, Issue:8

    Topics: Animals; Cell Differentiation; Chromatography, High Pressure Liquid; Dictyostelium; Gene Expression Regulation, Developmental; Hexanones; Mitogen-Activated Protein Kinase 1; Morphogenesis; Pentanones; Signal Transduction

2004
Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.
    Journal of pharmacological sciences, 2015, Volume: 127, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Agents; beta Catenin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HCT116 Cells; Hexanones; Humans; Mice, Transgenic; Oxidative Stress; Proto-Oncogene Proteins c-myc; RNA, Messenger; Signal Transduction; Transcription Factor 7-Like 2 Protein; Wnt Signaling Pathway

2015