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1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and zidovudine

1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine has been researched along with zidovudine in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's15 (83.33)18.2507
2000's0 (0.00)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baba, M; De Clercq, E; Miyasaka, T; Nitta, I; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT3
Goudgaon, NM; Schinazi, RF1
Baba, M; Hayakawa, H; Miyasaka, T; Nitta, I; Sakamaki, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M1
Baba, M; Miyasaka, T; Nakashima, H; Nitta, I; Saito, S; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT1
Baba, M; Balzarini, J; De Clercq, E; Hayakawa, H; Miyasaka, T; Tanaka, H; Walker, RT1
Andreola, ML; Aubertin, AM; Bisagni, E; Dollé, V; Fan, E; Jamieson, G; Kirn, A; Nguyen, CH; Tarrago-Litvak, L1
Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Jimeno, ML; San-Félix, A; Velázquez, S1
Baba, M; De Clercq, E; Inouye, N; Miyasaka, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT1
Gam, J; Kim, DK; Kim, HT; Kim, KH; Kim, YW; Lim, J1
Borrell, JI; Clotet, B; Esté, JA; Giménez, L; Gonzalo, E; Pascual, R; Pettersson, S; Puig-de-la-Bellacasa, R; Teixidó, J1
Andries, K; De Clercq, E; Debyser, Z; Pauwels, R1
Baba, M; De Clercq, E; Mori, S; Nitta, I; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Umezu, K; Walker, RT1
Mitsuya, H1
Baba, M; Balzarini, J; De Clercq, E; Miyasaka, T; Nakashima, H; Pauwels, R; Perno, CF; Schols, D; Tanaka, H; Walker, RT1
Bader, JP; Boyer, PL; Buckheit, RW; Chu, SH; Fliakas-Boltz, V; Hughes, SH; Mayers, DL; Pan, BC; Weislow, O; Yeagy-Bargo, S1
Danel, K; el-Emam, AA; Larsen, E; Nielsen, C; Pedersen, EB; Vaaben, GB1

Reviews

1 review(s) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and zidovudine

ArticleYear
Specific HIV-1 reverse transcriptase inhibitors.
    Journal of enzyme inhibition, 1992, Volume: 6, Issue:1

    Topics: Antiviral Agents; Benzodiazepines; HIV Reverse Transcriptase; HIV-1; Imidazoles; Models, Genetic; Reverse Transcriptase Inhibitors; Thymine; Transcription, Genetic; Zidovudine

1992

Other Studies

17 other study(ies) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and zidovudine

ArticleYear
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
    Journal of medicinal chemistry, 1992, Dec-11, Volume: 35, Issue:25

    Topics: Antiviral Agents; Cells, Cultured; HIV-1; Structure-Activity Relationship; Thymine; Virus Replication

1992
Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:11

    Topics: Animals; Antiviral Agents; HIV-1; HIV-2; Humans; Lymphocytes; Pyrimidine Nucleosides; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Vero Cells

1991
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.
    Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2

    Topics: Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; HIV-1; HIV-2; Structure-Activity Relationship; Thymine; Virus Replication

1992
A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Antiviral Agents; Cell Line; Cell Survival; HIV-1; Humans; Indicators and Reagents; Molecular Structure; Structure-Activity Relationship; Thymine

1991
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: Antiviral Agents; Cell Line; Cells, Cultured; HIV-1; HIV-2; Humans; Indicators and Reagents; Lymphocyte Activation; Lymphocytes; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; Thymine

1991
Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: Animals; Antiviral Agents; Cell Line; HIV-1; Humans; Molecular Structure; Structure-Activity Relationship; Thymine; Virus Replication

1991
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:12

    Topics: Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; HIV-1; HIV-2; Mice; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymine; Virus Replication

1989
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
    Journal of medicinal chemistry, 1995, Nov-10, Volume: 38, Issue:23

    Topics: Antiviral Agents; HIV Reverse Transcriptase; HIV-1; HIV-2; Kinetics; Molecular Structure; Pyridones; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Virus Replication

1995
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.
    Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10

    Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Polymers; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine; Uridine; Zidovudine

1995
Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
    Journal of medicinal chemistry, 1995, Jul-21, Volume: 38, Issue:15

    Topics: Animals; Antiviral Agents; Benzyl Compounds; HIV Infections; HIV-1; Humans; Lymphocytes; Mice; Microbial Sensitivity Tests; Structure-Activity Relationship; Thymine

1995
Synthesis and anti-HIV-1 activity of a series of 1-alkoxy-5-alkyl-6-(arylthio)uracils.
    Journal of medicinal chemistry, 1997, Jul-18, Volume: 40, Issue:15

    Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Spectrophotometry, Infrared; Structure-Activity Relationship; Uracil

1997
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors.
    European journal of medicinal chemistry, 2012, Volume: 54

    Topics: Cell Line; Chemistry Techniques, Synthetic; Combinatorial Chemistry Techniques; Drug Design; HIV Reverse Transcriptase; HIV-1; Reverse Transcriptase Inhibitors; Thymine

2012
Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives.
    Molecular pharmacology, 1991, Volume: 39, Issue:6

    Topics: Antiviral Agents; HIV-1; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine; Zidovudine

1991
[Inhibitors of HIV-1 reverse transcriptase and protease as chemotherapeutics for AIDS].
    Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Didanosine; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Reverse Transcriptase Inhibitors; Thymine; Zalcitabine; Zidovudine

1991
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.
    Biochemical and biophysical research communications, 1989, Dec-29, Volume: 165, Issue:3

    Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; HIV Antigens; HIV-1; HIV-2; Lymphocytes; Macrophages; Thymine; Virus Replication; Zalcitabine; Zidovudine

1989
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.
    Virology, 1995, Jun-20, Volume: 210, Issue:1

    Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine; Uracil; Zidovudine

1995
Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives.
    Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1996, Volume: 50, Issue:5

    Topics: Antiviral Agents; Thymine; Zidovudine

1996