1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine has been researched along with zidovudine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 15 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baba, M; De Clercq, E; Miyasaka, T; Nitta, I; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT | 3 |
| Goudgaon, NM; Schinazi, RF | 1 |
| Baba, M; Hayakawa, H; Miyasaka, T; Nitta, I; Sakamaki, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M | 1 |
| Baba, M; Miyasaka, T; Nakashima, H; Nitta, I; Saito, S; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Hayakawa, H; Miyasaka, T; Tanaka, H; Walker, RT | 1 |
| Andreola, ML; Aubertin, AM; Bisagni, E; Dollé, V; Fan, E; Jamieson, G; Kirn, A; Nguyen, CH; Tarrago-Litvak, L | 1 |
| Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Jimeno, ML; San-Félix, A; Velázquez, S | 1 |
| Baba, M; De Clercq, E; Inouye, N; Miyasaka, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT | 1 |
| Gam, J; Kim, DK; Kim, HT; Kim, KH; Kim, YW; Lim, J | 1 |
| Borrell, JI; Clotet, B; Esté, JA; Giménez, L; Gonzalo, E; Pascual, R; Pettersson, S; Puig-de-la-Bellacasa, R; Teixidó, J | 1 |
| Andries, K; De Clercq, E; Debyser, Z; Pauwels, R | 1 |
| Baba, M; De Clercq, E; Mori, S; Nitta, I; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Umezu, K; Walker, RT | 1 |
| Mitsuya, H | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Miyasaka, T; Nakashima, H; Pauwels, R; Perno, CF; Schols, D; Tanaka, H; Walker, RT | 1 |
| Bader, JP; Boyer, PL; Buckheit, RW; Chu, SH; Fliakas-Boltz, V; Hughes, SH; Mayers, DL; Pan, BC; Weislow, O; Yeagy-Bargo, S | 1 |
| Danel, K; el-Emam, AA; Larsen, E; Nielsen, C; Pedersen, EB; Vaaben, GB | 1 |
1 review(s) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and zidovudine
| Article | Year |
|---|---|
Specific HIV-1 reverse transcriptase inhibitors.
Topics: Antiviral Agents; Benzodiazepines; HIV Reverse Transcriptase; HIV-1; Imidazoles; Models, Genetic; Reverse Transcriptase Inhibitors; Thymine; Transcription, Genetic; Zidovudine | 1992 |
17 other study(ies) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and zidovudine
| Article | Year |
|---|---|
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
Topics: Antiviral Agents; Cells, Cultured; HIV-1; Structure-Activity Relationship; Thymine; Virus Replication | 1992 |
Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes.
Topics: Animals; Antiviral Agents; HIV-1; HIV-2; Humans; Lymphocytes; Pyrimidine Nucleosides; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Vero Cells | 1991 |
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.
Topics: Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; HIV-1; HIV-2; Structure-Activity Relationship; Thymine; Virus Replication | 1992 |
A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
Topics: Antiviral Agents; Cell Line; Cell Survival; HIV-1; Humans; Indicators and Reagents; Molecular Structure; Structure-Activity Relationship; Thymine | 1991 |
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
Topics: Antiviral Agents; Cell Line; Cells, Cultured; HIV-1; HIV-2; Humans; Indicators and Reagents; Lymphocyte Activation; Lymphocytes; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; Thymine | 1991 |
Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
Topics: Animals; Antiviral Agents; Cell Line; HIV-1; Humans; Molecular Structure; Structure-Activity Relationship; Thymine; Virus Replication | 1991 |
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
Topics: Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; HIV-1; HIV-2; Mice; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymine; Virus Replication | 1989 |
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
Topics: Antiviral Agents; HIV Reverse Transcriptase; HIV-1; HIV-2; Kinetics; Molecular Structure; Pyridones; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Virus Replication | 1995 |
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.
Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Polymers; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine; Uridine; Zidovudine | 1995 |
Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
Topics: Animals; Antiviral Agents; Benzyl Compounds; HIV Infections; HIV-1; Humans; Lymphocytes; Mice; Microbial Sensitivity Tests; Structure-Activity Relationship; Thymine | 1995 |
Synthesis and anti-HIV-1 activity of a series of 1-alkoxy-5-alkyl-6-(arylthio)uracils.
Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Spectrophotometry, Infrared; Structure-Activity Relationship; Uracil | 1997 |
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors.
Topics: Cell Line; Chemistry Techniques, Synthetic; Combinatorial Chemistry Techniques; Drug Design; HIV Reverse Transcriptase; HIV-1; Reverse Transcriptase Inhibitors; Thymine | 2012 |
Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives.
Topics: Antiviral Agents; HIV-1; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine; Zidovudine | 1991 |
[Inhibitors of HIV-1 reverse transcriptase and protease as chemotherapeutics for AIDS].
Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Didanosine; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Reverse Transcriptase Inhibitors; Thymine; Zalcitabine; Zidovudine | 1991 |
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.
Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; HIV Antigens; HIV-1; HIV-2; Lymphocytes; Macrophages; Thymine; Virus Replication; Zalcitabine; Zidovudine | 1989 |
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.
Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine; Uracil; Zidovudine | 1995 |
Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives.
Topics: Antiviral Agents; Thymine; Zidovudine | 1996 |