1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and thymine

1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine has been researched along with thymine in 59 studies

*Thymine: One of four constituent bases of DNA. [MeSH]

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (3.39)	18.7374
1990's	30 (50.85)	18.2507
2000's	18 (30.51)	29.6817
2010's	7 (11.86)	24.3611
2020's	2 (3.39)	2.80

Authors

Authors	Studies
Andries, K; De Clercq, E; Debyser, Z; Pauwels, R	1
Baba, M; De Clercq, E; Debyser, Z; Desmyter, J; Pauwels, R; Vandamme, AM	1
Baba, M; De Clercq, E; Miyasaka, T; Nitta, I; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT	3
Baba, M; De Clercq, E; Ito, M; Miyasaka, T; Shigeta, S; Tanaka, H; Walker, RT	1
Baba, M; De Clercq, E; Mori, S; Nitta, I; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Umezu, K; Walker, RT	1
Mitsuya, H	1
De Clercq, E	2
Baba, M; Hayakawa, H; Miyasaka, T; Nitta, I; Sakamaki, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M	1
Baba, M; Miyasaka, T; Nakashima, H; Nitta, I; Saito, S; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT	1
Baba, M; De Clereq, E; Miyasaka, T; Nitta, I; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT	1
Baba, M; Balzarini, J; De Clercq, E; Hayakawa, H; Miyasaka, T; Tanaka, H; Walker, RT	1
Baba, M; Balzarini, J; De Clercq, E; Miyasaka, T; Nakashima, H; Pauwels, R; Perno, CF; Schols, D; Tanaka, H; Walker, RT	1
Baba, M; Miyasaka, T; Tanaka, H	1
Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Jimeno, ML; San-Félix, A; Velázquez, S	1
Baba, M; Balzarini, J; De Clercq, E	1
Bader, JP; Boyer, PL; Buckheit, RW; Chu, SH; Fliakas-Boltz, V; Hughes, SH; Mayers, DL; Pan, BC; Weislow, O; Yeagy-Bargo, S	1
Esnouf, R; Jones, Y; Ren, J; Ross, C; Stammers, D; Stuart, D	1
Baba, M; De Clercq, E; Inouye, N; Miyasaka, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT	1
Boyd, MR; Boyer, PL; Currens, MJ; Hughes, SH; McMahon, JB	1
Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Pérez-Pérez, MJ	1
Balzarini, J; De Clercq, E; Karlsson, A	1
Baba, M; Miyasaka, T; Niwa, T; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT; Yabuuchi, S; Yamamoto, M; Yuasa, S	1
Danel, K; el-Emam, AA; Larsen, E; Nielsen, C; Pedersen, EB; Vaaben, GB	1
Danel, K; Larsen, E; Nielsen, C; Pedersen, EB; Vestergaard, BF	1
Freeman, S; Gardiner, JM	1
Hannongbua, S; Lawtrakul, L; Limtrakul, J	1
Chrétien, JR; Grierson, DS; Kireev, DB; Monneret, C	1
Danel, K; Nielsen, C; Pedersen, EB	1
Beyer, A; Hannongbua, S; Lawtrakul, L; Wolschann, P	1
Gupta, S; Madan, AK; Singh, M	1
Bazoui, H; Boulajaaj, S; Sebti, S; Zahouily, M; Zakarya, D	2
Gaudio, AC; Montanari, CA	1
Balzarini, J; Chen, FE; De Clercq, E; Meng, G; Pannecouque, C	1
Hannongbua, S; Pungpo, P; Wolschann, P	1
Cherqaoui, D; Douali, L; Villemin, D	1
Fogel, GB; Weekes, D	1
Cherqaoui, D; Douali, L; Villemin, D; Zyad, A	1
Debnath, B; Gayen, S; Jha, T; Samanta, S	1
Bajaj, S; Madan, AK; Sambi, SS	1
Solov'ev, VP; Varnek, A	1
Chu, N; Guo, W; Hu, X; Yin, C	1
Afantitis, A; Igglessi-Markopoulou, O; Koutentis, PA; Markopoulos, J; Melagraki, G; Sarimveis, H	1
Balzarini, J; Chen, FE; De Clercq, E; Feng, XQ; Ji, L; Pannecouque, C	1
D'Cruz, OJ; Uckun, FM	1
Bennett, EM; Salomon, C; Vince, R; Wang, Z; Wilson, DJ	1
Dinarvand, R; Ganjali, MR; Norouzi, P; Pourbasheer, E; Riahi, S	1
Abbasitabar, F; Zare-Shahabadi, V	1
La Colla, P; Loddo, R; Loksha, YM; Pedersen, EB	1
Ai, C; Hao, M; Li, Y; Mao, Y; Zhang, S	1
Akyüz, L; Kaya, E; Sarıpınar, E; Yanmaz, E	1
Chen, W; Li, Z; Liu, X; Wu, J; Zhan, P	1
Borrell, JI; Clotet, B; Esté, JA; Giménez, L; Gonzalo, E; Pascual, R; Pettersson, S; Puig-de-la-Bellacasa, R; Teixidó, J	1
Miljković, FN; Toropov, AA; Toropova, AP; Veselinović, AM; Veselinović, JB	1
Campos Delgado, LE; Cañizares-Carmenate, Y; Castillo-Garit, JA; Torrens, F	1
Chen, FE; Chen, XM; De Clercq, E; Hao, QQ; Pannecouque, C; Wang, S	1

Reviews

7 review(s) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and thymine

Article	Year
Specific HIV-1 reverse transcriptase inhibitors. Journal of enzyme inhibition, 1992, Volume: 6, Issue:1 Topics: Antiviral Agents; Benzodiazepines; HIV Reverse Transcriptase; HIV-1; Imidazoles; Models, Genetic; Reverse Transcriptase Inhibitors; Thymine; Transcription, Genetic; Zidovudine	1992
[HEPT and its related compounds as anti-HIV agents]. Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51 Suppl Topics: Antiviral Agents; HIV Reverse Transcriptase; HIV-1; Molecular Conformation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine	1993
HIV resistance to reverse transcriptase inhibitors. Biochemical pharmacology, 1994, Jan-20, Volume: 47, Issue:2 Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Mutation; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Thymine	1994
Acyclic nucleosides as antiviral compounds. Molecular biotechnology, 1996, Volume: 5, Issue:2 Topics: 2-Aminopurine; Acyclovir; Acylation; Animals; Antiviral Agents; Famciclovir; HIV-1; Humans; Nucleosides; Pentosyltransferases; Prodrugs; Thymine	1996
Comparative QSAR based on neural networks for the anti-HIV activity of HEPT derivatives. Current pharmaceutical design, 2003, Volume: 9, Issue:22 Topics: Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Humans; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2003
Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase. Journal of enzyme inhibition and medicinal chemistry, 2006, Volume: 21, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Anti-Retroviral Agents; Chemistry, Pharmaceutical; Drug Design; Drug Industry; HIV; HIV Reverse Transcriptase; Humans; Models, Chemical; Models, Molecular; Mutation; Pyrimidines; Reverse Transcriptase Inhibitors; Thiazoles; Thymine; Triazoles	2006
The development of HEPT-type HIV non-nucleoside reverse transcriptase inhibitors and its implications for DABO family. Current pharmaceutical design, 2012, Volume: 18, Issue:27 Topics: Anti-HIV Agents; Crystallography, X-Ray; Drug Design; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine	2012

Other Studies

52 other study(ies) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and thymine

Article	Year
Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine The Journal of biological chemistry, 1992, Jun-15, Volume: 267, Issue:17 Topics: Allosteric Regulation; Antiviral Agents; Base Sequence; Benzodiazepines; Cell Line; Deoxyguanine Nucleotides; Dideoxynucleotides; Electrophoresis, Agar Gel; HIV Reverse Transcriptase; HIV-1; Imidazoles; Kinetics; Molecular Sequence Data; Monocytes; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine; Transcription, Genetic; Virus Replication	1992
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. Journal of medicinal chemistry, 1992, Dec-11, Volume: 35, Issue:25 Topics: Antiviral Agents; Cells, Cultured; HIV-1; Structure-Activity Relationship; Thymine; Virus Replication	1992
Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT) and recombinant alpha interferon. Antiviral research, 1991, Volume: 15, Issue:4 Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytopathogenic Effect, Viral; Drug Synergism; Drug Therapy, Combination; HIV-1; Humans; Interferon Type I; Recombinant Proteins; Thymine; Virus Replication	1991
Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives. Molecular pharmacology, 1991, Volume: 39, Issue:6 Topics: Antiviral Agents; HIV-1; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine; Zidovudine	1991
[Inhibitors of HIV-1 reverse transcriptase and protease as chemotherapeutics for AIDS]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:9 Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Didanosine; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Reverse Transcriptase Inhibitors; Thymine; Zalcitabine; Zidovudine	1991
Chemotherapy of the acquired immune deficiency syndrome (AIDS): non-nucleoside inhibitors of the human immunodeficiency virus type 1 reverse transcriptase. International journal of immunopharmacology, 1991, Volume: 13 Suppl 1 Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Benzodiazepines; HIV-1; Humans; Imidazoles; Reverse Transcriptase Inhibitors; Thymine; Virus Replication	1991
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity. Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2 Topics: Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; HIV-1; HIV-2; Structure-Activity Relationship; Thymine; Virus Replication	1992
A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Antiviral Agents; Cell Line; Cell Survival; HIV-1; Humans; Indicators and Reagents; Molecular Structure; Structure-Activity Relationship; Thymine	1991
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Journal of medicinal chemistry, 1991, Volume: 34, Issue:4 Topics: Antiviral Agents; Cell Line; Cells, Cultured; HIV-1; HIV-2; Humans; Indicators and Reagents; Lymphocyte Activation; Lymphocytes; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; Thymine	1991
Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. Journal of medicinal chemistry, 1991, Volume: 34, Issue:4 Topics: Animals; Antiviral Agents; Cell Line; HIV-1; Humans; Molecular Structure; Structure-Activity Relationship; Thymine; Virus Replication	1991
Synthesis of novel 6-substituted acyclouridine derivatives and their anti-HIV-1 activity. Nucleic acids symposium series, 1990, Issue:22 Topics: Antiviral Agents; HIV-1; Molecular Structure; Thymine	1990
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. Journal of medicinal chemistry, 1989, Volume: 32, Issue:12 Topics: Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; HIV-1; HIV-2; Mice; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymine; Virus Replication	1989
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative. Biochemical and biophysical research communications, 1989, Dec-29, Volume: 165, Issue:3 Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; HIV Antigens; HIV-1; HIV-2; Lymphocytes; Macrophages; Thymine; Virus Replication; Zalcitabine; Zidovudine	1989
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase. Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10 Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Polymers; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine; Uridine; Zidovudine	1995
Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:4 Topics: Antiviral Agents; HIV Reverse Transcriptase; HIV-1; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine	1995
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase. Virology, 1995, Jun-20, Volume: 210, Issue:1 Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine; Uracil; Zidovudine	1995
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nature structural biology, 1995, Volume: 2, Issue:4 Topics: Antiviral Agents; Binding Sites; Crystallography, X-Ray; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Protein Conformation; Protein Structure, Secondary; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine	1995
Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. Journal of medicinal chemistry, 1995, Jul-21, Volume: 38, Issue:15 Topics: Animals; Antiviral Agents; Benzyl Compounds; HIV Infections; HIV-1; Humans; Lymphocytes; Mice; Microbial Sensitivity Tests; Structure-Activity Relationship; Thymine	1995
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase. Journal of virology, 1993, Volume: 67, Issue:4 Topics: Amino Acid Sequence; Antiviral Agents; Benzimidazoles; Coumarins; Drug Resistance, Microbial; HIV; HIV Reverse Transcriptase; Pyranocoumarins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Thymine	1993
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus. Virology, 1993, Volume: 196, Issue:2 Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Microbial Sensitivity Tests; Molecular Sequence Data; Nevirapine; Piperazines; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis; Spiro Compounds; Thymidine; Thymine; Uridine; Virus Replication	1993
Human immunodeficiency virus type 1 drug-resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. Molecular pharmacology, 1993, Volume: 44, Issue:4 Topics: Antiviral Agents; Base Sequence; DNA Primers; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Polydeoxyribonucleotides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Templates, Genetic; Thymine	1993
Effect of human serum on the in vitro anti-HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding. Biochemical pharmacology, 1993, Jun-22, Volume: 45, Issue:12 Topics: Acetylcysteine; Antiviral Agents; Blood; Blood Proteins; Cell Line; HIV-1; Protein Binding; Thymine; Virus Replication	1993
Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives. Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1996, Volume: 50, Issue:5 Topics: Antiviral Agents; Thymine; Zidovudine	1996
Synthesis and potent anti-HIV-1 activity of novel 6-benzyluracil analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. Journal of medicinal chemistry, 1996, Jun-07, Volume: 39, Issue:12 Topics: Alkylation; Antiviral Agents; Cell Division; Drug Design; HIV-1; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; T-Lymphocytes; Thymine; Uracil; Virus Replication	1996
Structure-activity correlation study of HIV-1 inhibitors: electronic and molecular parameters. Journal of computer-aided molecular design, 1996, Volume: 10, Issue:2 Topics: Antiviral Agents; Confidence Intervals; Drug Design; HIV-1; Models, Molecular; Molecular Conformation; Predictive Value of Tests; Regression Analysis; Reproducibility of Results; Structure-Activity Relationship; Thymine	1996
A 3D QSAR study of a series of HEPT analogues: the influence of conformational mobility on HIV-1 reverse transcriptase inhibition. Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26 Topics: Anti-HIV Agents; Drug Design; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Binding; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine	1997
Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones. Journal of medicinal chemistry, 1998, Jan-15, Volume: 41, Issue:2 Topics: Alkylation; Anti-HIV Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mesylates; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thiazoles; Thymine; Uracil; Virus Replication	1998
Conformational study of the HIV-1 reverse transcriptase inhibitor 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Biological chemistry, 1999, Volume: 380, Issue:2 Topics: Anti-HIV Agents; HIV Reverse Transcriptase; Humans; Molecular Structure; Reverse Transcriptase Inhibitors; Thymine	1999
Predicting anti-HIV activity: computational approach using a novel topological descriptor. Journal of computer-aided molecular design, 2001, Volume: 15, Issue:7 Topics: Anti-HIV Agents; Computer Simulation; Databases, Factual; Drug Design; HIV Reverse Transcriptase; Humans; Models, Chemical; Structure-Activity Relationship; Thymine	2001
Structure-cytotoxicity relationships for a series of HEPT derivatives. Journal of molecular modeling, 2002, Volume: 8, Issue:1 Topics: Animals; Anti-HIV Agents; Cell Line; Cell Survival; Linear Models; Neural Networks, Computer; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine	2002
HEPT derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase: QSAR studies agree with the crystal structures. Journal of computer-aided molecular design, 2002, Volume: 16, Issue:4 Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Drug Design; HIV Reverse Transcriptase; Models, Molecular; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2002
QSAR for anti-HIV activity of HEPT derivatives. SAR and QSAR in environmental research, 2002, Volume: 13, Issue:6 Topics: Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Linear Models; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2002
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues. Chemical & pharmaceutical bulletin, 2003, Volume: 51, Issue:7 Topics: Cell Line; HIV Reverse Transcriptase; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine; Uracil	2003
Hologram quantitative structure-activity relationships investigations of non-nucleoside reverse transcriptase inhibitors. Current medicinal chemistry, 2003, Volume: 10, Issue:17 Topics: Anti-HIV Agents; Benzodiazepines; HIV Reverse Transcriptase; Humans; Imidazoles; Molecular Structure; Pyridines; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2003
Evolutionary optimization, backpropagation, and data preparation issues in QSAR modeling of HIV inhibition by HEPT derivatives. Bio Systems, 2003, Volume: 72, Issue:1-2 Topics: Algorithms; Artificial Intelligence; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Lethal Dose 50; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Thymine	2003
Artificial neural networks: non-linear QSAR studies of HEPT derivatives as HIV-1 reverse transcriptase inhibitors. Molecular diversity, 2004, Volume: 8, Issue:1 Topics: Anti-HIV Agents; Drug Design; HIV Reverse Transcriptase; HIV-1; Molecular Structure; Neural Networks, Computer; Nonlinear Dynamics; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2004
QSAR study on some anti-HIV HEPT analogues using physicochemical and topological parameters. Bioorganic & medicinal chemistry, 2004, Mar-15, Volume: 12, Issue:6 Topics: Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2004
Topochemical model for prediction of anti-HIV activity of HEPT analogs. Bioorganic & medicinal chemistry letters, 2005, Jan-17, Volume: 15, Issue:2 Topics: Anti-HIV Agents; Computer Simulation; Databases, Factual; Flavonoids; Models, Chemical; Predictive Value of Tests; Structure-Activity Relationship; Thymine	2005
"In silico" design of potential anti-HIV actives using fragment descriptors. Combinatorial chemistry & high throughput screening, 2005, Volume: 8, Issue:5 Topics: Anti-HIV Agents; Benzodiazepines; Combinatorial Chemistry Techniques; Drug Design; HIV; Imidazoles; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Thymine; Virus Replication	2005
Quantitative structure-activity relationship studies on HEPTs by supervised stochastic resonance. Bioorganic & medicinal chemistry letters, 2006, Jun-01, Volume: 16, Issue:11 Topics: Molecular Structure; Quantitative Structure-Activity Relationship; Stochastic Processes; Thymine	2006
A novel simple QSAR model for the prediction of anti-HIV activity using multiple linear regression analysis. Molecular diversity, 2006, Volume: 10, Issue:3 Topics: Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Humans; Linear Models; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2006
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues. Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:9 Topics: Anti-HIV Agents; Binding Sites; Cell Line; Cell Proliferation; Chemical Phenomena; Chemistry, Physical; Drug Design; HIV Reverse Transcriptase; Humans; Hydrogen Bonding; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Stereoisomerism; Thymine	2006
Rationally designed dual inhibitors of HIV reverse transcriptase and integrase. Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15 Topics: Anti-HIV Agents; Crystallography, X-Ray; HIV Integrase Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; In Vitro Techniques; Ketones; Leukocytes, Mononuclear; Models, Molecular; Structure-Activity Relationship; Thymine	2007
Quantitative structure-activity relationship study on the anti-HIV-1 activity of novel 6-naphthylthio HEPT analogs. Chemical biology & drug design, 2009, Volume: 74, Issue:2 Topics: Algorithms; Anti-HIV Agents; Cell Line; HIV-1; Humans; Quantitative Structure-Activity Relationship; Software; Thymine	2009
Application of ant colony optimization in development of models for prediction of anti-HIV-1 activity of HEPT derivatives. Journal of computational chemistry, 2010, Volume: 31, Issue:12 Topics: Algorithms; Animals; Anti-HIV Agents; Ants; Artificial Intelligence; Drug Design; Models, Biological; Pheromones; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2010
Synthesis and anti-HIV-1 activity of new fluoro-HEPT analogues: an investigation on fluoro versus hydroxy substituents. Archiv der Pharmazie, 2011, Volume: 344, Issue:6 Topics: Anti-HIV Agents; Fluorine; HIV-1; Structure-Activity Relationship; Thymine	2011
Docking, molecular dynamics and quantitative structure-activity relationship studies for HEPTs and DABOs as HIV-1 reverse transcriptase inhibitors. Journal of molecular modeling, 2012, Volume: 18, Issue:5 Topics: Amino Acids; Anti-HIV Agents; Binding Sites; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; Protein Binding; Pyrimidinones; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2012
4D-QSAR study of HEPT derivatives by electron conformational-genetic algorithm method. SAR and QSAR in environmental research, 2012, Volume: 23, Issue:5-6 Topics: Algorithms; Anti-HIV Agents; Drug Discovery; HIV-1; Models, Chemical; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2012
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors. European journal of medicinal chemistry, 2012, Volume: 54 Topics: Cell Line; Chemistry Techniques, Synthetic; Combinatorial Chemistry Techniques; Drug Design; HIV Reverse Transcriptase; HIV-1; Reverse Transcriptase Inhibitors; Thymine	2012
QSAR models for HEPT derivates as NNRTI inhibitors based on Monte Carlo method. European journal of medicinal chemistry, 2014, Apr-22, Volume: 77 Topics: Anti-HIV Agents; Computer-Aided Design; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; Inhibitory Concentration 50; Molecular Structure; Monte Carlo Method; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Thymine	2014
Thorough evaluation of OECD principles in modelling of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives using QSARINS. SAR and QSAR in environmental research, 2020, Volume: 31, Issue:10 Topics: Anti-Retroviral Agents; Models, Chemical; Organisation for Economic Co-Operation and Development; Quantitative Structure-Activity Relationship; Thymine	2020
Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorganic chemistry, 2023, Volume: 133 Topics: Anti-HIV Agents; HIV Reverse Transcriptase; Molecular Docking Simulation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine	2023