1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine has been researched along with nevirapine in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balzarini, J; Camarasa, MJ; De Clercq, E; Pérez-Pérez, MJ; San-Félix, A | 1 |
| Darby, G; Esnouf, R; Garman, E; Jones, Y; Keeling, J; Kirby, I; Ren, J; Ross, C; Somers, D; Stuart, D | 1 |
| Jorgensen, WL; Rizzo, RC; Tirado-Rives, J | 1 |
| Jorgensen, WL; Kroeger Smith, MB; Rizzo, RC; Smith, RH; Tirado-Rives, J; Udier-Blagović, M; Wang, DP; Watkins, EK | 1 |
| Artico, M; Cadeddu, A; La Colla, P; Mai, A; Marturana, F; Massa, S; Mura, M; Musiu, C; Ragno, R; Sbardella, G | 1 |
| Balzarini, J; Chen, F; De Clercq, E; He, Y; Pannecouque, C; Sun, G; Wang, Y | 1 |
| Kang, X; Kollman, PA; Kuntz, ID; Wang, J | 1 |
| Balzarini, J; Chen, FE; De Clercq, E; Ji, L; Pannecouque, C | 1 |
| Borrell, JI; Clotet, B; Esté, JA; Giménez, L; Gonzalo, E; Pascual, R; Pettersson, S; Puig-de-la-Bellacasa, R; Teixidó, J | 1 |
| De Clercq, E | 1 |
| Bader, JP; Boyer, PL; Buckheit, RW; Chu, SH; Fliakas-Boltz, V; Hughes, SH; Mayers, DL; Pan, BC; Weislow, O; Yeagy-Bargo, S | 1 |
| Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Pérez-Pérez, MJ | 1 |
1 review(s) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and nevirapine
| Article | Year |
|---|---|
HIV resistance to reverse transcriptase inhibitors.
Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Mutation; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Thymine | 1994 |
11 other study(ies) available for 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine and nevirapine
| Article | Year |
|---|---|
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (
Topics: Antiviral Agents; Cells, Cultured; HIV-1; HIV-2; Humans; Molecular Structure; Pyrimidine Nucleosides; Simian Immunodeficiency Virus; Tumor Cells, Cultured; Virus Replication | 1992 |
High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Computer Graphics; Crystallography, X-Ray; Drug Design; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nevirapine; Point Mutation; Protein Conformation; Protein Structure, Secondary; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 1995 |
Estimation of binding affinities for HEPT and nevirapine analogues with HIV-1 reverse transcriptase via Monte Carlo simulations.
Topics: Anti-HIV Agents; HIV Reverse Transcriptase; Models, Molecular; Monte Carlo Method; Nevirapine; Protein Binding; Pyrimidinones; Regression Analysis; Reverse Transcriptase Inhibitors; Thermodynamics; Uracil | 2001 |
Prediction of activity for nonnucleoside inhibitors with HIV-1 reverse transcriptase based on Monte Carlo simulations.
Topics: Alkynes; Anilides; Benzoxazines; Computer Simulation; Cyclopropanes; HIV Reverse Transcriptase; Hydrogen Bonding; Models, Molecular; Monte Carlo Method; Nevirapine; Oxazines; Protein Binding; Quinoxalines; Regression Analysis; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil | 2002 |
Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C varia
Topics: Cell Line; Computer Simulation; Drug Design; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Models, Molecular; Mutation; Pyrimidinones; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors | 2004 |
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.
Topics: Anti-HIV Agents; Cell Line; HIV Reverse Transcriptase; Humans; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors | 2004 |
Hierarchical database screenings for HIV-1 reverse transcriptase using a pharmacophore model, rigid docking, solvation docking, and MM-PB/SA.
Topics: Allosteric Site; Anti-HIV Agents; Crystallography, X-Ray; Databases, Factual; Drug Design; HIV Reverse Transcriptase; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Statistics as Topic; Thermodynamics | 2005 |
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Cell Line, Tumor; Crystallography, X-Ray; HIV Reverse Transcriptase; Humans; Models, Molecular; Molecular Structure; Nitriles; Pyrimidinones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2007 |
Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors.
Topics: Cell Line; Chemistry Techniques, Synthetic; Combinatorial Chemistry Techniques; Drug Design; HIV Reverse Transcriptase; HIV-1; Reverse Transcriptase Inhibitors; Thymine | 2012 |
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.
Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine; Uracil; Zidovudine | 1995 |
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.
Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Microbial Sensitivity Tests; Molecular Sequence Data; Nevirapine; Piperazines; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis; Spiro Compounds; Thymidine; Thymine; Uridine; Virus Replication | 1993 |