Page last updated: 2024-09-03

(tetrazol-5-yl)glycine and glycine

(tetrazol-5-yl)glycine has been researched along with glycine in 13 studies

Compound Research Comparison

Studies
((tetrazol-5-yl)glycine)
Trials
((tetrazol-5-yl)glycine)
Recent Studies (post-2010)
((tetrazol-5-yl)glycine)
Studies
(glycine)
Trials
(glycine)
Recent Studies (post-2010) (glycine)
140135,1637568,415

Protein Interaction Comparison

ProteinTaxonomy(tetrazol-5-yl)glycine (IC50)glycine (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.4852
Sodium- and chloride-dependent glycine transporter 1Homo sapiens (human)106
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.3253
Sodium- and chloride-dependent glycine transporter 2Homo sapiens (human)128

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (61.54)18.2507
2000's4 (30.77)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Calligaro, DO; Heinz, LJ; Lunn, WH; O'Malley, PJ; Salhoff, CR; Schoepp, DD; Vasileff, RT1
Leander, JD; Lodge, D; Lunn, WH; Millar, JD; Sacaan, AI; Schoepp, DD; Smith, CL1
Oja, SS; Saransaari, P1
Lunn, WH; McDonald, JW; Salhoff, CR; Schoepp, DD1
Lookingland, KJ; Moore, KE; Wagner, EJ1
Bains, JS; Ferguson, AV1
Bonaventure, N; Jardon, BL1
Lembeck, F; Sieler, D1
Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F1
Camaioni, E; Costantino, G; Maltoni, K; Marinozzi, M; Pellicciari, R; Pin, JP; Prezeau, L1
Duncan, GE; Farrington, JS; Inada, K; Koller, BH; Moy, SS1
Duncan, GE; Farrington, JS; Inada, K; Koller, BH1
An, Y; Belevych, N; Chen, Q; Herschman, H; Quan, N; Wang, Y; Zhang, H1

Other Studies

13 other study(ies) available for (tetrazol-5-yl)glycine and glycine

ArticleYear
DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy.
    Journal of medicinal chemistry, 1992, Nov-27, Volume: 35, Issue:24

    Topics: Animals; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Molecular Structure; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles

1992
D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist.
    European journal of pharmacology, 1991, Oct-15, Volume: 203, Issue:2

    Topics: Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures; Tetrazoles; Tritium

1991
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors.
    Mechanisms of ageing and development, 1994, Oct-20, Volume: 76, Issue:2-3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dizocilpine Maleate; Female; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Glutamate; Tetrazoles

1994
The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin.
    European journal of pharmacology, 1994, Jan-03, Volume: 270, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glycine; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazoles

1994
Sexual differences in N-methyl-D-aspartate receptor-mediated regulation of tuberoinfundibular dopaminergic neurons in the rat.
    Brain research, 1993, May-14, Volume: 611, Issue:1

    Topics: Animals; Dizocilpine Maleate; Dopamine; Female; Glycine; Hypothalamus, Middle; Male; Neurons; Pipecolic Acids; Prolactin; Rats; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Tetrazoles

1993
Nitric oxide regulates NMDA-driven GABAergic inputs to type I neurones of the rat paraventricular nucleus.
    The Journal of physiology, 1997, Mar-15, Volume: 499 ( Pt 3)

    Topics: Animals; Bicuculline; Enzyme Inhibitors; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Membrane Potentials; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrazoles

1997
Involvement of NMDA in a plasticity phenomenon observed in the adult frog monocular optokinetic nystagmus.
    Vision research, 1997, Volume: 37, Issue:11

    Topics: Animals; Dark Adaptation; Glycine; N-Methylaspartate; Neuronal Plasticity; Nystagmus, Optokinetic; Photic Stimulation; Rana esculenta; Sensory Deprivation; Superior Colliculi; Tetrazoles; Time Factors; Vision, Monocular

1997
In vivo effects of the NMDA receptor agonist tetrazolyl-glycine related to the function of small-diameter primary afferents.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:1

    Topics: Afferent Pathways; Anesthesia; Animals; Blood Pressure; Capillary Permeability; Capsaicin; Decerebrate State; Electric Stimulation; Excitatory Amino Acid Agonists; Female; Glycine; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Skin; Tetrazoles

1999
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
    Neurochemistry international, 2001, Volume: 38, Issue:1

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles

2001
Synthesis and biological evaluation of 2-(3'-(1H-tetrazol-5-yl) bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:2

    Topics: Cell Line; Glutamine; Glycine; Humans; Inhibitory Concentration 50; Inositol Phosphates; Models, Molecular; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Tetrazoles

2001
Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: effects of clozapine and haloperidol.
    Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:7

    Topics: Animals; Clozapine; Glycine; Haloperidol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles

2007
Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction.
    Brain research, 2008, Jul-24, Volume: 1221

    Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Glutamic Acid; Glycine; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Seizures; Septal Nuclei; Solitary Nucleus; Synaptic Transmission; Tetrazoles

2008
Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge.
    Journal of neuroscience research, 2014, Volume: 92, Issue:4

    Topics: Analysis of Variance; Animals; Antigens, Differentiation; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation; Glycine; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Phosphopyruvate Hydratase; Tetrazoles

2014