(endo-n-8-methyl-8-azabicyclo-(3.2.1)oct-3-yl)-2-3-dihydro-3-isopropyl-2-oxo-1h-benzimidazol-1-carboxamide has been researched along with prucalopride* in 1 studies
1 other study(ies) available for (endo-n-8-methyl-8-azabicyclo-(3.2.1)oct-3-yl)-2-3-dihydro-3-isopropyl-2-oxo-1h-benzimidazol-1-carboxamide and prucalopride
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In-vitro acetylcholine release is not a straightforward model to study hippocampal 5-HT₄ receptors.
5-HT₄ receptor (5-HT₄R) activation induces procognitive effects. This might be related to stimulation of hippocampal acetylcholine release, which has been shown for 5-HT₄R agonists in in-vivo models. We investigated the influence of the 5-HT₄R agonists, prucalopride and BIMU-8, on acetylcholine release in rat hippocampal brain slices. In contrast to the report by Siniscalchi et al., no facilitating effect of 5-HT₄R agonists on electrically evoked acetylcholine could be shown. The in our hands absence of an effect by 5-HT₄R agonists illustrates that an in-vitro evaluation of 5-HT₄R agonists on hippocampal acetylcholine release is not a straightforward model to study the relationship between hippocampal 5-HT₄Rs and hippocampal acetylcholine release. Topics: Acetylcholine; Animals; Benzimidazoles; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Guinea Pigs; Hippocampus; Male; Models, Animal; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Synaptic Transmission | 2011 |