(endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide has been researched along with tropisetron in 4 studies
| Studies ((endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide) | Trials ((endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide) | Recent Studies (post-2010) ((endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide) | Studies (tropisetron) | Trials (tropisetron) | Recent Studies (post-2010) (tropisetron) |
|---|---|---|---|---|---|
| 24 | 0 | 0 | 944 | 218 | 150 |
| Protein | Taxonomy | (endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide (IC50) | tropisetron (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 3.1623 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 3.1623 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 3.45 | |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | 1.8 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.488 | |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | 1.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donetti, A; Giraldo, E; Maiocchi, L; Micheletti, R; Nicola, M; Quintero, MG; Turconi, M | 1 |
| Coccini, T; Manzo, L; Onori, L; Rizzi, CA; Tonini, M | 1 |
| Bockaert, J; Dumuis, A; Ladinsky, H; Monferini, E; Nicola, M; Sebben, M; Turconi, M | 1 |
| Contesse, V; Delarue, C; Hamel, C; Lefebvre, H; Vaudry, H | 1 |
4 other study(ies) available for (endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide and tropisetron
| Article | Year |
|---|---|
Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists.
Topics: Animals; Benzimidazoles; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chemical Phenomena; Chemistry; Computer Simulation; Hydrogen Bonding; Indoles; Models, Molecular; Molecular Structure; Radioligand Assay; Rats; Receptors, Serotonin; Reflex; Serotonin Antagonists; Structure-Activity Relationship; Tropisetron | 1990 |
Benzimidazolone derivatives: a new class of 5-hydroxytryptamine4 receptor agonists with prokinetic and acetylcholine releasing properties in the guinea pig ileum.
Topics: Acetylcholine; Animals; Benzimidazoles; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Electric Stimulation; Guinea Pigs; Ileum; Indoles; Male; Muscle, Smooth; Peristalsis; Receptors, Serotonin; Serotonin Antagonists; Tropisetron | 1992 |
Azabicycloalkyl benzimidazolone derivatives as a novel class of potent agonists at the 5-HT4 receptor positively coupled to adenylate cyclase in brain.
Topics: Adenylyl Cyclases; Animals; Benzimidazoles; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Cyclic AMP; Drug Interactions; Indoles; Mice; Neurons; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropisetron | 1991 |
Effect of a series of 5-HT4 receptor agonists and antagonists on steroid secretion by the adrenal gland in vitro.
Topics: Adrenal Glands; Aldosterone; Animals; Benzamides; Benzimidazoles; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Corticosterone; Dose-Response Relationship, Drug; Indoles; Male; Radioligand Assay; Ranidae; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tropisetron | 1994 |