(endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide has been researched along with benztropine in 1 studies
| Studies ((endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide) | Trials ((endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide) | Recent Studies (post-2010) ((endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide) | Studies (benztropine) | Trials (benztropine) | Recent Studies (post-2010) (benztropine) |
|---|---|---|---|---|---|
| 24 | 0 | 0 | 735 | 93 | 85 |
| Protein | Taxonomy | (endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide (IC50) | benztropine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.061 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 1.391 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.0366 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0037 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.002 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.544 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0005 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.065 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.395 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.0106 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.391 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.206 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.052 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.024 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.061 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0032 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.654 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.2 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 2.788 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.2948 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.139 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Childers, SR; Mach, RH; West, T; Whirrett, BR; Wu, L | 1 |
1 other study(ies) available for (endo-n-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazol-1-carboxamide and benztropine
| Article | Year |
|---|---|
The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors.
Topics: Analgesics; Animals; Atropine; Benzimidazoles; Benztropine; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Butyrates; Guinea Pigs; In Vitro Techniques; Ligands; Muscarinic Antagonists; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Receptors, sigma; Serotonin Antagonists; Sigma-1 Receptor; Structure-Activity Relationship; Tropanes | 1999 |