(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide has been researched along with capsazepine in 11 studies
| Studies ((e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide) | Trials ((e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide) | Recent Studies (post-2010) ((e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide) | Studies (capsazepine) | Trials (capsazepine) | Recent Studies (post-2010) (capsazepine) |
|---|---|---|---|---|---|
| 85 | 0 | 65 | 781 | 3 | 273 |
| Protein | Taxonomy | (e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide (IC50) | capsazepine (IC50) |
|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | 0.4293 | |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | 0.2587 | |
| Transient receptor potential cation channel subfamily V member 4 | Rattus norvegicus (Norway rat) | 0.6333 | |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | 0.6333 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bo, Y; Chakrabarti, PP; Chen, N; Doherty, EM; Fotsch, C; Gavva, N; Han, N; Kelly, MG; Kincaid, J; Klionsky, L; Liu, Q; Norman, MH; Ognyanov, VI; Tamir, R; Treanor, JJ; Wang, X; Zhu, J | 1 |
| Westaway, SM | 1 |
| Lee, LY; Ni, D | 1 |
| Lee, JS; Ro, JY; Zhang, Y | 1 |
| Brennan, FX; Bryant, RW; Devantier, HR; Long, DJ; Palmer, RK; Salemme, FR | 1 |
| Barahona, MV; Bustamante, S; Carballido, J; Fernandes, VS; García-Sacristán, A; Hernández, M; Martínez, AC; Martínez-Sáenz, A; Orensanz, LM; Prieto, D; Recio, P; Ribeiro, AS | 1 |
| Cai, J; Guo, J; Liu, FY; Sun, WL; Wan, Y; Xing, GG; Yang, F | 1 |
| Ide, S; Kojima, S; Nakanishi, Y; Nishino, K; Tanamachi, K; Tanuma, S; Tsukimoto, M | 1 |
| Hayakawa, C; Ikeda, K; Irie, S; Kawakami, K; Kotani, S; Lin, ST; Onimaru, H; Tani, M | 1 |
| Bae, IH; Burns, A; Choi, G; Choi, JK; Fagg, R; Gatfield, KM; Lee, CS; Naidoo, AA; Park, M; Park, YH; Powell, AJ; Vidgeon-Hart, M | 1 |
| Aso, H; Suemaru, K; Watanabe, M; Yoshikawa, M | 1 |
1 review(s) available for (e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide and capsazepine
| Article | Year |
|---|---|
The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.
Topics: Analgesics; Animals; Capsaicin; Humans; Pain; TRPV Cation Channels | 2007 |
10 other study(ies) available for (e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide and capsazepine
| Article | Year |
|---|---|
Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.
Topics: Administration, Oral; Animals; Biochemistry; Biological Availability; Calcium; Capsaicin; CHO Cells; Cinnamates; Cricetinae; Cricetulus; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Ion Channels; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Structure-Activity Relationship; TRPV Cation Channels | 2005 |
Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons.
Topics: Acrylamides; Animals; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Evoked Potentials; Hexamethonium; Hydrogen-Ion Concentration; Hyperthermia, Induced; Lung; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Temperature; TRPV Cation Channels; Vagus Nerve | 2008 |
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.
Topics: Acrylamides; Afferent Pathways; Animals; Ankyrins; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Hyperalgesia; Injections, Intramuscular; Male; Masticatory Muscles; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.
Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels | 2010 |
Hydrogen sulfide mediated inhibitory neurotransmission to the pig bladder neck: role of KATP channels, sensory nerves and calcium signaling.
Topics: Acetanilides; Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Calcium Signaling; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Glyburide; Guanylate Cyclase; Hydrogen Sulfide; Indomethacin; KATP Channels; Morpholines; Muscle, Smooth; Organothiophosphorus Compounds; Phenylephrine; Pituitary Adenylate Cyclase-Activating Polypeptide; Purines; Pyrazoles; Sensory Receptor Cells; Swine; Synaptic Transmission; Urinary Bladder | 2013 |
The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Central Nervous System Agents; Electric Stimulation; Formaldehyde; Freund's Adjuvant; Long-Term Potentiation; Male; Microelectrodes; Nociception; Posterior Horn Cells; Rats, Sprague-Dawley; Sciatic Nerve; TRPV Cation Channels | 2014 |
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.
Topics: Acrylamides; Anilides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line, Tumor; Cell Survival; Cinnamates; DNA Damage; Gamma Rays; Humans; Mice; Necrosis; Neoplasms; Pyrazines; Pyridines; Radiation-Sensitizing Agents; TRPV Cation Channels | 2016 |
Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats.
Topics: Acrylamides; Animals; Animals, Newborn; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Medulla Oblongata; Membrane Potentials; Neurons; Rats; Rats, Wistar; Respiration; Spinal Cord; TRPV Cation Channels; Voltage-Sensitive Dye Imaging | 2017 |
Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment.
Topics: Acrylamides; Animals; Anthracenes; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line; Cell Proliferation; Cell Survival; Cocarcinogenesis; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Piperidines; Primary Cell Culture; Pyridines; Pyrrolidines; Risk; Skin Neoplasms; TRPV Cation Channels; Urea | 2018 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Piperidines; Purines; Pyrazoles; Seizures; Time Factors; TRPV Cation Channels | 2018 |