(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide has been researched along with capsaicin in 29 studies
| Studies ((e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide) | Trials ((e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide) | Recent Studies (post-2010) ((e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide) | Studies (capsaicin) | Trials (capsaicin) | Recent Studies (post-2010) (capsaicin) |
|---|---|---|---|---|---|
| 85 | 0 | 65 | 11,238 | 661 | 3,410 |
| Protein | Taxonomy | (e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide (IC50) | capsaicin (IC50) |
|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | 0.019 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 0.6 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 3 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 2.6755 | |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | 0.008 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 22 (75.86) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bannon, AW; Doherty, EM; Gavva, NR; Immke, D; Klionsky, L; Louis, JC; Norman, MH; Porreca, F; Qu, Y; Tamir, R; Treanor, JJ; Vanderah, TW; Wang, J; Wild, KD; Zhang, TJ; Zhu, D | 1 |
| Bannon, AW; Deng, H; Gavva, NR; Gore, A; Han, B; Hovland, DN; Juan, T; Klionsky, L; Kuang, R; Le, A; Lehto, SG; Louis, JC; Magal, E; Norman, MH; Surapaneni, S; Tamir, R; Treanor, JJ; Wang, J; Youngblood, B; Zhu, D | 1 |
| Cristino, L; Davison, JS; Di Marzo, V; Guglielmotti, V; Oland, LD; Pittman, QJ; Sharkey, KA; Starowicz, K; Van Sickle, MD | 1 |
| Lee, LY; Ni, D | 1 |
| Banerjee, B; Lehmann, A; Medda, BK; Peles, S; Sengupta, JN; Shaker, R; Zhang, Z | 1 |
| Lee, JS; Ro, JY; Zhang, Y | 1 |
| Brennan, FX; Bryant, RW; Devantier, HR; Long, DJ; Palmer, RK; Salemme, FR | 1 |
| de Oliveira, SM; Ferreira, J; Gomez, MV; Hoffmeister, C; Rossato, MF; Trevisan, G | 1 |
| Benoit, M; Chen, X; Gudermann, T; Hofmann, T; Janssens, A; Kerselaers, S; Nilius, B; Oberwinkler, J; Owsianik, G; Philipp, SE; Stab, J; Vennekens, R; Voets, T; Vriens, J; Xue, F | 1 |
| Bakó, P; Czikora, Á; Édes, I; Facskó, A; Kark, T; Lizanecz, E; Magyar, J; Papp, Z; Pórszász, R; Rutkai, I; Ruzsnavszky, F; Tóth, A | 1 |
| Albrecht, D; Kulisch, C | 1 |
| Bouyer, PG; Matthews, JB; Shen, L; Tang, X; Turner, JR; Weber, CR | 1 |
| Chung, MK; Ro, JY; Saloman, JL | 1 |
| Barahona, MV; Bustamante, S; Carballido, J; Fernandes, VS; García-Sacristán, A; Hernández, M; Martínez, AC; Martínez-Sáenz, A; Orensanz, LM; Prieto, D; Recio, P; Ribeiro, AS | 1 |
| Córdova, MM; Montrucchio, DP; Santos, AR | 1 |
| Cai, J; Guo, J; Liu, FY; Sun, WL; Wan, Y; Xing, GG; Yang, F | 1 |
| Hu, Y; Liu, Z; Pasricha, PJ; Undem, BJ; Yu, S; Yu, X | 1 |
| Hu, Y; Yu, S; Yu, X | 2 |
| Clifton, HL; Inceoglu, B; Ma, L; Schaefer, S; Zheng, J | 1 |
| He, Q; Jian, T; Lan, L; Shi, H; Tang, M; Tang, Z; Wang, C; Wang, Z; Wu, G; Yang, N; Yang, Y; Yu, G; Yuan, X; Zhu, C | 1 |
| Belanger-Willoughby, N; Hirasawa, M; Linehan, V | 1 |
| Ide, S; Kojima, S; Nakanishi, Y; Nishino, K; Tanamachi, K; Tanuma, S; Tsukimoto, M | 1 |
| Bradshaw, H; Carey, LM; Cornett, B; Hohmann, AG; Leishman, E; Mackie, K; Slivicki, RA | 1 |
| Hayakawa, C; Ikeda, K; Irie, S; Kawakami, K; Kotani, S; Lin, ST; Onimaru, H; Tani, M | 1 |
| Bae, IH; Burns, A; Choi, G; Choi, JK; Fagg, R; Gatfield, KM; Lee, CS; Naidoo, AA; Park, M; Park, YH; Powell, AJ; Vidgeon-Hart, M | 1 |
| Davidova, A; Lesperance, LS; Macpherson, A; Mouchbahani-Constance, S; Petitjean, H; Prescott, SA; Sharif-Naeini, R | 1 |
| Aso, H; Suemaru, K; Watanabe, M; Yoshikawa, M | 1 |
| Bang, SH; Chang, SE; Moon, IJ; Song, Y | 1 |
29 other study(ies) available for (e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide and capsaicin
| Article | Year |
|---|---|
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
Topics: Acrylamides; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Humans; Hyperalgesia; Inflammation; Motor Activity; Neurons; Pain Measurement; Patch-Clamp Techniques; Protons; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Transfection | 2005 |
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation.
Topics: Acrylamides; Animals; Benzothiazoles; Blood-Brain Barrier; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cells, Cultured; CHO Cells; Conserved Sequence; Cricetinae; Cricetulus; Dogs; Female; Fever; Humans; Hypothermia; Macaca fascicularis; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfonamides; Thiourea; TRPV Cation Channels | 2007 |
Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.
Topics: Acrylamides; Animals; Antiemetics; Arachidonic Acids; Area Postrema; Autonomic Pathways; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Cannabinoids; Capsaicin; Dopamine; Emetics; Endocannabinoids; Ferrets; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Solitary Nucleus; TRPV Cation Channels; Vagus Nerve; Vomiting | 2007 |
Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons.
Topics: Acrylamides; Animals; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Evoked Potentials; Hexamethonium; Hydrogen-Ion Concentration; Hyperthermia, Induced; Lung; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Temperature; TRPV Cation Channels; Vagus Nerve | 2008 |
Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats.
Topics: Acrylamides; Afferent Pathways; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Chronic Disease; Esophagitis, Peptic; Esophagus; Hydrochloric Acid; Hydrogen-Ion Concentration; Male; Mechanotransduction, Cellular; Nerve Fibers; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiourea; TRPV Cation Channels; Vagus Nerve | 2009 |
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.
Topics: Acrylamides; Afferent Pathways; Animals; Ankyrins; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Hyperalgesia; Injections, Intramuscular; Male; Masticatory Muscles; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.
Topics: Acrylamides; Administration, Oral; Alkaloids; Anilides; Animals; Avoidance Learning; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Diterpenes; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazines; Pyridines; Taste; TRPM Cation Channels; TRPV Cation Channels | 2010 |
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Cromolyn Sodium; Disease Models, Animal; Diterpenes; Edema; Gabexate; Histamine; Male; Mast Cells; Methysergide; Pain; Promethazine; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Serotonin; Serotonin Antagonists; Tritium; TRPV Cation Channels; Uric Acid | 2011 |
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Capsaicin; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Humans; Hyperalgesia; Inflammation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nifedipine; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Plant Oils; Pregnenolone; Sensory Receptor Cells; Telemetry; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPM Cation Channels | 2011 |
Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1.
Topics: Acrylamides; Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; CHO Cells; Coronary Vessels; Cricetinae; Cricetulus; Dogs; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Myocytes, Smooth Muscle; Rats; Rats, Wistar; Sensory Receptor Cells; Structure-Activity Relationship; TRPV Cation Channels; Vasoconstriction; Vasoconstrictor Agents | 2012 |
Effects of single swim stress on changes in TRPV1-mediated plasticity in the amygdala.
Topics: Acrylamides; Amygdala; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dopamine; Electric Stimulation; Extracellular Space; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Stress, Psychological; Swimming; TRPV Cation Channels | 2013 |
Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.
Topics: Acrylamides; Animals; Biotinylation; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Cell Line; Chlorides; Colforsin; Colon; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Electric Conductivity; Epithelial Cells; Humans; Immunohistochemistry; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Time Factors; TRPV Cation Channels | 2013 |
P2X₃ and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons.
Topics: Acrylamides; Anesthetics, Local; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Cells, Cultured; Hyperalgesia; Male; Masseter Muscle; Phosphorylation; Purinergic P2X Receptor Agonists; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Sensory Receptor Cells; Sensory System Agents; Skin; Touch; Trigeminal Ganglion; TRPV Cation Channels | 2013 |
Hydrogen sulfide mediated inhibitory neurotransmission to the pig bladder neck: role of KATP channels, sensory nerves and calcium signaling.
Topics: Acetanilides; Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Calcium Signaling; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Glyburide; Guanylate Cyclase; Hydrogen Sulfide; Indomethacin; KATP Channels; Morpholines; Muscle, Smooth; Organothiophosphorus Compounds; Phenylephrine; Pituitary Adenylate Cyclase-Activating Polypeptide; Purines; Pyrazoles; Sensory Receptor Cells; Swine; Synaptic Transmission; Urinary Bladder | 2013 |
Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels.
Topics: Acetone; Acrolein; Acrylamides; Acute Disease; Alkaloids; Analgesics; Animals; Aporphines; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Chronic Pain; Cold Temperature; Freund's Adjuvant; Gene Expression; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Pain Measurement; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2013 |
The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Central Nervous System Agents; Electric Stimulation; Formaldehyde; Freund's Adjuvant; Long-Term Potentiation; Male; Microelectrodes; Nociception; Posterior Horn Cells; Rats, Sprague-Dawley; Sciatic Nerve; TRPV Cation Channels | 2014 |
Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilic Esophagitis; Esophagus; Guinea Pigs; Heartburn; Hydrogen-Ion Concentration; Male; Membrane Potentials; Nodose Ganglion; Ovalbumin; Time Factors; TRPV Cation Channels; Vagotomy; Vagus Nerve | 2014 |
Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus.
Topics: Acids; Acrylamides; Action Potentials; Amiloride; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Esophagus; Guinea Pigs; Heartburn; In Vitro Techniques; Male; Nerve Fibers, Unmyelinated; Nociception; Nodose Ganglion; TRPV Cation Channels; Vagus Nerve | 2014 |
TRPV1 channels are involved in niacin-induced cutaneous vasodilation in mice.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Flushing; Mice; Mice, Knockout; Niacin; Sensory System Agents; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2015 |
TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch.
Topics: Acetanilides; Acrylamides; Animals; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Histamine Agonists; Imidazoles; Mice; Neurons; Piperidines; Pruritus; Purines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; TRPV Cation Channels; Type C Phospholipases | 2016 |
Thermosensing mechanisms and their impairment by high-fat diet in orexin neurons.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Diet, High-Fat; Excitatory Postsynaptic Potentials; Hot Temperature; Hypothalamic Area, Lateral; Hypothalamic Hormones; Iridoids; KATP Channels; Male; Melanins; Miniature Postsynaptic Potentials; Neurons; Neurotransmitter Agents; Orexins; Patch-Clamp Techniques; Pituitary Hormones; Rats, Sprague-Dawley; Thermosensing; Tissue Culture Techniques; TRPV Cation Channels; Uncoupling Protein 2 | 2016 |
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.
Topics: Acrylamides; Anilides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line, Tumor; Cell Survival; Cinnamates; DNA Damage; Gamma Rays; Humans; Mice; Necrosis; Neoplasms; Pyrazines; Pyridines; Radiation-Sensitizing Agents; TRPV Cation Channels | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels | 2016 |
Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats.
Topics: Acrylamides; Animals; Animals, Newborn; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Medulla Oblongata; Membrane Potentials; Neurons; Rats; Rats, Wistar; Respiration; Spinal Cord; TRPV Cation Channels; Voltage-Sensitive Dye Imaging | 2017 |
Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment.
Topics: Acrylamides; Animals; Anthracenes; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line; Cell Proliferation; Cell Survival; Cocarcinogenesis; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Piperidines; Primary Cell Culture; Pyridines; Pyrrolidines; Risk; Skin Neoplasms; TRPV Cation Channels; Urea | 2018 |
Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors.
Topics: Acrylamides; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Binding Proteins; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fish Venoms; Ganglia, Spinal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Hyperalgesia; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurogenic Inflammation; Oncogene Proteins v-fos; Pain; Pain Measurement; Sensory Receptor Cells; Time Factors; Touch; TRPV Cation Channels | 2018 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Piperidines; Purines; Pyrazoles; Seizures; Time Factors; TRPV Cation Channels | 2018 |
QX-314 inhibits acid-induced activation of esophageal nociceptive C fiber neurons.
Topics: Acrylamides; Action Potentials; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Esophagus; Guinea Pigs; Hydrochloric Acid; Lidocaine; Nerve Fibers, Unmyelinated; Nociception; Patch-Clamp Techniques; TRPV Cation Channels | 2019 |
Transient receptor potential vanilloid 1 (TRPV1) inhibition is related to the suppression of inflammation-associated hypermelanosis.
Topics: Acrylamides; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line; Dermatitis, Contact; Facial Dermatoses; Humans; Immunohistochemistry; Melanocytes; Melanosis; Skin; TRPV Cation Channels; Up-Regulation | 2020 |