(8)-shogaol and (10)-shogaol

(8)-shogaol has been researched along with (10)-shogaol* in 2 studies

Other Studies

2 other study(ies) available for (8)-shogaol and (10)-shogaol

Article	Year
Formation of 6-, 8- and 10-Shogaol in Ginger through Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity. Molecules (Basel, Switzerland), 2018, 07-05, Volume: 23, Issue:7 Topics: Anti-Infective Agents; Antioxidants; Catechols; Chromatography, High Pressure Liquid; Desiccation; Fatty Alcohols; Gram-Negative Bacteria; Gram-Positive Bacteria; Guaiacol; Microbial Sensitivity Tests; Oils, Volatile; Plant Extracts; Plant Oils; Zingiber officinale	2018
Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol. Molecular nutrition & food research, 2013, Volume: 57, Issue:3 Shogaols, a series of major constituents in dried ginger with the most abundant being [6]-, [8]-, and [10]-shogaols, show much higher anticancer potencies than gingerols. Previously, we reported the mercapturic acid pathway as a major metabolic route for [6]-shogaol in mice. However, it is still unclear how the side chain length affects the metabolism of shogaols and how shogaols are metabolized in humans.. We first investigate the metabolism of [10]-shogaol in mouse urine, and then investigate the biotransformation of shogaols in human urine. Our results show that eight major thiol-conjugated metabolites of [10]-shogaol were detected in mouse urine, while six major thiol-conjugated metabolites of [6]-shogaol, two thiol-conjugated metabolites of [8]-shogaol, and two thiol-conjugated metabolites of [10]-shogaol were detected in urine collected from human after drinking ginger tea, using LC/ESI-MS/MS. Our results clearly indicate the mercapturic acid pathway is a major metabolic route for [10]-shogaol in mice and for shogaols in human. Furthermore, we also investigated the regulation of glutathione (GSH) by [6]-shogaol in human colon cancer cells HCT-116. Our results show [6]-shogaol, after initially depleting glutathione levels, can subsequently restore and increase GSH levels over time.. Shogaols are metabolized extensively in mouse and human to form thiol-conjugated metabolites and GSH might play an important role in the cancer-preventive activity of ginger. Topics: Acetylcysteine; Adult; Animals; Antineoplastic Agents, Phytogenic; Beverages; Catechols; Cell Line, Tumor; Female; Glutathione; Guaiacol; HCT116 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Sulfhydryl Compounds; Tandem Mass Spectrometry; Zingiber officinale	2013

Article

Year

Formation of 6-, 8- and 10-Shogaol in Ginger through Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity.

Molecules (Basel, Switzerland), 2018, 07-05, Volume: 23, Issue:7

Topics: Anti-Infective Agents; Antioxidants; Catechols; Chromatography, High Pressure Liquid; Desiccation; Fatty Alcohols; Gram-Negative Bacteria; Gram-Positive Bacteria; Guaiacol; Microbial Sensitivity Tests; Oils, Volatile; Plant Extracts; Plant Oils; Zingiber officinale

2018

Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.

Molecular nutrition & food research, 2013, Volume: 57, Issue:3

Shogaols, a series of major constituents in dried ginger with the most abundant being [6]-, [8]-, and [10]-shogaols, show much higher anticancer potencies than gingerols. Previously, we reported the mercapturic acid pathway as a major metabolic route for [6]-shogaol in mice. However, it is still unclear how the side chain length affects the metabolism of shogaols and how shogaols are metabolized in humans.. We first investigate the metabolism of [10]-shogaol in mouse urine, and then investigate the biotransformation of shogaols in human urine. Our results show that eight major thiol-conjugated metabolites of [10]-shogaol were detected in mouse urine, while six major thiol-conjugated metabolites of [6]-shogaol, two thiol-conjugated metabolites of [8]-shogaol, and two thiol-conjugated metabolites of [10]-shogaol were detected in urine collected from human after drinking ginger tea, using LC/ESI-MS/MS. Our results clearly indicate the mercapturic acid pathway is a major metabolic route for [10]-shogaol in mice and for shogaols in human. Furthermore, we also investigated the regulation of glutathione (GSH) by [6]-shogaol in human colon cancer cells HCT-116. Our results show [6]-shogaol, after initially depleting glutathione levels, can subsequently restore and increase GSH levels over time.. Shogaols are metabolized extensively in mouse and human to form thiol-conjugated metabolites and GSH might play an important role in the cancer-preventive activity of ginger.

Topics: Acetylcysteine; Adult; Animals; Antineoplastic Agents, Phytogenic; Beverages; Catechols; Cell Line, Tumor; Female; Glutathione; Guaiacol; HCT116 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Sulfhydryl Compounds; Tandem Mass Spectrometry; Zingiber officinale

2013