Compounds > (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
Page last updated: 2024-08-16

(3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone and anandamide

(3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone has been researched along with anandamide in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (16.67)18.2507
2000's10 (55.56)29.6817
2010's4 (22.22)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Bisogno, T; Brizzi, A; Brizzi, V; Cascio, MG; Di Marzo, V; Sirianni, R1
Blond, O; Briley, EM; Felder, CC; Joyce, KE; Lai, Y; Ma, AL; Mackie, K; Mansouri, J; Mitchell, RL1
Abood, ME; Compton, DR; Martin, BR; Showalter, VM1
Fan, P; Goutopoulos, A; Khanolkar, AD; Lin, S; Makriyannis, A; Papahadjis, D; Qin, C1
Bianchi, A; Cruciani, G; Fichera, M; Musumarra, G1
Fernández-Ruiz, J; González, S; Lastres-Becker, I; López-Rodríguez, ML; Ortega-Gutiérrez, S; Ramos, JA; Viso, A1
Abood, ME; Anavi-Goffer, S; Barnett-Norris, J; Hurst, DP; Lynch, DL; McAllister, SD; Reggio, PH; Rizvi, G1
Fowler, CJ; Lambert, DM1
Buonerba, M; Cascio, MG; Cavallo, P; De Martino, G; Di Marzo, V; Saturnino, C; Urbani, P1
Bisogno, T; Brizzi, A; Brizzi, V; Cascio, MG; Di Marzo, V; Dinatolo, MT; Martinelli, A; Tuccinardi, T1
Angus, JA; Christopoulos, A; McRae, K; Moloney, GP; Robertson, AD; Robinson, M; Stoermer, MJ; Wright, CE1
Brizzi, A; Brizzi, V; Cascio, MG; Corelli, F; Di Marzo, V; Guida, F; Ligresti, A; Maione, S; Martinelli, A; Pasquini, S; Tuccinardi, T1
Cano, C; Goya, P; Martín, MI; Páez, JA; Pavón, J; Rodríguez de Fonseca, F; Serrano, A; Suardíaz, M1
Aiello, F; Biotti, I; Brizzi, A; Brizzi, V; Cascio, MG; Corelli, F; Di Marzo, V; Frosini, M; Ligresti, A; Pertwee, RG1
Buzard, DJ; Han, S; Jones, RM; Thatte, J1
Aiello, F; Brizzi, A; Brizzi, V; Cascio, MG; Corelli, F; De Petrocellis, L; Di Marzo, V; Lamponi, S; Ligresti, A; Luongo, L; Maione, S; Marini, P; Pertwee, RG1
Carrillo-Salinas, FJ; Fernández-Ruiz, J; Franco, R; Gómez-Cañas, M; Goya, P; Guaza, C; Hurst, DP; Jagerovic, N; Lagartera, L; Morales, P; Navarro, G; Pazos, R; Reggio, PH1
Aiello, F; Boccella, S; Brizzi, A; Cascio, MG; Corelli, F; De Petrocellis, L; Di Marzo, V; Frosini, M; Gado, F; Ligresti, A; Luongo, L; Maione, S; Manera, C; Marini, P; Mugnaini, C; Pertwee, RG; Pessina, F1

Reviews

2 review(s) available for (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone and anandamide

ArticleYear
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.
    Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16

    Topics: Amides; Amidohydrolases; Amines; Animals; Arachidonic Acids; Binding Sites; Cannabinoid Receptor Modulators; Drug Design; Endocannabinoids; Esters; Ethers; Glycerides; Humans; Ligands; Monoacylglycerol Lipases; Polyunsaturated Alkamides; Receptors, Cannabinoid

2005
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.
    Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21

    Topics: Animals; Drug Design; Humans; Ligands; Models, Molecular; Molecular Conformation; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Substrate Specificity

2013

Other Studies

16 other study(ies) available for (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone and anandamide

ArticleYear
Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors.
    Journal of medicinal chemistry, 2005, Nov-17, Volume: 48, Issue:23

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Brain; Caproates; Cell Line; Cyclic AMP; Drug Design; Endocannabinoids; Fatty Acids; In Vitro Techniques; Ligands; Membrane Transport Proteins; Palmitates; Polyunsaturated Alkamides; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spleen; Structure-Activity Relationship

2005
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.
    Molecular pharmacology, 1995, Volume: 48, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amidohydrolases; Animals; Arachidonic Acids; Base Sequence; Binding, Competitive; Calcium; Calcium Channel Blockers; Cannabinoids; CHO Cells; Cricetinae; Endocannabinoids; Enzyme Activation; Humans; Intracellular Fluid; Ion Channels; Kinetics; Mice; Molecular Sequence Data; Phospholipases; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection

1995
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3

    Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Guanine Nucleotides; Humans; Ligands; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Sodium; Structure-Activity Relationship; Transfection

1996
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.
    Journal of medicinal chemistry, 1998, Dec-31, Volume: 41, Issue:27

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Cannabinoids; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Mice; Polyunsaturated Alkamides; Radioligand Assay; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Serine Proteinase Inhibitors; Spleen; Structure-Activity Relationship; Tosyl Compounds

1998
A 3D-QSAR study on the structural requirements for binding to CB(1) and CB(2) cannabinoid receptors.
    Journal of medicinal chemistry, 2000, Jun-15, Volume: 43, Issue:12

    Topics: Arachidonic Acids; Cannabinoids; Drug Design; Endocannabinoids; Indoles; Ligands; Models, Biological; Models, Molecular; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship

2000
Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.
    Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26

    Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Carrier Proteins; Cell Line; Cerebellum; Drug Design; Endocannabinoids; Furans; Humans; In Vitro Techniques; Membranes; Polyunsaturated Alkamides; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord; Structure-Activity Relationship

2001
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.
    Journal of medicinal chemistry, 2003, Nov-20, Volume: 46, Issue:24

    Topics: Benzoxazines; Binding Sites; Cyclohexanols; Humans; Immunochemistry; Ligands; Models, Molecular; Morpholines; Naphthalenes; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant

2003
New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies.
    Bioorganic & medicinal chemistry letters, 2006, Jan-01, Volume: 16, Issue:1

    Topics: Amides; Amidohydrolases; Arachidonic Acid; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line; Chemistry, Pharmaceutical; Chromatography; Drug Design; Endocannabinoids; Fatty Acids; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Models, Chemical; Polyunsaturated Alkamides; Protein Binding; Protein Structure, Tertiary; Receptors, Cannabinoid; Recombinant Proteins

2006
Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.
    Bioorganic & medicinal chemistry, 2007, Aug-15, Volume: 15, Issue:16

    Topics: Chemical Phenomena; Chemistry, Physical; Drug Design; Ligands; Models, Molecular; Molecular Structure; Receptors, Cannabinoid; Structure-Activity Relationship

2007
Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Analgesics; Animals; Binding Sites; Cannabinoids; Drug Design; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Indoles; Inhibitory Concentration 50; Mice; Oxadiazoles; Rats; Receptor, Cannabinoid, CB1; Substrate Specificity

2008
New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.
    Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8

    Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chlorocebus aethiops; COS Cells; Drug Partial Agonism; Endocannabinoids; Humans; Ligands; Mice; Models, Molecular; Pain Measurement; Phenols; Polyunsaturated Alkamides; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Stereotyped Behavior; Structure-Activity Relationship

2009
Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:12

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cells, Cultured; Endocannabinoids; Enzyme Inhibitors; Male; Molecular Structure; Polyunsaturated Alkamides; Rats; Sulfonamides; Vas Deferens

2009
Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor.
    Journal of medicinal chemistry, 2011, Dec-22, Volume: 54, Issue:24

    Topics: Animals; Arachidonic Acids; Brain; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 CYP3A; Endocannabinoids; Esterases; Esters; Ethers; Glycerides; HEK293 Cells; Humans; In Vitro Techniques; Mice; Molecular Mimicry; Monoglycerides; Phenols; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Stereoisomerism; Structure-Activity Relationship

2011
Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.
    Bioorganic & medicinal chemistry, 2014, Sep-01, Volume: 22, Issue:17

    Topics: Analgesics; Animals; Calcium Channels; Cell Survival; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Humans; Ligands; Male; Mice; Molecular Structure; Nerve Tissue Proteins; NIH 3T3 Cells; Nociception; Pain; Pain Measurement; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Structure-Activity Relationship; Transient Receptor Potential Channels; TRPA1 Cation Channel

2014
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.
    Journal of medicinal chemistry, 2016, 07-28, Volume: 59, Issue:14

    Topics: Dose-Response Relationship, Drug; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Multiple Sclerosis; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship

2016
Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity.
    Bioorganic & medicinal chemistry, 2020, 06-01, Volume: 28, Issue:11

    Topics: Amides; Analgesics; Animals; Cell Line; Dose-Response Relationship, Drug; Humans; Male; Mice; Molecular Structure; Rats; Receptors, Cannabinoid; Resorcinols; Structure-Activity Relationship; TRPV Cation Channels

2020