(3R-5S)-fluvastatin and mevastatin

(3R-5S)-fluvastatin has been researched along with mevastatin* in 1 studies

Other Studies

1 other study(ies) available for (3R-5S)-fluvastatin and mevastatin

Article	Year
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton. Among them, sodium (E,3R,5S)-7-(2-(4-fluorophenyl)-4-(3-phenylpentan-3-yl)phenyl)-3,5-dihydroxy-hept-6-enoate showed potent HMG-CoA reductase-inhibitory activity comparable with that of clinically useful mevastatin. Topics: Androgens; Animals; Chemistry, Pharmaceutical; Drug Design; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitory Concentration 50; Lovastatin; Models, Chemical; Molecular Structure; Pentanes; Rats; Structure-Activity Relationship	2009

Article

Year

Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.

Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton. Among them, sodium (E,3R,5S)-7-(2-(4-fluorophenyl)-4-(3-phenylpentan-3-yl)phenyl)-3,5-dihydroxy-hept-6-enoate showed potent HMG-CoA reductase-inhibitory activity comparable with that of clinically useful mevastatin.

Topics: Androgens; Animals; Chemistry, Pharmaceutical; Drug Design; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitory Concentration 50; Lovastatin; Models, Chemical; Molecular Structure; Pentanes; Rats; Structure-Activity Relationship

2009