(3-nitrobenzoyl)alanine has been researched along with ro 61-8048 in 7 studies
| Studies ((3-nitrobenzoyl)alanine) | Trials ((3-nitrobenzoyl)alanine) | Recent Studies (post-2010) ((3-nitrobenzoyl)alanine) | Studies (ro 61-8048) | Trials (ro 61-8048) | Recent Studies (post-2010) (ro 61-8048) |
|---|---|---|---|---|---|
| 15 | 0 | 3 | 46 | 0 | 24 |
| Protein | Taxonomy | (3-nitrobenzoyl)alanine (IC50) | ro 61-8048 (IC50) |
|---|---|---|---|
| Kynurenine 3-monooxygenase | Homo sapiens (human) | 0.0813 | |
| Kynurenine 3-monooxygenase | Rattus norvegicus (Norway rat) | 0.0295 | |
| Kynurenine 3-monooxygenase | Mus musculus (house mouse) | 0.09 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cesura, AM; Huguenin, P; Kettler, R; Röver, S; Szente, A | 1 |
| Dounay, AB; Tuttle, JB; Verhoest, PR | 1 |
| Chiarugi, A; Moroni, F; Rapizzi, E | 1 |
| Carpenedo, R; Cozzi, A; Moroni, F | 1 |
| Chiarugi, A; Moroni, F | 1 |
| Carpenedo, R; Cozzi, A; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F | 1 |
| Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F | 1 |
1 review(s) available for (3-nitrobenzoyl)alanine and ro 61-8048
| Article | Year |
|---|---|
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.
Topics: Animals; Antineoplastic Agents; Central Nervous System Diseases; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Signal Transduction; Transaminases | 2015 |
6 other study(ies) available for (3-nitrobenzoyl)alanine and ro 61-8048
| Article | Year |
|---|---|
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.
Topics: Animals; Brain; Enzyme Inhibitors; Extracellular Space; Gerbillinae; Kidney; Kinetics; Kynurenic Acid; Kynurenine 3-Monooxygenase; Liver; Mitochondria; Mixed Function Oxygenases; Molecular Structure; Neuroprotective Agents; Rats; Structure-Activity Relationship; Sulfonamides; Thiazoles | 1997 |
The kynurenine metabolic pathway in the eye: studies on 3-hydroxykynurenine, a putative cataractogenic compound.
Topics: Alanine; Animals; Cataract; Ciliary Body; Eye; Hydrolases; Iris; Kynurenine; Kynurenine 3-Monooxygenase; Lens, Crystalline; Lyases; Male; Mixed Function Oxygenases; Rabbits; Sulfonamides; Thiazoles; Tissue Distribution; Transaminases; Tryptophan Oxygenase | 1999 |
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Enzyme Inhibitors; Gerbillinae; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles | 1999 |
Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase.
Topics: Alanine; Animals; Brain; Enzyme Inhibitors; Hydroxylation; Kynurenine 3-Monooxygenase; Liver; Male; Mice; Mixed Function Oxygenases; Pokeweed Mitogens; Quinolinic Acid; Spleen; Sulfonamides; Thiazoles | 1999 |
Neuroprotective effects of kynurenine-3-hydroxylase inhibitors in models of brain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Gerbillinae; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Sulfonamides; Thiazoles | 1999 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles | 2002 |