(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine has been researched along with piperidines in 8 studies
| Studies ((2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine) | Trials ((2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine) | Recent Studies (post-2010) ((2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 9 | 0 | 1 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Armour, DR; Bays, DE; Evans, B; Giblin, GM; Heron, N; Hubbard, T; Liang, K; Middlemiss, D; Mordaunt, J; Ward, P | 1 |
| Beattie, DT; Beresford, IJ; Birch, PJ; Bowers, J; Connor, HE; Hagan, RM; Hawcock, AB; Marshall, FH; Ward, P | 1 |
| Bountra, C; Dale, TJ; Gale, JD; Gardner, CJ; Jordan, CC; Kilpatrick, GJ; Twissell, DJ; Ward, P | 1 |
| Armour, DR; Beattie, DT; Gale, JD; Gardner, CJ; Hawcock, AB; Kilpatrick, GJ; Twissell, DJ; Ward, P | 1 |
| Alfieri, A; Gardner, C | 1 |
| Alfieri, AB; Gardner, CJ | 1 |
| Bergström, M; Cable, KM; Fasth, KJ; Kilpatrick, G; Långström, B; Sutherland, DR; Ward, P; Wipperman, MD | 1 |
| Gallantine, EL; Meert, TF | 1 |
8 other study(ies) available for (2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine and piperidines
| Article | Year |
|---|---|
Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity.
Topics: Animals; Antiemetics; Biological Availability; Cell Membrane; CHO Cells; Cricetinae; Dogs; Female; Ferrets; Gerbillinae; Magnetic Resonance Spectroscopy; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Tachykinins; Tetrazoles; Vomiting; Whole-Body Irradiation | 1995 |
The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist.
Topics: Animals; Binding, Competitive; Brain; Cattle; Cells, Cultured; Cerebral Arteries; CHO Cells; Cricetinae; Dogs; Ferrets; Gerbillinae; Hemodynamics; Humans; Ileum; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Portal Vein; Rabbits; Rats; Receptors, Neurotransmitter; Substance P; Tetrazoles; Transfection | 1995 |
The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040.
Topics: Animals; Antiemetics; Dogs; Dose-Response Relationship, Drug; Emetics; Ferrets; Male; Motion Sickness; Neurokinin-1 Receptor Antagonists; Piperidines; Radiation Injuries, Experimental; Shrews; Tetrazoles; Vomiting | 1995 |
GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity.
Topics: Administration, Oral; Animals; Antiemetics; Cisplatin; Dogs; Dose-Response Relationship, Drug; Ferrets; Humans; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Shrews; Stereoisomerism; Tetrazoles | 1996 |
The NK1 antagonist GR203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder.
Topics: Animals; Blood Proteins; Cyclophosphamide; Ferrets; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Tetrazoles; Urinary Bladder | 1997 |
Effects of GR203040, an NK1 antagonist, on radiation- and cisplatin-induced tissue damage in the ferret.
Topics: Animals; Antiemetics; Antineoplastic Agents; Capillary Permeability; Cisplatin; Duodenum; Ferrets; Histocytochemistry; Jejunum; Kidney; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Tetrazoles; Urinary Bladder; Whole-Body Irradiation | 1998 |
Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171--PET studies in rhesus monkey.
Topics: Animals; Brain; Carbon Radioisotopes; Ligands; Macaca mulatta; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Binding; Receptors, Neurokinin-1; Tetrazoles; Tomography, Emission-Computed | 2000 |
Attenuation of the gerbil writhing response by mu-, kappa- and delta-opioids, and NK-1, -2 and -3 receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdomen; Acetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; Biphenyl Compounds; Butanols; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Fentanyl; Gerbillinae; Malates; Morphine; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Pain Measurement; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrazoles | 2004 |