Compounds > (1-2-bis(1-2-benzisoselenazolone-3(2h)-ketone))ethane

(1-2-bis(1-2-benzisoselenazolone-3(2h)-ketone))ethane and ebselen

(1-2-bis(1-2-benzisoselenazolone-3(2h)-ketone))ethane has been researched along with ebselen* in 1 studies

Other Studies

1 other study(ies) available for (1-2-bis(1-2-benzisoselenazolone-3(2h)-ketone))ethane and ebselen

Article	Year
Synthesis and in vitro antiproliferative evaluation of novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone. Chemical & pharmaceutical bulletin, 2015, Volume: 63, Issue:6 Novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone were designed, synthesized and evaluated for their in vitro antiproliferative activities by CCK-8 assay against three types of human cancer cell lines, SMMC-7721, MCF-7 and A549 cells. The preliminary bioassay results demonstrated that all tested compounds 4a-p showed potent antiproliferative activities, and some compounds exhibited better effects than positive control ethaselen and 5-fluorouracil (5-FU) against various cancer cell lines. Furthermore, compound 4g showed significant antiproliferative activities against SMMC-7721 cells with an IC50 value of 2.08 µM. Compounds 4b and 4m displayed highly effective biological activities against MCF-7 cells with an IC50 values of 2.03 and 2.06 µM, respectively. Compound 4i exhibited the best inhibitory effect against A549 cells with an IC50 value of 1.03 µM. Topics: Antineoplastic Agents; Azoles; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Isoindoles; MCF-7 Cells; Neoplasms; Organoselenium Compounds; Thiadiazoles	2015

Article

Year

Synthesis and in vitro antiproliferative evaluation of novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone.

Chemical & pharmaceutical bulletin, 2015, Volume: 63, Issue:6

Novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone were designed, synthesized and evaluated for their in vitro antiproliferative activities by CCK-8 assay against three types of human cancer cell lines, SMMC-7721, MCF-7 and A549 cells. The preliminary bioassay results demonstrated that all tested compounds 4a-p showed potent antiproliferative activities, and some compounds exhibited better effects than positive control ethaselen and 5-fluorouracil (5-FU) against various cancer cell lines. Furthermore, compound 4g showed significant antiproliferative activities against SMMC-7721 cells with an IC50 value of 2.08 µM. Compounds 4b and 4m displayed highly effective biological activities against MCF-7 cells with an IC50 values of 2.03 and 2.06 µM, respectively. Compound 4i exhibited the best inhibitory effect against A549 cells with an IC50 value of 1.03 µM.

Topics: Antineoplastic Agents; Azoles; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Isoindoles; MCF-7 Cells; Neoplasms; Organoselenium Compounds; Thiadiazoles

2015