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(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid and gamma-aminobutyric acid

(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid has been researched along with gamma-aminobutyric acid in 31 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.45)18.2507
2000's24 (77.42)29.6817
2010's5 (16.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chebib, M; Johnston, GA; Mattsson, JP; Nilsson, K; Qiu, J; Rydström, K; Silverman, RB; Stevenson, SH1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Bang-Andersen, B; Ebert, B; Frølund, B; Hansen, CP; Jensen, AA; Kristiansen, U; Krogsgaard-Larsen, P; Larsen, M; Liljefors, T; Madsen, C; Nielsen, B1
Chebib, M; Hanrahan, JR; Hibbs, DE; Johnston, GA; Kim, HL; Kumar, RJ; Salam, NK1
Chebib, M; Doddareddy, MR; Gavande, N; Hanrahan, JR; Johnston, GA; Kim, HL1
Ballerini, L; Nistri, A; Rozzo, A1
Dreyfus, H; Jellali, A; Pattnaik, B; Picaud, S; Sahel, J1
Attwell, D; Billups, D; Hanley, JG; Moss, SJ; Orme, M1
Delaney, AJ; Sah, P1
Platt, B; White, AM1
Grillner, S; Hill, RH; Schmitt, DE1
Hull, C; von Gersdorff, H1
Barberis, A; Lu, C; Mozrzymas, JW; Vicini, S1
Khalili, P; Pan, Y; Qian, H; Ripps, H1
Gibbs, ME; Johnston, GA1
Calvo, DJ; Escobar, AL; Goutman, JD1
Ivanova, E; Müller, U; Wässle, H1
Lee, S; Zhou, ZJ1
Mulè, F; Serio, R; Zizzo, MG1
Molnar, A; Werblin, F1
Sastry, BR; Xu, JY; Yang, B1
Chupakhin, VI; Osolodkin, DI; Palyulin, VA; Zefirov, NS1
Fujiwara, A; Kamei, C; Takechi, K; Watanabe, Y1
Delgado, LM; Kähne, T; Palacios, AG; Schmachtenberg, O; Vielma, AH1
Gong, HQ; Liang, PJ; Liu, X; Zhang, YY1
Fu, Z; Vicini, S1
Albanna, W; Banat, M; Hescheler, J; Lüke, M; Schneider, T; Siapich, SA1
Angulo, MC; Audinat, E; Butt, AM; Maldonado, PP; Vélez-Fort, M1
Bruzik, KS; Frølund, B; Pepperberg, DR; Qian, H; Xie, A; Yue, L1
Aubrey, KR; Drew, GM; Jeong, HJ; Lau, BK; Vaughan, CW1
Hernández-Santos, JA; Martínez-Torres, A; Miledi, R; Reyes-Haro, D1

Other Studies

31 other study(ies) available for (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid and gamma-aminobutyric acid

ArticleYear
Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists.
    Bioorganic & medicinal chemistry letters, 1999, Nov-01, Volume: 9, Issue:21

    Topics: Animals; Brain; GABA Antagonists; Humans; Molecular Structure; Oocytes; Patch-Clamp Techniques; Phenols; Rats; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Xenopus

1999
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
    Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17

    Topics: Animals; Brain; Cell Line; GABA Agonists; GABA-A Receptor Agonists; Humans; Imidazoles; In Vitro Techniques; Ligands; Membrane Potentials; Models, Molecular; Mutation; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Protein Subunits; Radioligand Assay; Rats; Receptors, GABA; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship

2007
Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Animals; Female; GABA Antagonists; Ligands; Models, Molecular; Molecular Structure; Oocytes; Structure-Activity Relationship; Xenopus laevis

2008
Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of ρ1 GABAC Receptors.
    ACS medicinal chemistry letters, 2013, Apr-11, Volume: 4, Issue:4

    Topics:

2013
Antagonism by (1,2,5,6-tetrahydropyridine-4-yl) methylphosphinic acid of synaptic transmission in the neonatal rat spinal cord in vitro: an electrophysiological study.
    Neuroscience, 1999, Volume: 90, Issue:3

    Topics: Animals; Animals, Newborn; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Phosphinic Acids; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Spinal Cord; Synaptic Transmission

1999
GABAC receptors are localized with microtubule-associated protein 1B in mammalian cone photoreceptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Sep-15, Volume: 20, Issue:18

    Topics: Animals; Cell Separation; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C3H; Microtubule-Associated Proteins; Patch-Clamp Techniques; Pentobarbital; Phosphinic Acids; Pyridazines; Pyridines; Receptors, GABA; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells

2000
GABAC receptor sensitivity is modulated by interaction with MAP1B.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Dec-01, Volume: 20, Issue:23

    Topics: Amino Acid Transport Systems, Neutral; Animals; Binding Sites; Binding, Competitive; Blotting, Western; Carrier Proteins; Cells, Cultured; COS Cells; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Glutathione Transferase; Glycine Agents; Glycine Plasma Membrane Transport Proteins; In Vitro Techniques; Microtubule-Associated Proteins; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Peptides; Phosphinic Acids; Protein Structure, Tertiary; Pyridines; Receptors, GABA; Receptors, GABA-B; Recombinant Fusion Proteins; Retina; Transfection

2000
Pathway-specific targeting of GABA(A) receptor subtypes to somatic and dendritic synapses in the central amygdala.
    Journal of neurophysiology, 2001, Volume: 86, Issue:2

    Topics: Amygdala; Animals; Bicuculline; Dendrites; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Phosphinic Acids; Pyridines; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A; Synapses

2001
Gamma-aminobutyric acid-induced calcium signalling in rat superior collicular neurones.
    Neuroscience letters, 2002, Dec-13, Volume: 334, Issue:2

    Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Cytarabine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Isoxazoles; Neurons; Phosphinic Acids; Pyridines; Rats; Receptors, GABA; Superior Colliculi

2002
The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network.
    Journal of neurophysiology, 2004, Volume: 92, Issue:4

    Topics: Algorithms; Animals; Calcium Channel Blockers; Chloride Channels; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Lampreys; Locomotion; Models, Neurological; Nerve Net; Phosphinic Acids; Picrotoxin; Potassium Channels, Calcium-Activated; Propanolamines; Pyridazines; Pyridines; Receptors, GABA; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Spinal Cord

2004
Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal.
    Neuron, 2004, Oct-28, Volume: 44, Issue:3

    Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Chelating Agents; Chlorides; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Endocytosis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Goldfish; In Vitro Techniques; Ionophores; Membrane Potentials; Microscopy, Electron, Transmission; Models, Neurological; Neural Inhibition; Neurons; Nystatin; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Presynaptic Terminals; Pyridines; Quinoxalines; Retina; Time Factors; Valine

2004
Developmental changes of GABA synaptic transient in cerebellar granule cells.
    Molecular pharmacology, 2005, Volume: 67, Issue:4

    Topics: Age Factors; Animals; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Phosphinic Acids; Pyridines; Receptors, GABA-A; Synaptic Transmission

2005
Pharmacology of GABAC receptors: responses to agonists and antagonists distinguish A- and B-subtypes of homomeric rho receptors expressed in Xenopus oocytes.
    Neuroscience letters, 2005, Mar-07, Volume: 376, Issue:1

    Topics: Alanine; Animals; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Perches; Phosphinic Acids; Protein Conformation; Protein Subunits; Pyridines; Receptors, GABA; Taurine; Xenopus laevis

2005
Opposing roles for GABAA and GABAC receptors in short-term memory formation in young chicks.
    Neuroscience, 2005, Volume: 131, Issue:3

    Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Bicuculline; Chickens; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Inhibition, Psychological; Male; Memory, Short-Term; Organophosphates; ortho-Aminobenzoates; Phosphinic Acids; Pyridines; Receptors, GABA; Receptors, GABA-A; Reinforcement, Psychology; Retention, Psychology; Time Factors

2005
Analysis of macroscopic ionic currents mediated by GABArho1 receptors during lanthanide modulation predicts novel states controlling channel gating.
    British journal of pharmacology, 2005, Volume: 146, Issue:7

    Topics: Chloride Channels; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Lanthanoid Series Elements; Phosphinic Acids; Picrotoxin; Protein Subunits; Pyridines; Receptors, GABA

2005
Characterization of the glycinergic input to bipolar cells of the mouse retina.
    The European journal of neuroscience, 2006, Volume: 23, Issue:2

    Topics: Animals; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Green Fluorescent Proteins; Immunohistochemistry; In Vitro Techniques; Lewis X Antigen; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Protein Kinase C-alpha; Pyridazines; Pyridines; Receptors, Glycine; Retina; Strychnine; Synaptic Transmission; Time Factors; Transducin

2006
The synaptic mechanism of direction selectivity in distal processes of starburst amacrine cells.
    Neuron, 2006, Sep-21, Volume: 51, Issue:6

    Topics: Action Potentials; Amacrine Cells; Animals; Cadmium; Calcium; Cells, Cultured; GABA Antagonists; gamma-Aminobutyric Acid; Patch-Clamp Techniques; Phosphinic Acids; Potassium; Pyridazines; Pyridines; Rabbits; Receptors, GABA; Synaptic Transmission

2006
Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: role of GABA(A) and GABA(C) receptors.
    Neuropharmacology, 2007, Volume: 52, Issue:8

    Topics: Animals; Bicuculline; Cytarabine; Dose-Response Relationship, Drug; Drug Interactions; Duodenum; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Muscimol; Muscle Contraction; Muscle, Smooth; Phosphinic Acids; Pyridines; Receptors, GABA; Receptors, GABA-B

2007
Inhibitory feedback shapes bipolar cell responses in the rabbit retina.
    Journal of neurophysiology, 2007, Volume: 98, Issue:6

    Topics: Aminobutyrates; Animals; Axons; Electrophysiology; Feedback; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Image Processing, Computer-Assisted; In Vitro Techniques; Patch-Clamp Techniques; Phosphinic Acids; Photic Stimulation; Pyridines; Rabbits; Receptors, GABA; Retina; Retinal Bipolar Cells; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Strychnine

2007
The involvement of GABA-C receptors in paired-pulse depression of inhibitory postsynaptic currents in rat hippocampal CA1 pyramidal neurons.
    Experimental neurology, 2009, Volume: 216, Issue:1

    Topics: Animals; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Long-Term Synaptic Depression; Male; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Phosphinic Acids; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Receptors, GABA; Synaptic Transmission

2009
Molecular modeling of ligand-receptor interactions in GABA C receptor.
    Journal of molecular graphics & modelling, 2009, Volume: 27, Issue:7

    Topics: Amino Acid Sequence; Arginine; Binding Sites; Computer Simulation; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Phosphinic Acids; Protein Conformation; Pyridines; Receptors, GABA; Static Electricity; Tyrosine

2009
Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice.
    Epilepsy research, 2009, Volume: 84, Issue:2-3

    Topics: Animals; Anti-Bacterial Agents; Bicuculline; Brain; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electroencephalography; Epilepsy; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Nipecotic Acids; Oximes; Phosphinic Acids; Pyridines; Teicoplanin

2009
The GABAergic system in the retina of neonate and adult Octodon degus, studied by immunohistochemistry and electroretinography.
    The Journal of comparative neurology, 2009, Jun-10, Volume: 514, Issue:5

    Topics: Animals; Animals, Newborn; Bicuculline; Blotting, Western; Electroretinography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; Octodon; Phosphinic Acids; Photic Stimulation; Pyridines; Receptors, GABA; Retina; Sensory Thresholds; Signal Transduction; Ultraviolet Rays; Vision, Ocular

2009
The GABA(A) receptor-mediated inhibitory pathway increases the correlated activities in retinal ganglion cells.
    Sheng li xue bao : [Acta physiologica Sinica], 2009, Apr-25, Volume: 61, Issue:2

    Topics: Action Potentials; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mice; Muscimol; Phosphinic Acids; Pyridines; Receptors, GABA-A; Retina; Retinal Ganglion Cells

2009
Neuroligin-2 accelerates GABAergic synapse maturation in cerebellar granule cells.
    Molecular and cellular neurosciences, 2009, Volume: 42, Issue:1

    Topics: Animals; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Cerebellum; Coculture Techniques; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Humans; Inhibitory Postsynaptic Potentials; Membrane Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Protein Subunits; Pyridines; Receptors, GABA-A; RNA Interference; Synapses; Transfection; Zolpidem

2009
Antagonists of ionotropic gamma-aminobutyric acid receptors impair the NiCl2-mediated stimulation of the electroretinogram b-wave amplitude from the isolated superfused vertebrate retina.
    Acta ophthalmologica, 2009, Volume: 87, Issue:8

    Topics: Animals; Bicuculline; Calcium Channels; Calcium Channels, R-Type; Cation Transport Proteins; Cattle; Dose-Response Relationship, Drug; Drug Combinations; Electroretinography; GABA Antagonists; gamma-Aminobutyric Acid; Glycine Agents; In Vitro Techniques; Nickel; Night Vision; Phosphinic Acids; Photoreceptor Cells, Vertebrate; Pyridines; Receptors, Glycine; Retina; Signal Transduction; Strychnine

2009
Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, May-19, Volume: 30, Issue:20

    Topics: Age Factors; Animals; Animals, Newborn; Biophysics; Calcium; Cell Line, Transformed; Cerebral Cortex; Electric Conductivity; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Luminescent Proteins; Lysine; Mice; Mice, Transgenic; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oligodendroglia; Oximes; Patch-Clamp Techniques; Phosphinic Acids; Pyridazines; Pyridines; Quinoxalines; Statistics, Nonparametric; Stem Cells; Synapses; Synaptic Transmission

2010
Potentiating action of propofol at GABAA receptors of retinal bipolar cells.
    Investigative ophthalmology & visual science, 2011, Volume: 52, Issue:5

    Topics: Anesthetics, Intravenous; Animals; Drug Synergism; Electroretinography; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Membrane Potentials; Patch-Clamp Techniques; Phosphinic Acids; Propofol; Pyridines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, GABA-A; Retinal Bipolar Cells

2011
Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses.
    The Journal of physiology, 2017, 01-01, Volume: 595, Issue:1

    Topics: Animals; Calcium; Endocannabinoids; Female; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Methoxyhydroxyphenylglycol; Periaqueductal Gray; Phosphinic Acids; Piperidines; Pyrazoles; Pyridines; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses

2017
GABAρ selective antagonist TPMPA partially inhibits GABA-mediated currents recorded from neurones and astrocytes in mouse striatum.
    Neuropharmacology, 2017, Volume: 113, Issue:Pt A

    Topics: Animals; Astrocytes; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Transgenic; Neostriatum; Neural Inhibition; Neurons; Phosphinic Acids; Pyridines; Receptors, GABA-A

2017