Page last updated: 2024-09-27

delta-Thalassemia

A hereditary disorder characterized by reduced or absent DELTA-GLOBIN thus effecting the level of HEMOGLOBIN A2, a minor component of adult hemoglobin monitored in the diagnosis of BETA-THALASSEMIA.

Synonyms(1)

Synonym
delta-Thalassemia

Research

Studies (10)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (10.00)18.1394
2010's6 (60.00)28.8240
2020's3 (30.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
incb-0184240low10

Protein Targets (475)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Leukotriene C4 synthase0011
EWS/FLI fusion protein1001
tyrosine-protein kinase Yes1001
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0011
Serine/threonine-protein kinase PLK40011
Serine/threonine-protein kinase 250011
ATP-dependent RNA helicase DDX3X0011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70011
Serine/threonine-protein kinase Chk10011
Inhibitor of nuclear factor kappa-B kinase subunit beta0011
Peripheral plasma membrane protein CASK0011
Aurora kinase A0011
Cyclin-G-associated kinase0112
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0011
Muscle, skeletal receptor tyrosine-protein kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Mitogen-activated protein kinase 130011
3-phosphoinositide-dependent protein kinase 10011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
NUAK family SNF1-like kinase 10011
Dynamin-like 120 kDa protein, mitochondrial0011
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Tyrosine-protein kinase JAK20224
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 17B0011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Cyclin-dependent kinase 140011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Serine/threonine-protein kinase OSR10011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Serine/threonine-protein kinase Chk20011
Tyrosine-protein kinase ABL10011
Epidermal growth factor receptor0011
RAF proto-oncogene serine/threonine-protein kinase0011
Receptor tyrosine-protein kinase erbB-20011
High affinity nerve growth factor receptor0011
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20011
Cytochrome P450 1A20101
Protein kinase C beta type0011
Insulin receptor0011
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Macrophage colony-stimulating factor 1 receptor0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Proto-oncogene tyrosine-protein kinase ROS0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Serine/threonine-protein kinase A-Raf0011
Mast/stem cell growth factor receptor Kit0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Insulin receptor-related protein0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Platelet-derived growth factor receptor alpha0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
Vascular endothelial growth factor receptor 1 0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Interferon-induced, double-stranded RNA-activated protein kinase0011
Casein kinase II subunit alpha'0011
Serine/threonine-protein kinase MAK0011
Cyclin-dependent kinase 11B0011
Ephrin type-A receptor 10011
Fibroblast growth factor receptor 20011
Receptor tyrosine-protein kinase erbB-30011
Multifunctional protein ADE20011
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10224
Protein kinase C eta type0011
Cyclin-dependent kinase 20011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Activin receptor type-2A0011
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Ephrin type-B receptor 20011
Leukocyte tyrosine kinase receptor0011
Non-receptor tyrosine-protein kinase TYK20224
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
Tyrosine-protein kinase receptor UFO0011
Mitogen-activated protein kinase 40011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
G protein-coupled receptor kinase 40011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Prostaglandin G/H synthase 20011
Myosin-100011
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 30011
Vascular endothelial growth factor receptor 20011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0011
Serine/threonine-protein kinase mTOR0011
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase TXK0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
Tyrosine-protein kinase ZAP-700011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0011
MAP kinase-activated protein kinase 20011
Cyclin-dependent kinase 80011
Elongation factor Tu, mitochondrial0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Tyrosine-protein kinase Blk0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Cytoplasmic tyrosine-protein kinase BMX0011
cAMP-dependent protein kinase catalytic subunit PRKX0011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Serine/threonine-protein kinase Nek40011
Tyrosine-protein kinase JAK30213
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
Death-associated protein kinase 10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 120011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-B receptor 10011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Oxysterols receptor LXR-beta0101
Adenosine kinase0011
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10011
Receptor-interacting serine/threonine-protein kinase 40011
Spike glycoprotein1001
Ras-related protein Rab-100011
Cell division control protein 2 homolog0011
Actin-related protein 30011
Actin-related protein 20011
Calcium-dependent protein kinase 10011
GTP-binding nuclear protein Ran0011
Casein kinase II subunit alpha0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
Casein kinase I isoform gamma-20011
Mitogen-activated protein kinase kinase kinase 90011
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase 30011
Cyclin-dependent kinase-like 10011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Protein kinase C epsilon type0011
Dual specificity mitogen-activated protein kinase kinase 10011
Angiopoietin-1 receptor0011
Mitogen-activated protein kinase kinase kinase 100011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Tyrosine-protein kinase receptor TYRO30011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Tyrosine-protein kinase ITK/TSK0011
Myotonin-protein kinase0011
Mitogen-activated protein kinase kinase kinase kinase 20011
Mitogen-activated protein kinase kinase kinase 120011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Serine/threonine-protein kinase PAK 10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
cGMP-dependent protein kinase 20011
Integrin-linked protein kinase0011
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Serine/threonine-protein kinase PRP4 homolog0011
Receptor-interacting serine/threonine-protein kinase 10011
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Calcium/calmodulin-dependent protein kinase type 10011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Serine/threonine-protein kinase D10011
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40011
Ribosomal protein S6 kinase alpha-20011
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10112
Myosin light chain kinase 30011
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase TNNI3K0011
Leucine-rich repeat serine/threonine-protein kinase 20011
Serine/threonine-protein kinase MRCK alpha0011
Tyrosine-protein kinase JAK2 0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase Nek50011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Dual serine/threonine and tyrosine protein kinase0011
Mitogen-activated protein kinase kinase kinase 150011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Mitogen-activated protein kinase kinase kinase kinase 30011
Cyclin-dependent kinase-like 30011
MAP kinase-activated protein kinase 50011
Serine/threonine-protein kinase BRSK20011
Serine/threonine-protein kinase NIM10011
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Serine/threonine-protein kinase ULK20011
Misshapen-like kinase 10011
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Serine/threonine-protein kinase Nek70011
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
ATP-dependent RNA helicase DDX10011
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Mitogen-activated protein kinase kinase kinase kinase 10011
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
Cyclin-dependent kinase 150011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
SRSF protein kinase 10011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Serine/threonine-protein kinase 330011
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
Serine/threonine-protein kinase DCLK30011
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
Myosin light chain kinase 2, skeletal/cardiac muscle0011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase PAK 60011
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Serine/threonine-protein kinase 32B0011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase PLK20011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase PAK 50011
Serine/threonine-protein kinase 260011
eIF-2-alpha kinase GCN20011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
Phosphatidylinositol 4-kinase beta0011
Histone deacetylase 60101
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Death-associated protein kinase 20011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase tousled-like 10011
Serine/threonine-protein kinase TAO20011
ALK tyrosine kinase receptor0011
SRSF protein kinase 30011
Serine/threonine-protein kinase ICK0011
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase 38-like0011
Microtubule-associated serine/threonine-protein kinase 10011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]