White Muscle Disease

A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)

Synonyms(1)

Synonym
White Muscle Disease

Research Excerpts

Context

Excerpt	Reference
"White muscle disease has been observed in foals from birth to 1 year of age, particularly those foals born to dams fed selenium-deficient diets, during gestation."	( Löfstedt, J, 1997)

Research

Studies (57)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	40 (70.18)	23.3326
1990's	4 (7.02)	12.5806
2000's	7 (12.28)	18.1394
2010's	5 (8.77)	28.8240
2020's	1 (1.75)	9.53

Drug	Relationship Strength	Studies
carnitine	low	1
glycine	low	1
selenious acid	low	1
disulfiram	low	1
methionine	low	1
malondialdehyde	low	1
d-alpha tocopherol	medium	20
selenomethionine	low	1
sodium selenite	low	1
retinol	low	2
coenzyme q10	low	1
lysophosphatidylcholines	low	1
selenium	medium	46
ubiquinone	low	1
deoxyguanosine	low	1
8-hydroxy-2'-deoxyguanosine	low	1

Protein Targets (269)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Bile salt export pump	0	2	0	2
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
peripheral myelin protein 22	3	0	0	3
lamin isoform A-delta10	4	0	0	4
USP1 protein, partial	3	0	0	3
Microtubule-associated protein tau	3	0	0	3
AR protein	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
estrogen-related nuclear receptor alpha	5	0	0	5
estrogen nuclear receptor alpha	4	0	0	4
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
heat shock protein beta-1	3	0	0	3
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cellular tumor antigen p53	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
TDP1 protein	3	0	0	3
67.9K protein	1	0	0	1
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Cruzipain	2	0	0	2
Luciferase	1	0	0	1
acetylcholinesterase	2	0	0	2
thioredoxin reductase	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
RAR-related orphan receptor gamma	4	0	0	4
SMAD family member 2	3	0	0	3
ATAD5 protein, partial	1	0	0	1
Fumarate hydratase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
GLS protein	1	0	0	1
PPM1D protein	1	0	0	1
SMAD family member 3	3	0	0	3
GLI family zinc finger 3	2	0	0	2
Thrombopoietin	1	0	0	1
Smad3	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
hypothetical protein, conserved	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
progesterone receptor	2	0	0	2
regulator of G-protein signaling 4	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
nonstructural protein 1	1	0	0	1
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoid X nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	2	0	0	2
G	1	0	0	1
cytochrome P450 2D6	1	0	0	1
polyprotein	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
caspase-3	2	0	0	2
IDH1	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
type-1 angiotensin II receptor	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
perilipin-5	0	1	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
chromobox protein homolog 1	1	0	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	3	0	0	3
histone deacetylase 9 isoform 3	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
huntingtin isoform 2	1	0	0	1
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Vpr	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Amyloid-beta precursor protein	1	1	0	2
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Integrin beta-3	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Ornithine decarboxylase	1	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Replicase polyprotein 1a	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Glutamate receptor 2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	1	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
C-C chemokine receptor type 2	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Spike glycoprotein	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
TAR DNA-binding protein 43	1	0	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
GABA theta subunit	2	0	0	2
Inositol hexakisphosphate kinase 1	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Monoglyceride lipase	0	1	0	1
Ataxin-2	3	0	0	3
Angiotensin-converting enzyme 2	0	1	0	1
Gasdermin-D	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
heat shock protein 90, putative	0	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
large T antigen	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Proton-coupled amino acid transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
interleukin 8	1	0	0	1
pregnane X receptor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Nuclear receptor ROR-gamma	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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