Page last updated: 2024-09-27

Vulvar Vestibulitis

Inflammation of the vulvar vestibular region at the entrance of the VAGINA, generally involving surface mucosa and submucosal vestibular glands. It is characterized by ERYTHEMA and chronic recurrent pain in this area.

Synonyms(2)

Synonym
Vulvar Vestibulitis
Vulvar Vestibulitis Syndrome

Research

Studies (9)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's3 (33.33)18.1394
2010's4 (44.44)28.8240
2020's2 (22.22)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
gabapentin0low10
lidocaine0medium31
estriol0medium11
phenyl acetate0low10
capsaicin0low20
tamoxifen0medium11
ospemifene0medium11
montelukast0low10

Protein Targets (350)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase2002
RAR-related orphan receptor gamma3003
GLS protein2002
TDP1 protein3003
GLI family zinc finger 33003
Microtubule-associated protein tau3003
AR protein4004
aldehyde dehydrogenase 1 family, member A13003
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor3003
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha2002
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha3003
67.9K protein2002
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
chromobox protein homolog 13003
thyroid hormone receptor beta isoform 23003
mitogen-activated protein kinase 12002
nuclear factor erythroid 2-related factor 2 isoform 12002
DNA polymerase iota isoform a (long)1001
nuclear receptor ROR-gamma isoform 12002
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
transient receptor potential cation channel subfamily V member 11001
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi3205
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0101
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0505
NADH-ubiquinone oxidoreductase chain 10101
Cytochrome P450 1A20101
Polyunsaturated fatty acid 5-lipoxygenase0202
Gamma-aminobutyric acid receptor subunit beta-13205
Gamma-aminobutyric acid receptor subunit delta3205
Gamma-aminobutyric acid receptor subunit gamma-23216
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-53205
Gamma-aminobutyric acid receptor subunit alpha-33205
Cannabinoid receptor 10101
Acetylcholinesterase0101
Prostaglandin G/H synthase 10202
Gamma-aminobutyric acid receptor subunit gamma-13205
Gamma-aminobutyric acid receptor subunit alpha-23205
Gamma-aminobutyric acid receptor subunit alpha-43205
Gamma-aminobutyric acid receptor subunit gamma-33205
Gamma-aminobutyric acid receptor subunit alpha-63205
Cannabinoid receptor 2 0101
Nuclear receptor ROR-gamma1001
Spike glycoprotein2013
D(2) dopamine receptor0011
Gamma-aminobutyric acid receptor subunit alpha-13216
Gamma-aminobutyric acid receptor subunit beta-33205
Gamma-aminobutyric acid receptor subunit beta-23216
Inositol monophosphatase 11001
Potassium voltage-gated channel subfamily A member 10101
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
GABA theta subunit3205
Transient receptor potential cation channel subfamily V member 40011
Gamma-aminobutyric acid receptor subunit epsilon3205
Transient receptor potential cation channel subfamily V member 20011
ATP-dependent phosphofructokinase2002
glucocorticoid receptor [Homo sapiens]3003
geminin4004
Estrogen receptor0416
Glucocorticoid receptor0202
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Androgen receptor0303
UDP-glucuronosyltransferase 2B70001
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Sodium-dependent serotonin transporter0404
Alpha-synuclein1102
Solute carrier organic anion transporter family member 1A10101
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20011
UDP-glucuronosyltransferase 1A100001
USP1 protein, partial2002
thioredoxin glutathione reductase1001
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 43003
EWS/FLI fusion protein1001
euchromatic histone-lysine N-methyltransferase 24004
Bloom syndrome protein isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
muscarinic acetylcholine receptor M12002
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Chain A, Ferritin light chain2002
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
thioredoxin reductase2002
ATAD5 protein, partial1001
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B2002
arylsulfatase A2002
D(1A) dopamine receptor2002
thyroid hormone receptor beta isoform a1001
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 11001
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, Beta-lactamase2002
IDH12002
flap endonuclease 11001
Potassium channel subfamily K member 30101
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Canalicular multispecific organic anion transporter 10202
Multidrug and toxin extrusion protein 10101
Sodium channel protein type 3 subunit alpha0101
Epidermal growth factor receptor0202
Tyrosine-protein kinase Fyn0202
Beta-2 adrenergic receptor0202
Aldo-keto reductase family 1 member B10404
Alpha-2A adrenergic receptor0404
Adenosine receptor A30404
Cytochrome P450 2C80101
Muscarinic acetylcholine receptor M10404
Beta-3 adrenergic receptor0404
Alpha-1B adrenergic receptor0404
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30404
Substance-K receptor0404
Sodium-dependent noradrenaline transporter 0404
Thromboxane-A synthase 0202
D(3) dopamine receptor0404
Delta-type opioid receptor0404
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0404
Sodium-dependent dopamine transporter 0404
Uracil nucleotide/cysteinyl leukotriene receptor0101
Mitogen-activated protein kinase 140101
Leukotriene C4 synthase0101
Cysteinyl leukotriene receptor 10101
Cysteinyl leukotriene receptor 20101
Cysteinyl leukotriene receptor 10213
Chain A, CES1 protein0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit1001
SMAD family member 21001
Fumarate hydratase1001
PPM1D protein1001
SMAD family member 31001
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
caspase 7, apoptosis-related cysteine protease1001
retinoid X nuclear receptor alpha1001
farnesoid X nuclear receptor1001
polyprotein1001
caspase-31001
thyroid stimulating hormone receptor1001
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
vitamin D3 receptor isoform VDRA1001
caspase-31001
heat shock protein beta-11001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
M-phase phosphoprotein 81001
streptokinase A precursor0011
lethal factor (plasmid)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Interferon beta1001
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p531001
Integrin beta-31001
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Progesterone receptor0101
Procathepsin L0011
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10213
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40101
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0202
Cytochrome P450 2B60101
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Histamine H2 receptor1001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]