Page last updated: 2024-09-27

Upper Extremity Deformities, Congenital

Congenital structural abnormalities of the UPPER EXTREMITY.

Synonyms(2)

Synonym
Upper Extremity Deformities, Congenital
Upper Limb Deformities, Congenital

Research

Studies (37)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (2.70)23.3326
1990's0 (0.00)12.5806
2000's12 (32.43)18.1394
2010's18 (48.65)28.8240
2020's6 (16.22)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
cytosine0low10
carbamazepine0low20
valproic acid0low30
lamotrigine0low10
thalidomide0low60
quinazolines0low10
cadmium chloride0low10
trolamine salicylate0low10
oxcarbazepine0low10
buquineran0low10
methotrexate0low10
tretinoin0low10
retinol0low10
retinol palmitate0low10
atrial natriuretic factor0low10
guanine0low10
rifampin0low20
eye0low10

Protein Targets (448)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Chain A, Beta-lactamase2002
acetylcholinesterase2002
RAR-related orphan receptor gamma6006
USP1 protein, partial7007
TDP1 protein8008
AR protein7007
thyroid stimulating hormone receptor4004
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 15005
estrogen-related nuclear receptor alpha6006
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha110011
IDH13003
euchromatic histone-lysine N-methyltransferase 29009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 13003
geminin9009
Vpr1001
lamin isoform A-delta103003
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40506
Bile salt export pump0606
Bile salt export pump0909
Albumin0011
Major prion protein0011
Cellular tumor antigen p536006
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
Cytochrome P450 2C9 0112
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60022
Sodium channel protein type 4 subunit alpha0204
Cytochrome P450 2J20101
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
Canalicular multispecific organic anion transporter 10505
P2X purinoceptor 40202
GLI family zinc finger 37007
Deoxycytidine kinase0001
Luciferase3003
cytochrome P450 family 3 subfamily A polypeptide 45005
potassium voltage-gated channel subfamily H member 2 isoform d4004
Solute carrier family 22 member 1 0101
Nuclear receptor subfamily 1 group I member 20022
ATP-dependent translocase ABCB10101
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0314
Kappa-type opioid receptor0202
Histamine H1 receptor0101
Mu-type opioid receptor0213
D(3) dopamine receptor0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10202
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
thioredoxin reductase5005
GALC protein2002
EWS/FLI fusion protein3003
cytochrome P450 2D62002
Bloom syndrome protein isoform 16006
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
D(1A) dopamine receptor2002
muscarinic acetylcholine receptor M12002
Dihydrofolate reductase0426
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, Ferritin light chain3003
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial3003
phosphopantetheinyl transferase4004
ATAD5 protein, partial1001
Microtubule-associated protein tau5005
aldehyde dehydrogenase 1 family, member A18008
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor2002
retinoid X nuclear receptor alpha7007
farnesoid X nuclear receptor5005
67.9K protein1001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
Histone H2A.x2002
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
vitamin D3 receptor isoform VDRA4004
chromobox protein homolog 12002
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 25005
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 11001
snurportin-11001
nuclear factor erythroid 2-related factor 2 isoform 16006
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)3003
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 13003
peripheral myelin protein 225005
survival motor neuron protein isoform d3003
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 13003
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Voltage-dependent calcium channel gamma-2 subunit2002
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20314
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Glutamate receptor 22002
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein2002
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 431001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Solute carrier organic anion transporter family member 1B30204
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20102
ATP-dependent phosphofructokinase2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
nonstructural protein 12002
polyadenylate-binding protein 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor1001
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4116
Gamma-aminobutyric acid receptor subunit beta-14116
Gamma-aminobutyric acid receptor subunit delta4116
Gamma-aminobutyric acid receptor subunit gamma-24116
Gamma-aminobutyric acid receptor subunit alpha-54116
Gamma-aminobutyric acid receptor subunit alpha-34116
Gamma-aminobutyric acid receptor subunit gamma-14116
Gamma-aminobutyric acid receptor subunit alpha-24116
Gamma-aminobutyric acid receptor subunit alpha-44116
Gamma-aminobutyric acid receptor subunit gamma-34116
Gamma-aminobutyric acid receptor subunit alpha-64116
Gamma-aminobutyric acid receptor subunit alpha-14116
Gamma-aminobutyric acid receptor subunit beta-34116
Gamma-aminobutyric acid receptor subunit beta-24116
GABA theta subunit4116
Gamma-aminobutyric acid receptor subunit epsilon4116
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
GLS protein2002
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
G3003
caspase-31001
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
heat shock protein beta-14004
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90002
5-hydroxytryptamine receptor 40202
Carbonic anhydrase 10303
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Aldo-keto reductase family 1 member B10303
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Prostaglandin G/H synthase 10202
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0404
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
Inositol hexakisphosphate kinase 13003
UDP-glucuronosyltransferase 1A80001
cytochrome P450 2C9, partial3003
Epidermal growth factor receptor0101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Chain A, Cruzipain3003
interleukin 82002
pregnane X receptor3003
SMAD family member 21001
SMAD family member 31001
thyroid stimulating hormone receptor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear receptor ROR-gamma isoform 13003
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0202
Alpha-synuclein0303
Nuclear receptor ROR-gamma2114
Disintegrin and metalloproteinase domain-containing protein 171001
thioredoxin glutathione reductase2002
Rap guanine nucleotide exchange factor 31001
Guanine nucleotide-binding protein G1001
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Solute carrier organic anion transporter family member 2B1 0202
Albumin0112
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0202
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
Histamine H2 receptor1001
10 kDa heat shock protein, mitochondrial0202
Glutathione S-transferase omega-10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0101
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0202
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Solute carrier organic anion transporter family member 1B10203
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Cereblon isoform 40202
arylsulfatase A1001
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, Nuclear Receptor ROR-beta0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
hypoxia-inducible factor 1 alpha subunit1001
regulator of G-protein signaling 41001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
aryl hydrocarbon receptor1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
caspase-31001
Ornithine decarboxylase0001
Cytochrome P450 1A20011
Cytochrome P450 3A40011
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
Cytochrome P450 2D60011
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Alpha-1A adrenergic receptor0202
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Cocaine esterase0101
Histone deacetylase 30202
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]