Type 2 von Willebrand Disease

A subtype of von Willebrand disease that results from qualitative deficiencies of VON WILLEBRAND FACTOR. The subtype is divided into several variants with each variant having a distinctive pattern of PLATELET-interaction.

Synonyms(20)

Synonym
von Willebrand Disease, Type II
Type IIN von Willebrand Disease
Type IIM von Willebrand Disease
Type IIB von Willebrand Disease
Type IIA von Willebrand Disease
von Willebrand Disease, Type 2M
von Willebrand Disease, Type IIB
Type 2B von Willebrand Disease
Type 2N von Willebrand Disease
Type II von Willebrand Disease
Type 2A von Willebrand Disease
Type 2M von Willebrand Disease
von Willebrand Disease, Type 2
Type 2 von Willebrand Disease
von Willebrand Disease, Type 2N
von Willebrand Disease, Type 2B
von Willebrand Disease, Type 2A
von Willebrand Disease, Type IIA
von Willebrand Disease, Type IIM
von Willebrand Disease, Type IIN

Research Excerpts

Treatment

Excerpt	Reference
"Patients with type 1 and type 2 von Willebrand disease (VWD) can be treated with desmopressin."	( Atiq, F; Boender, J; Cnossen, MH; de Meris, J; Eikenboom, J; Fijnvandraat, K; Heijdra, J; Kempers, E; Krouwel, S; Leebeek, FWG; Maas, DPMSM; Meijer, K; Schols, SEM; Schoormans, SC; Snijders, F; van der Bom, JG; van Galen, KPM; van Heerde, WL, 2022)

Research

Studies (44)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	3 (6.82)	18.1394
2010's	38 (86.36)	28.8240
2020's	3 (6.82)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	2	0
aminocaproic acid	low	2	0
thalidomide	low	1	0
tranexamic acid	low	2	0
edetic acid	low	1	0
hydrazine	low	1	0
deoxycytidine	low	1	0
ferric chloride	low	1	0
gemcitabine	low	1	0
doripenem	low	1	0
fibrinogen	low	1	0
carbapenems	low	1	0
deamino arginine vasopressin	medium	17	2
cysteine	low	1	0
ristocetin	low	11	0
warfarin	low	1	0
amg531	low	1	0

Protein Targets (158)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	1	0	0	1
acetylcholinesterase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
estrogen receptor 2 (ER beta)	1	0	0	1
progesterone receptor	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
EWS/FLI fusion protein	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	4	0	0	4
G	2	0	0	2
cytochrome P450 2D6	2	0	0	2
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	3	0	0	3
heat shock protein beta-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	2	3
Thrombopoietin receptor	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, PLASMINOGEN	0	0	2	2
Chain A, PLASMINOGEN	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
ATAD5 protein, partial	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
regulator of G-protein signaling 4	1	0	0	1
nonstructural protein 1	1	0	0	1
glucocorticoid receptor [Homo sapiens]	2	0	0	2
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
chromobox protein homolog 1	1	0	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
geminin	2	0	0	2
histone acetyltransferase KAT2A isoform 1	1	0	0	1
lamin isoform A-delta10	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Plasminogen	0	4	2	6
Proton-coupled amino acid transporter 1	0	1	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
USP1 protein, partial	1	0	0	1
TDP1 protein	2	0	0	2
retinoid X nuclear receptor alpha	2	0	0	2
pregnane X nuclear receptor	2	0	0	2
vitamin D3 receptor isoform VDRA	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	1
Bile salt export pump	0	3	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Beta-lactamase	0	0	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Beta-lactamase TEM	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
AR protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
estrogen-related nuclear receptor alpha	2	0	0	2
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Cellular tumor antigen p53	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Glutamate receptor 2	1	0	0	1
Histamine H2 receptor	1	0	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Spike glycoprotein	0	0	1	1
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Cereblon isoform 4	0	2	0	2
GLI family zinc finger 3	2	0	0	2
Bloom syndrome protein isoform 1	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Urokinase-type plasminogen activator	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
PPM1D protein	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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