Page last updated: 2024-09-28

Sun Stroke

Heat stroke caused by exposure to the sun. It is characterized by dangerously high BODY TEMPERATURE; red, hot skin; DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.

Synonyms(2)

Synonym
Sun Stroke
Sunstroke

Research Excerpts

Overview

Excerpt	Reference
"Sunstroke is too restrictive to fit the multiplicity of regions and motifs."	( Arnold, WN; Loftus, LS, 1991)

Research

Studies (14)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	12 (85.71)	23.3326
1990's	1 (7.14)	12.5806
2000's	1 (7.14)	18.1394
2010's	0 (0.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
urea	low	1
chlorpromazine	low	1
isoproterenol	low	1
mannitol	low	1
xylitol	low	1
atropine	low	1
santonin	low	1
fibrin	low	1
digitoxin	low	1
D-fructopyranose	low	1
bilirubin	low	1
enerbol	low	1

Protein Targets (361)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
GLI family zinc finger 3	7	0	0	7
AR protein	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoid X nuclear receptor alpha	6	0	0	6
pregnane X nuclear receptor	5	0	0	5
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	2	0	2
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
5-hydroxytryptamine receptor 4	0	4	0	4
Bile salt export pump	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	3	1	6
Muscarinic acetylcholine receptor M4	0	3	1	6
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	1	7
Alpha-1D adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	0	4
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	1	3
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	3	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Cruzipain	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
USP1 protein, partial	3	0	0	3
Microtubule-associated protein tau	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	5	0	0	5
Caspase-7	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Proteasome subunit beta type-11	0	0	0	1
acetylcholinesterase	2	0	0	2
thioredoxin reductase	2	0	0	2
RAR-related orphan receptor gamma	3	0	0	3
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
TDP1 protein	3	0	0	3
Thrombopoietin	1	0	0	1
Smad3	2	0	0	2
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	3	0	0	3
progesterone receptor	2	0	0	2
NADPH oxidase 1	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
estrogen-related nuclear receptor alpha	6	0	0	6
farnesoid X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	5	0	0	5
G	1	0	0	1
cytochrome P450 2D6	2	0	0	2
polyprotein	1	0	0	1
67.9K protein	2	0	0	2
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Snq2p	0	0	0	1
caspase-3	2	0	0	2
IDH1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
Adenylate cyclase type 1	0	2	0	2
thyroid stimulating hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	3	0	0	3
Caspase-7	1	0	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
cytochrome P450 2D6 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
chromobox protein homolog 1	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
geminin	5	0	0	5
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Bile salt export pump	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	3	0	0	3
Major prion protein	0	0	1	1
Integrin beta-3	1	0	0	1
Cytochrome P450 1A2	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	2
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Cytochrome P450 2D6	0	1	1	2
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	3	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Alpha-1B adrenergic receptor	0	4	0	4
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	3	0	4
D(4) dopamine receptor	0	3	0	4
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	4	0	4
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Alpha-1D adrenergic receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
Trypanothione reductase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	1	2
D(3) dopamine receptor	0	3	0	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	4	0	4
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	1	1	1	3
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	2	0	3
Calmodulin	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	1	1	2
Glutamate receptor ionotropic, NMDA 2C	0	1	1	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	1	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	1	2
GABA theta subunit	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Ataxin-2	2	0	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	1	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
STAT3, partial	0	1	0	1
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Glutamate receptor 2	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
glp-1 receptor, partial	1	0	0	1
GLS protein	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
beta-2 adrenergic receptor	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-2 adrenergic receptor	0	2	2	5
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	0	2	2
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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