Sun Stroke

Heat stroke caused by exposure to the sun. It is characterized by dangerously high BODY TEMPERATURE; red, hot skin; DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.

Synonym
Sun Stroke
Sunstroke

Excerpt	Reference
"Sunstroke is too restrictive to fit the multiplicity of regions and motifs."	( Arnold, WN; Loftus, LS, 1991)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	12 (85.71)	23.3326
1990's	1 (7.14)	12.5806
2000's	1 (7.14)	18.1394
2010's	0 (0.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
urea	low	1
chlorpromazine	low	1
isoproterenol	low	1
mannitol	low	1
xylitol	low	1
atropine	low	1
santonin	low	1
fibrin	low	1
digitoxin	low	1
D-fructopyranose	low	1
bilirubin	low	1
enerbol	low	1

Protein Targets (361)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
GLI family zinc finger 3	7	0	0	7
AR protein	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoid X nuclear receptor alpha	6	0	0	6
pregnane X nuclear receptor	5	0	0	5
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	2	0	2
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
5-hydroxytryptamine receptor 4	0	4	0	4
Bile salt export pump	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	3	1	6
Muscarinic acetylcholine receptor M4	0	3	1	6
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	1	7
Alpha-1D adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	0	4
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	1	3
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	3	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Cruzipain	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
USP1 protein, partial	3	0	0	3
Microtubule-associated protein tau	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	5	0	0	5
Caspase-7	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Proteasome subunit beta type-11	0	0	0	1
acetylcholinesterase	2	0	0	2
thioredoxin reductase	2	0	0	2
RAR-related orphan receptor gamma	3	0	0	3
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
TDP1 protein	3	0	0	3
Thrombopoietin	1	0	0	1
Smad3	2	0	0	2
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	3	0	0	3
progesterone receptor	2	0	0	2
NADPH oxidase 1	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
estrogen-related nuclear receptor alpha	6	0	0	6
farnesoid X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	5	0	0	5
G	1	0	0	1
cytochrome P450 2D6	2	0	0	2
polyprotein	1	0	0	1
67.9K protein	2	0	0	2
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Snq2p	0	0	0	1
caspase-3	2	0	0	2
IDH1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
Adenylate cyclase type 1	0	2	0	2
thyroid stimulating hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	3	0	0	3
Caspase-7	1	0	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
cytochrome P450 2D6 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
chromobox protein homolog 1	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
geminin	5	0	0	5
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Bile salt export pump	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	3	0	0	3
Major prion protein	0	0	1	1
Integrin beta-3	1	0	0	1
Cytochrome P450 1A2	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	2
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Cytochrome P450 2D6	0	1	1	2
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	3	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Alpha-1B adrenergic receptor	0	4	0	4
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	3	0	4
D(4) dopamine receptor	0	3	0	4
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	4	0	4
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Alpha-1D adrenergic receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
Trypanothione reductase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	1	2
D(3) dopamine receptor	0	3	0	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	4	0	4
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	1	1	1	3
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	2	0	3
Calmodulin	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	1	1	2
Glutamate receptor ionotropic, NMDA 2C	0	1	1	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	1	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	1	2
GABA theta subunit	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Ataxin-2	2	0	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	1	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
STAT3, partial	0	1	0	1
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Glutamate receptor 2	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
glp-1 receptor, partial	1	0	0	1
GLS protein	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
beta-2 adrenergic receptor	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-2 adrenergic receptor	0	2	2	5
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	0	2	2
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Research

Studies (14)

Protein Targets (361)

Sun Stroke

Synonyms(2)

Research Excerpts

Overview

Research

Studies (14)

Drugs Studied (18)

Protein Targets (361)